rowid,run.accession,experiment.accession,sample.accession,study.accession,bioproject,study.title,study.alias,study.type,study.abstract,study.attributes,study.PMIDs,sample.description,sample.title,sample.alias,sample.centername,sample.attributes,GEOsample.title,GEOsample.dataprocessing,GEOsample.source,GEOsample.treatmentprotocol,GEOsample.extractprotocol,GEOsample.growthprotocol,GEOsample.characteristics,GEOsample.accession,experiment.title,experiment.alias,experiment.library_name,experiment.design_description,experiment.library_construction_protocol,experiment.attributes,experiment.library_strategy,experiment.library_source,experiment.library_selection,experiment.library_layout,experiment.platform,experiment.instrument_model,experiment.spot_descriptor,experiment.study_ref,run.title,run.attributes,run.filename,run.semantic_name,run.total_bases,run.total_spots,run.alias,run.read_lengths,run.base_counts,run.r1_length,run.r2_length,run.r3_length,run.r4_length,run.Acount,run.Ccount,run.Gcount,run.Tcount,run.Ncount,run.experiment,run.pool_member,submission.accession,submission.srasource,submission.bioprojectsource,seqdetective.n_mates,seqdetective.mapping_rate.mate1,seqdetective.mapping_rate.mate2,seqdetective.nofeature_rate.mate1,seqdetective.nofeature_rate.mate2,seqdetective.sparsity.mate1,seqdetective.sparsity.mate2,seqdetective.pos_strand_rate.mate1,seqdetective.pos_strand_rate.mate2,seqdetective.readlen.mate1,seqdetective.readlen.mate2,seqdetective.judgement.mate1,seqdetective.judgement.mate2,seqdetective.judgement.reason,platform_family,instrument_generation,read_bias,selection_class,prep_kit,sc_or_bulk,tech_class,technology,tech_variant,submission.bioprojectsource.country,earliest_date,devstage_curation,devstage_curation_coarse,tissue_curation,tissue_curation_coarse 30691,SRR28270998,SRX23880961,SRS20704477,SRP494117,PRJNA1085662,Roxithromycin exposure induces motoneuron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells,PRJNA1085662,Other,Roxithromycin ROX a commonly used macrolide antibiotic is extensively employed in human medicine and livestock industries. Due to its structural stability and resistance to biological degradation ROX persists as a resilient environmental contaminant detectable in aquatic ecosystems and food products. However our understanding of the potential health risks to humans from continuous ROX exposure remains limited. In this study we used the zebrafish as a vertebrate model to explore the potential developmental toxicity of early ROX exposure particularly focusing on its effects on locomotor functionality and motoneuron development. Early exposure to ROX induces marked developmental toxicity in zebrafish embryos significantly reducing hatch rates body lengths and increased malformation rates. Moreover ROX exposure adversely affected the locomotive capacity of zebrafish embryos and observations in transgenic zebrafish Tghb9:eGFP revealed axonal loss in motor neurons evident through reduced or irregular axonal lengths. Concurrently abnormal apoptosis in ROX exposed zebrafish embryos intensified alongside the upregulation of apoptosis related genes bax bcl2 caspase 3a. Single cell sequencing further disclosed substantial effects of ROX on genes involved in the differentiation of motor neuron progenitor cells ngn1 olig2 axon development cd82a mbpa plp1b sema5a and neuroimmunity aplnrb aplnra in zebrafish larvae. Furthermore the motor neuron defects induced by ROX can be rescued by administering ngn1 agonist. In summary ROX exposure leads to early life abnormalities in zebrafish motor neurons and locomotor behavior by hindering the differentiation of motor neuron progenitor cells and inducing abnormal apoptosis.,,,,,WT,,strain:not provided|isolate:not provided|breed:not provided|cultivar:not provided|ecotype:not provided|age:not provided|dev stage:not provided|collection date:not provided|geo loc name:not provided|sex:not provided|tissue:Cerebrum|BioSampleModel:Model organism or animal,,,,,,,,,Roxithromycin exposure induces mot1uron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells,DANIO,DANIO,Illumina Second Generation Sequencing,,,RNA-Seq,TRANSCRIPTOMIC,cDNA_oligo_dT,SINGLE,BGISEQ,BGISEQ-500,,SRP494117,,,WT_S1_L001_I1_001.fastq.gz,fastq,7991376264.0,998922033.0,WT S1 L001 I1 001.fastq.gz,0:8,A:2573734851;C:1426474966;G:1492966198;T:2498173074;N:27175,8,,,,2573734851,1426474966,1492966198,2498173074,27175,SRX23880961,SRS20704477,SRA1820072,shantou university|Neurobiology Center,shantou university,1,0.0,,0.0,,1.0,,,,8,,T,,under 1.2% mapping rate,bgi,bgi,unknown,poly_a,unknown,sc_generic,single_cell_generic,generic-scrnaseq-only,,China,2024-03-11,Undetermined,Multi-stage,Brain,Nervous System 35865,SRR33094447,SRX28358130,SRS24687221,SRP578075,PRJNA1249535,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,PRJNA1249535,Other,Single cell transcriptome sequencing provides high resolution transcriptome data on the molecular mechanisms by which Tau P301S mediates Alzheimer's disease like pathological changes in zebrafish providing unique insights into the pathogenesis of Tau pathology mediated cell to cell interactions in AD.,,,TauP301S 4,,TauP301S 4,,breed:zebrafish|age:4 month|collection date:2024 05 18|geo loc name:China:Shantou|sex:not determined|tissue:brain|BioSampleModel:Model organism or animal,,,,,,,,,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,TauP301S 4,TauP301S 4,tissue,,,RNA-Seq,TRANSCRIPTOMIC SINGLE CELL,PolyA,PAIRED,BGISEQ,BGISEQ-500,,SRP578075,,,AD4_S1_L001_R1_001.fastq.gz AD4_S1_L001_R2_001.fastq.gz,fastq fastq,129145897746.0,427635423.0,AD4 S1 L001 R1 001.fastq.gz,0:151 1:151,A:37870495722;C:24917123133;G:22536537853;T:43764941649;N:56799389,151,151,,,37870495722,24917123133,22536537853,43764941649,56799389,SRX28358130,SRS24687221,SRA2110625,Shantou university medical college|Neuroscience Center,Shantou university medical college,,,,,,,,,,,,T,B,mate1 technical by mapping diff,bgi,bgi,unknown,poly_a,unknown,sc,unknown,unknown,,China,2025-04-13,Adult,Adult,Brain,Nervous System 35866,SRR33094448,SRX28358129,SRS24687220,SRP578075,PRJNA1249535,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,PRJNA1249535,Other,Single cell transcriptome sequencing provides high resolution transcriptome data on the molecular mechanisms by which Tau P301S mediates Alzheimer's disease like pathological changes in zebrafish providing unique insights into the pathogenesis of Tau pathology mediated cell to cell interactions in AD.,,,TauP301S 3,,TauP301S 3,,breed:zebrafish|age:4 month|collection date:2024 05 17|geo loc name:China:Shantou|sex:not determined|tissue:brain|BioSampleModel:Model organism or animal,,,,,,,,,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,TauP301S 3,TauP301S 3,tissue,,,RNA-Seq,TRANSCRIPTOMIC SINGLE CELL,PolyA,PAIRED,BGISEQ,BGISEQ-500,,SRP578075,,,AD3_S1_L001_R1_001.fastq.gz AD3_S1_L001_R2_001.fastq.gz,fastq fastq,130723873718.0,432860509.0,AD3 S1 L001 R1 001.fastq.gz,0:151 1:151,A:38509426012;C:25238065771;G:22586405501;T:44332442791;N:57533643,151,151,,,38509426012,25238065771,22586405501,44332442791,57533643,SRX28358129,SRS24687220,SRA2110625,Shantou university medical college|Neuroscience Center,Shantou university medical college,,,,,,,,,,,,T,B,mate1 technical by mapping diff,bgi,bgi,unknown,poly_a,unknown,sc,unknown,unknown,,China,2025-04-13,Adult,Adult,Brain,Nervous System 35867,SRR33094449,SRX28358128,SRS24687219,SRP578075,PRJNA1249535,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,PRJNA1249535,Other,Single cell transcriptome sequencing provides high resolution transcriptome data on the molecular mechanisms by which Tau P301S mediates Alzheimer's disease like pathological changes in zebrafish providing unique insights into the pathogenesis of Tau pathology mediated cell to cell interactions in AD.,,,TauP301S 2,,TauP301S 2,,breed:zebrafish|age:4 month|collection date:2024 05 16|geo loc name:China:Shantou|sex:not determined|tissue:brain|BioSampleModel:Model organism or animal,,,,,,,,,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,TauP301S 2,TauP301S 2,tissue,,,RNA-Seq,TRANSCRIPTOMIC SINGLE CELL,PolyA,PAIRED,BGISEQ,BGISEQ-500,,SRP578075,,,AD2_S1_L001_R1_001.fastq.gz AD2_S1_L001_R2_001.fastq.gz,fastq fastq,130145208498.0,430944399.0,AD2 S1 L001 R1 001.fastq.gz,0:151 1:151,A:37802929660;C:22980541562;G:20982421471;T:48304142442;N:75173363,151,151,,,37802929660,22980541562,20982421471,48304142442,75173363,SRX28358128,SRS24687219,SRA2110625,Shantou university medical college|Neuroscience Center,Shantou university medical college,,,,,,,,,,,,T,B,mate1 