rowid,run.accession,experiment.accession,sample.accession,study.accession,bioproject,study.title,study.alias,study.type,study.abstract,study.attributes,study.PMIDs,sample.description,sample.title,sample.alias,sample.centername,sample.attributes,GEOsample.title,GEOsample.dataprocessing,GEOsample.source,GEOsample.treatmentprotocol,GEOsample.extractprotocol,GEOsample.growthprotocol,GEOsample.characteristics,GEOsample.accession,experiment.title,experiment.alias,experiment.library_name,experiment.design_description,experiment.library_construction_protocol,experiment.attributes,experiment.library_strategy,experiment.library_source,experiment.library_selection,experiment.library_layout,experiment.platform,experiment.instrument_model,experiment.spot_descriptor,experiment.study_ref,run.title,run.attributes,run.filename,run.semantic_name,run.total_bases,run.total_spots,run.alias,run.read_lengths,run.base_counts,run.r1_length,run.r2_length,run.r3_length,run.r4_length,run.Acount,run.Ccount,run.Gcount,run.Tcount,run.Ncount,run.experiment,run.pool_member,submission.accession,submission.srasource,submission.bioprojectsource,seqdetective.n_mates,seqdetective.mapping_rate.mate1,seqdetective.mapping_rate.mate2,seqdetective.nofeature_rate.mate1,seqdetective.nofeature_rate.mate2,seqdetective.sparsity.mate1,seqdetective.sparsity.mate2,seqdetective.pos_strand_rate.mate1,seqdetective.pos_strand_rate.mate2,seqdetective.readlen.mate1,seqdetective.readlen.mate2,seqdetective.judgement.mate1,seqdetective.judgement.mate2,seqdetective.judgement.reason,platform_family,instrument_generation,read_bias,selection_class,prep_kit,sc_or_bulk,tech_class,technology,tech_variant,submission.bioprojectsource.country,earliest_date,devstage_curation,devstage_curation_coarse,tissue_curation,tissue_curation_coarse 58533,SRR11355387,SRX7957249,SRS6343356,SRP253408,PRJNA613558,Transcriptomic assessments RNA sequencing in ovaries following treatments of gravid female zebrafish to an antibiotic mixture,PRJNA613558,Other,As the use of antimicrobials during pregnancy and the perinatal period may lead to adverse outcomes such as miscarriages and newborn disease the purpose of present study was to evaluate the influence of antibiotic exposure in offspring following treatments of gravid female zebrafish to an antibiotic mixture. For the F0 generation adult zebrafish AB strain at sexual maturity 150 dpf dpf were selected for experimentation 50% male and 50% pregnant female. Given a significant change occurred in eggs production and F1 survival at birth in present study combined with antibiotics bioaccumulated in ovary we suspect that antibiotic exposure might impact the ovary of F0 generation zebrafish and thus affect egg production and survival. Therefore ovaries of the F0 generation were evaluated for transcriptional effects in different antibiotics mixture exposure 0 1 and 100 ug/L using a HTS approach coupled with advanced bioinformatic tools.,,,,C2 3,C2 3,,strain:AB|isolate:C2|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:not applicable|dev stage:not applicable|sex:female|tissue:ovary|collection date:2019 11 01|geo loc name:China: Shenzhen Guangdong|replicate:biological replicate 3|BioSampleModel:Model organism or animal,,,,,,,,,RNA seq of zebrafish,C2 320200327,C2 320200327,RNA seq of zebrafish in different conditions,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM PCR,PAIRED,BGISEQ,BGISEQ-500,,SRP253408,,,C2_3_1.fq.gz C2_3_2.fq.gz,fastq fastq,6857650800.0,45717672.0,C2 3 1.fq.gz,0:150 1:150,A:1826466263;C:1599272942;G:1580689630;T:1851144875;N:77090,150,150,,,1826466263,1599272942,1580689630,1851144875,77090,SRX7957249,SRS6343356,SRA1056819,Southern University of Science and Technology|School of Environmental Science and Engineering,Southern University of Science and Technology,1,0.93222,,0.02854,,0.75138,,0.50759,,150,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-03-20,Undetermined,Adult,Gonad,Reproductive System 58534,SRR11355388,SRX7957248,SRS6343355,SRP253408,PRJNA613558,Transcriptomic assessments RNA sequencing in ovaries following treatments of gravid female zebrafish to an antibiotic mixture,PRJNA613558,Other,As the use of antimicrobials during pregnancy and the perinatal period may lead to adverse outcomes such as miscarriages and newborn disease the purpose of present study was to evaluate the influence of antibiotic exposure in offspring following treatments of gravid female zebrafish to an antibiotic mixture. For