run_metadata: 59041
This data as json
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 59041 | SRR11578956 | SRX8146800 | SRS6509412 | SRP257662 | PRJNA627095 | Transcriptional profile of SAG neurod+ neuroblasts from clo mutant and sibling embryos at 54 hpf | PRJNA627095 | Other | In many organs stem cell function depends on the communication with their niche partners. Cranial sensory neurons develop in close proximity to blood vessels however whether vasculature is an integral component of their niches is yet unknown. Here two separate novel roles for vasculature in cranial sensory neurogenesis in zebrafish are uncovered. The first involves a restrain of neuroblast proliferation at early stages. The second instead requires blood flow to trigger a transcriptional response which has been identified thanks to a RNAseq analysis. This transcriptional change modifies neuroblast metabolic status and induces sensory neuron differentiation. Altogether we demonstrate that the cranial vasculature constitutes a hitherto unrecognized niche component of the sensory ganglia that regulates the pace of their growth and differentiation dynamics. | Clo | 54Clo3 | 54Clo3 | strain:TgBACneurod:gfpnl1|age:54 hpf|sex:not applicable|tissue:SAG tissue|collection date:2018 11 14|geo loc name:Spain: Barcelona|lat lon:41.3851 N 2.1734 E|filename:54Clo3 R1 001.fastq.gz|filename2:54Clo3 R2 001.fastq.gz|BioSampleModel:Model organism or animal | 54Clo3 | S6 | S6 | low input mRNA sequencing | RNA-Seq | TRANSCRIPTOMIC | PolyA | PAIRED | ILLUMINA | NextSeq 500 | SRP257662 | 54Clo3_R2_001.fastq.gz 54Clo3_R1_001.fastq.gz | fastq fastq | 5822390786.0 | 38650567.0 | 54Clo3 R1 001.fastq.gz | 0:75.32 1:75.32 | A:1619353584;C:1299190067;G:1337336722;T:1565486844;N:1023569 | 75 | 75 | 1619353584 | 1299190067 | 1337336722 | 1565486844 | 1023569 | SRX8146800 | SRS6509412 | SRA1067518 | UPF|Genomics | UPF | 2 | 0.91509 | 0.91425 | 0.10591 | 0.10604 | 0.76386 | 0.7693 | 0.46813 | 0.46524 | 76 | 76 | B | B | biological fallback assumption | illumina | nextseq | unknown | poly_a | unknown | bulk | unknown | unknown | Unknown | 2020-04-21 | Hatching | Embryo | Undetermined | Embryo Imprecise |