rowid,run.accession,experiment.accession,sample.accession,study.accession,bioproject,study.title,study.alias,study.type,study.abstract,study.attributes,study.PMIDs,sample.description,sample.title,sample.alias,sample.centername,sample.attributes,GEOsample.title,GEOsample.dataprocessing,GEOsample.source,GEOsample.treatmentprotocol,GEOsample.extractprotocol,GEOsample.growthprotocol,GEOsample.characteristics,GEOsample.accession,experiment.title,experiment.alias,experiment.library_name,experiment.design_description,experiment.library_construction_protocol,experiment.attributes,experiment.library_strategy,experiment.library_source,experiment.library_selection,experiment.library_layout,experiment.platform,experiment.instrument_model,experiment.spot_descriptor,experiment.study_ref,run.title,run.attributes,run.filename,run.semantic_name,run.total_bases,run.total_spots,run.alias,run.read_lengths,run.base_counts,run.r1_length,run.r2_length,run.r3_length,run.r4_length,run.Acount,run.Ccount,run.Gcount,run.Tcount,run.Ncount,run.experiment,run.pool_member,submission.accession,submission.srasource,submission.bioprojectsource,seqdetective.n_mates,seqdetective.mapping_rate.mate1,seqdetective.mapping_rate.mate2,seqdetective.nofeature_rate.mate1,seqdetective.nofeature_rate.mate2,seqdetective.sparsity.mate1,seqdetective.sparsity.mate2,seqdetective.pos_strand_rate.mate1,seqdetective.pos_strand_rate.mate2,seqdetective.readlen.mate1,seqdetective.readlen.mate2,seqdetective.judgement.mate1,seqdetective.judgement.mate2,seqdetective.judgement.reason,platform_family,instrument_generation,read_bias,selection_class,prep_kit,sc_or_bulk,tech_class,technology,tech_variant,submission.bioprojectsource.country,earliest_date,devstage_curation,devstage_curation_coarse,tissue_curation,tissue_curation_coarse 57271,SRR12577970,SRX9064853,SRS7314026,SRP279881,PRJNA612371,Danio rerio strain:TU Raw sequence reads,PRJNA612371,Whole Genome Sequencing,Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.,,,,,Ctrl 3 zebrafish,,strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 6'|BioSampleModel:Model organism or animal,,,,,,,,,Ctrl 3 zebrafish,Ctrl 3 zebrafish,Ctrl 3 zebrafish,transcriptome,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP279881,,,Ctrl_3_1.fq.gz,fastq,1061227250.0,21224545.0,Ctrl 3 1.fq.gz,0:50,A:286099732;C:241244619;G:246876865;T:287006034;N:0,50,,,,286099732,241244619,246876865,287006034,0,SRX9064853,SRS7314026,SRA1120721,Shanghai University of Traditional Chinese Medicine|Longhua Hospital,Shanghai University of Traditional Chinese Medicine,1,0.94563,,0.10453,,0.70552,,0.46655,,50,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2020-09-03,Hatching,Embryo,Head,Nervous System 57272,SRR12577971,SRX9064852,SRS7314025,SRP279881,PRJNA612371,Danio rerio strain:TU Raw sequence reads,PRJNA612371,Whole Genome Sequencing,Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.,,,,,Ctrl 2 zebrafish,,strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 5 prime|BioSampleModel:Model organism or animal,,,,,,,,,Ctrl 2 zebrafish,Ctrl 2 zebrafish,Ctrl 2 zebrafish,transcriptome,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP279881,,,Ctrl_2_1.fq.gz,fastq,1058116700.0,21162334.0,Ctrl 2 1.fq.gz,0:50,A:287223905;C:238707750;G:244987559;T:287197486;N:0,50,,,,287223905,238707750,244987559,287197486,0,SRX9064852,SRS7314025,SRA1120721,Shanghai University of Traditional Chinese Medicine|Longhua Hospital,Shanghai University of Traditional Chinese Medicine,1,0.94534,,0.11174,,0.70104,,0.47946,,50,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2020-09-03,Hatching,Embryo,Head,Nervous System 57273,SRR12577972,SRX9064851,SRS7314024,SRP279881,PRJNA612371,Danio rerio strain:TU Raw sequence reads,PRJNA612371,Whole Genome Sequencing,Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.,,,,,Ctrl 1 zebrafish,,strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 4'|BioSampleModel:Model organism or animal,,,,,,,,,Ctrl 1 zebrafish,Ctrl 1 zebrafish,Ctrl 1 zebrafish,transcriptome,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP279881,,,Ctrl_1_1.fq.gz,fastq,1065919600.0,21318392.0,Ctrl 1 