rowid,run.accession,experiment.accession,sample.accession,study.accession,bioproject,study.title,study.alias,study.type,study.abstract,study.attributes,study.PMIDs,sample.description,sample.title,sample.alias,sample.centername,sample.attributes,GEOsample.title,GEOsample.dataprocessing,GEOsample.source,GEOsample.treatmentprotocol,GEOsample.extractprotocol,GEOsample.growthprotocol,GEOsample.characteristics,GEOsample.accession,experiment.title,experiment.alias,experiment.library_name,experiment.design_description,experiment.library_construction_protocol,experiment.attributes,experiment.library_strategy,experiment.library_source,experiment.library_selection,experiment.library_layout,experiment.platform,experiment.instrument_model,experiment.spot_descriptor,experiment.study_ref,run.title,run.attributes,run.filename,run.semantic_name,run.total_bases,run.total_spots,run.alias,run.read_lengths,run.base_counts,run.r1_length,run.r2_length,run.r3_length,run.r4_length,run.Acount,run.Ccount,run.Gcount,run.Tcount,run.Ncount,run.experiment,run.pool_member,submission.accession,submission.srasource,submission.bioprojectsource,seqdetective.n_mates,seqdetective.mapping_rate.mate1,seqdetective.mapping_rate.mate2,seqdetective.nofeature_rate.mate1,seqdetective.nofeature_rate.mate2,seqdetective.sparsity.mate1,seqdetective.sparsity.mate2,seqdetective.pos_strand_rate.mate1,seqdetective.pos_strand_rate.mate2,seqdetective.readlen.mate1,seqdetective.readlen.mate2,seqdetective.judgement.mate1,seqdetective.judgement.mate2,seqdetective.judgement.reason,platform_family,instrument_generation,read_bias,selection_class,prep_kit,sc_or_bulk,tech_class,technology,tech_variant,submission.bioprojectsource.country,earliest_date,devstage_curation,devstage_curation_coarse,tissue_curation,tissue_curation_coarse
64122,SRR14272168,SRX10633820,SRS8730202,SRP315319,PRJNA722925,Reinforcing one carbon metabolism via folic acid/Folr1 promotes beta cell differentiation,PRJNA722925,Other,Diabetes can be caused by an insufficiency in beta cell mass. Here  we performed a genetic screen in a zebrafish model of beta cell loss to identify pathways promoting beta cell regeneration. We found that both folate receptor 1 folr1 overexpression and treatment with folinic acid  stimulated beta cell differentiation in zebrafish. Treatment with folinic acid also stimulated beta cell differentiation in cultures of neonatal pig islets  showing that the effect could be translated to a mammalian system. In both zebrafish and neonatal pig islets  the increased beta cell differentiation originated from ductal cells. Mechanistically  comparative metabolomic analysis of zebrafish with/without xxx cell ablation and with/without xxx acid treatment indicated beta cell regeneration could be attributed to changes in the pyrimidine  carnitine  and serine pathways. Overall  our results suggest evolutionarily conserved and previously unknown roles for folic acid and one carbon metabolism in the generation of beta cells.,,,,Pancreas islets   Pancreas islet 6dpf B2,Pancreas islets   Islet 6d B2 AGN000787,,strain:TU/AB|age:not applicable|dev stage:Day 6|sex:pooled male and female|tissue:pancreas|molecule:mRNA|selection:pA|sample ref:AGS000684|replicate ref:AGN000787|replicate order:2|BioSampleModel:Model organism or animal,,,,,,,,,Pancreas islets   Pancreas islet 6dpf B2,AGR001074,AGR001074,mRNA,,,RNA-Seq,TRANSCRIPTOMIC,unspecified,SINGLE,ILLUMINA,Illumina HiSeq 2000,,SRP315319,,,AGR001074_R1.fastq.gz,fastq,467368080.0,6149580.0,AGR001074 R1.fastq.gz,0:76 1:0,A:144866246;C:90980862;G:90828673;T:140671264;N:21035,76,0,,,144866246,90980862,90828673,140671264,21035,SRX10633820,SRS8730202,SRA1220217,Yale_Giraldez|Genetics,Yale_Giraldez_Group,1,0.86223,,0.47625,,0.68556,,0.52132,,76,,B,,usable mapping rate,illumina,hiseq_era,unknown,poly_a,unknown,bulk,unknown,unknown,,United States,2021-04-19,Larval,Larval,Pancreas,Endocrine System