technical by mapping diff,bgi,bgi,unknown,poly_a,unknown,sc,unknown,unknown,,China,2025-04-13,Adult,Adult,Brain,Nervous System 35868,SRR33094450,SRX28358127,SRS24687218,SRP578075,PRJNA1249535,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,PRJNA1249535,Other,Single cell transcriptome sequencing provides high resolution transcriptome data on the molecular mechanisms by which Tau P301S mediates Alzheimer's disease like pathological changes in zebrafish providing unique insights into the pathogenesis of Tau pathology mediated cell to cell interactions in AD.,,,TauP301S 1,,TauP301S 1,,breed:zebrafish|age:4 month|collection date:2024 05 15|geo loc name:China:Shantou|sex:not determined|tissue:brain|BioSampleModel:Model organism or animal,,,,,,,,,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,TauP301S 1,TauP301S 1,tissue,,,RNA-Seq,TRANSCRIPTOMIC SINGLE CELL,PolyA,PAIRED,BGISEQ,BGISEQ-500,,SRP578075,,,AD1_S1_L001_R1_001.fastq.gz AD1_S1_L001_R2_001.fastq.gz,fastq fastq,151897861402.0,502973051.0,AD1 S1 L001 R1 001.fastq.gz,0:151 1:151,A:44290580650;C:26864167508;G:24611898618;T:56043760812;N:87453814,151,151,,,44290580650,26864167508,24611898618,56043760812,87453814,SRX28358127,SRS24687218,SRA2110625,Shantou university medical college|Neuroscience Center,Shantou university medical college,,,,,,,,,,,,T,B,mate1 technical by mapping diff,bgi,bgi,unknown,poly_a,unknown,sc,unknown,unknown,,China,2025-04-13,Adult,Adult,Brain,Nervous System 35869,SRR33094451,SRX28358126,SRS24687216,SRP578075,PRJNA1249535,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,PRJNA1249535,Other,Single cell transcriptome sequencing provides high resolution transcriptome data on the molecular mechanisms by which Tau P301S mediates Alzheimer's disease like pathological changes in zebrafish providing unique insights into the pathogenesis of Tau pathology mediated cell to cell interactions in AD.,,,Wildtype2,,Wildtype2,,breed:zebrafish|age:4 month|collection date:2024 05 14|geo loc name:China:Shantou|sex:not determined|tissue:brain|BioSampleModel:Model organism or animal,,,,,,,,,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,Wildtype2,Wildtype2,tissue,,,RNA-Seq,TRANSCRIPTOMIC SINGLE CELL,PolyA,SINGLE,BGISEQ,BGISEQ-500,,SRP578075,,,WT2_S1_L001_I1_001.fastq.gz,fastq,15183539264.0,1897942408.0,WT2 S1 L001 I1 001.fastq.gz,0:8,A:5024041949;C:2632487194;G:2782260146;T:4744243552;N:506423,8,,,,5024041949,2632487194,2782260146,4744243552,506423,SRX28358126,SRS24687216,SRA2110625,Shantou university medical college|Neuroscience Center,Shantou university medical college,,,,,,,,,,,,T,,under 1.2% mapping rate,bgi,bgi,unknown,poly_a,unknown,sc,unknown,unknown,,China,2025-04-18,Adult,Adult,Brain,Nervous System 35870,SRR33094452,SRX28358125,SRS24687217,SRP578075,PRJNA1249535,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,PRJNA1249535,Other,Single cell transcriptome sequencing provides high resolution transcriptome data on the molecular mechanisms by which Tau P301S mediates Alzheimer's disease like pathological changes in zebrafish providing unique insights into the pathogenesis of Tau pathology mediated cell to cell interactions in AD.,,,Wildtype1,,Wildtype1,,breed:zebrafish|age:4 month|collection date:2024 05 13|geo loc name:China:Shantou|sex:not determined|tissue:brain|BioSampleModel:Model organism or animal,,,,,,,,,P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy,Wildtype1,Wildtype1,tissue,,,RNA-Seq,TRANSCRIPTOMIC SINGLE CELL,PolyA,SINGLE,BGISEQ,BGISEQ-500,,SRP578075,,,WT1_S1_L001_I1_001.fastq.gz,fastq,7991376264.0,998922033.0,WT1 S1 L001 I1 001.fastq.gz,0:8,A:2573734851;C:1426474966;G:1492966198;T:2498173074;N:27175,8,,,,2573734851,1426474966,1492966198,2498173074,27175,SRX28358125,SRS24687217,SRA2110625,Shantou university medical college|Neuroscience Center,Shantou university medical college,,,,,,,,,,,,T,,under 1.2% mapping rate,bgi,bgi,unknown,poly_a,unknown,sc,unknown,unknown,,China,2025-04-18,Adult,Adult,Brain,Nervous System 55992,SRR10895898,SRX7564581,SRS6001800,SRP241982,PRJNA599026,Project of basal ray finned fishes,PRJNA599026,Other,The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.,,pubmed:33545088;pubmed:12470943,,,Zebrafish 005,,strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult,CL100103858 L01 10,CL100103858 L01 10,,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM,PAIRED,BGISEQ,BGISEQ-500,,SRP241982,,,CL100103858_L01_513_1.fq.gz CL100103858_L01_513_2.fq.gz,fastq fastq,9129585000.0,91295850.0,CL100103858 L01 513 1.fq.gz,0:100 1:100,A:2497450580;C:2015129450;G:2071393661;T:2529809771;N:15801538,100,100,,,2497450580,2015129450,2071393661,2529809771,15801538,SRX7564581,SRS6001800,SRA1026516,BGI|BGI-Research,BGI,1,0.93396,,0.13,,0.71431,,0.54518,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-15,Adult,Adult,Brain,Nervous System 55993,SRR10895899,SRX7564580,SRS6001800,SRP241982,PRJNA599026,Project of basal ray finned fishes,PRJNA599026,Other,The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.,,pubmed:33545088;pubmed:12470943,,,Zebrafish 005,,strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult,CL100103858 L01 9,CL100103858 L01 9,,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM,PAIRED,BGISEQ,BGISEQ-500,,SRP241982,,,CL100103858_L01_509_2.fq.gz CL100103858_L01_509_1.fq.gz,fastq fastq,9063446600.0,90634466.0,CL100103858 L01 509 1.fq.gz,0:100 1:100,A:2470522817;C:2005905195;G:2066552125;T:2504876588;N:15589875,100,100,,,2470522817,2005905195,2066552125,2504876588,15589875,SRX7564580,SRS6001800,SRA1026516,BGI|BGI-Research,BGI,1,0.9334,,0.13676,,0.71614,,0.54289,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-15,Adult,Adult,Brain,Nervous System 55994,SRR10895900,SRX7564579,SRS6001800,SRP241982,PRJNA599026,Project of basal ray finned fishes,PRJNA599026,Other,The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.,,pubmed:33545088;pubmed:12470943,,,Zebrafish 005,,strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult,CL100103858 L01 8,CL100103858 L01 8,,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM,PAIRED,BGISEQ,BGISEQ-500,,SRP241982,,,CL100103858_L01_510_1.fq.gz CL100103858_L01_510_2.fq.gz,fastq fastq,10414313800.0,104143138.0,CL100103858 L01 510 1.fq.gz,0:100 1:100,A:2858166440;C:2289999240;G:2356174514;T:2892047112;N:17926494,100,100,,,2858166440,2289999240,2356174514,2892047112,17926494,SRX7564579,SRS6001800,SRA1026516,BGI|BGI-Research,BGI,1,0.93036,,0.13448,,0.71045,,0.53846,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-15,Adult,Adult,Brain,Nervous System 55995,SRR10895901,SRX7564578,SRS6001800,SRP241982,PRJNA599026,Project of basal ray finned fishes,PRJNA599026,Other,The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.,,pubmed:33545088;pubmed:12470943,,,Zebrafish 005,,strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult,CL100103858 L01 7,CL100103858 L01 7,,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM,PAIRED,BGISEQ,BGISEQ-500,,SRP241982,,,CL100103858_L01_511_2.fq.gz CL100103858_L01_511_1.fq.gz,fastq fastq,10057553400.0,100575534.0,CL100103858 L01 511 1.fq.gz,0:100 1:100,A:2762495630;C:2212266487;G:2274060113;T:2791456239;N:17274931,100,100,,,2762495630,2212266487,2274060113,2791456239,17274931,SRX7564578,SRS6001800,SRA1026516,BGI|BGI-Research,BGI,1,0.93578,,0.11695,,0.72005,,0.51093,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-15,Adult,Adult,Brain,Nervous System 55996,SRR10895903,SRX7564576,SRS6001800,SRP241982,PRJNA599026,Project of basal ray finned fishes,PRJNA599026,Other,The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.,,pubmed:33545088;pubmed:12470943,,,Zebrafish 005,,strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult,CL100103858 L01 6,CL100103858 L01 6,,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM,PAIRED,BGISEQ,BGISEQ-500,,SRP241982,,,CL100103858_L01_512_1.fq.gz CL100103858_L01_512_2.fq.gz,fastq fastq,8575207600.0,85752076.0,CL100103858 L01 512 1.fq.gz,0:100 1:100,A:2340755177;C:1898089765;G:1951995517;T:2369794410;N:14572731,100,100,,,2340755177,1898089765,1951995517,2369794410,14572731,SRX7564576,SRS6001800,SRA1026516,BGI|BGI-Research,BGI,1,0.93429,,0.12481,,0.71384,,0.52278,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-15,Adult,Adult,Brain,Nervous System 60203,SRR12173066,SRX8687829,SRS6966493,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,100B,GSM4661929,,source name:SCA12|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male,100B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA12,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M,GSM4661929,GSM4661929: 100B; Danio rerio; RNA