1.fq.gz,0:50,A:295920720;C:242146677;G:242962633;T:284889570;N:0,50,,,,295920720,242146677,242962633,284889570,0,SRX9064851,SRS7314024,SRA1120721,Shanghai University of Traditional Chinese Medicine|Longhua Hospital,Shanghai University of Traditional Chinese Medicine,1,0.94228,,0.15007,,0.68028,,0.46845,,50,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2020-09-03,Hatching,Embryo,Head,Nervous System 57274,SRR12577973,SRX9064850,SRS7314023,SRP279881,PRJNA612371,Danio rerio strain:TU Raw sequence reads,PRJNA612371,Whole Genome Sequencing,Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.,,,,,Ator STS 3 zebrafish,,strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 3 prime|BioSampleModel:Model organism or animal,,,,,,,,,Ator STS 3 zebrafish,Ator STS 3 zebrafish,Ator STS 3 zebrafish,transcriptome,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP279881,,,Ator_STS_3_1.fq.gz,fastq,1059717350.0,21194347.0,Ator STS 3 1.fq.gz,0:50,A:287279590;C:239708340;G:245740313;T:286989107;N:0,50,,,,287279590,239708340,245740313,286989107,0,SRX9064850,SRS7314023,SRA1120721,Shanghai University of Traditional Chinese Medicine|Longhua Hospital,Shanghai University of Traditional Chinese Medicine,1,0.94345,,0.10458,,0.69686,,0.4755,,50,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2020-09-03,Hatching,Embryo,Head,Nervous System 57275,SRR12577974,SRX9064849,SRS7314022,SRP279881,PRJNA612371,Danio rerio strain:TU Raw sequence reads,PRJNA612371,Whole Genome Sequencing,Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.,,,,,Ator STS 2 zebrafish,,strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 2'|BioSampleModel:Model organism or animal,,,,,,,,,Ator STS 2 zebrafish,Ator STS 2 zebrafish,Ator STS 2 zebrafish,transcriptome,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP279881,,,Ator_STS_2_1.fq.gz,fastq,1057950250.0,21159005.0,Ator STS 2 1.fq.gz,0:50,A:286256354;C:238832868;G:244078781;T:288782247;N:0,50,,,,286256354,238832868,244078781,288782247,0,SRX9064849,SRS7314022,SRA1120721,Shanghai University of Traditional Chinese Medicine|Longhua Hospital,Shanghai University of Traditional Chinese Medicine,1,0.94307,,0.10974,,0.69631,,0.4703,,50,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2020-09-03,Hatching,Embryo,Head,Nervous System 57276,SRR12577975,SRX9064848,SRS7314021,SRP279881,PRJNA612371,Danio rerio strain:TU Raw sequence reads,PRJNA612371,Whole Genome Sequencing,Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.,,,,,Ator STS 1 zebrafish,,strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 1'|BioSampleModel:Model organism or animal,,,,,,,,,Ator STS 1 zebrafish,Ator STS 1 zebrafish,Ator STS 1 zebrafish,transcriptome,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP279881,,,Ator_STS_1_1.fq.gz,fastq,1070136700.0,21402734.0,Ator STS 1 1.fq.gz,0:50,A:297601042;C:243837062;G:243583907;T:285114689;N:0,50,,,,297601042,243837062,243583907,285114689,0,SRX9064848,SRS7314021,SRA1120721,Shanghai University of Traditional Chinese Medicine|Longhua Hospital,Shanghai University of Traditional Chinese Medicine,1,0.94665,,0.12219,,0.67953,,0.46393,,50,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2020-09-03,Hatching,Embryo,Head,Nervous System 57277,SRR12577976,SRX9064847,SRS7314020,SRP279881,PRJNA612371,Danio rerio strain:TU Raw sequence reads,PRJNA612371,Whole Genome Sequencing,Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.,,,,,Ator 3 zebrafish,,strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 3 prime|BioSampleModel:Model organism or animal,,,,,,,,,Ator 3 zebrafish,Ator 3 zebrafish,Ator 3 zebrafish,transcriptome,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP279881,,,Ator_3_1.fq.gz,fastq,1058031900.0,21160638.0,Ator 3 1.fq.gz,0:50,A:285399527;C:239993172;G:245571467;T:287067734;N:0,50,,,,285399527,239993172,245571467,287067734,0,SRX9064847,SRS7314020,SRA1120721,Shanghai University of Traditional Chinese Medicine|Longhua Hospital,Shanghai University of Traditional Chinese Medicine,1,0.94536,,0.11052,,0.6957,,0.48195,,50,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2020-09-03,Hatching,Embryo,Head,Nervous System 57278,SRR12577977,SRX9064846,SRS7314019,SRP279881,PRJNA612371,Danio rerio strain:TU