rowid,run.accession,experiment.accession,sample.accession,study.accession,bioproject,study.title,study.alias,study.type,study.abstract,study.attributes,study.PMIDs,sample.description,sample.title,sample.alias,sample.centername,sample.attributes,GEOsample.title,GEOsample.dataprocessing,GEOsample.source,GEOsample.treatmentprotocol,GEOsample.extractprotocol,GEOsample.growthprotocol,GEOsample.characteristics,GEOsample.accession,experiment.title,experiment.alias,experiment.library_name,experiment.design_description,experiment.library_construction_protocol,experiment.attributes,experiment.library_strategy,experiment.library_source,experiment.library_selection,experiment.library_layout,experiment.platform,experiment.instrument_model,experiment.spot_descriptor,experiment.study_ref,run.title,run.attributes,run.filename,run.semantic_name,run.total_bases,run.total_spots,run.alias,run.read_lengths,run.base_counts,run.r1_length,run.r2_length,run.r3_length,run.r4_length,run.Acount,run.Ccount,run.Gcount,run.Tcount,run.Ncount,run.experiment,run.pool_member,submission.accession,submission.srasource,submission.bioprojectsource,seqdetective.n_mates,seqdetective.mapping_rate.mate1,seqdetective.mapping_rate.mate2,seqdetective.nofeature_rate.mate1,seqdetective.nofeature_rate.mate2,seqdetective.sparsity.mate1,seqdetective.sparsity.mate2,seqdetective.pos_strand_rate.mate1,seqdetective.pos_strand_rate.mate2,seqdetective.readlen.mate1,seqdetective.readlen.mate2,seqdetective.judgement.mate1,seqdetective.judgement.mate2,seqdetective.judgement.reason,platform_family,instrument_generation,read_bias,selection_class,prep_kit,sc_or_bulk,tech_class,technology,tech_variant,submission.bioprojectsource.country,earliest_date,devstage_curation,devstage_curation_coarse,tissue_curation,tissue_curation_coarse 31825,SRR28700412,SRX24268115,SRS21034395,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,PN 2,,isolate:PN2|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 2|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,PN 2,PN 2,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,PN_2_1.fq.gz PN_2_2.fq.gz,fastq fastq,6385048200.0,21283494.0,PN 2 1.fq.gz,0:150 1:150,A:1722127999;C:1463645587;G:1483173818;T:1716100796;N:0,150,150,,,1722127999,1463645587,1483173818,1716100796,0,SRX24268115,SRS21034395,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31826,SRR28700413,SRX24268114,SRS21034397,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,PN 1,,isolate:PN1|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 1|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,PN 1,PN 1,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,PN_1_1.fq.gz PN_1_2.fq.gz,fastq fastq,6692894100.0,22309647.0,PN 1 1.fq.gz,0:150 1:150,A:1827107021;C:1513034624;G:1533077624;T:1819674831;N:0,150,150,,,1827107021,1513034624,1533077624,1819674831,0,SRX24268114,SRS21034397,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31827,SRR28700414,SRX24268113,SRS21034396,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,EC 4,,isolate:EC4|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 4|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,EC 4,EC 4,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,EC_4_1.fq.gz EC_4_2.fq.gz,fastq fastq,6688857000.0,22296190.0,EC 4 1.fq.gz,0:150 1:150,A:1820989545;C:1516814697;G:1537970654;T:1813082104;N:0,150,150,,,1820989545,1516814697,1537970654,1813082104,0,SRX24268113,SRS21034396,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31828,SRR28700415,SRX24268112,SRS21034392,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,EC 3,,isolate:EC3|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 3|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,EC 3,EC 3,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,EC_3_1.fq.gz EC_3_2.fq.gz,fastq fastq,6696553800.0,22321846.0,EC 3 1.fq.gz,0:150 1:150,A:1821249100;C:1520587242;G:1541238550;T:1813478908;N:0,150,150,,,1821249100,1520587242,1541238550,1813478908,0,SRX24268112,SRS21034392,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31829,SRR28700416,SRX24268111,SRS21034391,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,EC 2,,isolate:EC2|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 2|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,EC 2,EC 2,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,EC_2_1.fq.gz EC_2_2.fq.gz,fastq fastq,6702179400.0,22340598.0,EC 2 1.fq.gz,0:150 1:150,A:1816692261;C:1527379142;G:1547365810;T:1810742187;N:0,150,150,,,1816692261,1527379142,1547365810,1810742187,0,SRX24268111,SRS21034391,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31830,SRR28700417,SRX24268110,SRS21034390,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,EC 