rowid,run.accession,experiment.accession,sample.accession,study.accession,bioproject,study.title,study.alias,study.type,study.abstract,study.attributes,study.PMIDs,sample.description,sample.title,sample.alias,sample.centername,sample.attributes,GEOsample.title,GEOsample.dataprocessing,GEOsample.source,GEOsample.treatmentprotocol,GEOsample.extractprotocol,GEOsample.growthprotocol,GEOsample.characteristics,GEOsample.accession,experiment.title,experiment.alias,experiment.library_name,experiment.design_description,experiment.library_construction_protocol,experiment.attributes,experiment.library_strategy,experiment.library_source,experiment.library_selection,experiment.library_layout,experiment.platform,experiment.instrument_model,experiment.spot_descriptor,experiment.study_ref,run.title,run.attributes,run.filename,run.semantic_name,run.total_bases,run.total_spots,run.alias,run.read_lengths,run.base_counts,run.r1_length,run.r2_length,run.r3_length,run.r4_length,run.Acount,run.Ccount,run.Gcount,run.Tcount,run.Ncount,run.experiment,run.pool_member,submission.accession,submission.srasource,submission.bioprojectsource,seqdetective.n_mates,seqdetective.mapping_rate.mate1,seqdetective.mapping_rate.mate2,seqdetective.nofeature_rate.mate1,seqdetective.nofeature_rate.mate2,seqdetective.sparsity.mate1,seqdetective.sparsity.mate2,seqdetective.pos_strand_rate.mate1,seqdetective.pos_strand_rate.mate2,seqdetective.readlen.mate1,seqdetective.readlen.mate2,seqdetective.judgement.mate1,seqdetective.judgement.mate2,seqdetective.judgement.reason,platform_family,instrument_generation,read_bias,selection_class,prep_kit,sc_or_bulk,tech_class,technology,tech_variant,submission.bioprojectsource.country,earliest_date,devstage_curation,devstage_curation_coarse,tissue_curation,tissue_curation_coarse
52210,SRR9021058,SRX5799154,SRS4730324,SRP195685,PRJNA541367,Global transcriptomic analysis of zebrafish glucagon receptor mutant,PRJNA541367,Other,We performed RNA sequencing RNA seq analysis of whole fish to provide a comprehensive view of its global transcriptomic regulation in this study.,,,,,WT 1,,replicate:biological replicate 1|strain:AB|age:7 days|sex:not applicable|tissue:total|BioSampleModel:Model organism or animal,,,,,,,,,Diano rerio transcriptome,WT 1 20190506 1,WT 1 20190506 1,RNA seq of WT Diano rerio,,,RNA-Seq,TRANSCRIPTOMIC,other,SINGLE,BGISEQ,BGISEQ-500,,SRP195685,,loader:fastq load.py,WT1.1.fq,fastq,1094498950.0,21889979.0,WT1.1.fq,0:50,A:291195764;C:255539280;G:262638316;T:284737693;N:387897,50,,,,291195764,255539280,262638316,284737693,387897,SRX5799154,SRS4730324,SRA883435,Xiamen University|School of Pharmaceutical Sciences,Xiamen University,1,0.94195,,0.09713,,0.66689,,0.47749,,50,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-18,Larval,Larval,Undetermined,Undetermined
52211,SRR9021059,SRX5799153,SRS4730323,SRP195685,PRJNA541367,Global transcriptomic analysis of zebrafish glucagon receptor mutant,PRJNA541367,Other,We performed RNA sequencing RNA seq analysis of whole fish to provide a comprehensive view of its global transcriptomic regulation in this study.,,,,,WT 2,,replicate:biological replicate 2|strain:AB|age:7 days|sex:not applicable|tissue:total|BioSampleModel:Model organism or animal,,,,,,,,,Diano rerio transcriptome,WT 2 20190506 2,WT 2 20190506 2,RNA seq of WT Diano rerio,,,RNA-Seq,TRANSCRIPTOMIC,other,SINGLE,BGISEQ,BGISEQ-500,,SRP195685,,loader:fastq load.py,WT2.1.fq,fastq,1095133200.0,21902664.0,WT2.1.fq,0:50,A:290594757;C:255644044;G:259681140;T:288014102;N:1199157,50,,,,290594757,255644044,259681140,288014102,1199157,SRX5799153,SRS4730323,SRA883435,Xiamen University|School of Pharmaceutical Sciences,Xiamen University,1,0.93368,,0.09166,,0.67085,,0.46523,,50,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-18,Larval,Larval,Undetermined,Undetermined
