metadata: run_metadata: 17 rows where experiment.library_selection = "unspecified" and tissue

17 rows where experiment.library_selection = "unspecified" and tissue_curation = "Endothelium"

descending

Link	rowid ▼	run.accession	experiment.accession	sample.accession	study.accession	bioproject	study.title	study.alias	study.type	study.abstract	sample.title	sample.alias	sample.attributes	experiment.title	experiment.alias	experiment.library_name	experiment.design_description	experiment.library_strategy	experiment.library_source	experiment.library_selection	experiment.library_layout	experiment.platform	experiment.instrument_model	experiment.study_ref	run.filename	run.semantic_name	run.total_bases	run.total_spots	run.alias	run.read_lengths	run.base_counts	run.r1_length	run.Acount	run.Ccount	run.Gcount	run.Tcount	run.Ncount	run.experiment	run.pool_member	submission.accession	submission.srasource	submission.bioprojectsource	seqdetective.n_mates	seqdetective.mapping_rate.mate1	seqdetective.nofeature_rate.mate1	seqdetective.sparsity.mate1	seqdetective.pos_strand_rate.mate1	seqdetective.readlen.mate1	seqdetective.judgement.mate1	seqdetective.judgement.reason	platform_family	instrument_generation	read_bias	selection_class	prep_kit	sc_or_bulk	tech_class	technology	submission.bioprojectsource.country	earliest_date	devstage_curation	devstage_curation_coarse	tissue_curation	tissue_curation_coarse
41827	41827	SRR5251446	SRX2557171	SRS1974564	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs WT miR139 B1	nicoli mutmir AG01645	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|molecule:mRNA\|condition:miR 139\|replicate:1\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs WT miR139 B1	AG01645.1	AG01645.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01645.1_R1.fastq.gz	fastq	1574284140.0	20714265.0	AG01645.1 R1.fastq.gz	0:76	A:485471345;C:270854124;G:374164721;T:443766613;N:27337	76	485471345	270854124	374164721	443766613	27337	SRX2557171	SRS1974564	SRA537606	Yale University\|Genetics	Yale University	1	0.82142	0.14068	0.8002	0.5444	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-27	Undetermined	Embryo	Endothelium	Cardiovascular System
41828	41828	SRR5251445	SRX2557170	SRS1974563	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs WT miR139 B2	nicoli mutmir AG01646	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|molecule:mRNA\|condition:miR 139\|replicate:2\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs WT miR139 B2	AG01646.1	AG01646.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01646.1_R1.fastq.gz	fastq	1484740104.0	19536054.0	AG01646.1 R1.fastq.gz	0:76	A:453388316;C:246477203;G:365031959;T:419816346;N:26280	76	453388316	246477203	365031959	419816346	26280	SRX2557170	SRS1974563	SRA537606	Yale University\|Genetics	Yale University	1	0.82649	0.1897	0.79862	0.52759	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41829	41829	SRR5251444	SRX2557169	SRS1974562	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs WT miR139 B3	nicoli mutmir AG01647	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|molecule:mRNA\|condition:miR 139\|replicate:3\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs WT miR139 B3	AG01647.1	AG01647.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01647.1_R1.fastq.gz	fastq	881298660.0	11596035.0	AG01647.1 R1.fastq.gz	0:76	A:270675838;C:160127586;G:228157662;T:222301246;N:36328	76	270675838	160127586	228157662	222301246	36328	SRX2557169	SRS1974562	SRA537606	Yale University\|Genetics	Yale University	1	0.76133	0.15034	0.83341	0.56596	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41830	41830	SRR5251443	SRX2557168	SRS1974561	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs Mut miR139 B1	nicoli mutmir AG01648	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|genotype:miR 139 ya302/ya302\|molecule:mRNA\|condition:miR 139\|replicate:1\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs Mut miR139 B1	AG01648.1	AG01648.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01648.1_R1.fastq.gz	fastq	637896880.0	8393380.0	AG01648.1 R1.fastq.gz	0:76	A:192829278;C:112701153;G:153321271;T:179019095;N:26083	76	192829278	112701153	153321271	179019095	26083	SRX2557168	SRS1974561	SRA537606	Yale University\|Genetics	Yale University	1	0.75971	0.1181	0.82171	0.56797	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41831	41831	SRR5251442	SRX2557167	SRS1974560	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs Mut miR139 B2	nicoli mutmir AG01649	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|genotype:miR 139 ya302/ya302\|molecule:mRNA\|condition:miR 139\|replicate:2\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs Mut miR139 B2	AG01649.1	AG01649.