Seq,GSM4661929,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661929,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,100B_2.fq 100B_1.fq,fastq fastq,4300755000.0,43007550.0,GSM4661929 r1,0:100 1:100,A:1195013481;C:933832983;G:962461499;T:1209447037;N:0,100,100,,,1195013481,933832983,962461499,1209447037,0,SRX8687829,SRS6966493,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91912,,0.15522,,0.71829,,0.50865,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60204,SRR12173065,SRX8687828,SRS6966492,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,99B,GSM4661928,,source name:SCA10|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male,99B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA10,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M,GSM4661928,GSM4661928: 99B; Danio rerio; RNA Seq,GSM4661928,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661928,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,99B_2.fq 99B_1.fq,fastq fastq,4953251000.0,49532510.0,GSM4661928 r1,0:100 1:100,A:1415039103;C:1040525484;G:1060332314;T:1437354099;N:0,100,100,,,1415039103,1040525484,1060332314,1437354099,0,SRX8687828,SRS6966492,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91619,,0.16544,,0.71922,,0.51996,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60205,SRR12173064,SRX8687827,SRS6966491,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,121B,GSM4661927,,source name:SCA14|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male,121B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA14,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M,GSM4661927,GSM4661927: 121B; Danio rerio; RNA Seq,GSM4661927,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661927,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,121B_1.fq 121B_2.fq,fastq fastq,4482694600.0,44826946.0,GSM4661927 r1,0:100 1:100,A:1292365837;C:920169200;G:950296696;T:1319862867;N:0,100,100,,,1292365837,920169200,950296696,1319862867,0,SRX8687827,SRS6966491,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90277,,0.17799,,0.72295,,0.51987,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60206,SRR12173063,SRX8687826,SRS6966490,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,97B,GSM4661926,,source name:SCA5|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male,97B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA5,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M,GSM4661926,GSM4661926: 97B; Danio rerio; RNA Seq,GSM4661926,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661926,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,97B_1.fq 97B_2.fq,fastq fastq,5178357000.0,51783570.0,GSM4661926 r1,0:100 1:100,A:1442148425;C:1119935128;G:1149243236;T:1467030211;N:0,100,100,,,1442148425,1119935128,1149243236,1467030211,0,SRX8687826,SRS6966490,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91869,,0.1619,,0.71047,,0.50907,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60207,SRR12173062,SRX8687825,SRS6966489,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,80B,GSM4661925,,source name:SCA8|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female,80B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA8,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F,GSM4661925,GSM4661925: 80B; Danio rerio; RNA Seq,GSM4661925,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661925,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,80B_1.fq 80B_2.fq,fastq fastq,4927736800.0,49277368.0,GSM4661925 r1,0:100 1:100,A:1384189069;C:1048151377;G:1079300714;T:1416095640;N:0,100,100,,,1384189069,1048151377,1079300714,1416095640,0,SRX8687825,SRS6966489,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.9104,,0.17333,,0.71102,,0.50853,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60208,SRR12173061,SRX8687824,SRS6966488,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,79B,GSM4661924,,source name:SCA7|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female,79B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA7,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F,GSM4661924,GSM4661924: 79B; Danio rerio; RNA Seq,GSM4661924,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661924,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,79B_1.fq 79B_2.fq,fastq fastq,5158717400.0,51587174.0,GSM4661924 r1,0:100 1:100,A:1423369091;C:1127803059;G:1156903341;T:1450641909;N:0,100,100,,,1423369091,1127803059,1156903341,1450641909,0,SRX8687824,SRS6966488,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91578,,0.15498,,0.70841,,0.50875,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60209,SRR12173060,SRX8687823,SRS6966487,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,78B,GSM4661923,,source name:SCA6|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female,78B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA6,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F,GSM4661923,GSM4661923: 78B; Danio rerio; RNA Seq,GSM4661923,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661923,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,78B_2.fq 78B_1.fq,fastq fastq,4080284000.0,40802840.0,GSM4661923 r1,0:100 1:100,A:1146760011;C:872005355;G:893480498;T:1168038136;N:0,100,100,,,1146760011,872005355,893480498,1168038136,0,SRX8687823,SRS6966487,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.89506,,0.16061,,0.7147,,0.51109,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60210,SRR12173059,SRX8687822,SRS6966486,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,77B,GSM4661922,,source name:SCA4|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female,77B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA4,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F,GSM4661922,GSM4661922: 77B; Danio rerio; RNA Seq,GSM4661922,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661922,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,77B_1.fq 77B_2.fq,fastq fastq,5053965200.0,50539652.0,GSM4661922 r1,0:100 1:100,A:1432899891;C:1065155546;G:1092749323;T:1463160440;N:0,100,100,,,1432899891,1065155546,1092749323,1463160440,0,SRX8687822,SRS6966486,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90965,,0.17028,,0.71259,,0.51804,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60211,SRR12173058,SRX8687821,SRS6966485,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,95B,GSM4661921,,source name:PH8|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male,95B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH8,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M,GSM4661921,GSM4661921: 95B; Danio rerio; RNA Seq,GSM4661921,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661921,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,95B_2.fq 95B_1.fq,fastq fastq,4984910800.0,49849108.0,GSM4661921 r1,0:100 1:100,A:1404088729;C:1063272664;G:1094657988;T:1422891419;N:0,100,100,,,1404088729,1063272664,1094657988,1422891419,0,SRX8687821,SRS6966485,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91574,,0.16729,,0.71776,,0.51526,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60212,SRR12173057,SRX8687820,SRS6966484,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,94B,GSM4661920,,source name:PH7|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male,94B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH7,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M,GSM4661920,GSM4661920: 94B; Danio rerio; RNA Seq,GSM4661920,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661920,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,94B_2.fq 94B_1.fq,fastq fastq,4973104000.0,49731040.0,GSM4661920 r1,0:100 1:100,A:1403074698;C:1055981307;G:1089110444;T:1424937551;N:0,100,100,,,1403074698,1055981307,1089110444,1424937551,0,SRX8687820,SRS6966484,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91432,,0.16183,,0.72001,,0.51323,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60213,SRR12173056,SRX8687819,SRS6966483,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,93B,GSM4661919,,source name:PH6|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male,93B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH6,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M,GSM4661919,GSM4661919: 93B; Danio rerio; RNA Seq,GSM4661919,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661919,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,93B_2.fq 93B_1.fq,fastq fastq,4896774400.0,48967744.0,GSM4661919 r1,0:100 