52212,SRR9021060,SRX5799152,SRS4730322,SRP195685,PRJNA541367,Global transcriptomic analysis of zebrafish glucagon receptor mutant,PRJNA541367,Other,We performed RNA sequencing RNA seq analysis of whole fish to provide a comprehensive view of its global transcriptomic regulation in this study.,,,,,WT 3,,replicate:biological replicate 3|strain:AB|age:7 days|sex:not applicable|tissue:total|BioSampleModel:Model organism or animal,,,,,,,,,Diano rerio transcriptome,WT 3 20190506 3,WT 3 20190506 3,RNA seq of WT Diano rerio,,,RNA-Seq,TRANSCRIPTOMIC,other,SINGLE,BGISEQ,BGISEQ-500,,SRP195685,,loader:fastq load.py,WT3.1.fq,fastq,1096083900.0,21921678.0,WT3.1.fq,0:50,A:290332094;C:256993500;G:263043956;T:285349722;N:364628,50,,,,290332094,256993500,263043956,285349722,364628,SRX5799152,SRS4730322,SRA883435,Xiamen University|School of Pharmaceutical Sciences,Xiamen University,1,0.94147,,0.10157,,0.66135,,0.47301,,50,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-18,Larval,Larval,Undetermined,Undetermined
52213,SRR9021061,SRX5799151,SRS4730320,SRP195685,PRJNA541367,Global transcriptomic analysis of zebrafish glucagon receptor mutant,PRJNA541367,Other,We performed RNA sequencing RNA seq analysis of whole fish to provide a comprehensive view of its global transcriptomic regulation in this study.,,,,,gcgr 1,,replicate:biological replicate 1|strain:AB|age:7 days|sex:not applicable|tissue:total|BioSampleModel:Model organism or animal,,,,,,,,,Diano rerio transcriptome,gcgr 1 20190506 1,gcgr 1 20190506 1,RNA seq of Diano rerio with gcgr mutant,,,RNA-Seq,TRANSCRIPTOMIC,other,SINGLE,BGISEQ,BGISEQ-500,,SRP195685,,loader:fastq load.py,gcgr1.1.fq,fastq,1096307200.0,21926144.0,gcgr1.1.fq,0:50,A:288839446;C:258297625;G:264630675;T:284199738;N:339716,50,,,,288839446,258297625,264630675,284199738,339716,SRX5799151,SRS4730320,SRA883435,Xiamen University|School of Pharmaceutical Sciences,Xiamen University,1,0.94131,,0.09307,,0.67574,,0.46993,,50,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-18,Larval,Larval,Undetermined,Undetermined
52214,SRR9021062,SRX5799150,SRS4730321,SRP195685,PRJNA541367,Global transcriptomic analysis of zebrafish glucagon receptor mutant,PRJNA541367,Other,We performed RNA sequencing RNA seq analysis of whole fish to provide a comprehensive view of its global transcriptomic regulation in this study.,,,,,gcgr 2,,replicate:biological replicate 2|strain:AB|age:7 days|sex:not applicable|tissue:total|BioSampleModel:Model organism or animal,,,,,,,,,Diano rerio transcriptome,gcgr 2 20190506 2,gcgr 2 20190506 2,RNA seq of Diano rerio with gcgr mutant,,,RNA-Seq,TRANSCRIPTOMIC,other,SINGLE,BGISEQ,BGISEQ-500,,SRP195685,,loader:fastq load.py,gcgr2.1.fq,fastq,1094410100.0,21888202.0,gcgr2.1.fq,0:50,A:290062779;C:256358687;G:264488431;T:282812212;N:687991,50,,,,290062779,256358687,264488431,282812212,687991,SRX5799150,SRS4730321,SRA883435,Xiamen University|School of Pharmaceutical Sciences,Xiamen University,1,0.94074,,0.09337,,0.67633,,0.46861,,50,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-18,Larval,Larval,Undetermined,Undetermined