64123,SRR14272169,SRX10633819,SRS8730201,SRP315319,PRJNA722925,Reinforcing one carbon metabolism via folic acid/Folr1 promotes beta cell differentiation,PRJNA722925,Other,Diabetes can be caused by an insufficiency in beta cell mass. Here  we performed a genetic screen in a zebrafish model of beta cell loss to identify pathways promoting beta cell regeneration. We found that both folate receptor 1 folr1 overexpression and treatment with folinic acid  stimulated beta cell differentiation in zebrafish. Treatment with folinic acid also stimulated beta cell differentiation in cultures of neonatal pig islets  showing that the effect could be translated to a mammalian system. In both zebrafish and neonatal pig islets  the increased beta cell differentiation originated from ductal cells. Mechanistically  comparative metabolomic analysis of zebrafish with/without xxx cell ablation and with/without xxx acid treatment indicated beta cell regeneration could be attributed to changes in the pyrimidine  carnitine  and serine pathways. Overall  our results suggest evolutionarily conserved and previously unknown roles for folic acid and one carbon metabolism in the generation of beta cells.,,,,Pancreas islets   Pancreas islet 6dpf B1,Pancreas islets   Islet 6d B1 AGN000786,,strain:TU/AB|age:not applicable|dev stage:Day 6|sex:pooled male and female|tissue:pancreas|molecule:mRNA|selection:pA|sample ref:AGS000684|replicate ref:AGN000786|replicate order:1|BioSampleModel:Model organism or animal,,,,,,,,,Pancreas islets   Pancreas islet 6dpf B1,AGR001073,AGR001073,mRNA,,,RNA-Seq,TRANSCRIPTOMIC,unspecified,SINGLE,ILLUMINA,Illumina HiSeq 2000,,SRP315319,,,AGR001073_R1.fastq.gz,fastq,592506792.0,7796142.0,AGR001073 R1.fastq.gz,0:76 1:0,A:179281934;C:120318002;G:119990438;T:172891644;N:24774,76,0,,,179281934,120318002,119990438,172891644,24774,SRX10633819,SRS8730201,SRA1220217,Yale_Giraldez|Genetics,Yale_Giraldez_Group,1,0.84252,,0.35277,,0.69219,,0.54723,,76,,B,,usable mapping rate,illumina,hiseq_era,unknown,poly_a,unknown,bulk,unknown,unknown,,United States,2021-04-19,Larval,Larval,Pancreas,Endocrine System
64128,SRR14272174,SRX10633814,SRS8730196,SRP315319,PRJNA722925,Reinforcing one carbon metabolism via folic acid/Folr1 promotes beta cell differentiation,PRJNA722925,Other,Diabetes can be caused by an insufficiency in beta cell mass. Here  we performed a genetic screen in a zebrafish model of beta cell loss to identify pathways promoting beta cell regeneration. We found that both folate receptor 1 folr1 overexpression and treatment with folinic acid  stimulated beta cell differentiation in zebrafish. Treatment with folinic acid also stimulated beta cell differentiation in cultures of neonatal pig islets  showing that the effect could be translated to a mammalian system. In both zebrafish and neonatal pig islets  the increased beta cell differentiation originated from ductal cells. Mechanistically  comparative metabolomic analysis of zebrafish with/without xxx cell ablation and with/without xxx acid treatment indicated beta cell regeneration could be attributed to changes in the pyrimidine  carnitine  and serine pathways. Overall  our results suggest evolutionarily conserved and previously unknown roles for folic acid and one carbon metabolism in the generation of beta cells.,,,,Pancreas islets   Pancreas islet 4dpf somatostatin transgene sst2:RFP beta cell ablation B2,Pancreas islets   Islet SST b cell abt 4d B2 AGN000782,,strain:TU/AB|age:not applicable|dev stage:Day 4|sex:pooled male and