run_metadata: 74174
This data as json
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| 74174 | SRR23576638 | SRX19463419 | SRS16856040 | SRP423783 | PRJNA937311 | Telomere elongation in the gut extends systemic healthspan of zebrafish | PRJNA937311 | Other | Telomere shortening is a hallmark of aging and is counteracted by telomerase. zebrafish gut is one of the organs with the fastest rate of telomere decline. However whether telomere dependent aging of an individual organ the gut causes systemic aging remains unknown. Here we show that preventing telomere shortening in the gut through tissue specific telomerase expression rescues premature aging of tert / . Conclusively we show that gut specific telomerase expression extends lifespan of tert / by 40 % while ameliorating natural aging. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish. | M3 | strain:AB|age:9 month|dev stage:adulte|sex:male|tissue:gut|biomaterial provider:EL MAI Mounir|birth date:2019/11/20|birth location:Nice France|treatment:gut tert without xxx R3|BioSampleModel:Model organism or animal | RNA Seq of Danio rerio : adult male gut | M3 | M3 | RNA Seq of Danio rerio : adult male gut | RNA-Seq | TRANSCRIPTOMIC | Oligo-dT | PAIRED | BGISEQ | BGISEQ-500 | SRP423783 | M3_1.fq.gz M3_2.fq.gz | fastq fastq | 10811204400.0 | 108112044.0 | M3 1.fq.gz | 0:100 1:100 | A:2826338851;C:2514522241;G:2594843889;T:2875499419;N:0 | 100 | 100 | 2826338851 | 2514522241 | 2594843889 | 2875499419 | 0 | SRX19463419 | SRS16856040 | SRA1593824 | Sun Yat-sen University Cancer Center|State Key Laboratory of Oncology in South China | Sun Yat-sen University Cancer Center Miguel Godinho Ferreira | 1 | 0.95049 | 0.05611 | 0.79127 | 0.60997 | 100 | B | usable mapping rate | bgi | bgi | unknown | poly_a | unknown | bulk | unknown | unknown | China | 2023-02-21 | Adult | Adult | Gut | Digestive System |