52215,SRR9021063,SRX5799149,SRS4730319,SRP195685,PRJNA541367,Global transcriptomic analysis of zebrafish glucagon receptor mutant,PRJNA541367,Other,We performed RNA sequencing RNA seq analysis of whole fish to provide a comprehensive view of its global transcriptomic regulation in this study.,,,,,gcgr 3,,replicate:biological replicate 3|strain:AB|age:7 days|sex:not applicable|tissue:total|BioSampleModel:Model organism or animal,,,,,,,,,Diano rerio transcriptome,gcgr 3 20190506 3,gcgr 3 20190506 3,RNA seq of Diano rerio with gcgr mutant,,,RNA-Seq,TRANSCRIPTOMIC,other,SINGLE,BGISEQ,BGISEQ-500,,SRP195685,,loader:fastq load.py,gcgr3.1.fq,fastq,1094284800.0,21885696.0,gcgr3.1.fq,0:50,A:289313514;C:257096636;G:264011408;T:283143600;N:719642,50,,,,289313514,257096636,264011408,283143600,719642,SRX5799149,SRS4730319,SRA883435,Xiamen University|School of Pharmaceutical Sciences,Xiamen University,1,0.94222,,0.09557,,0.67521,,0.46664,,50,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-01-18,Larval,Larval,Undetermined,Undetermined
66964,SRR16965143,SRX13156592,SRS11088496,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,1mix,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:10 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :mixture group,mix 1,mix 1,96hpf zebrafish larvae mixture group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,mix2_1_2.fq.gz,fastq,3313823250.0,22092155.0,mix2 1 2.fq.gz,0:0 1:150,A:895726357;C:763402657;G:745765587;T:908922686;N:5963,0,150,,,895726357,763402657,745765587,908922686,5963,SRX13156592,SRS11088496,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.93604,,0.10794,,0.65587,,0.47956,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined
66965,SRR16965144,SRX13156591,SRS11088495,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,3enf,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:9 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :enrofloxacin group,enf 3,enf 3,96hpf zebrafish larvae enrofloxacin group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,enf_3.fq.gz,fastq,3304972350.0,22033149.0,enf 3.fq.gz,0:150 1:0,A:899427202;C:745999066;G:759917309;T:899625137;N:3636,150,0,,,899427202,745999066,759917309,899625137,3636,SRX13156591,SRS11088495,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94353,,0.10795,,0.66212,,0.47773,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined
66967,SRR16965146,SRX13156589,SRS11088492,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,3car,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:6 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :carbendazim group,car 3,car 3,96hpf zebrafish larvae carbendazim group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,car_3_1.fq.gz,fastq,3335622150.0,22237481.0,car 3 1.fq.gz,0:150 1:0,A:853229671;C:807433601;G:820478265;T:854475092;N:5521,150,0,,,853229671,807433601,820478265,854475092,5521,SRX13156589,SRS11088492,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.96567,,0.03093,,0.70997,,0.47751,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined
66968,SRR16965147,SRX13156588,SRS11088494,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,1car,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:4 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :carbendazim group,car 1,car 1,96hpf zebrafish larvae carbendazim group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,car_1_1.fq.gz,fastq,3378056400.0,22520376.0,car 1 1.fq.gz,0:150 1:0,A:886009175;C:795203398;G:809447342;T:887390300;N:6185,150,0,,,886009175,795203398,809447342,887390300,6185,SRX13156588,SRS11088494,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95701,,0.05956,,0.67836,,0.4884,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined
66969,SRR16965148,SRX13156587,SRS11088491,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,3con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:3 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :control group,con 3,con 3,96hpf zebrafish larvae control group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,con_3_2.fq.gz,fastq,3359054500.0,33590545.0,con 3 2.fq.gz,0:100 1:0,A:914533337;C:755914202;G:773676246;T:914930715;N:0,100,0,,,914533337,755914202,773676246,914930715,0,SRX13156587,SRS11088491,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95076,,0.10478,,0.65646,,0.49594,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined
66970,SRR16965149,SRX13156586,SRS11088489,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,3mix,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:12 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :mixture group,mix 3,mix 3,96hpf zebrafish larvae mixture group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,,mix2_3_1.fq.gz,fastq,3362094000.0,33620940.0,mix2 3 1.fq.gz,0:100 1:0,A:916124379;C:755910593;G:768246534;T:921812494;N:0,100,0,,,916124379,755910593,768246534,921812494,0,SRX13156586,SRS11088489,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94894,,0.10416,,0.65342,,0.49475,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-17,Larval,Larval,Undetermined,Undetermined
66972,SRR16965151,SRX13156584,SRS11088488,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,2con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:2 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :control group,con 2,con 2,96hpf zebrafish larvae control group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,loader:fastq load.py,con_2_2.fq,fastq,3324287550.0,22161917.0,con 2 2.fq.gz,0:150,A:848766265;C:812477645;G:798995610;T:864040426;N:7604,150,,,,848766265,812477645,798995610,864040426,7604,SRX13156584,SRS11088488,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95546,,0.03524,,0.70027,,0.48649,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-22,Larval,Larval,Undetermined,Undetermined
66973,SRR16965152,SRX13156583,SRS11088487,SRP346547,PRJNA780808,transcriptomics of carbendazim and enrofloxacin on zebrafish embryos,PRJNA780808,Other,reveal a interaction between ENF and CAR on metabolic regulation during development,,,,,1con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:1 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio :control group,con 1,con 1,96hpf zebrafish larvae control group,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346547,,loader:fastq load.py,con_1_1.fq,fastq,3330724500.0,22204830.0,con 1 1.fq.gz,0:150,A:896812508;C:762246067;G:774062043;T:897597946;N:5936,150,,,,896812508,762246067,774062043,897597946,5936,SRX13156583,SRS11088487,SRA1329868,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94926,,0.08711,,0.66789,,0.48628,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-22,Larval,Larval,Undetermined,Undetermined
66975,SRR16959539,SRX13151073,SRS11083379,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,2dim,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:8 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : dimethomorph group,dim 2,dim 2,The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,dim_2_1.fq.gz,fastq,3344257500.0,22295050.0,dim 2 1.fq.gz,0:150 1:0,A:895700119;C:767415749;G:784994320;T:896143585;N:3727,150,0,,,895700119,767415749,784994320,896143585,3727,SRX13151073,SRS11083379,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.9497,,0.08418,,0.66352,,0.49341,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined
66976,SRR16959540,SRX13151072,SRS11083378,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,1dim,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:7 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : dimethomorph group,dim 1,dim 1,The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,dim_1_1.fq.gz,fastq,3318812250.0,22125415.0,dim 1 1.fq.gz,0:150 1:0,A:908481293;C:742787936;G:755930542;T:911608821;N:3658,150,0,,,908481293,742787936,755930542,911608821,3658,SRX13151072,SRS11083378,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94211,,0.11824,,0.65344,,0.47716,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined
66977,SRR16959541,SRX13151071,SRS11083377,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,3dif,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:6 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : difenoconazole group,dif 3,dif 3,The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,dif_3_1.fq.gz,fastq,3318453000.0,22123020.0,dif 3 1.fq.gz,0:150 1:0,A:893975607;C:758489621;G:772391705;T:893592335;N:3732,150,0,,,893975607,758489621,772391705,893592335,3732,SRX13151071,SRS11083377,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94838,,0.08393,,0.66543,,0.4818,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined
66978,SRR16959542,SRX13151070,SRS11083376,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,2dif,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:5 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : difenoconazole group,dif 2,dif 2,The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,dif_2_2.fq.gz,fastq,3304972350.0,22033149.0,dif 2 2.fq.gz,0:0 1:150,A:890456734;C:764917766;G:744757536;T:904833787;N:6527,0,150,,,890456734,764917766,744757536,904833787,6527,SRX13151070,SRS11083376,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.93514,,0.107,,0.6633,,0.47599,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined
66979,SRR16959543,SRX13151069,SRS11083375,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,1dif,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:4 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : difenoconazole group,dif 1,dif 1,The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,dif_1_1.fq.gz,fastq,3295443900.0,21969626.0,dif 1 1.fq.gz,0:150 1:0,A:887936493;C:751636494;G:765508757;T:890358629;N:3527,150,0,,,887936493,751636494,765508757,890358629,3527,SRX13151069,SRS11083375,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94623,,0.09138,,0.66478,,0.4828,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined
66980,SRR16959544,SRX13151068,SRS11083374,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,3+con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:3 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : control group,con 3,con 3,The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,con_3_1.fq.gz,fastq,3306406800.0,22042712.0,con 3 1.fq.gz,0:150 1:0,A:872740236;C:773482184;G:788334419;T:871846539;N:3422,150,0,,,872740236,773482184,788334419,871846539,3422,SRX13151068,SRS11083374,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95458,,0.06103,,0.67409,,0.48439,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined
66982,SRR16959546,SRX13151066,SRS11083372,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,2+con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:2 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : control group,con 2,con 2,The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,con_2_2.fq.gz,fastq,3324287550.0,22161917.0,con 2 2.fq.gz,0:0 1:150,A:848766265;C:812477645;G:798995610;T:864040426;N:7604,0,150,,,848766265,812477645,798995610,864040426,7604,SRX13151066,SRS11083372,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.95548,,0.03524,,0.70021,,0.4867,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined
66983,SRR16959547,SRX13151065,SRS11083371,SRP346418,PRJNA780940,transcriptomics of difenoconazole and dimethomorph on zebrafish embryos,PRJNA780940,Other,Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.,,,,,1+con,,strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:1 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : control group,con 1,con 1,The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,SINGLE,BGISEQ,BGISEQ-500,,SRP346418,,,con_1_1.fq.gz,fastq,3330724500.0,22204830.0,con 1 1.fq.gz,0:150 1:0,A:896812508;C:762246067;G:774062043;T:897597946;N:5936,150,0,,,896812508,762246067,774062043,897597946,5936,SRX13151065,SRS11083371,SRA1330365,China Agricultural University|College of animal science and technology,China Agricultural University,1,0.94925,,0.08711,,0.66772,,0.48635,,150,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2021-11-16,Larval,Larval,Undetermined,Undetermined
68473,SRR17793192,SRX13955361,SRS11795776,SRP357103,PRJNA801348,Global studies of Nur77 on metabolism of zebrafish,PRJNA801348,Other,We created a global Nur77 knockout zebrafish model by CRISPR/Cas9 technique  and then performed the whole organism RNA sequencing analysis in wild type and nur77 deficient zebrafish to dissect the changes genes in metabolic related pathways.,,,,,WT3,,strain:WT replicate 3|age:6 dpf|sex:male and female|tissue:Total|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: 6 dpf larvea,Li lab Nur77 6,Li lab Nur77 6,There are two groups: WT and Nur77 mutant. Every group has three replicates.,,,RNA-Seq,TRANSCRIPTOMIC,cDNA,SINGLE,BGISEQ,BGISEQ-500,,SRP357103,,,WT3.fq.gz,fastq,1076798350.0,21535967.0,WT3.fq.gz,0:50 1:0,A:290308649;C:238961327;G:249860004;T:297257553;N:410817,50,0,,,290308649,238961327,249860004,297257553,410817,SRX13955361,SRS11795776,SRA1363249,Xiamen University|School of pharmaceutical sciences,Xiamen University,1,0.9388,,0.12749,,0.66087,,0.4989,,50,,B,,usable mapping rate,bgi,bgi,unknown,cdna_unspecified,unknown,bulk,unknown,unknown,,China,2022-01-27,Larval,Larval,Undetermined,Undetermined
68474,SRR17793193,SRX13955360,SRS11795775,SRP357103,PRJNA801348,Global studies of Nur77 on metabolism of zebrafish,PRJNA801348,Other,We created a global Nur77 knockout zebrafish model by CRISPR/Cas9 technique  and then performed the whole organism RNA sequencing analysis in wild type and nur77 deficient zebrafish to dissect the changes genes in metabolic related pathways.,,,,,WT2,,strain:WT replicate 2|age:6 dpf|sex:male and female|tissue:Total|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: 6 dpf larvea,Li lab Nur77 5,Li lab Nur77 5,There are two groups: WT and Nur77 mutant. Every group has three replicates.,,,RNA-Seq,TRANSCRIPTOMIC,cDNA,SINGLE,BGISEQ,BGISEQ-500,,SRP357103,,,WT2.fq.gz,fastq,1076181450.0,21523629.0,WT2.fq.gz,0:50 1:0,A:289932885;C:238687076;G:249724577;T:297412345;N:424567,50,0,,,289932885,238687076,249724577,297412345,424567,SRX13955360,SRS11795775,SRA1363249,Xiamen University|School of pharmaceutical sciences,Xiamen University,1,0.93932,,0.1297,,0.66038,,0.48203,,50,,B,,usable mapping rate,bgi,bgi,unknown,cdna_unspecified,unknown,bulk,unknown,unknown,,China,2022-01-27,Larval,Larval,Undetermined,Undetermined
68475,SRR17793194,SRX13955359,SRS11795774,SRP357103,PRJNA801348,Global studies of Nur77 on metabolism of zebrafish,PRJNA801348,Other,We created a global Nur77 knockout zebrafish model by CRISPR/Cas9 technique  and then performed the whole organism RNA sequencing analysis in wild type and nur77 deficient zebrafish to dissect the changes genes in metabolic related pathways.,,,,,WT1,,strain:WT replicate 1|age:6 dpf|sex:male and female|tissue:Total|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: 6 dpf larvea,Li lab Nur77 4,Li lab Nur77 4,There are two groups: WT and Nur77 mutant. Every group has three replicates.,,,RNA-Seq,TRANSCRIPTOMIC,cDNA,SINGLE,BGISEQ,BGISEQ-500,,SRP357103,,,WT1.fq.gz,fastq,1076191400.0,21523828.0,WT1.fq.gz,0:50 1:0,A:291276889;C:238480546;G:249179972;T:296814696;N:439297,50,0,,,291276889,238480546,249179972,296814696,439297,SRX13955359,SRS11795774,SRA1363249,Xiamen University|School of pharmaceutical sciences,Xiamen University,1,0.93825,,0.12843,,0.66119,,0.49668,,50,,B,,usable mapping rate,bgi,bgi,unknown,cdna_unspecified,unknown,bulk,unknown,unknown,,China,2022-01-27,Larval,Larval,Undetermined,Undetermined