the F0 generation adult zebrafish AB strain at sexual maturity 150 dpf dpf were selected for experimentation 50% male and 50% pregnant female. Given a significant change occurred in eggs production and F1 survival at birth in present study combined with antibiotics bioaccumulated in ovary we suspect that antibiotic exposure might impact the ovary of F0 generation zebrafish and thus affect egg production and survival. Therefore ovaries of the F0 generation were evaluated for transcriptional effects in different antibiotics mixture exposure 0 1 and 100 ug/L using a HTS approach coupled with advanced bioinformatic tools.,,,,C2 2,C2 2,,strain:AB|isolate:C2|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:not applicable|dev stage:not applicable|sex:female|tissue:ovary|collection date:2019 11 01|geo loc name:China: Shenzhen Guangdong|replicate:biological replicate 2|BioSampleModel:Model organism or animal,,,,,,,,,RNA seq of zebrafish,C2 220200326,C2 220200326,RNA seq of zebrafish in different conditions,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM PCR,PAIRED,BGISEQ,BGISEQ-500,,SRP253408,,,C2_2_1.fq.gz C2_2_2.fq.gz,fastq fastq,6859954800.0,45733032.0,C2 2 1.fq.gz,0:150 1:150,A:1836618967;C:1591135182;G:1572318102;T:1859806048;N:76501,150,150,,,1836618967,1591135182,1572318102,1859806048,76501,SRX7957248,SRS6343355,SRA1056819,Southern University of Science and Technology|School of Environmental Science and Engineering,Southern University of Science and Technology,1,0.93237,,0.03248,,0.74663,,0.5081,,150,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-03-20,Undetermined,Adult,Gonad,Reproductive System 58535,SRR11355389,SRX7957247,SRS6343354,SRP253408,PRJNA613558,Transcriptomic assessments RNA sequencing in ovaries following treatments of gravid female zebrafish to an antibiotic mixture,PRJNA613558,Other,As the use of antimicrobials during pregnancy and the perinatal period may lead to adverse outcomes such as miscarriages and newborn disease the purpose of present study was to evaluate the influence of antibiotic exposure in offspring following treatments of gravid female zebrafish to an antibiotic mixture. For the F0 generation adult zebrafish AB strain at sexual maturity 150 dpf dpf were selected for experimentation 50% male and 50% pregnant female. Given a significant change occurred in eggs production and F1 survival at birth in present study combined with antibiotics bioaccumulated in ovary we suspect that antibiotic exposure might impact the ovary of F0 generation zebrafish and thus affect egg production and survival. Therefore ovaries of the F0 generation were evaluated for transcriptional effects in different antibiotics mixture exposure 0 1 and 100 ug/L using a HTS approach coupled with advanced bioinformatic tools.,,,,C2 1,C2 1,,strain:AB|isolate:C2|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:not applicable|dev stage:not applicable|sex:female|tissue:ovary|collection date:2019 11 01|geo loc name:China: Shenzhen Guangdong|replicate:biological replicate 1|BioSampleModel:Model organism or animal,,,,,,,,,RNA seq of zebrafish,C2 120200325,C2 120200325,RNA seq of zebrafish in different conditions,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM PCR,PAIRED,BGISEQ,BGISEQ-500,,SRP253408,,,C2_1_1.fq.gz C2_1_2.fq.gz,fastq fastq,6618974400.0,44126496.0,C2 1 1.fq.gz,0:150 1:150,A:1774116288;C:1533828286;G:1511526952;T:1799423408;N:79466,150,150,,,1774116288,1533828286,1511526952,1799423408,79466,SRX7957247,SRS6343354,SRA1056819,Southern University of Science and Technology|School of Environmental Science and Engineering,Southern University of Science and Technology,1,0.9326,,0.02973,,0.75426,,0.50678,,150,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-03-20,Undetermined,Adult,Gonad,Reproductive System 58536,SRR11355390,SRX7957246,SRS6343353,SRP253408,PRJNA613558,Transcriptomic assessments RNA sequencing in ovaries following treatments of gravid female zebrafish to an antibiotic mixture,PRJNA613558,Other,As the use of antimicrobials during pregnancy and the perinatal period may lead to adverse outcomes such as miscarriages and newborn disease the purpose of present study was to evaluate the influence of antibiotic exposure in offspring following treatments of gravid female zebrafish to an antibiotic mixture. For the F0 generation adult zebrafish AB strain at sexual maturity 150 dpf dpf were selected for experimentation 50% male and 50% pregnant female. Given