1:100,A:1403923710;C:1011507726;G:1048273729;T:1433069235;N:0,100,100,,,1403923710,1011507726,1048273729,1433069235,0,SRX8687819,SRS6966483,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91124,,0.1598,,0.72247,,0.54532,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60214,SRR12173055,SRX8687818,SRS6966482,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,92B,GSM4661918,,source name:PH4|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male,92B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH4,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M,GSM4661918,GSM4661918: 92B; Danio rerio; RNA Seq,GSM4661918,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661918,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,92B_1.fq 92B_2.fq,fastq fastq,5153962600.0,51539626.0,GSM4661918 r1,0:100 1:100,A:1429538166;C:1118723084;G:1151444792;T:1454256558;N:0,100,100,,,1429538166,1118723084,1151444792,1454256558,0,SRX8687818,SRS6966482,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91817,,0.15904,,0.71088,,0.51009,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60215,SRR12173054,SRX8687817,SRS6966481,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,75B,GSM4661917,,source name:PH10|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female,75B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH10,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F,GSM4661917,GSM4661917: 75B; Danio rerio; RNA Seq,GSM4661917,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661917,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,75B_1.fq 75B_2.fq,fastq fastq,4868261600.0,48682616.0,GSM4661917 r1,0:100 1:100,A:1376009816;C:1028298503;G:1057930129;T:1406023152;N:0,100,100,,,1376009816,1028298503,1057930129,1406023152,0,SRX8687817,SRS6966481,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.9126,,0.1697,,0.71638,,0.50591,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60216,SRR12173053,SRX8687816,SRS6966480,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,74B,GSM4661916,,source name:PH9|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female,74B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH9,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F,GSM4661916,GSM4661916: 74B; Danio rerio; RNA Seq,GSM4661916,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661916,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,74B_1.fq 74B_2.fq,fastq fastq,5179173200.0,51791732.0,GSM4661916 r1,0:100 1:100,A:1449133916;C:1117631254;G:1139937410;T:1472470620;N:0,100,100,,,1449133916,1117631254,1139937410,1472470620,0,SRX8687816,SRS6966480,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91222,,0.16046,,0.71029,,0.50076,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60217,SRR12173052,SRX8687815,SRS6966479,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,72B,GSM4661915,,source name:PH2|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female,72B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH2,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F,GSM4661915,GSM4661915: 72B; Danio rerio; RNA Seq,GSM4661915,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661915,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,72B_1.fq 72B_2.fq,fastq fastq,5878512600.0,58785126.0,GSM4661915 r1,0:100 1:100,A:1639773073;C:1271766251;G:1298391071;T:1668582205;N:0,100,100,,,1639773073,1271766251,1298391071,1668582205,0,SRX8687815,SRS6966479,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91084,,0.16615,,0.70713,,0.5033,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60218,SRR12173051,SRX8687814,SRS6966478,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,71B,GSM4661914,,source name:PH1|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female,71B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH1,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F,GSM4661914,GSM4661914: 71B; Danio rerio; RNA Seq,GSM4661914,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661914,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,71B_1.fq 71B_2.fq,fastq fastq,2921419400.0,29214194.0,GSM4661914 r1,0:100 1:100,A:838032642;C:606973028;G:618918524;T:857495206;N:0,100,100,,,838032642,606973028,618918524,857495206,0,SRX8687814,SRS6966478,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90765,,0.17712,,0.71015,,0.48691,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60219,SRR12173050,SRX8687813,SRS6966477,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,173B,GSM4661913,,source name:SCA10|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male,173B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA10,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M,GSM4661913,GSM4661913: 173B; Danio rerio; RNA Seq,GSM4661913,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661913,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB44-68_1.fq.gz V300016697_L3_DKRT190808OligoTB44-68_2.fq.gz,fastq fastq,4933950400.0,49339504.0,GSM4661913 r1,0:100 1:100,A:1477278267;C:971417805;G:982397108;T:1502857220;N:0,100,100,,,1477278267,971417805,982397108,1502857220,0,SRX8687813,SRS6966477,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90094,,0.26419,,0.73066,,0.51886,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60220,SRR12173049,SRX8687812,SRS6966476,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,172B,GSM4661912,,source name:SCA7|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male,172B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA7,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M,GSM4661912,GSM4661912: 172B; Danio rerio; RNA Seq,GSM4661912,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661912,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB43-67_1.fq.gz V300016697_L3_DKRT190808OligoTB43-67_2.fq.gz,fastq fastq,4916317800.0,49163178.0,GSM4661912 r1,0:100 1:100,A:1456100891;C:983643530;G:996293468;T:1480279911;N:0,100,100,,,1456100891,983643530,996293468,1480279911,0,SRX8687812,SRS6966476,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90484,,0.24497,,0.72563,,0.51605,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60221,SRR12173048,SRX8687811,SRS6966475,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,171B,GSM4661911,,source name:SCA5|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male,171B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA5,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M,GSM4661911,GSM4661911: 171B; Danio rerio; RNA Seq,GSM4661911,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661911,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB42-66_1.fq.gz V300016697_L3_DKRT190808OligoTB42-66_2.fq.gz,fastq fastq,4935261800.0,49352618.0,GSM4661911 r1,0:100 1:100,A:1445056643;C:1003559733;G:1015728708;T:1470916716;N:0,100,100,,,1445056643,1003559733,1015728708,1470916716,0,SRX8687811,SRS6966475,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90817,,0.23047,,0.72086,,0.5134,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60222,SRR12173047,SRX8687810,SRS6966474,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,170B,GSM4661910,,source name:SCA3|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male,170B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA3,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M,GSM4661910,GSM4661910: 170B; Danio rerio; RNA Seq,GSM4661910,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661910,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB41-65_1.fq.gz V300016697_L3_DKRT190808OligoTB41-65_2.fq.gz,fastq fastq,4925193600.0,49251936.0,GSM4661910 r1,0:100 1:100,A:1463488890;C:982336799;G:993110731;T:1486257180;N:0,100,100,,,1463488890,982336799,993110731,1486257180,0,SRX8687810,SRS6966474,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90727,,0.24322,,0.72659,,0.52026,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60223,SRR12173046,SRX8687809,SRS6966473,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,168B,GSM4661909,,source name:SCA9|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female,168B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA9,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F,GSM4661909,GSM4661909: 168B; Danio rerio; RNA Seq,GSM4661909,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661909,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB40-64_1.fq.gz V300016697_L3_DKRT190808OligoTB40-64_2.fq.gz,fastq fastq,4921204600.0,49212046.0,GSM4661909 r1,0:100 1:100,A:1472696868;C:970527278;G:980479163;T:1497501291;N:0,100,100,,,1472696868,970527278,980479163,1497501291,0,SRX8687809,SRS6966473,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.89853,,0.26909,,0.72934,,0.50679,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60224,SRR12173045,SRX8687808,SRS6966472,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,167B,GSM4661908,,source