run_metadata: 39692
This data as json
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 39692 | SRR2051100 | SRX1048363 | SRS952727 | SRP059060 | PRJNA285816 | Danio rerio Raw sequence reads | PRJNA285816 | Whole Genome Sequencing | Here we have generated and validated zebrafish models for mild moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different concentrations of the prototypic OP compound chlorpyrifos oxon. Our results show that zebrafish models mimic most of the aspects of this toxidrome in humans including acetylcholinesterase inhibition NMDA receptor activation calcium dysregulation and inflammatory and immune response. | P28 | breed:Wild type|dev stage:larvae|sex:not applicable|tissue:whole organism|treatment:Moderate phenotype|BioSampleModel:Model organism or animal | D. rerio OP 1.0 uM CPO Rep 3 | P28 | 1 | 1 | RNA-Seq | TRANSCRIPTOMIC | unspecified | SINGLE | ILLUMINA | Illumina HiSeq 2500 | <SPOT_DESCRIPTOR><SPOT_DECODE_SPEC><SPOT_LENGTH>101</SPOT_LENGTH><READ_SPEC><READ_INDEX>0</READ_INDEX><READ_CLASS>Application Read</READ_CLASS><READ_TYPE>Forward</READ_TYPE><BASE_COORD>1</BASE_COORD></READ_SPEC></SPOT_DECODE_SPEC></SPOT_DESCRIPTOR> | SRP059060 | P28_EL4509_CAGATC_L008_R1_001.fastq.gz P28_EL4509_CAGATC_L007_R1_001.fastq.gz P28_EL4509_CAGATC_L002_R1_001.fastq.gz P28_EL4509_CAGATC_L001_R1_001.fastq.gz | fastq fastq fastq fastq | 4032678914.0 | 39927514.0 | P28 | 0:101 | A:1015356577;C:970369004;G:937306142;T:1108957703;N:689488 | 101 | 1015356577 | 970369004 | 937306142 | 1108957703 | 689488 | SRX1048363 | SRS952727 | SRA271167 | Mississippi State University|IGBB | US Army ERDC | 1 | 0.93887 | 0.13869 | 0.69079 | 0.52237 | 101 | B | usable mapping rate | illumina | hiseq_era | unknown | unknown | unknown | bulk | unknown | unknown | United States | 2015-06-04 | Larval | Larval | Whole Organism | All anatomical structures |