a significant change occurred in eggs production and F1 survival at birth in present study combined with antibiotics bioaccumulated in ovary we suspect that antibiotic exposure might impact the ovary of F0 generation zebrafish and thus affect egg production and survival. Therefore ovaries of the F0 generation were evaluated for transcriptional effects in different antibiotics mixture exposure 0 1 and 100 ug/L using a HTS approach coupled with advanced bioinformatic tools.,,,,C1 3,C1 3,,strain:AB|isolate:C1|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:not applicable|dev stage:not applicable|sex:female|tissue:ovary|collection date:2019 11 01|geo loc name:China: Shenzhen Guangdong|replicate:biological replicate 3|BioSampleModel:Model organism or animal,,,,,,,,,RNA seq of zebrafish,C1 320200324,C1 320200324,RNA seq of zebrafish in different conditions,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM PCR,PAIRED,BGISEQ,BGISEQ-500,,SRP253408,,,C1_3_1.fq.gz C1_3_2.fq.gz,fastq fastq,6837729600.0,45584864.0,C1 3 1.fq.gz,0:150 1:150,A:1831266308;C:1587032733;G:1565071069;T:1853950421;N:409069,150,150,,,1831266308,1587032733,1565071069,1853950421,409069,SRX7957246,SRS6343353,SRA1056819,Southern University of Science and Technology|School of Environmental Science and Engineering,Southern University of Science and Technology,1,0.93541,,0.03212,,0.74681,,0.50268,,150,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-03-20,Undetermined,Adult,Gonad,Reproductive System 58537,SRR11355391,SRX7957245,SRS6343352,SRP253408,PRJNA613558,Transcriptomic assessments RNA sequencing in ovaries following treatments of gravid female zebrafish to an antibiotic mixture,PRJNA613558,Other,As the use of antimicrobials during pregnancy and the perinatal period may lead to adverse outcomes such as miscarriages and newborn disease the purpose of present study was to evaluate the influence of antibiotic exposure in offspring following treatments of gravid female zebrafish to an antibiotic mixture. For the F0 generation adult zebrafish AB strain at sexual maturity 150 dpf dpf were selected for experimentation 50% male and 50% pregnant female. Given a significant change occurred in eggs production and F1 survival at birth in present study combined with antibiotics bioaccumulated in ovary we suspect that antibiotic exposure might impact the ovary of F0 generation zebrafish and thus affect egg production and survival. Therefore ovaries of the F0 generation were evaluated for transcriptional effects in different antibiotics mixture exposure 0 1 and 100 ug/L using a HTS approach coupled with advanced bioinformatic tools.,,,,C1 2,C1 2,,strain:AB|isolate:C1|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:not applicable|dev stage:not applicable|sex:female|tissue:ovary|collection date:2019 11 01|geo loc name:China: Shenzhen Guangdong|replicate:biological replicate 2|BioSampleModel:Model organism or animal,,,,,,,,,RNA seq of zebrafish,C1 220200323,C1 220200323,RNA seq of zebrafish in different conditions,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM PCR,PAIRED,BGISEQ,BGISEQ-500,,SRP253408,,,C1_2_2.fq.gz C1_2_1.fq.gz,fastq fastq,6860328000.0,45735520.0,C1 2 1.fq.gz,0:150 1:150,A:1838176072;C:1591277709;G:1569605888;T:1861063734;N:204597,150,150,,,1838176072,1591277709,1569605888,1861063734,204597,SRX7957245,SRS6343352,SRA1056819,Southern University of Science and Technology|School of Environmental Science and Engineering,Southern University of Science and Technology,1,0.93763,,0.033,,0.74617,,0.50287,,150,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-03-20,Undetermined,Adult,Gonad,Reproductive System 58538,SRR11355392,SRX7957244,SRS6343351,SRP253408,PRJNA613558,Transcriptomic assessments RNA sequencing in ovaries following treatments of gravid female zebrafish to an antibiotic mixture,PRJNA613558,Other,As the use of antimicrobials during pregnancy and the perinatal period may lead to adverse outcomes such as miscarriages and newborn disease the purpose of present study was to evaluate the influence of antibiotic exposure in offspring following treatments of gravid female zebrafish to an antibiotic mixture. For the F0 generation adult zebrafish AB strain at sexual maturity 150 dpf dpf were selected for experimentation 50% male and 50% pregnant female. Given a significant change occurred in eggs production and F1 survival at birth in present study combined with antibiotics bioaccumulated in ovary we suspect