name:SCA8|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female,167B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA8,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F,GSM4661908,GSM4661908: 167B; Danio rerio; RNA Seq,GSM4661908,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661908,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB39-63_1.fq.gz V300016697_L3_DKRT190808OligoTB39-63_2.fq.gz,fastq fastq,4929648000.0,49296480.0,GSM4661908 r1,0:100 1:100,A:1444571687;C:1001131050;G:1014059660;T:1469885603;N:0,100,100,,,1444571687,1001131050,1014059660,1469885603,0,SRX8687808,SRS6966472,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90469,,0.23511,,0.71644,,0.50939,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60225,SRR12173044,SRX8687807,SRS6966471,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,166B,GSM4661907,,source name:SCA6|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female,166B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA6,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F,GSM4661907,GSM4661907: 166B; Danio rerio; RNA Seq,GSM4661907,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661907,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB38-62_1.fq.gz V300016697_L3_DKRT190808OligoTB38-62_2.fq.gz,fastq fastq,4934480200.0,49344802.0,GSM4661907 r1,0:100 1:100,A:1465270023;C:983677716;G:995361912;T:1490170549;N:0,100,100,,,1465270023,983677716,995361912,1490170549,0,SRX8687807,SRS6966471,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.89941,,0.25615,,0.72127,,0.50512,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60226,SRR12173043,SRX8687806,SRS6966470,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,165B,GSM4661906,,source name:SCA4|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female,165B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA4,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F,GSM4661906,GSM4661906: 165B; Danio rerio; RNA Seq,GSM4661906,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661906,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB37-61_1.fq.gz V300016697_L3_DKRT190808OligoTB37-61_2.fq.gz,fastq fastq,4919775200.0,49197752.0,GSM4661906 r1,0:100 1:100,A:1439207243;C:1003073787;G:1015357028;T:1462137142;N:0,100,100,,,1439207243,1003073787,1015357028,1462137142,0,SRX8687806,SRS6966470,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90664,,0.23232,,0.71652,,0.49875,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60227,SRR12173042,SRX8687805,SRS6966469,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,163B,GSM4661905,,source name:PH9|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male,163B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH9,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M,GSM4661905,GSM4661905: 163B; Danio rerio; RNA Seq,GSM4661905,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661905,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB36-60_1.fq.gz V300016697_L3_DKRT190808OligoTB36-60_2.fq.gz,fastq fastq,4916788400.0,49167884.0,GSM4661905 r1,0:100 1:100,A:1450695371;C:989044062;G:1001626000;T:1475422967;N:0,100,100,,,1450695371,989044062,1001626000,1475422967,0,SRX8687805,SRS6966469,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90357,,0.24123,,0.72023,,0.50955,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60228,SRR12173041,SRX8687804,SRS6966468,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,161B,GSM4661904,,source name:PH6|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male,161B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH6,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M,GSM4661904,GSM4661904: 161B; Danio rerio; RNA Seq,GSM4661904,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661904,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB35-59_1.fq.gz V300016697_L3_DKRT190808OligoTB35-59_2.fq.gz,fastq fastq,4926157600.0,49261576.0,GSM4661904 r1,0:100 1:100,A:1467853995;C:977298660;G:990198306;T:1490806639;N:0,100,100,,,1467853995,977298660,990198306,1490806639,0,SRX8687804,SRS6966468,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.9013,,0.25482,,0.72912,,0.51654,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60229,SRR12173040,SRX8687803,SRS6966467,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,160B,GSM4661903,,source name:PH12|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male,160B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH12,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M,GSM4661903,GSM4661903: 160B; Danio rerio; RNA Seq,GSM4661903,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661903,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB34-58_1.fq.gz V300016697_L3_DKRT190808OligoTB34-58_2.fq.gz,fastq fastq,4937891400.0,49378914.0,GSM4661903 r1,0:100 1:100,A:1466862905;C:983988502;G:997702772;T:1489337221;N:0,100,100,,,1466862905,983988502,997702772,1489337221,0,SRX8687803,SRS6966467,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.8994,,0.2581,,0.72906,,0.51649,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60230,SRR12173039,SRX8687802,SRS6966466,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,159B,GSM4661902,,source name:PH11|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male,159B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH11,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M,GSM4661902,GSM4661902: 159B; Danio rerio; RNA Seq,GSM4661902,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661902,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB33-57_1.fq.gz V300016697_L3_DKRT190808OligoTB33-57_2.fq.gz,fastq fastq,4912693200.0,49126932.0,GSM4661902 r1,0:100 1:100,A:1466260254;C:970920251;G:984105331;T:1491407364;N:0,100,100,,,1466260254,970920251,984105331,1491407364,0,SRX8687802,SRS6966466,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90041,,0.25314,,0.73381,,0.53543,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60231,SRR12173038,SRX8687801,SRS6966465,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,158B,GSM4661901,,source name:PH16|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female,158B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH16,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F,GSM4661901,GSM4661901: 158B; Danio rerio; RNA Seq,GSM4661901,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661901,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB32-56_1.fq.gz V300016697_L3_DKRT190808OligoTB32-56_2.fq.gz,fastq fastq,4945853000.0,49458530.0,GSM4661901 r1,0:100 1:100,A:1483522148;C:971739399;G:982030279;T:1508561174;N:0,100,100,,,1483522148,971739399,982030279,1508561174,0,SRX8687801,SRS6966465,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.89835,,0.26809,,0.73036,,0.51167,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60232,SRR12173037,SRX8687800,SRS6966464,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,157B,GSM4661900,,source name:PH5|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female,157B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH5,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F,GSM4661900,GSM4661900: 157B; Danio rerio; RNA Seq,GSM4661900,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661900,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L3_DKRT190808OligoTB31-55_2.fq.gz V300016697_L3_DKRT190808OligoTB31-55_1.fq.gz,fastq fastq,4930661000.0,49306610.0,GSM4661900 r1,0:100 1:100,A:1479111656;C:968782080;G:980526976;T:1502240288;N:0,100,100,,,1479111656,968782080,980526976,1502240288,0,SRX8687800,SRS6966464,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.8997,,0.26769,,0.72894,,0.52069,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60233,SRR12173036,SRX8687799,SRS6966463,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,156B,GSM4661899,,source name:PH4|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female,156B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH4,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F,GSM4661899,GSM4661899: 156B; Danio rerio; RNA Seq,GSM4661899,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661899,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L2_DKRT190808OligoTB30-54_1.fq.gz V300016697_L2_DKRT190808OligoTB30-54_2.fq.gz,fastq fastq,5008041200.0,50080412.0,GSM4661899 r1,0:100 