Raw sequence reads,PRJNA612371,Whole Genome Sequencing,Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.,,,,,Ator 2 zebrafish,,strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 2'|BioSampleModel:Model organism or animal,,,,,,,,,Ator 2 zebrafish,Ator 2 zebrafish,Ator 2 zebrafish,transcriptome,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP279881,,,Ator_2_1.fq.gz,fastq,1059618400.0,21192368.0,Ator 2 1.fq.gz,0:50,A:283429136;C:243023053;G:248904818;T:284261393;N:0,50,,,,283429136,243023053,248904818,284261393,0,SRX9064846,SRS7314019,SRA1120721,Shanghai University of Traditional Chinese Medicine|Longhua Hospital,Shanghai University of Traditional Chinese Medicine,1,0.94743,,0.09493,,0.70218,,0.475,,50,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2020-09-03,Hatching,Embryo,Head,Nervous System 57279,SRR12577978,SRX9064845,SRS7314018,SRP279881,PRJNA612371,Danio rerio strain:TU Raw sequence reads,PRJNA612371,Whole Genome Sequencing,Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.,,,,,Ator 1 zebrafish,,strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 1'|BioSampleModel:Model organism or animal,,,,,,,,,Ator 1 zebrafish,Ator 1 zebrafish,Ator 1 zebrafish,transcriptome,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP279881,,,Ator_1_1.fq.gz,fastq,1075695950.0,21513919.0,Ator 1 1.fq.gz,0:50,A:297768036;C:244470267;G:243768925;T:289688722;N:0,50,,,,297768036,244470267,243768925,289688722,0,SRX9064845,SRS7314018,SRA1120721,Shanghai University of Traditional Chinese Medicine|Longhua Hospital,Shanghai University of Traditional Chinese Medicine,1,0.94468,,0.13183,,0.68363,,0.46288,,50,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2020-09-03,Hatching,Embryo,Head,Nervous System 65944,SRR15700565,SRX11996477,SRS10003992,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,R01,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,R01,R01,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,R01_1.fq.gz R01_2.fq.gz,fastq fastq,6781182900.0,45207886.0,R01 1.fq.gz,0:150 1:150,A:1988991157;C:1393829563;G:1402027963;T:1996312981;N:21236,150,150,,,1988991157,1393829563,1402027963,1996312981,21236,SRX11996477,SRS10003992,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91278,,0.20165,,0.71054,,0.54354,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65945,SRR15700566,SRX11996476,SRS10003991,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EH3,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EH3,EH3,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EH3_1.fq.gz EH3_2.fq.gz,fastq fastq,6798939900.0,45326266.0,EH3 1.fq.gz,0:150 1:150,A:1958992563;C:1429773625;G:1441958341;T:1968192397;N:22974,150,150,,,1958992563,1429773625,1441958341,1968192397,22974,SRX11996476,SRS10003991,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91681,,0.18245,,0.7083,,0.5369,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65946,SRR15700567,SRX11996475,SRS10003990,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EH2,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EH2,EH2,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EH2_1.fq.gz EH2_2.fq.gz,fastq fastq,6792825900.0,45285506.0,EH2 1.fq.gz,0:150 1:150,A:1958355652;C:1427389031;G:1440081079;T:1966978334;N:21804,150,150,,,1958355652,1427389031,1440081079,1966978334,21804,SRX11996475,SRS10003990,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91907,,0.17888,,0.70575,,0.54118,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65947,SRR15700568,SRX11996474,SRS10003989,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EH1,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EH1,EH1,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EH1_1.fq.gz EH1_2.fq.gz,fastq fastq,6723154200.0,44821028.0,EH1 1.fq.gz,0:150 1:150,A:1939940725;C:1412087358;G:1424339686;T:1946764075;N:22356,150,150,,,1939940725,1412087358,1424339686,1946764075,22356,SRX11996474,SRS10003989,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91848,,0.1756,,0.71293,,0.54795,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65948,SRR15700569,SRX11996473,SRS10003988,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EL3,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EL3,EL3,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EL3_1.fq.gz