1,,isolate:EC1|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 1|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,EC 1,EC 1,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,EC_1_1.fq.gz EC_1_2.fq.gz,fastq fastq,6686053500.0,22286845.0,EC 1 1.fq.gz,0:150 1:150,A:1812022780;C:1524359858;G:1544847441;T:1804823421;N:0,150,150,,,1812022780,1524359858,1544847441,1804823421,0,SRX24268110,SRS21034390,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31831,SRR28700418,SRX24268109,SRS21034388,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,Control 4,,isolate:con4|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 4|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,Control 4,Control 4,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,Control_4_1.fq.gz Control_4_2.fq.gz,fastq fastq,6669700500.0,22232335.0,Control 4 1.fq.gz,0:150 1:150,A:1804178265;C:1523547469;G:1543839484;T:1798135282;N:0,150,150,,,1804178265,1523547469,1543839484,1798135282,0,SRX24268109,SRS21034388,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31832,SRR28700419,SRX24268108,SRS21034387,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,Control 3,,isolate:con3|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 3|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,Control 3,Control 3,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,Control_3_1.fq.gz Control_3_2.fq.gz,fastq fastq,6683518800.0,22278396.0,Control 3 1.fq.gz,0:150 1:150,A:1808495506;C:1525725204;G:1545930043;T:1803368047;N:0,150,150,,,1808495506,1525725204,1545930043,1803368047,0,SRX24268108,SRS21034387,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31833,SRR28700420,SRX24268107,SRS21034386,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,PN 4,,isolate:PN4|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 4|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,PN 4,PN 4,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,PN_4_1.fq.gz PN_4_2.fq.gz,fastq fastq,6649316100.0,22164387.0,PN 4 1.fq.gz,0:150 1:150,A:1809816121;C:1508072480;G:1528272654;T:1803154845;N:0,150,150,,,1809816121,1508072480,1528272654,1803154845,0,SRX24268107,SRS21034386,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31834,SRR28700421,SRX24268106,SRS21034389,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,PN 3,,isolate:PN3|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 3|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,PN 3,PN 3,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,PN_3_1.fq.gz PN_3_2.fq.gz,fastq fastq,6616113900.0,22053713.0,PN 3 1.fq.gz,0:150 1:150,A:1802283686;C:1499008018;G:1519150002;T:1795672194;N:0,150,150,,,1802283686,1499008018,1519150002,1795672194,0,SRX24268106,SRS21034389,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31835,SRR28700422,SRX24268105,SRS21034385,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,Control 2,,isolate:con2|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 2|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,Control 2,Control 2,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,Control_2_1.fq.gz Control_2_2.fq.gz,fastq fastq,6701719200.0,22339064.0,Control 2 1.fq.gz,0:150 1:150,A:1812352260;C:1531672703;G:1551377072;T:1806317165;N:0,150,150,,,1812352260,1531672703,1551377072,1806317165,0,SRX24268105,SRS21034385,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 31836,SRR28700423,SRX24268104,SRS21034384,SRP501894,PRJNA1100624,Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis,PRJNA1100624,Other,Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.,,,,,Control 1,,isolate:con1|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 1|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebrafish,Control 1,Control 1,Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP501894,,,Control_1_1.fq.gz Control_1_2.fq.gz,fastq fastq,6720214500.0,22400715.0,Control 1 1.fq.gz,0:150 1:150,A:1814883015;C:1537948710;G:1559376116;T:1808006659;N:0,150,150,,,1814883015,1537948710,1559376116,1808006659,0,SRX24268104,SRS21034384,,,"Xiangyang No.1 People's Hospital, Hubei University of Medicine",,,,,,,,,,,,B,B,biological fallback assumption,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2024-04-15,Larval,Larval,Undetermined,Undetermined 55643,SRR10604044,SRX7283593,SRS5777402,SRP235014,PRJNA594101,Danio rerio Transcriptome,PRJNA594101,Other,Danio rerio Transcriptome post cGAS and STING knockout,,,,,stko2,,strain:not collected|isolate:sting knockout 