1:100,A:1499313897;C:986298102;G:997520882;T:1524908319;N:0,100,100,,,1499313897,986298102,997520882,1524908319,0,SRX8687799,SRS6966463,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.89791,,0.26891,,0.72782,,0.50905,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60234,SRR12173035,SRX8687798,SRS6966462,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,155B,GSM4661898,,source name:PH3|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female,155B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH3,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F,GSM4661898,GSM4661898: 155B; Danio rerio; RNA Seq,GSM4661898,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661898,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L2_DKRT190808OligoTB29-53_1.fq.gz V300016697_L2_DKRT190808OligoTB29-53_2.fq.gz,fastq fastq,5012833000.0,50128330.0,GSM4661898 r1,0:100 1:100,A:1498301491;C:989903310;G:1001505041;T:1523123158;N:0,100,100,,,1498301491,989903310,1001505041,1523123158,0,SRX8687798,SRS6966462,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90134,,0.26756,,0.72535,,0.49696,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60235,SRR12173034,SRX8687797,SRS6966461,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,40B,GSM4661897,,source name:SCA17|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male,40B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA17,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M,GSM4661897,GSM4661897: 40B; Danio rerio; RNA Seq,GSM4661897,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661897,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L2_DKRT190808OligoTB28-52_1.fq.gz V300016697_L2_DKRT190808OligoTB28-52_2.fq.gz,fastq fastq,5024116600.0,50241166.0,GSM4661897 r1,0:100 1:100,A:1477107167;C:1016848490;G:1027973874;T:1502187069;N:0,100,100,,,1477107167,1016848490,1027973874,1502187069,0,SRX8687797,SRS6966461,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90915,,0.22952,,0.71658,,0.49092,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60236,SRR12173033,SRX8687796,SRS6966460,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,38B,GSM4661896,,source name:SCA10|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male,38B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA10,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M,GSM4661896,GSM4661896: 38B; Danio rerio; RNA Seq,GSM4661896,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661896,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L2_DKRT190808OligoTB27-51_1.fq.gz V300016697_L2_DKRT190808OligoTB27-51_2.fq.gz,fastq fastq,5008056600.0,50080566.0,GSM4661896 r1,0:100 1:100,A:1461495870;C:1022836043;G:1036957625;T:1486767062;N:0,100,100,,,1461495870,1022836043,1036957625,1486767062,0,SRX8687796,SRS6966460,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91105,,0.21297,,0.71419,,0.51046,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60237,SRR12173032,SRX8687795,SRS6966459,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,37B,GSM4661895,,source name:SCA6|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male,37B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA6,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M,GSM4661895,GSM4661895: 37B; Danio rerio; RNA Seq,GSM4661895,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661895,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L2_DKRT190808OligoTB26-50_1.fq.gz V300016697_L2_DKRT190808OligoTB26-50_2.fq.gz,fastq fastq,4970945000.0,49709450.0,GSM4661895 r1,0:100 1:100,A:1452650065;C:1013500708;G:1027205899;T:1477588328;N:0,100,100,,,1452650065,1013500708,1027205899,1477588328,0,SRX8687795,SRS6966459,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91153,,0.21127,,0.71567,,0.51669,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60238,SRR12173031,SRX8687794,SRS6966458,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,36B,GSM4661894,,source name:SCA2|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male,36B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA2,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M,GSM4661894,GSM4661894: 36B; Danio rerio; RNA Seq,GSM4661894,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661894,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L2_DKRT190808OligoTB25-49_2.fq.gz V300016697_L2_DKRT190808OligoTB25-49_1.fq.gz,fastq fastq,4965885400.0,49658854.0,GSM4661894 r1,0:100 1:100,A:1447470026;C:1015061012;G:1029974741;T:1473379621;N:0,100,100,,,1447470026,1015061012,1029974741,1473379621,0,SRX8687794,SRS6966458,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91108,,0.21513,,0.71816,,0.50811,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60239,SRR12173030,SRX8687793,SRS6966457,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,35B,GSM4661893,,source name:SCA18|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female,35B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA18,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F,GSM4661893,GSM4661893: 35B; Danio rerio; RNA Seq,GSM4661893,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661893,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB24-32_2.fq.gz V300016697_L4_DKRT190808OligoTB24-32_1.fq.gz,fastq fastq,5015053400.0,50150534.0,GSM4661893 r1,0:100 1:100,A:1457835767;C:1029178424;G:1044039825;T:1483999384;N:0,100,100,,,1457835767,1029178424,1044039825,1483999384,0,SRX8687793,SRS6966457,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90833,,0.21925,,0.71672,,0.50097,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60240,SRR12173029,SRX8687792,SRS6966456,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,34B,GSM4661892,,source name:SCA16|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female,34B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA16,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F,GSM4661892,GSM4661892: 34B; Danio rerio; RNA Seq,GSM4661892,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661892,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB23-31_1.fq.gz V300016697_L4_DKRT190808OligoTB23-31_2.fq.gz,fastq fastq,4986700200.0,49867002.0,GSM4661892 r1,0:100 1:100,A:1462869969;C:1011992988;G:1024320004;T:1487517239;N:0,100,100,,,1462869969,1011992988,1024320004,1487517239,0,SRX8687792,SRS6966456,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90718,,0.22544,,0.71342,,0.5072,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60241,SRR12173028,SRX8687791,SRS6966455,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,33B,GSM4661891,,source name:SCA15|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female,33B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA15,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F,GSM4661891,GSM4661891: 33B; Danio rerio; RNA Seq,GSM4661891,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661891,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB22-30_1.fq.gz V300016697_L4_DKRT190808OligoTB22-30_2.fq.gz,fastq fastq,5002163800.0,50021638.0,GSM4661891 r1,0:100 1:100,A:1458240783;C:1023254938;G:1035393042;T:1485275037;N:0,100,100,,,1458240783,1023254938,1035393042,1485275037,0,SRX8687791,SRS6966455,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90922,,0.2217,,0.7097,,0.51063,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60242,SRR12173027,SRX8687790,SRS6966454,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,32B,GSM4661890,,source name:SCA14|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female,32B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,SCA14,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F,GSM4661890,GSM4661890: 32B; Danio rerio; RNA Seq,GSM4661890,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661890,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB21-29_1.fq.gz V300016697_L4_DKRT190808OligoTB21-29_2.fq.gz,fastq fastq,5004918600.0,50049186.0,GSM4661890 r1,0:100 1:100,A:1478882760;C:1005298319;G:1018268859;T:1502468662;N:0,100,100,,,1478882760,1005298319,1018268859,1502468662,0,SRX8687790,SRS6966454,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90266,,0.24047,,0.71997,,0.50514,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60243,SRR12173026,SRX8687789,SRS6966453,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,30B,GSM4661889,,source name:PH22|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male,30B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH22,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M,GSM4661889,GSM4661889: 30B; Danio rerio; RNA Seq,GSM4661889,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661889,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB20-28_2.fq.gz V300016697_L4_DKRT190808OligoTB20-28_1.fq.gz,fastq