that antibiotic exposure might impact the ovary of F0 generation zebrafish and thus affect egg production and survival. Therefore ovaries of the F0 generation were evaluated for transcriptional effects in different antibiotics mixture exposure 0 1 and 100 ug/L using a HTS approach coupled with advanced bioinformatic tools.,,,,C1 1,C1 1,,strain:AB|isolate:C1|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:not applicable|dev stage:not applicable|sex:female|tissue:ovary|collection date:2019 11 01|geo loc name:China: Shenzhen Guangdong|replicate:biological replicate 1|BioSampleModel:Model organism or animal,,,,,,,,,RNA seq of zebrafish,C1 120200322,C1 120200322,RNA seq of zebrafish in different conditions,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM PCR,PAIRED,BGISEQ,BGISEQ-500,,SRP253408,,,C1_1_1.fq.gz C1_1_2.fq.gz,fastq fastq,6865547700.0,45770318.0,C1 1 1.fq.gz,0:150 1:150,A:1841774713;C:1591288582;G:1570400871;T:1861867728;N:215806,150,150,,,1841774713,1591288582,1570400871,1861867728,215806,SRX7957244,SRS6343351,SRA1056819,Southern University of Science and Technology|School of Environmental Science and Engineering,Southern University of Science and Technology,1,0.93567,,0.03152,,0.74653,,0.50239,,150,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-03-20,Undetermined,Adult,Gonad,Reproductive System 58539,SRR11355393,SRX7957243,SRS6343350,SRP253408,PRJNA613558,Transcriptomic assessments RNA sequencing in ovaries following treatments of gravid female zebrafish to an antibiotic mixture,PRJNA613558,Other,As the use of antimicrobials during pregnancy and the perinatal period may lead to adverse outcomes such as miscarriages and newborn disease the purpose of present study was to evaluate the influence of antibiotic exposure in offspring following treatments of gravid female zebrafish to an antibiotic mixture. For the F0 generation adult zebrafish AB strain at sexual maturity 150 dpf dpf were selected for experimentation 50% male and 50% pregnant female. Given a significant change occurred in eggs production and F1 survival at birth in present study combined with antibiotics bioaccumulated in ovary we suspect that antibiotic exposure might impact the ovary of F0 generation zebrafish and thus affect egg production and survival. Therefore ovaries of the F0 generation were evaluated for transcriptional effects in different antibiotics mixture exposure 0 1 and 100 ug/L using a HTS approach coupled with advanced bioinformatic tools.,,,,C0 3,C0 3,,strain:AB|isolate:C0|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:not applicable|dev stage:not applicable|sex:female|tissue:ovary|collection date:2019 11 01|geo loc name:China: Shenzhen Guangdong|replicate:biological replicate 3|BioSampleModel:Model organism or animal,,,,,,,,,RNA seq of zebrafish,C0 320200321,C0 320200321,RNA seq of zebrafish in different conditions,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM PCR,PAIRED,BGISEQ,BGISEQ-500,,SRP253408,,,C0_3_1.fq.gz C0_3_2.fq.gz,fastq fastq,6824622600.0,45497484.0,C0 3 1.fq.gz,0:150 1:150,A:1833660953;C:1578510104;G:1558095174;T:1854128169;N:228200,150,150,,,1833660953,1578510104,1558095174,1854128169,228200,SRX7957243,SRS6343350,SRA1056819,Southern University of Science and Technology|School of Environmental Science and Engineering,Southern University of Science and Technology,1,0.93758,,0.0323,,0.75024,,0.50852,,150,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-03-20,Undetermined,Adult,Gonad,Reproductive System 58540,SRR11355394,SRX7957242,SRS6343349,SRP253408,PRJNA613558,Transcriptomic assessments RNA sequencing in ovaries following treatments of gravid female zebrafish to an antibiotic mixture,PRJNA613558,Other,As the use of antimicrobials during pregnancy and the perinatal period may lead to adverse outcomes such as miscarriages and newborn disease the purpose of present study was to evaluate the influence of antibiotic exposure in offspring following treatments of gravid female zebrafish to an antibiotic mixture. For the F0 generation adult zebrafish AB strain at sexual maturity 150 dpf dpf were selected for experimentation 50% male and 50% pregnant female. Given a significant change occurred in eggs production and F1 survival at birth in present study combined with antibiotics bioaccumulated in ovary we suspect that antibiotic exposure might impact the ovary of F0 generation zebrafish and thus affect egg production and survival. Therefore ovaries of the F0 