2|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebraish larvae,sting knockout 2,sting knockout 2,RNA seq,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP235014,,,stko2_1.fastq.gz stko2_2.fastq.gz,fastq fastq,10635609300.0,70904062.0,stko2 1.fastq.gz,0:150 1:150,A:2864931942;C:2450585568;G:2436540783;T:2882828480;N:722527,150,150,,,2864931942,2450585568,2436540783,2882828480,722527,SRX7283593,SRS5777402,SRA1007465,Shantou university medical college|Neuroscience Center,Shantou university medical college,1,0.93079,,0.07849,,0.70301,,0.47872,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2019-12-08,Larval,Larval,Undetermined,Undetermined 55644,SRR10604045,SRX7283592,SRS5777401,SRP235014,PRJNA594101,Danio rerio Transcriptome,PRJNA594101,Other,Danio rerio Transcriptome post cGAS and STING knockout,,,,,stko1,,strain:not collected|isolate:sting knockout 1|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebraish larvae,sting knockout 1,sting knockout 1,RNA seq,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP235014,,,stko1_1.fastq.gz stko1_2.fastq.gz,fastq fastq,10453959000.0,69693060.0,stko1 1.fastq.gz,0:150 1:150,A:2823253748;C:2400078679;G:2379662427;T:2850274552;N:689594,150,150,,,2823253748,2400078679,2379662427,2850274552,689594,SRX7283592,SRS5777401,SRA1007465,Shantou university medical college|Neuroscience Center,Shantou university medical college,1,0.92736,,0.08475,,0.69822,,0.47233,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2019-12-08,Larval,Larval,Undetermined,Undetermined 55645,SRR10604046,SRX7283591,SRS5777400,SRP235014,PRJNA594101,Danio rerio Transcriptome,PRJNA594101,Other,Danio rerio Transcriptome post cGAS and STING knockout,,,,,cgko2,,strain:not collected|isolate:cgas knockout 2|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebraish larvae,cgas knockout 2,cgas knockout 2,RNA seq,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP235014,,,cgko2_1.fastq.gz cgko2_2.fastq.gz,fastq fastq,10462236900.0,69748246.0,cgko2 1.fastq.gz,0:150 1:150,A:2836737922;C:2388112649;G:2370425883;T:2866326601;N:633845,150,150,,,2836737922,2388112649,2370425883,2866326601,633845,SRX7283591,SRS5777400,SRA1007465,Shantou university medical college|Neuroscience Center,Shantou university medical college,1,0.93603,,0.10606,,0.67765,,0.46153,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2019-12-08,Larval,Larval,Undetermined,Undetermined 55646,SRR10604047,SRX7283590,SRS5777399,SRP235014,PRJNA594101,Danio rerio Transcriptome,PRJNA594101,Other,Danio rerio Transcriptome post cGAS and STING knockout,,,,,cgko1,,strain:not collected|isolate:cgas knockout 1|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebraish larvae,cgas knockout 1,cgas knockout 1,RNA seq,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP235014,,,cgko1_2.fastq.gz cgko1_1.fastq.gz,fastq fastq,10498495500.0,69989970.0,cgko1 1.fastq.gz,0:150 1:150,A:2845684832;C:2398817161;G:2379300746;T:2874108573;N:584188,150,150,,,2845684832,2398817161,2379300746,2874108573,584188,SRX7283590,SRS5777399,SRA1007465,Shantou university medical college|Neuroscience Center,Shantou university medical college,1,0.93684,,0.10589,,0.67933,,0.48363,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2019-12-08,Larval,Larval,Undetermined,Undetermined 55647,SRR10604048,SRX7283589,SRS5777398,SRP235014,PRJNA594101,Danio rerio Transcriptome,PRJNA594101,Other,Danio rerio Transcriptome post cGAS and STING knockout,,,,,wt2,,strain:not collected|isolate:normal 2|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebraish larvae,wt normal 2,wt normal 2,RNA seq,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP235014,,,wt2_1.fastq.gz wt2_2.fastq.gz,fastq fastq,10660916400.0,71072776.0,wt2 1.fastq.gz,0:150 1:150,A:2906473511;C:2417423798;G:2405111864;T:2931146507;N:760720,150,150,,,2906473511,2417423798,2405111864,2931146507,760720,SRX7283589,SRS5777398,SRA1007465,Shantou university medical college|Neuroscience Center,Shantou university medical college,1,0.94167,,0.11781,,0.66831,,0.4757,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2019-12-08,Larval,Larval,Undetermined,Undetermined 55648,SRR10604049,SRX7283588,SRS5777397,SRP235014,PRJNA594101,Danio rerio Transcriptome,PRJNA594101,Other,Danio rerio Transcriptome post cGAS and STING knockout,,,,,wt1,,strain:not collected|isolate:normal 1|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of zebraish larvae,wt nomal 1,wt nomal 1,RNA seq,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP235014,,,wt1_1.fastq.gz wt1_2.fastq.gz,fastq fastq,10599804000.0,70665360.0,wt1 1.fastq.gz,0:150 