fastq,5004549600.0,50045496.0,GSM4661889 r1,0:100 1:100,A:1464234691;C:1019451110;G:1029365798;T:1491498001;N:0,100,100,,,1464234691,1019451110,1029365798,1491498001,0,SRX8687789,SRS6966453,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90749,,0.21628,,0.71784,,0.51498,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60244,SRR12173025,SRX8687788,SRS6966452,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,29B,GSM4661888,,source name:PH19|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male,29B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH19,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M,GSM4661888,GSM4661888: 29B; Danio rerio; RNA Seq,GSM4661888,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661888,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB19-27_1.fq.gz V300016697_L4_DKRT190808OligoTB19-27_2.fq.gz,fastq fastq,5002749400.0,50027494.0,GSM4661888 r1,0:100 1:100,A:1467188892;C:1015426772;G:1028344254;T:1491789482;N:0,100,100,,,1467188892,1015426772,1028344254,1491789482,0,SRX8687788,SRS6966452,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90801,,0.22987,,0.71823,,0.50663,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60245,SRR12173024,SRX8687787,SRS6966451,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,28B,GSM4661887,,source name:PH17|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male,28B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH17,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M,GSM4661887,GSM4661887: 28B; Danio rerio; RNA Seq,GSM4661887,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661887,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB18-26_2.fq.gz V300016697_L4_DKRT190808OligoTB18-26_1.fq.gz,fastq fastq,5006123800.0,50061238.0,GSM4661887 r1,0:100 1:100,A:1456441519;C:1027857948;G:1041287742;T:1480536591;N:0,100,100,,,1456441519,1027857948,1041287742,1480536591,0,SRX8687787,SRS6966451,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.91262,,0.21085,,0.71662,,0.51982,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60246,SRR12173023,SRX8687786,SRS6966450,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,26B,GSM4661886,,source name:PH12|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male,26B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH12,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M,GSM4661886,GSM4661886: 26B; Danio rerio; RNA Seq,GSM4661886,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661886,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB17-25_1.fq.gz V300016697_L4_DKRT190808OligoTB17-25_2.fq.gz,fastq fastq,5009606600.0,50096066.0,GSM4661886 r1,0:100 1:100,A:1500013398;C:985021902;G:996549130;T:1528022170;N:0,100,100,,,1500013398,985021902,996549130,1528022170,0,SRX8687786,SRS6966450,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90128,,0.25532,,0.73359,,0.52879,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60247,SRR12173022,SRX8687785,SRS6966449,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,25B,GSM4661885,,source name:PH16|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female,25B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH16,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F,GSM4661885,GSM4661885: 25B; Danio rerio; RNA Seq,GSM4661885,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661885,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB16-24_1.fq.gz V300016697_L4_DKRT190808OligoTB16-24_2.fq.gz,fastq fastq,5015052800.0,50150528.0,GSM4661885 r1,0:100 1:100,A:1465175690;C:1021710593;G:1034828694;T:1493337823;N:0,100,100,,,1465175690,1021710593,1034828694,1493337823,0,SRX8687785,SRS6966449,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90728,,0.22634,,0.71486,,0.50164,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60248,SRR12173021,SRX8687784,SRS6966448,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,24B,GSM4661884,,source name:PH15|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female,24B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH15,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F,GSM4661884,GSM4661884: 24B; Danio rerio; RNA Seq,GSM4661884,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661884,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB15-23_1.fq.gz V300016697_L4_DKRT190808OligoTB15-23_2.fq.gz,fastq fastq,5007208200.0,50072082.0,GSM4661884 r1,0:100 1:100,A:1467951978;C:1015424803;G:1028177858;T:1495653561;N:0,100,100,,,1467951978,1015424803,1028177858,1495653561,0,SRX8687784,SRS6966448,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90528,,0.23927,,0.71555,,0.50336,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60249,SRR12173020,SRX8687783,SRS6966447,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,21B,GSM4661883,,source name:PH9|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female,21B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH9,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F,GSM4661883,GSM4661883: 21B; Danio rerio; RNA Seq,GSM4661883,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661883,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB14-22_1.fq.gz V300016697_L4_DKRT190808OligoTB14-22_2.fq.gz,fastq fastq,5024734000.0,50247340.0,GSM4661883 r1,0:100 1:100,A:1486766175;C:1007118234;G:1018199457;T:1512650134;N:0,100,100,,,1486766175,1007118234,1018199457,1512650134,0,SRX8687783,SRS6966447,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.89909,,0.24852,,0.7249,,0.5102,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 60250,SRR12173019,SRX8687782,SRS6966446,SRP270926,PRJNA644883,Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L,GSE154020,Transcriptome Analysis,In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation,,pubmed:33752003,,22B,GSM4661882,,source name:PH10|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female,22B,Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.,PH10,,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,,tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F,GSM4661882,GSM4661882: 22B; Danio rerio; RNA Seq,GSM4661882,,1,Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol,GEO Accession:GSM4661882,RNA-Seq,TRANSCRIPTOMIC,cDNA,PAIRED,BGISEQ,BGISEQ-500,,SRP270926,,,V300016697_L4_DKRT190808OligoTB13-21_1.fq.gz V300016697_L4_DKRT190808OligoTB13-21_2.fq.gz,fastq fastq,5016105600.0,50161056.0,GSM4661882 r1,0:100 1:100,A:1470011990;C:1017729527;G:1032133240;T:1496230843;N:0,100,100,,,1470011990,1017729527,1032133240,1496230843,0,SRX8687782,SRS6966446,SRA1096323,GEO,"UMR MARBEC, INRAE",1,0.90507,,0.24172,,0.71459,,0.50712,,100,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,France,2020-07-08,Adult,Adult,Brain,Nervous System 65944,SRR15700565,SRX11996477,SRS10003992,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,R01,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,R01,R01,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,R01_1.fq.gz R01_2.fq.gz,fastq fastq,6781182900.0,45207886.0,R01 1.fq.gz,0:150 1:150,A:1988991157;C:1393829563;G:1402027963;T:1996312981;N:21236,150,150,,,1988991157,1393829563,1402027963,1996312981,21236,SRX11996477,SRS10003992,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91278,,0.20165,,0.71054,,0.54354,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65945,SRR15700566,SRX11996476,SRS10003991,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EH3,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EH3,EH3,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EH3_1.fq.gz EH3_2.fq.gz,fastq fastq,6798939900.0,45326266.0,EH3 1.fq.gz,0:150 1:150,A:1958992563;C:1429773625;G:1441958341;T:1968192397;N:22974,150,150,,,1958992563,1429773625,1441958341,1968192397,22974,SRX11996476,SRS10003991,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91681,,0.18245,,0.7083,,0.5369,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65946,SRR15700567,SRX11996475,SRS10003990,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EH2,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EH2,EH2,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EH2_1.fq.gz EH2_2.fq.gz,fastq fastq,6792825900.0,45285506.0,EH2 1.fq.gz,0:150 1:150,A:1958355652;C:1427389031;G:1440081079;T:1966978334;N:21804,150,150,,,1958355652,1427389031,1440081079,1966978334,21804,SRX11996475,SRS10003990,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91907,,0.17888,,0.70575,,0.54118,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65947,SRR15700568,SRX11996474,SRS10003989,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EH1,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EH1,EH1,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EH1_1.fq.gz