female|tissue:pancreas|treatment:metronidazole|molecule:mRNA|selection:pA|sample ref:AGS000680|replicate ref:AGN000782|replicate order:2|BioSampleModel:Model organism or animal,,,,,,,,,Pancreas islets   Pancreas islet 4dpf somatostatin transgene sst2:RFP beta cell ablation B2,AGR001070,AGR001070,mRNA,,,RNA-Seq,TRANSCRIPTOMIC,unspecified,SINGLE,ILLUMINA,Illumina HiSeq 2000,,SRP315319,,,AGR001070_R1.fastq.gz,fastq,481320616.0,6333166.0,AGR001070 R1.fastq.gz,0:76 1:0,A:151409804;C:91026556;G:90673968;T:148189727;N:20561,76,0,,,151409804,91026556,90673968,148189727,20561,SRX10633814,SRS8730196,SRA1220217,Yale_Giraldez|Genetics,Yale_Giraldez_Group,1,0.82954,,0.59765,,0.75538,,0.53049,,76,,B,,usable mapping rate,illumina,hiseq_era,unknown,poly_a,unknown,bulk,unknown,unknown,,United States,2021-04-19,Larval,Larval,Pancreas,Endocrine System
64129,SRR14272175,SRX10633813,SRS8730195,SRP315319,PRJNA722925,Reinforcing one carbon metabolism via folic acid/Folr1 promotes beta cell differentiation,PRJNA722925,Other,Diabetes can be caused by an insufficiency in beta cell mass. Here  we performed a genetic screen in a zebrafish model of beta cell loss to identify pathways promoting beta cell regeneration. We found that both folate receptor 1 folr1 overexpression and treatment with folinic acid  stimulated beta cell differentiation in zebrafish. Treatment with folinic acid also stimulated beta cell differentiation in cultures of neonatal pig islets  showing that the effect could be translated to a mammalian system. In both zebrafish and neonatal pig islets  the increased beta cell differentiation originated from ductal cells. Mechanistically  comparative metabolomic analysis of zebrafish with/without xxx cell ablation and with/without xxx acid treatment indicated beta cell regeneration could be attributed to changes in the pyrimidine  carnitine  and serine pathways. Overall  our results suggest evolutionarily conserved and previously unknown roles for folic acid and one carbon metabolism in the generation of beta cells.,,,,Pancreas islets   Pancreas islet 4dpf somatostatin transgene sst2:RFP beta cell ablation B1,Pancreas islets   Islet SST b cell abt 4d B1 AGN000781,,strain:TU/AB|age:not applicable|dev stage:Day 4|sex:pooled male and female|tissue:pancreas|treatment:metronidazole|molecule:mRNA|selection:pA|sample ref:AGS000680|replicate ref:AGN000781|replicate order:1|BioSampleModel:Model organism or animal,,,,,,,,,Pancreas islets   Pancreas islet 4dpf somatostatin transgene sst2:RFP beta cell ablation B1,AGR001069,AGR001069,mRNA,,,RNA-Seq,TRANSCRIPTOMIC,unspecified,SINGLE,ILLUMINA,Illumina HiSeq 2000,,SRP315319,,,AGR001069_R1.fastq.gz,fastq,379230956.0,4989881.0,AGR001069 R1.fastq.gz,0:76 1:0,A:116227158;C:75587948;G:75371178;T:112027929;N:16743,76,0,,,116227158,75587948,75371178,112027929,16743,SRX10633813,SRS8730195,SRA1220217,Yale_Giraldez|Genetics,Yale_Giraldez_Group,1,0.87385,,0.38949,,0.69242,,0.47061,,76,,B,,usable mapping rate,illumina,hiseq_era,unknown,poly_a,unknown,bulk,unknown,unknown,,United States,2021-04-19,Larval,Larval,Pancreas,Endocrine System
64133,SRR14272179,SRX10633809,SRS8730192,SRP315319,PRJNA722925,Reinforcing one carbon metabolism via folic acid/Folr1 promotes beta cell differentiation,PRJNA722925,Other,Diabetes can be caused by an insufficiency in beta cell mass. Here  we performed a genetic screen in a zebrafish model of beta cell loss to identify pathways promoting beta cell regeneration. We found that both folate receptor 1 folr1 overexpression and treatment with folinic acid  stimulated beta cell differentiation in zebrafish. Treatment with folinic acid also stimulated beta cell differentiation in cultures of neonatal pig islets  showing that the effect could be