1:150,A:2896989124;C:2397285811;G:2382705623;T:2922067937;N:755505,150,150,,,2896989124,2397285811,2382705623,2922067937,755505,SRX7283588,SRS5777397,SRA1007465,Shantou university medical college|Neuroscience Center,Shantou university medical college,1,0.93947,,0.11723,,0.67203,,0.45826,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2019-12-08,Larval,Larval,Undetermined,Undetermined 66964,SRR16965143,SRX13156592,SRS11088496,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,1mix,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:10 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :mixture group,mix 1,mix 1,96hpf zebrafish larvae mixture group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,mix2_1_2.fq.gz,fastq,3313823250.0,22092155.0,mix2 1 2.fq.gz,0:0 1:150,A:895726357;C:763402657;G:745765587;T:908922686;N:5963,0,150,,,895726357,763402657,745765587,908922686,5963,SRX13156592,SRS11088496,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.93604,,0.10794,,0.65587,,0.47956,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined 66965,SRR16965144,SRX13156591,SRS11088495,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,3enf,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:9 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :enrofloxacin group,enf 3,enf 3,96hpf zebrafish larvae enrofloxacin group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,enf_3.fq.gz,fastq,3304972350.0,22033149.0,enf 3.fq.gz,0:150 1:0,A:899427202;C:745999066;G:759917309;T:899625137;N:3636,150,0,,,899427202,745999066,759917309,899625137,3636,SRX13156591,SRS11088495,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94353,,0.10795,,0.66212,,0.47773,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined 66966,SRR16965145,SRX13156590,SRS11088493,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,1enf,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:7 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :enrofloxacin group,enf 1,enf 1,96hpf zebrafish larvae enrofloxacin group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP346547,,,enf_1.fq.gz enf_2.fq.gz,fastq fastq,6652389300.0,44349262.0,enf 1.fq.gz,0:150 1:150,A:1759651033;C:1563446116;G:1556912596;T:1772370048;N:9507,150,150,,,1759651033,1563446116,1556912596,1772370048,9507,SRX13156590,SRS11088493,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94992,,0.06316,,0.66979,,0.48987,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined 66967,SRR16965146,SRX13156589,SRS11088492,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,3car,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:6 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :carbendazim group,car 3,car 3,96hpf zebrafish larvae carbendazim group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,car_3_1.fq.gz,fastq,3335622150.0,22237481.0,car 3 1.fq.gz,0:150 1:0,A:853229671;C:807433601;G:820478265;T:854475092;N:5521,150,0,,,853229671,807433601,820478265,854475092,5521,SRX13156589,SRS11088492,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.96567,,0.03093,,0.70997,,0.47751,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined 66968,SRR16965147,SRX13156588,SRS11088494,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,1car,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:4 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :carbendazim group,car 1,car 1,96hpf zebrafish larvae carbendazim group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,car_1_1.fq.gz,fastq,3378056400.0,22520376.0,car 1 1.fq.gz,0:150 1:0,A:886009175;C:795203398;G:809447342;T:887390300;N:6185,150,0,,,886009175,795203398,809447342,887390300,6185,SRX13156588,SRS11088494,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95701,,0.05956,,0.67836,,0.4884,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined 66969,SRR16965148,SRX13156587,SRS11088491,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,3con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:3 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :control group,con 3,con 3,96hpf zebrafish larvae control group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,con_3_2.fq.gz,fastq,3359054500.0,33590545.0,con 3 2.fq.gz,0:100 1:0,A:914533337;C:755914202;G:773676246;T:914930715;N:0,100,0,,,914533337,755914202,773676246,914930715,0,SRX13156587,SRS11088491,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95076,,0.10478,,0.65646,,0.49594,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined 66970,SRR16965149,SRX13156586,SRS11088489,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,3mix,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:12 