generation were evaluated for transcriptional effects in different antibiotics mixture exposure 0 1 and 100 ug/L using a HTS approach coupled with advanced bioinformatic tools.,,,,C0 2,C0 2,,strain:AB|isolate:C0|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:not applicable|dev stage:not applicable|sex:female|tissue:ovary|collection date:2019 11 01|geo loc name:China: Shenzhen Guangdong|replicate:biological replicate 2|BioSampleModel:Model organism or animal,,,,,,,,,RNA seq of zebrafish,C0 220200320,C0 220200320,RNA seq of zebrafish in different conditions,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM PCR,PAIRED,BGISEQ,BGISEQ-500,,SRP253408,,,C0_2_2.fq.gz C0_2_1.fq.gz,fastq fastq,6819326400.0,45462176.0,C0 2 1.fq.gz,0:150 1:150,A:1837661215;C:1571877614;G:1550458835;T:1859103408;N:225328,150,150,,,1837661215,1571877614,1550458835,1859103408,225328,SRX7957242,SRS6343349,SRA1056819,Southern University of Science and Technology|School of Environmental Science and Engineering,Southern University of Science and Technology,1,0.93697,,0.0339,,0.74793,,0.5035,,150,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-03-20,Undetermined,Adult,Gonad,Reproductive System 58541,SRR11355395,SRX7957241,SRS6343348,SRP253408,PRJNA613558,Transcriptomic assessments RNA sequencing in ovaries following treatments of gravid female zebrafish to an antibiotic mixture,PRJNA613558,Other,As the use of antimicrobials during pregnancy and the perinatal period may lead to adverse outcomes such as miscarriages and newborn disease the purpose of present study was to evaluate the influence of antibiotic exposure in offspring following treatments of gravid female zebrafish to an antibiotic mixture. For the F0 generation adult zebrafish AB strain at sexual maturity 150 dpf dpf were selected for experimentation 50% male and 50% pregnant female. Given a significant change occurred in eggs production and F1 survival at birth in present study combined with antibiotics bioaccumulated in ovary we suspect that antibiotic exposure might impact the ovary of F0 generation zebrafish and thus affect egg production and survival. Therefore ovaries of the F0 generation were evaluated for transcriptional effects in different antibiotics mixture exposure 0 1 and 100 ug/L using a HTS approach coupled with advanced bioinformatic tools.,,,,C0 1,C0 1,,strain:AB|isolate:C0|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:not applicable|dev stage:not applicable|sex:female|tissue:ovary|collection date:2019 11 01|geo loc name:China: Shenzhen Guangdong|replicate:biological replicate 1|BioSampleModel:Model organism or animal,,,,,,,,,RNA seq of zebrafish,C0 120200319,C0 120200319,RNA seq of zebrafish in different conditions,,,RNA-Seq,TRANSCRIPTOMIC,RANDOM PCR,PAIRED,BGISEQ,BGISEQ-500,,SRP253408,,,C0_1_1.fq.gz C0_1_2.fq.gz,fastq fastq,7030804800.0,46872032.0,C0 1 1.fq.gz,0:150 1:150,A:1891469955;C:1624531422;G:1603124564;T:1911444454;N:234405,150,150,,,1891469955,1624531422,1603124564,1911444454,234405,SRX7957241,SRS6343348,SRA1056819,Southern University of Science and Technology|School of Environmental Science and Engineering,Southern University of Science and Technology,1,0.93519,,0.0328,,0.74602,,0.48272,,150,,B,,usable mapping rate,bgi,bgi,unknown,random_priming,unknown,bulk,unknown,unknown,,China,2020-03-20,Undetermined,Adult,Gonad,Reproductive System 74160,SRR23576624,SRX19463433,SRS16856056,SRP423783,PRJNA937311,Telomere elongation in the gut extends systemic healthspan of zebrafish,PRJNA937311,Other,Telomere shortening is a hallmark of aging and is counteracted by telomerase. zebrafish gut is one of the organs with the fastest rate of telomere decline. However whether telomere dependent aging of an individual organ the gut causes systemic aging remains unknown. Here we show that preventing telomere shortening in the gut through tissue specific telomerase expression rescues premature aging of tert / . Conclusively we show that gut specific telomerase expression extends lifespan of tert / by 40 % while ameliorating natural aging. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.,,,,,T1B,,strain:AB|age:9 month|dev stage:adulte|sex:male|tissue:testis|biomaterial provider:EL MAI Mounir|birth date:2019/11/20|birth location:Nice France|treatment:testis tert no Cre R1|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult male testis,T1B,T1B,RNA Seq of Danio rerio : adult male testis,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP423783,,,T1B_1.fq.gz T1B_2.fq.gz,fastq fastq,12301883400.0,123018834.0,T1B 1.fq.gz,0:100 1:100,A:3241228917;C:2853095411;G:2904960052;T:3302599020;N:0,100,100,,,3241228917,2853095411,2904960052,3302599020,0,SRX19463433,SRS16856056,SRA1593824,Sun Yat-sen University Cancer Center|State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Miguel Godinho Ferreira,1,0.95272,,0.09396,,0.68469,,0.54489,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2023-02-21,Adult,Adult,Gonad,Reproductive System 74177,SRR23576641,SRX19463416,SRS16856039,SRP423783,PRJNA937311,Telomere elongation in the gut extends systemic healthspan of zebrafish,PRJNA937311,Other,Telomere shortening is a hallmark of aging and is counteracted by telomerase. zebrafish gut is one of the organs with the fastest rate of telomere decline. However whether telomere dependent aging of an individual organ the gut causes systemic aging remains unknown. Here we show that preventing telomere shortening in the gut through tissue specific telomerase expression rescues premature aging of tert / . Conclusively we show that gut specific telomerase expression extends lifespan of tert / by 40 % while ameliorating natural aging. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.,,,,,T9,,strain:AB|age:9 month|dev stage:adulte|sex:male|tissue:testis|biomaterial provider:EL MAI Mounir|birth date:2019/11/20|birth location:Nice France|treatment:testis WT R3|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult male testis,T9,T9,RNA Seq of Danio rerio : adult male testis,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP423783,,,T9_1.fq.gz T9_2.fq.gz,fastq fastq,12386772800.0,123867728.0,T9 1.fq.gz,0:100 1:100,A:3400599530;C:2772066139;G:2813890387;T:3400216744;N:0,100,100,,,3400599530,2772066139,2813890387,3400216744,0,SRX19463416,SRS16856039,SRA1593824,Sun Yat-sen University Cancer Center|State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Miguel Godinho Ferreira,1,0.93775,,0.12024,,0.63838,,0.49765,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2023-02-21,Adult,Adult,Gonad,Reproductive System 74178,SRR23576642,SRX19463415,SRS16856037,SRP423783,PRJNA937311,Telomere elongation in the gut extends systemic healthspan of zebrafish,PRJNA937311,Other,Telomere shortening is a hallmark of aging and is counteracted by telomerase. zebrafish gut is one of the organs with the fastest rate of telomere decline. However whether telomere dependent aging of an individual organ the gut causes systemic aging remains unknown. Here we show that preventing telomere shortening in the gut through tissue specific telomerase expression rescues premature aging of tert / . Conclusively we show that gut specific telomerase expression extends lifespan of tert / by 40 % while ameliorating natural aging. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.,,,,,T8,,strain:AB|age:9 month|dev stage:adulte|sex:male|tissue:testis|biomaterial provider:EL MAI Mounir|birth date:2019/11/20|birth location:Nice France|treatment:testis WT R2|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult male testis,T8,T8,RNA Seq of Danio rerio : adult male testis,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP423783,,,T8_1.fq.gz T8_2.fq.gz,fastq fastq,12176715600.0,121767156.0,T8 1.fq.gz,0:100 1:100,A:3287270041;C:2775700062;G:2808469679;T:3305275818;N:0,100,100,,,3287270041,2775700062,2808469679,3305275818,0,SRX19463415,SRS16856037,SRA1593824,Sun Yat-sen University Cancer Center|State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Miguel Godinho Ferreira,1,0.94261,,0.12625,,0.63838,,0.49901,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2023-02-21,Adult,Adult,Gonad,Reproductive System 74179,SRR23576643,SRX19463414,SRS16856038,SRP423783,PRJNA937311,Telomere elongation in the gut extends systemic healthspan of zebrafish,PRJNA937311,Other,Telomere shortening is a hallmark of aging and is counteracted by telomerase. zebrafish gut is one of the organs with the fastest rate of telomere decline. However whether telomere dependent aging of an individual organ the gut causes systemic aging remains unknown. Here we show that preventing telomere shortening in the gut through tissue specific telomerase expression rescues premature aging of tert / . Conclusively we show that gut specific telomerase expression extends lifespan of tert / by 40 % while ameliorating natural aging. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.,,,,,T7,,strain:AB|age:9 month|dev stage:adulte|sex:male|tissue:testis|biomaterial provider:EL MAI Mounir|birth date:2019/11/20|birth location:Nice France|treatment:testis WT R1|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult male testis,T7,T7,RNA Seq of Danio rerio : adult male testis,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP423783,,,T7_1.fq.gz T7_2.fq.gz,fastq fastq,12172655600.0,121726556.0,T7 1.fq.gz,0:100 1:100,A:3248593263;C:2809119242;G:2855399333;T:3259543762;N:0,100,100,,,3248593263,2809119242,2855399333,3259543762,0,SRX19463414,SRS16856038,SRA1593824,Sun Yat-sen University Cancer Center|State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Miguel Godinho Ferreira,1,0.94602,,0.10229,,0.63603,,0.48805,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2023-02-21,Adult,Adult,Gonad,Reproductive System 74180,SRR23576644,SRX19463413,SRS16856036,SRP423783,PRJNA937311,Telomere elongation in the gut extends systemic healthspan of zebrafish,PRJNA937311,Other,Telomere shortening is a hallmark of aging and is counteracted by telomerase. zebrafish gut is one of the organs with the fastest rate of telomere decline. However whether telomere dependent aging of an individual organ the gut causes systemic aging remains unknown. Here we show that preventing telomere shortening in the gut through tissue specific telomerase expression rescues premature aging of tert / . Conclusively we show that gut specific telomerase expression extends lifespan of tert / by 40 % while ameliorating natural aging. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.,,,,,T6,,strain:AB|age:9 month|dev stage:adulte|sex:male|tissue:testis|biomaterial provider:EL MAI Mounir|birth date:2019/11/20|birth location:Nice France|treatment:testis tert Cre R3|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult male testis,T6,T6,RNA Seq of Danio rerio : adult male testis,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP423783,,,T6_1.fq.gz T6_2.fq.gz,fastq fastq,12378860000.0,123788600.0,T6 1.fq.gz,0:100 1:100,A:3314969512;C:2848487369;G:2903637904;T:3311765215;N:0,100,100,,,3314969512,2848487369,2903637904,3311765215,0,SRX19463413,SRS16856036,SRA1593824,Sun Yat-sen University Cancer Center|State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Miguel Godinho Ferreira,1,0.94452,,0.10777,,0.62422,,0.49742,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2023-02-21,Adult,Adult,Gonad,Reproductive System 74181,SRR23576645,SRX19463412,SRS16856034,SRP423783,PRJNA937311,Telomere elongation in the gut extends systemic healthspan of zebrafish,PRJNA937311,Other,Telomere shortening is a hallmark of aging and is counteracted by telomerase. zebrafish gut is one of the organs with the fastest rate of telomere decline. However whether telomere dependent aging of an individual organ the gut causes systemic aging remains unknown. Here we show that preventing telomere shortening in the gut through tissue specific telomerase expression rescues premature aging of tert / . Conclusively we show that gut specific telomerase expression extends lifespan of tert / by 40 % while ameliorating natural aging. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.,,,,,T5,,strain:AB|age:9 month|dev stage:adulte|sex:male|tissue:testis|biomaterial provider:EL MAI Mounir|birth date:2019/11/20|birth location:Nice France|treatment:testis tert Cre R2|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult male testis,T5,T5,RNA Seq of Danio rerio : adult male testis,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP423783,,,T5_1.fq.gz T5_2.fq.gz,fastq fastq,12128636200.0,121286362.0,T5 1.fq.gz,0:100 1:100,A:3365971947;C:2671909728;G:2726788212;T:3363966313;N:0,100,100,,,3365971947,2671909728,2726788212,3363966313,0,SRX19463412,SRS16856034,SRA1593824,Sun Yat-sen University Cancer Center|State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Miguel Godinho Ferreira,1,0.93852,,0.14946,,0.63747,,0.52613,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2023-02-21,Adult,Adult,Gonad,Reproductive System 74182,SRR23576646,SRX19463411,SRS16856032,SRP423783,PRJNA937311,Telomere elongation in the gut extends systemic healthspan of zebrafish,PRJNA937311,Other,Telomere shortening is a hallmark of aging and is counteracted by telomerase. zebrafish gut is one of the organs with the fastest rate of telomere decline. However whether telomere dependent aging of an individual organ the gut causes systemic aging remains unknown. Here we show that preventing telomere shortening in the gut through tissue specific telomerase expression rescues premature aging of tert / . Conclusively we show that gut specific telomerase expression extends lifespan of tert / by 40 % while ameliorating natural aging. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.,,,,,T4,,strain:AB|age:9 month|dev stage:adulte|sex:male|tissue:testis|biomaterial provider:EL MAI Mounir|birth date:2019/11/20|birth location:Nice France|treatment:testis tert Cre R1|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult male testis,T4,T4,RNA Seq of Danio rerio : adult male testis,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP423783,,,T4_1.fq.gz T4_2.fq.gz,fastq fastq,12162901400.0,121629014.0,T4 1.fq.gz,0:100 1:100,A:3278648055;C:2767244505;G:2825703918;T:3291304922;N:0,100,100,,,3278648055,2767244505,2825703918,3291304922,0,SRX19463411,SRS16856032,SRA1593824,Sun Yat-sen University Cancer Center|State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Miguel Godinho Ferreira,1,0.94511,,0.11642,,0.63258,,0.4913,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2023-02-21,Adult,Adult,Gonad,Reproductive System 74183,SRR23576647,SRX19463410,SRS16856035,SRP423783,PRJNA937311,Telomere elongation in the gut extends systemic healthspan of zebrafish,PRJNA937311,Other,Telomere shortening is a hallmark of aging and is counteracted by telomerase. zebrafish gut is one of the organs with the fastest rate of telomere decline. However whether telomere dependent aging of an individual organ the gut causes systemic aging remains unknown. Here we show that preventing telomere shortening in the gut through tissue specific telomerase expression rescues premature aging of tert / . Conclusively we show that gut specific telomerase expression extends lifespan of tert / by 40 % while ameliorating natural aging. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.,,,,,T3,,strain:AB|age:9 month|dev stage:adulte|sex:male|tissue:testis|biomaterial provider:EL MAI Mounir|birth date:2019/11/20|birth location:Nice France|treatment:testis tert no Cre R3|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult male testis,T3,T3,RNA Seq of Danio rerio : adult male testis,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP423783,,,T3_1.fq.gz T3_2.fq.gz,fastq fastq,12163321600.0,121633216.0,T3 1.fq.gz,0:100 1:100,A:3285334843;C:2767357208;G:2816394061;T:3294235488;N:0,100,100,,,3285334843,2767357208,2816394061,3294235488,0,SRX19463410,SRS16856035,SRA1593824,Sun Yat-sen University Cancer Center|State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Miguel Godinho Ferreira,1,0.9415,,0.11969,,0.62666,,0.50292,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2023-02-21,Adult,Adult,Gonad,Reproductive System 74184,SRR23576648,SRX19463409,SRS16856033,SRP423783,PRJNA937311,Telomere elongation in the gut extends systemic healthspan of zebrafish,PRJNA937311,Other,Telomere shortening is a hallmark of aging and is counteracted by telomerase. zebrafish gut is one of the organs with the fastest rate of telomere decline. However whether telomere dependent aging of an individual organ the gut causes systemic aging remains unknown. Here we show that preventing telomere shortening in the gut through tissue specific telomerase expression rescues premature aging of tert / . Conclusively we show that gut specific telomerase expression extends lifespan of tert / by 40 % while ameliorating natural aging. Our work demonstrates that delaying telomere shortening in the gut is sufficient to systemically counteract aging in zebrafish.,,,,,T2B,,strain:AB|age:9 month|dev stage:adulte|sex:male|tissue:testis|biomaterial provider:EL MAI Mounir|birth date:2019/11/20|birth location:Nice France|treatment:testis tert no Cre R2|BioSampleModel:Model organism or animal,,,,,,,,,RNA Seq of Danio rerio : adult male testis,T2B,T2B,RNA Seq of Danio rerio : adult male testis,,,RNA-Seq,TRANSCRIPTOMIC,Oligo-dT,PAIRED,BGISEQ,BGISEQ-500,,SRP423783,,,T2B_1.fq.gz T2B_2.fq.gz,fastq fastq,12317978600.0,123179786.0,T2B 1.fq.gz,0:100 1:100,A:3182137355;C:2913584264;G:2974241242;T:3248015739;N:0,100,100,,,3182137355,2913584264,2974241242,3248015739,0,SRX19463409,SRS16856033,SRA1593824,Sun Yat-sen University Cancer Center|State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Miguel Godinho Ferreira,1,0.95364,,0.08029,,0.6882,,0.53887,,100,,B,,usable mapping rate,bgi,bgi,unknown,poly_a,unknown,bulk,unknown,unknown,,China,2023-02-21,Adult,Adult,Gonad,Reproductive System