EL3_2.fq.gz,fastq fastq,6756746700.0,45044978.0,EL3 1.fq.gz,0:150 1:150,A:1958754520;C:1411572406;G:1418753117;T:1967647023;N:19634,150,150,,,1958754520,1411572406,1418753117,1967647023,19634,SRX11996473,SRS10003988,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91873,,0.18319,,0.71027,,0.55277,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65949,SRR15700570,SRX11996472,SRS10003987,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EL2,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EL2,EL2,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EL2_1.fq.gz EL2_2.fq.gz,fastq fastq,6811200600.0,45408004.0,EL2 1.fq.gz,0:150 1:150,A:1961542081;C:1433135536;G:1446857456;T:1969644200;N:21327,150,150,,,1961542081,1433135536,1446857456,1969644200,21327,SRX11996472,SRS10003987,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91853,,0.17639,,0.71076,,0.54175,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65950,SRR15700571,SRX11996471,SRS10003986,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,EL1,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,EL1,EL1,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,EL1_1.fq.gz EL1_2.fq.gz,fastq fastq,6764302200.0,45095348.0,EL1 1.fq.gz,0:150 1:150,A:1943560425;C:1428175041;G:1441358638;T:1951185256;N:22840,150,150,,,1943560425,1428175041,1441358638,1951185256,22840,SRX11996471,SRS10003986,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91885,,0.17456,,0.71423,,0.53356,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65951,SRR15700572,SRX11996470,SRS10003985,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,E03,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,E03,E03,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,E03_1.fq.gz E03_2.fq.gz,fastq fastq,6762334500.0,45082230.0,E03 1.fq.gz,0:150 1:150,A:1941432663;C:1429093210;G:1444693949;T:1947091388;N:23290,150,150,,,1941432663,1429093210,1444693949,1947091388,23290,SRX11996470,SRS10003985,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91902,,0.17577,,0.71413,,0.54672,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65952,SRR15700573,SRX11996469,SRS10003984,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RH3,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RH3,RH3,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RH3_1.fq.gz RH3_2.fq.gz,fastq fastq,6620159400.0,44134396.0,RH3 1.fq.gz,0:150 1:150,A:1906961918;C:1396128146;G:1402603611;T:1914452217;N:13508,150,150,,,1906961918,1396128146,1402603611,1914452217,13508,SRX11996469,SRS10003984,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91596,,0.18007,,0.70307,,0.53072,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65953,SRR15700574,SRX11996468,SRS10003983,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RH2,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RH2,RH2,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RH2_1.fq.gz RH2_2.fq.gz,fastq fastq,6779957400.0,45199716.0,RH2 1.fq.gz,0:150 1:150,A:1943750299;C:1436936087;G:1447253724;T:1952003667;N:13623,150,150,,,1943750299,1436936087,1447253724,1952003667,13623,SRX11996468,SRS10003983,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91806,,0.17416,,0.70364,,0.53449,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65954,SRR15700575,SRX11996467,SRS10003982,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RH1,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RH1,RH1,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RH1_1.fq.gz RH1_2.fq.gz,fastq fastq,6803711400.0,45358076.0,RH1 1.fq.gz,0:150 1:150,A:1919109429;C:1472916047;G:1485344758;T:1926327627;N:13539,150,150,,,1919109429,1472916047,1485344758,1926327627,13539,SRX11996467,SRS10003982,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.92595,,0.14064,,0.71392,,0.5508,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65955,SRR15700576,SRX11996466,SRS10003981,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RL3,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RL3,RL3,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RL3_1.fq.gz