EH1_2.fq.gz,fastq fastq,6723154200.0,44821028.0,EH1 1.fq.gz,0:150 1:150,A:1939940725;C:1412087358;G:1424339686;T:1946764075;N:22356,150,150,,,1939940725,1412087358,1424339686,1946764075,22356,SRX11996474,SRS10003989,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91848,,0.1756,,0.71293,,0.54795,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65948,SRR15700569,SRX11996473,SRS10003988,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EL3,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EL3,EL3,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EL3_1.fq.gz EL3_2.fq.gz,fastq fastq,6756746700.0,45044978.0,EL3 1.fq.gz,0:150 1:150,A:1958754520;C:1411572406;G:1418753117;T:1967647023;N:19634,150,150,,,1958754520,1411572406,1418753117,1967647023,19634,SRX11996473,SRS10003988,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91873,,0.18319,,0.71027,,0.55277,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65949,SRR15700570,SRX11996472,SRS10003987,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EL2,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EL2,EL2,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EL2_1.fq.gz EL2_2.fq.gz,fastq fastq,6811200600.0,45408004.0,EL2 1.fq.gz,0:150 1:150,A:1961542081;C:1433135536;G:1446857456;T:1969644200;N:21327,150,150,,,1961542081,1433135536,1446857456,1969644200,21327,SRX11996472,SRS10003987,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91853,,0.17639,,0.71076,,0.54175,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65950,SRR15700571,SRX11996471,SRS10003986,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EL1,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EL1,EL1,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EL1_1.fq.gz EL1_2.fq.gz,fastq fastq,6764302200.0,45095348.0,EL1 1.fq.gz,0:150 1:150,A:1943560425;C:1428175041;G:1441358638;T:1951185256;N:22840,150,150,,,1943560425,1428175041,1441358638,1951185256,22840,SRX11996471,SRS10003986,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91885,,0.17456,,0.71423,,0.53356,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65951,SRR15700572,SRX11996470,SRS10003985,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,E03,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,E03,E03,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,E03_1.fq.gz E03_2.fq.gz,fastq fastq,6762334500.0,45082230.0,E03 1.fq.gz,0:150 1:150,A:1941432663;C:1429093210;G:1444693949;T:1947091388;N:23290,150,150,,,1941432663,1429093210,1444693949,1947091388,23290,SRX11996470,SRS10003985,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91902,,0.17577,,0.71413,,0.54672,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65952,SRR15700573,SRX11996469,SRS10003984,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RH3,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RH3,RH3,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RH3_1.fq.gz RH3_2.fq.gz,fastq fastq,6620159400.0,44134396.0,RH3 1.fq.gz,0:150 1:150,A:1906961918;C:1396128146;G:1402603611;T:1914452217;N:13508,150,150,,,1906961918,1396128146,1402603611,1914452217,13508,SRX11996469,SRS10003984,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91596,,0.18007,,0.70307,,0.53072,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65953,SRR15700574,SRX11996468,SRS10003983,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RH2,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RH2,RH2,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RH2_1.fq.gz RH2_2.fq.gz,fastq fastq,6779957400.0,45199716.0,RH2 1.fq.gz,0:150 1:150,A:1943750299;C:1436936087;G:1447253724;T:1952003667;N:13623,150,150,,,1943750299,1436936087,1447253724,1952003667,13623,SRX11996468,SRS10003983,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91806,,0.17416,,0.70364,,0.53449,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65954,SRR15700575,SRX11996467,SRS10003982,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RH1,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RH1,RH1,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RH1_1.fq.gz RH1_2.fq.gz,fastq fastq,6803711400.0,45358076.0,RH1 1.fq.gz,0:150 1:150,A:1919109429;C:1472916047;G:1485344758;T:1926327627;N:13539,150,150,,,1919109429,1472916047,1485344758,1926327627,13539,SRX11996467,SRS10003982,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.92595,,0.14064,,0.71392,,0.5508,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65955,SRR15700576,SRX11996466,SRS10003981,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RL3,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RL3,RL3,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RL3_1.fq.gz RL3_2.fq.gz,fastq fastq,6775779300.0,45171862.0,RL3 1.fq.gz,0:150 1:150,A:1977555439;C:1404514814;G:1412262159;T:1981432811;N:14077,150,150,,,1977555439,1404514814,1412262159,1981432811,14077,SRX11996466,SRS10003981,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91883,,0.1833,,0.71638,,0.55343,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65956,SRR15700577,SRX11996465,SRS10003979,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RL2,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RL2,RL2,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RL2_1.fq.gz RL2_2.fq.gz,fastq fastq,6716301900.0,44775346.0,RL2 1.fq.gz,0:150 1:150,A:1959165761;C:1392977724;G:1400724963;T:1963418595;N:14857,150,150,,,1959165761,1392977724,1400724963,1963418595,14857,SRX11996465,SRS10003979,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.92114,,0.18164,,0.7217,,0.55665,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65957,SRR15700578,SRX11996464,SRS10003980,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RL1,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RL1,RL1,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RL1_1.fq.gz RL1_2.fq.gz,fastq fastq,6632905200.0,44219368.0,RL1 1.fq.gz,0:150 1:150,A:1930258593;C:1379056686;G:1391344096;T:1932223405;N:22420,150,150,,,1930258593,1379056686,1391344096,1932223405,22420,SRX11996464,SRS10003980,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91966,,0.18087,,0.72121,,0.5664,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65958,SRR15700579,SRX11996463,SRS10003978,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,R03,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,R03,R03,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,R03_1.fq.gz R03_2.fq.gz,fastq fastq,6574600200.0,43830668.0,R03 1.fq.gz,0:150 1:150,A:1940343461;C:1342685356;G:1350150434;T:1941399481;N:21468,150,150,,,1940343461,1342685356,1350150434,1941399481,21468,SRX11996463,SRS10003978,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91867,,0.19479,,0.72707,,0.57885,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65959,SRR15700580,SRX11996462,SRS10003977,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,R02,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,R02,R02,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,R02_1.fq.gz R02_2.fq.gz,fastq fastq,6399007800.0,42660052.0,R02 1.fq.gz,0:150 1:150,A:1884110766;C:1308008993;G:1315054545;T:1891764364;N:69132,150,150,,,1884110766,1308008993,1315054545,1891764364,69132,SRX11996462,SRS10003977,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91477,,0.19859,,0.72417,,0.55394,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65960,SRR15700581,SRX11996461,SRS10003976,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,E02,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,E02,E02,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,E02_1.fq.gz E02_2.fq.gz,fastq fastq,6588207000.0,43921380.0,E02 1.fq.gz,0:150 1:150,A:1905685715;C:1379753621;G:1389708827;T:1913038146;N:20691,150,150,,,1905685715,1379753621,1389708827,1913038146,20691,SRX11996461,SRS10003976,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91596,,0.18027,,0.70903,,0.54349,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65961,SRR15700582,SRX11996460,SRS10003975,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,E01,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,E01,E01,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,E01_1.fq.gz E01_2.fq.gz,fastq fastq,6766213800.0,45108092.0,E01 1.fq.gz,0:150 1:150,A:1963125745;C:1410900205;G:1420069949;T:1972096961;N:20940,150,150,,,1963125745,1410900205,1420069949,1972096961,20940,SRX11996460,SRS10003975,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91884,,0.18555,,0.71585,,0.5455,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System