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :mixture group,mix 3,mix 3,96hpf zebrafish larvae mixture group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,mix2_3_1.fq.gz,fastq,3362094000.0,33620940.0,mix2 3 1.fq.gz,0:100 1:0,A:916124379;C:755910593;G:768246534;T:921812494;N:0,100,0,,,916124379,755910593,768246534,921812494,0,SRX13156586,SRS11088489,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94894,,0.10416,,0.65342,,0.49475,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined 66971,SRR16965150,SRX13156585,SRS11088490,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,2mix,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:11 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :mixture group,mix 2,mix 2,96hpf zebrafish larvae mixture group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP346547,,,car_2_2.fq.gz mix2_2_1.fq.gz,fastq fastq,6669719100.0,44464794.0,car 2 2.fq.gz,0:150 1:150,A:1815824677;C:1515086864;G:1506360115;T:1832433148;N:14296,150,150,,,1815824677,1515086864,1506360115,1832433148,14296,SRX13156585,SRS11088490,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.93884,,0.11657,,0.65527,,0.48114,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined 66972,SRR16965151,SRX13156584,SRS11088488,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,2con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:2 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :control group,con 2,con 2,96hpf zebrafish larvae control group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,loader:fastq load.py,con_2_2.fq,fastq,3324287550.0,22161917.0,con 2 2.fq.gz,0:150,A:848766265;C:812477645;G:798995610;T:864040426;N:7604,150,,,,848766265,812477645,798995610,864040426,7604,SRX13156584,SRS11088488,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95546,,0.03524,,0.70027,,0.48649,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-22,Larval,Larval,Undetermined,Undetermined 66973,SRR16965152,SRX13156583,SRS11088487,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,1con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:1 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :control group,con 1,con 1,96hpf zebrafish larvae control group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,loader:fastq load.py,con_1_1.fq,fastq,3330724500.0,22204830.0,con 1 1.fq.gz,0:150,A:896812508;C:762246067;G:774062043;T:897597946;N:5936,150,,,,896812508,762246067,774062043,897597946,5936,SRX13156583,SRS11088487,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94926,,0.08711,,0.66789,,0.48628,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-22,Larval,Larval,Undetermined,Undetermined 66974,SRR16959538,SRX13151074,SRS11083380,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,1+mix,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:10 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : mixture group,mix 1,mix 1,The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP346418,,,mix1_3_2.fq.gz mix1_1_1.fq.gz,fastq fastq,6639699600.0,44264664.0,mix1 1 1.fq.gz,0:150 1:150,A:1738687157;C:1575344731;G:1569683716;T:1755974708;N:9288,150,150,,,1738687157,1575344731,1569683716,1755974708,9288,SRX13151074,SRS11083380,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95161,,0.05697,,0.6817,,0.48485,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined 66975,SRR16959539,SRX13151073,SRS11083379,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,2dim,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:8 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : dimethomorph group,dim 2,dim 2,The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,dim_2_1.fq.gz,fastq,3344257500.0,22295050.0,dim 2 1.fq.gz,0:150 1:0,A:895700119;C:767415749;G:784994320;T:896143585;N:3727,150,0,,,895700119,767415749,784994320,896143585,3727,SRX13151073,SRS11083379,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.9497,,0.08418,,0.66352,,0.49341,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined 66976,SRR16959540,SRX13151072,SRS11083378,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,1dim,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:7 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : dimethomorph group,dim 1,dim 1,The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,dim_1_1.fq.gz,fastq,3318812250.0,22125415.0,dim 1 1.fq.gz,0:150 1:0,A:908481293;C:742787936;G:755930542;T:911608821;N:3658,150,0,,,908481293,742787936,755930542,911608821,3658,SRX13151072,SRS11083378,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94211,,0.11824,,0.65344,,0.47716,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined 66977,SRR16959541,SRX13151071,SRS11083377,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,3dif,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:6 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : difenoconazole group,dif 3,dif 3,The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,dif_3_1.fq.gz,fastq,3318453000.0,22123020.0,dif 3 1.fq.gz,0:150 1:0,A:893975607;C:758489621;G:772391705;T:893592335;N:3732,150,0,,,893975607,758489621,772391705,893592335,3732,SRX13151071,SRS11083377,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94838,,0.08393,,0.66543,,0.4818,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined 66978,SRR16959542,SRX13151070,SRS11083376,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,2dif,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:5 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : difenoconazole group,dif 2,dif 2,The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,dif_2_2.fq.gz,fastq,3304972350.0,22033149.0,dif 2 2.fq.gz,0:0 1:150,A:890456734;C:764917766;G:744757536;T:904833787;N:6527,0,150,,,890456734,764917766,744757536,904833787,6527,SRX13151070,SRS11083376,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.93514,,0.107,,0.6633,,0.47599,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined 66979,SRR16959543,SRX13151069,SRS11083375,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,1dif,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:4 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : difenoconazole group,dif 1,dif 1,The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,dif_1_1.fq.gz,fastq,3295443900.0,21969626.0,dif 1 1.fq.gz,0:150 1:0,A:887936493;C:751636494;G:765508757;T:890358629;N:3527,150,0,,,887936493,751636494,765508757,890358629,3527,SRX13151069,SRS11083375,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94623,,0.09138,,0.66478,,0.4828,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined 66980,SRR16959544,SRX13151068,SRS11083374,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,3+con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:3 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : control group,con 3,con 3,The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,con_3_1.fq.gz,fastq,3306406800.0,22042712.0,con 3 1.fq.gz,0:150 1:0,A:872740236;C:773482184;G:788334419;T:871846539;N:3422,150,0,,,872740236,773482184,788334419,871846539,3422,SRX13151068,SRS11083374,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95458,,0.06103,,0.67409,,0.48439,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined 66981,SRR16959545,SRX13151067,SRS11083373,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,2+mix,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:11 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : mixture group,mix 2,mix 2,The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP346418,,,mix1_2_1.fq.gz dim_3_2.fq.gz,fastq fastq,6589866900.0,43932446.0,dim 3 2.fq.gz,0:150 1:150,A:1782755416;C:1508342477;G:1501934674;T:1796820276;N:14057,150,150,,,1782755416,1508342477,1501934674,1796820276,14057,SRX13151067,SRS11083373,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.93861,,0.10685,,0.66393,,0.47194,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined 66982,SRR16959546,SRX13151066,SRS11083372,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,2+con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:2 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : control group,con 2,con 2,The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,con_2_2.fq.gz,fastq,3324287550.0,22161917.0,con 2 2.fq.gz,0:0 1:150,A:848766265;C:812477645;G:798995610;T:864040426;N:7604,0,150,,,848766265,812477645,798995610,864040426,7604,SRX13151066,SRS11083372,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95548,,0.03524,,0.70021,,0.4867,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined 66983,SRR16959547,SRX13151065,SRS11083371,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,1+con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:1 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : control group,con 1,con 1,The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,con_1_1.fq.gz,fastq,3330724500.0,22204830.0,con 1 1.fq.gz,0:150 1:0,A:896812508;C:762246067;G:774062043;T:897597946;N:5936,150,0,,,896812508,762246067,774062043,897597946,5936,SRX13151065,SRS11083371,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94925,,0.08711,,0.66772,,0.48635,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined