run_metadata: 31833
This data as json
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 31833 | SRR28700420 | SRX24268107 | SRS21034386 | SRP501894 | PRJNA1100624 | Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis | PRJNA1100624 | Other | Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP. | PN 4 | isolate:PN4|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 4|BioSampleModel:Model organism or animal | RNA Seq of zebrafish | PN 4 | PN 4 | Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library. | RNA-Seq | TRANSCRIPTOMIC | Oligo-dT | PAIRED | BGISEQ | BGISEQ-500 | SRP501894 | PN_4_1.fq.gz PN_4_2.fq.gz | fastq fastq | 6649316100.0 | 22164387.0 | PN 4 1.fq.gz | 0:150 1:150 | A:1809816121;C:1508072480;G:1528272654;T:1803154845;N:0 | 150 | 150 | 1809816121 | 1508072480 | 1528272654 | 1803154845 | 0 | SRX24268107 | SRS21034386 | Xiangyang No.1 People's Hospital, Hubei University of Medicine | B | B | biological fallback assumption | bgi | bgi | unknown | poly_a | unknown | bulk | unknown | unknown | China | 2024-04-15 | Larval | Larval | Undetermined | Undetermined |