68476,SRR17793195,SRX13955358,SRS11795773,SRP357103,PRJNA801348,Global studies of Nur77 on metabolism of zebrafish,PRJNA801348,Other,We created a global Nur77 knockout zebrafish model by CRISPR/Cas9 technique  and then performed the whole organism RNA sequencing analysis in wild type and nur77 deficient zebrafish to dissect the changes genes in metabolic related pathways.,,,,,nur77KO3,,strain:nur77KO replicate 3|age:6 dpf|sex:male and female|tissue:Total|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: 6 dpf larvea,Li lab Nur77 3,Li lab Nur77 3,There are two groups: WT and Nur77 mutant. Every group has three replicates.,,,RNA-Seq,TRANSCRIPTOMIC,cDNA,SINGLE,BGISEQ,BGISEQ-500,,SRP357103,,,Nur773.fq.gz,fastq,1076004450.0,21520089.0,Nur773.fq.gz,0:50 1:0,A:290229363;C:238956151;G:246664664;T:299742511;N:411761,50,0,,,290229363,238956151,246664664,299742511,411761,SRX13955358,SRS11795773,SRA1363249,Xiamen University|School of pharmaceutical sciences,Xiamen University,1,0.93696,,0.13828,,0.66397,,0.48777,,50,,B,,usable mapping rate,bgi,bgi,unknown,cdna_unspecified,unknown,bulk,unknown,unknown,,China,2022-01-27,Larval,Larval,Undetermined,Undetermined
68477,SRR17793196,SRX13955357,SRS11795772,SRP357103,PRJNA801348,Global studies of Nur77 on metabolism of zebrafish,PRJNA801348,Other,We created a global Nur77 knockout zebrafish model by CRISPR/Cas9 technique  and then performed the whole organism RNA sequencing analysis in wild type and nur77 deficient zebrafish to dissect the changes genes in metabolic related pathways.,,,,,nur77KO2,,strain:nur77KO replicate 2|age:6 dpf|sex:male and female|tissue:Total|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: 6 dpf larvea,Li lab Nur77 2,Li lab Nur77 2,There are two groups: WT and Nur77 mutant. Every group has three replicates.,,,RNA-Seq,TRANSCRIPTOMIC,cDNA,SINGLE,BGISEQ,BGISEQ-500,,SRP357103,,,Nur772.fq.gz,fastq,1075868050.0,21517361.0,Nur772.fq.gz,0:50 1:0,A:288260097;C:241294246;G:250714084;T:295165628;N:433995,50,0,,,288260097,241294246,250714084,295165628,433995,SRX13955357,SRS11795772,SRA1363249,Xiamen University|School of pharmaceutical sciences,Xiamen University,1,0.94112,,0.11813,,0.66582,,0.48643,,50,,B,,usable mapping rate,bgi,bgi,unknown,cdna_unspecified,unknown,bulk,unknown,unknown,,China,2022-01-27,Larval,Larval,Undetermined,Undetermined
68478,SRR17793197,SRX13955356,SRS11795771,SRP357103,PRJNA801348,Global studies of Nur77 on metabolism of zebrafish,PRJNA801348,Other,We created a global Nur77 knockout zebrafish model by CRISPR/Cas9 technique  and then performed the whole organism RNA sequencing analysis in wild type and nur77 deficient zebrafish to dissect the changes genes in metabolic related pathways.,,,,,nur77KO1,,strain:nur77KO replicate 1|age:6 dpf|sex:male and female|tissue:Total|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio: 6 dpf larvea,Li lab Nur77 1,Li lab Nur77 1,There are two groups: WT and Nur77 mutant. Every group has three replicates.,,,RNA-Seq,TRANSCRIPTOMIC,cDNA,SINGLE,BGISEQ,BGISEQ-500,,SRP357103,,,Nur771.fq.gz,fastq,1075810450.0,21516209.0,Nur771.fq.gz,0:50 1:0,A:287851992;C:241486200;G:251500529;T:294560911;N:410818,50,0,,,287851992,241486200,251500529,294560911,410818,SRX13955356,SRS11795771,SRA1363249,Xiamen University|School of pharmaceutical sciences,Xiamen University,1,0.94193,,0.11554,,0.6676,,0.49728,,50,,B,,usable mapping rate,bgi,bgi,unknown,cdna_unspecified,unknown,bulk,unknown,unknown,,China,2022-01-27,Larval,Larval,Undetermined,Undetermined