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01649.1_R1.fastq.gz	fastq	849868328.0	11182478.0	AG01649.1 R1.fastq.gz	0:76	A:258225905;C:148467172;G:205165181;T:237974100;N:35970	76	258225905	148467172	205165181	237974100	35970	SRX2557167	SRS1974560	SRA537606	Yale University\|Genetics	Yale University	1	0.75096	0.14506	0.81507	0.5545	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41832	41832	SRR5251441	SRX2557166	SRS1974559	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs Mut miR139 B3	nicoli mutmir AG01650	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|genotype:miR 139 ya302/ya302\|molecule:mRNA\|condition:miR 139\|replicate:3\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs Mut miR139 B3	AG01650.1	AG01650.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01650.1_R1.fastq.gz	fastq	998464668.0	13137693.0	AG01650.1 R1.fastq.gz	0:76	A:311526420;C:176545041;G:251852786;T:258497630;N:42791	76	311526420	176545041	251852786	258497630	42791	SRX2557166	SRS1974559	SRA537606	Yale University\|Genetics	Yale University	1	0.76479	0.11192	0.82674	0.54621	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41833	41833	SRR5251440	SRX2557165	SRS1974558	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs WT miR24 B1	nicoli mutmir AG01651	strain:TU/AB\|age:51.0\|sex:pooled male and female\|tissue:endothelial cells\|molecule:mRNA\|condition:miR 24\|replicate:1\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs WT miR24 B1	AG01651.1	AG01651.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01651.1_R1.fastq.gz	fastq	570492252.0	7506477.0	AG01651.1 R1.fastq.gz	0:76	A:162512811;C:104071716;G:135730697;T:168149427;N:27601	76	162512811	104071716	135730697	168149427	27601	SRX2557165	SRS1974558	SRA537606	Yale University\|Genetics	Yale University	1	0.73988	0.10157	0.86647	0.54252	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41834	41834	SRR5251439	SRX2557164	SRS1974557	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs WT miR24 B2	nicoli mutmir AG01652	strain:TU/AB\|age:51.0\|sex:pooled male and female\|tissue:endothelial cells\|molecule:mRNA\|condition:miR 24\|replicate:2\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs WT miR24 B2	AG01652.1	AG01652.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01652.1_R1.fastq.gz	fastq	1072886148.0	14116923.0	AG01652.1 R1.fastq.gz	0:76	A:338399596;C:192703439;G:242960887;T:298769761;N:52465	76	338399596	192703439	242960887	298769761	52465	SRX2557164	SRS1974557	SRA537606	Yale University\|Genetics	Yale University	1	0.76456	0.11024	0.89197	0.59214	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41835	41835	SRR5251438	SRX2557163	SRS1974556	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs WT miR24 B3	nicoli mutmir AG01653	strain:TU/AB\|age:51.0\|sex:pooled male and female\|tissue:endothelial cells\|molecule:mRNA\|condition:miR 24\|replicate:3\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs WT miR24 B3	AG01653.1	AG01653.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01653.1_R1.fastq.gz	fastq	1016374144.0	13373344.0	AG01653.1 R1.fastq.gz	0:76	A:310958343;C:168702106;G:223420046;T:313241363;N:52286	76	310958343	168702106	223420046	313241363	52286	SRX2557163	SRS1974556	SRA537606	Yale University\|Genetics	Yale University	1	0.75735	0.12224	0.79756	0.55136	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-02-13	Undetermined	Embryo	Endothelium	Cardiovascular System
41836	41836	SRR5251437	SRX2557162	SRS1974555	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs Mut miR24 B1	nicoli mutmir AG01654	strain:TU/AB\|age:51.0\|sex:pooled male and female\|tissue:endothelial cells\|genotype:miR 24 ya324/? ya325/? ya326/? ya327/?\|molecule:mRNA\|condition:miR 24\|replicate:1\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs Mut miR24 B1	AG01654.1	AG01654.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01654.1_R1.fastq.gz	fastq	782170112.0	10291712.0	AG01654.1 R1.fastq.gz	0:76	A:238316720;C:132163709;G:179301544;T:232350598;N:37541	76	238316720	132163709	179301544	232350598	37541	SRX2557162	SRS1974555	SRA537606	Yale University\|Genetics	Yale University	1	0.7683	0.10712	0.80034	0.55804	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41837	41837	SRR5251436	SRX2557161	SRS1974554	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs Mut miR24 B2	nicoli mutmir AG01655	strain:TU/AB\|age:51.0\|sex:pooled male and female\|tissue:endothelial cells\|genotype:miR 24 ya324/? ya325/? ya326/? ya327/?\|molecule:mRNA\|condition:miR 24\|replicate:2\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs Mut miR24 B2	AG01655.1	AG01655.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01655.1_R1.fastq.gz	fastq	1053946340.0	13867715.0	AG01655.1 R1.fastq.gz	0:76	A:318351311;C:191163031;G:240348413;T:304030367;N:53218	76	318351311	191163031	240348413	304030367	53218	SRX2557161	SRS1974554	SRA537606	Yale University\|Genetics	Yale University	1	0.77588	0.07983	0.83934	0.56228	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41838	41838	SRR5251435	SRX2557160	SRS1974553	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs Mut miR24 B3	nicoli mutmir AG01656	strain:TU/AB\|age:51.0\|sex:pooled male and female\|tissue:endothelial cells\|genotype:miR 24 ya324/? ya325/? ya326/? ya327/?\|molecule:mRNA\|condition:miR 24\|replicate:3\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs Mut miR24 B3	AG01656.1	AG01656.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01656.1_R1.fastq.gz	fastq	1182467736.0	15558786.0	AG01656.1 R1.fastq.gz	0:76	A:344465226;C:204677242;G:269228338;T:364036735;N:60195	76	344465226	204677242	269228338	364036735	60195	SRX2557160	SRS1974553	SRA537606	Yale University\|Genetics	Yale University	1	0.78956	0.13495	0.81517	0.56342	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-02-13	Undetermined	Embryo	Endothelium	Cardiovascular System
41839	41839	SRR5251434	SRX2557159	SRS1974552	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs WT miR223 B1	nicoli mutmir AG01657	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|molecule:mRNA\|condition:miR 223\|replicate:1\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs WT miR223 B1	AG01657.1	AG01657.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01657.1_R1.fastq.gz	fastq	536336712.0	7057062.0	AG01657.1 R1.fastq.gz	0:76	A:158301607;C:93070120;G:121382262;T:163555487;N:27236	76	158301607	93070120	121382262	163555487	27236	SRX2557159	SRS1974552	SRA537606	Yale University\|Genetics	Yale University	1	0.76425	0.1278	0.84222	0.55305	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-02-13	Undetermined	Embryo	Endothelium	Cardiovascular System
41840	41840	SRR5251433	SRX2557158	SRS1974551	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs WT miR223 B2	nicoli mutmir AG01658	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|molecule:mRNA\|condition:miR 223\|replicate:2\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs WT miR223 B2	AG01658.1	AG01658.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01658.1_R1.fastq.gz	fastq	798581856.0	10507656.0	AG01658.1 R1.fastq.gz	0:76	A:241352089;C:134327379;G:183394123;T:239469845;N:38420	76	241352089	134327379	183394123	239469845	38420	SRX2557158	SRS1974551	SRA537606	Yale University\|Genetics	Yale University	1	0.76221	0.13398	0.82459	0.55228	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41841	41841	SRR5251432	SRX2557157	SRS1974550	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs WT miR223 B3	nicoli mutmir AG01659	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|molecule:mRNA\|condition:miR 223\|replicate:3\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs WT miR223 B3	AG01659.1	AG01659.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01659.1_R1.fastq.gz	fastq	1093998948.0	14394723.0	AG01659.1 R1.fastq.gz	0:76	A:330741822;C:186325335;G:249557623;T:327320449;N:53719	76	330741822	186325335	249557623	327320449	53719	SRX2557157	SRS1974550	SRA537606	Yale University\|Genetics	Yale University	1	0.77108	0.14674	0.80955	0.55819	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System
41842	41842	SRR5251431	SRX2557156	SRS1974549	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs Mut miR223 B1	nicoli mutmir AG01660	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|genotype:miR 223 ya304/ya304\|molecule:mRNA\|condition:miR 223\|replicate:1\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs Mut miR223 B1	AG01660.1	AG01660.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01660.1_R1.fastq.gz	fastq	849905492.0	11182967.0	AG01660.1 R1.fastq.gz	0:76	A:250953875;C:146191904;G:190040699;T:262674911;N:44103	76	250953875	146191904	190040699	262674911	44103	SRX2557156	SRS1974549	SRA537606	Yale University\|Genetics	Yale University	1	0.7687	0.14192	0.82842	0.5344	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-02-13	Undetermined	Embryo	Endothelium	Cardiovascular System
41843	41843	SRR5251430	SRX2557155	SRS1974548	SRP099466	PRJNA374579	microRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos	PRJNA374579	Other	Proper functioning of an organism requires cells and tissues to behave in uniform well organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here we carried out a multifaceted and single cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi gene miRNA families. We found that embryos lacking particular miRNA dependent signaling pathways develop a vascular trait similar to wild type but with a profound increase in phenotypic heterogeneity. Aberrant trait variance in miRNA mutant embryos uniquely sensitizes their vascular system to environmental perturbations. We uncovered a previously unrecognized role for specific vertebrate miRNAs to protect tissue development against phenotypic variability. This discovery marks an important advance in our comprehension of how miRNAs function in the development of higher organisms.	QuantSeq mutant miRNAs Mut miR223 B2	nicoli mutmir AG01661	strain:TU/AB\|age:27.0\|sex:pooled male and female\|tissue:endothelial cells\|genotype:miR 223 ya304/ya304\|molecule:mRNA\|condition:miR 223\|replicate:2\|BioSampleModel:Model organism or animal	QuantSeq mutant miRNAs Mut miR223 B2	AG01661.1	AG01661.1	1	OTHER	TRANSCRIPTOMIC	unspecified	SINGLE	ILLUMINA	Illumina HiSeq 2000	SRP099466	AG01661.1_R1.fastq.gz	fastq	840115400.0	11054150.0	AG01661.1 R1.fastq.gz	0:76	A:257057495;C:141775085;G:188281166;T:252960590;N:41064	76	257057495	141775085	188281166	252960590	41064	SRX2557155	SRS1974548	SRA537606	Yale University\|Genetics	Yale University	1	0.74292	0.10759	0.83615	0.55136	76	B	usable mapping rate	illumina	hiseq_era	unknown	small_rna	lexogen	bulk	unknown	unknown	United States	2017-03-28	Undetermined	Embryo	Endothelium	Cardiovascular System

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CREATE TABLE run_metadata("run.accession" VARCHAR, "experiment.accession" VARCHAR, "sample.accession" VARCHAR, "study.accession" VARCHAR, bioproject VARCHAR, "study.title" VARCHAR, "study.alias" VARCHAR, "study.type" VARCHAR, "study.abstract" VARCHAR, "study.attributes" VARCHAR, "study.PMIDs" VARCHAR, "sample.description" VARCHAR, "sample.title" VARCHAR, "sample.alias" VARCHAR, "sample.centername" VARCHAR, "sample.attributes" VARCHAR, "GEOsample.title" VARCHAR, "GEOsample.dataprocessing" VARCHAR, "GEOsample.source" VARCHAR, "GEOsample.treatmentprotocol" VARCHAR, "GEOsample.extractprotocol" VARCHAR, "GEOsample.growthprotocol" VARCHAR, "GEOsample.characteristics" VARCHAR, "GEOsample.accession" VARCHAR, "experiment.title" VARCHAR, "experiment.alias" VARCHAR, "experiment.library_name" VARCHAR, "experiment.design_description" VARCHAR, "experiment.library_construction_protocol" VARCHAR, "experiment.attributes" VARCHAR, "experiment.library_strategy" VARCHAR, "experiment.library_source" VARCHAR, "experiment.library_selection" VARCHAR, "experiment.library_layout" VARCHAR, "experiment.platform" VARCHAR, "experiment.instrument_model" VARCHAR, "experiment.spot_descriptor" VARCHAR, "experiment.study_ref" VARCHAR, "run.title" VARCHAR, "run.attributes" VARCHAR, "run.filename" VARCHAR, "run.semantic_name" VARCHAR, "run.total_bases" DOUBLE, "run.total_spots" DOUBLE, "run.alias" VARCHAR, "run.read_lengths" VARCHAR, "run.base_counts" VARCHAR, "run.r1_length" BIGINT, "run.r2_length" BIGINT, "run.r3_length" BIGINT, "run.r4_length" BIGINT, "run.Acount" BIGINT, "run.Ccount" BIGINT, "run.Gcount" BIGINT, "run.Tcount" BIGINT, "run.Ncount" BIGINT, "run.experiment" VARCHAR, "run.pool_member" VARCHAR, "submission.accession" VARCHAR, "submission.srasource" VARCHAR, "submission.bioprojectsource" VARCHAR, "seqdetective.n_mates" BIGINT, "seqdetective.mapping_rate.mate1" DOUBLE, "seqdetective.mapping_rate.mate2" DOUBLE, "seqdetective.nofeature_rate.mate1" DOUBLE, "seqdetective.nofeature_rate.mate2" DOUBLE, "seqdetective.sparsity.mate1" DOUBLE, "seqdetective.sparsity.mate2" DOUBLE, "seqdetective.pos_strand_rate.mate1" DOUBLE, "seqdetective.pos_strand_rate.mate2" DOUBLE, "seqdetective.readlen.mate1" BIGINT, "seqdetective.readlen.mate2" BIGINT, "seqdetective.judgement.mate1" VARCHAR, "seqdetective.judgement.mate2" VARCHAR, "seqdetective.judgement.reason" VARCHAR, platform_family VARCHAR, instrument_generation VARCHAR, read_bias VARCHAR, selection_class VARCHAR, prep_kit VARCHAR, sc_or_bulk VARCHAR, tech_class VARCHAR, technology VARCHAR, tech_variant VARCHAR, "submission.bioprojectsource.country" VARCHAR, earliest_date DATE, devstage_curation VARCHAR, devstage_curation_coarse VARCHAR, tissue_curation VARCHAR, tissue_curation_coarse VARCHAR);;
CREATE INDEX idx_run_bioproject ON run_metadata(bioproject);;
CREATE INDEX idx_run_run_accession ON run_metadata("run.accession");;