RL3_2.fq.gz,fastq fastq,6775779300.0,45171862.0,RL3 1.fq.gz,0:150 1:150,A:1977555439;C:1404514814;G:1412262159;T:1981432811;N:14077,150,150,,,1977555439,1404514814,1412262159,1981432811,14077,SRX11996466,SRS10003981,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91883,,0.1833,,0.71638,,0.55343,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65956,SRR15700577,SRX11996465,SRS10003979,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RL2,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RL2,RL2,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RL2_1.fq.gz RL2_2.fq.gz,fastq fastq,6716301900.0,44775346.0,RL2 1.fq.gz,0:150 1:150,A:1959165761;C:1392977724;G:1400724963;T:1963418595;N:14857,150,150,,,1959165761,1392977724,1400724963,1963418595,14857,SRX11996465,SRS10003979,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.92114,,0.18164,,0.7217,,0.55665,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65957,SRR15700578,SRX11996464,SRS10003980,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,RL1,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,RL1,RL1,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,RL1_1.fq.gz RL1_2.fq.gz,fastq fastq,6632905200.0,44219368.0,RL1 1.fq.gz,0:150 1:150,A:1930258593;C:1379056686;G:1391344096;T:1932223405;N:22420,150,150,,,1930258593,1379056686,1391344096,1932223405,22420,SRX11996464,SRS10003980,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91966,,0.18087,,0.72121,,0.5664,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65958,SRR15700579,SRX11996463,SRS10003978,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,R03,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,R03,R03,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,R03_1.fq.gz R03_2.fq.gz,fastq fastq,6574600200.0,43830668.0,R03 1.fq.gz,0:150 1:150,A:1940343461;C:1342685356;G:1350150434;T:1941399481;N:21468,150,150,,,1940343461,1342685356,1350150434,1941399481,21468,SRX11996463,SRS10003978,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91867,,0.19479,,0.72707,,0.57885,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65959,SRR15700580,SRX11996462,SRS10003977,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 21 DAY RECOVERY,,R02,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,R02,R02,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,R02_1.fq.gz R02_2.fq.gz,fastq fastq,6399007800.0,42660052.0,R02 1.fq.gz,0:150 1:150,A:1884110766;C:1308008993;G:1315054545;T:1891764364;N:69132,150,150,,,1884110766,1308008993,1315054545,1891764364,69132,SRX11996462,SRS10003977,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91477,,0.19859,,0.72417,,0.55394,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65960,SRR15700581,SRX11996461,SRS10003976,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,E02,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,E02,E02,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,E02_1.fq.gz E02_2.fq.gz,fastq fastq,6588207000.0,43921380.0,E02 1.fq.gz,0:150 1:150,A:1905685715;C:1379753621;G:1389708827;T:1913038146;N:20691,150,150,,,1905685715,1379753621,1389708827,1913038146,20691,SRX11996461,SRS10003976,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91596,,0.18027,,0.70903,,0.54349,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System 65961,SRR15700582,SRX11996460,SRS10003975,SRP335395,PRJNA759881,Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio,PRJNA759881,Other,Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.,,,END OF 7 DAY EXPOSURE,,E01,,strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: adult female brain,E01,E01,a standardized procedure at the Beijing Genome Institute,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP335395,,,E01_1.fq.gz E01_2.fq.gz,fastq fastq,6766213800.0,45108092.0,E01 1.fq.gz,0:150 1:150,A:1963125745;C:1410900205;G:1420069949;T:1972096961;N:20940,150,150,,,1963125745,1410900205,1420069949,1972096961,20940,SRX11996460,SRS10003975,SRA1288076,Jiangsu University|Institute of Environmental Health and Ecological S,Jiangsu University,1,0.91884,,0.18555,,0.71585,,0.5455,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-09-02,Adult,Adult,Brain,Nervous System