translated to a mammalian system. In both zebrafish and neonatal pig islets  the increased beta cell differentiation originated from ductal cells. Mechanistically  comparative metabolomic analysis of zebrafish with/without xxx cell ablation and with/without xxx acid treatment indicated beta cell regeneration could be attributed to changes in the pyrimidine  carnitine  and serine pathways. Overall  our results suggest evolutionarily conserved and previously unknown roles for folic acid and one carbon metabolism in the generation of beta cells.,,,,Pancreas islets   Pancreas islet 4dpf somatostatin transgene sst2:RFP B2,Pancreas islets   Islet SST 4d B2 AGN000780,,strain:TU/AB|age:not applicable|dev stage:Day 4|sex:pooled male and female|tissue:pancreas|molecule:mRNA|selection:pA|sample ref:AGS000678|replicate ref:AGN000780|replicate order:2|BioSampleModel:Model organism or animal,,,,,,,,,Pancreas islets   Pancreas islet 4dpf somatostatin transgene sst2:RFP B2,AGR001068,AGR001068,mRNA,,,RNA-Seq,TRANSCRIPTOMIC,unspecified,SINGLE,ILLUMINA,Illumina HiSeq 2000,,SRP315319,,,AGR001068_R1.fastq.gz,fastq,1025641204.0,13495279.0,AGR001068 R1.fastq.gz,0:76 1:0,A:313399325;C:201992871;G:202026959;T:308179140;N:42909,76,0,,,313399325,201992871,202026959,308179140,42909,SRX10633809,SRS8730192,SRA1220217,Yale_Giraldez|Genetics,Yale_Giraldez_Group,1,0.8692,,0.47406,,0.68081,,0.54006,,76,,B,,usable mapping rate,illumina,hiseq_era,unknown,poly_a,unknown,bulk,unknown,unknown,,United States,2021-04-19,Larval,Larval,Pancreas,Endocrine System
64134,SRR14272180,SRX10633808,SRS8730191,SRP315319,PRJNA722925,Reinforcing one carbon metabolism via folic acid/Folr1 promotes beta cell differentiation,PRJNA722925,Other,Diabetes can be caused by an insufficiency in beta cell mass. Here  we performed a genetic screen in a zebrafish model of beta cell loss to identify pathways promoting beta cell regeneration. We found that both folate receptor 1 folr1 overexpression and treatment with folinic acid  stimulated beta cell differentiation in zebrafish. Treatment with folinic acid also stimulated beta cell differentiation in cultures of neonatal pig islets  showing that the effect could be translated to a mammalian system. In both zebrafish and neonatal pig islets  the increased beta cell differentiation originated from ductal cells. Mechanistically  comparative metabolomic analysis of zebrafish with/without xxx cell ablation and with/without xxx acid treatment indicated beta cell regeneration could be attributed to changes in the pyrimidine  carnitine  and serine pathways. Overall  our results suggest evolutionarily conserved and previously unknown roles for folic acid and one carbon metabolism in the generation of beta cells.,,,,Pancreas islets   Pancreas islet 4dpf somatostatin transgene sst2:RFP B1,Pancreas islets   Islet SST 4d B1 AGN000779,,strain:TU/AB|age:not applicable|dev stage:Day 4|sex:pooled male and female|tissue:pancreas|molecule:mRNA|selection:pA|sample ref:AGS000678|replicate ref:AGN000779|replicate order:1|BioSampleModel:Model organism or animal,,,,,,,,,Pancreas islets   Pancreas islet 4dpf somatostatin transgene sst2:RFP B1,AGR001067,AGR001067,mRNA,,,RNA-Seq,TRANSCRIPTOMIC,unspecified,SINGLE,ILLUMINA,Illumina HiSeq 2000,,SRP315319,,,AGR001067_R1.fastq.gz,fastq,645391392.0,8491992.0,AGR001067 R1.fastq.gz,0:76 1:0,A:198297729;C:127050955;G:126777924;T:193238145;N:26639,76,0,,,198297729,127050955,126777924,193238145,26639,SRX10633808,SRS8730191,SRA1220217,Yale_Giraldez|Genetics,Yale_Giraldez_Group,1,0.85746,,0.50636,,0.68286,,0.48271,,76,,B,,usable mapping rate,illumina,hiseq_era,unknown,poly_a,unknown,bulk,unknown,unknown,,United States,2021-04-19,Larval,Larval,Pancreas,Endocrine System