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run_metadata

147 rows where experiment.library_selection = "Oligo-dT" and experiment.platform = "BGISEQ"

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tissue_curation 8

devstage_curation_coarse 3

devstage_curation 3

experiment.library_layout 2

technology 1

experiment.platform 1

  • BGISEQ · 147 ✖

experiment.library_strategy 1

experiment.library_source 1

experiment.library_selection 1

  • Oligo-dT · 147 ✖
Link rowid ▼ run.accession experiment.accession sample.accession study.accession bioproject study.title study.alias study.type study.abstract study.attributes study.PMIDs sample.description sample.title sample.alias sample.centername sample.attributes GEOsample.title GEOsample.dataprocessing GEOsample.source GEOsample.treatmentprotocol GEOsample.extractprotocol GEOsample.growthprotocol GEOsample.characteristics GEOsample.accession experiment.title experiment.alias experiment.library_name experiment.design_description experiment.library_construction_protocol experiment.attributes experiment.library_strategy experiment.library_source experiment.library_selection experiment.library_layout experiment.platform experiment.instrument_model experiment.spot_descriptor experiment.study_ref run.title run.attributes run.filename run.semantic_name run.total_bases run.total_spots run.alias run.read_lengths run.base_counts run.r1_length run.r2_length run.r3_length run.r4_length run.Acount run.Ccount run.Gcount run.Tcount run.Ncount run.experiment run.pool_member submission.accession submission.srasource submission.bioprojectsource seqdetective.n_mates seqdetective.mapping_rate.mate1 seqdetective.mapping_rate.mate2 seqdetective.nofeature_rate.mate1 seqdetective.nofeature_rate.mate2 seqdetective.sparsity.mate1 seqdetective.sparsity.mate2 seqdetective.pos_strand_rate.mate1 seqdetective.pos_strand_rate.mate2 seqdetective.readlen.mate1 seqdetective.readlen.mate2 seqdetective.judgement.mate1 seqdetective.judgement.mate2 seqdetective.judgement.reason platform_family instrument_generation read_bias selection_class prep_kit sc_or_bulk tech_class technology tech_variant submission.bioprojectsource.country earliest_date devstage_curation devstage_curation_coarse tissue_curation tissue_curation_coarse
31825 31825 SRR28700412 SRX24268115 SRS21034395 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         PN 2   isolate:PN2|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 2|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish PN 2 PN 2 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     PN_2_1.fq.gz PN_2_2.fq.gz fastq fastq 6385048200.0 21283494.0 PN 2 1.fq.gz 0:150 1:150 A:1722127999;C:1463645587;G:1483173818;T:1716100796;N:0 150 150     1722127999 1463645587 1483173818 1716100796 0 SRX24268115 SRS21034395     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31826 31826 SRR28700413 SRX24268114 SRS21034397 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         PN 1   isolate:PN1|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 1|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish PN 1 PN 1 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     PN_1_1.fq.gz PN_1_2.fq.gz fastq fastq 6692894100.0 22309647.0 PN 1 1.fq.gz 0:150 1:150 A:1827107021;C:1513034624;G:1533077624;T:1819674831;N:0 150 150     1827107021 1513034624 1533077624 1819674831 0 SRX24268114 SRS21034397     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31827 31827 SRR28700414 SRX24268113 SRS21034396 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         EC 4   isolate:EC4|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 4|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish EC 4 EC 4 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     EC_4_1.fq.gz EC_4_2.fq.gz fastq fastq 6688857000.0 22296190.0 EC 4 1.fq.gz 0:150 1:150 A:1820989545;C:1516814697;G:1537970654;T:1813082104;N:0 150 150     1820989545 1516814697 1537970654 1813082104 0 SRX24268113 SRS21034396     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31828 31828 SRR28700415 SRX24268112 SRS21034392 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         EC 3   isolate:EC3|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 3|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish EC 3 EC 3 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     EC_3_1.fq.gz EC_3_2.fq.gz fastq fastq 6696553800.0 22321846.0 EC 3 1.fq.gz 0:150 1:150 A:1821249100;C:1520587242;G:1541238550;T:1813478908;N:0 150 150     1821249100 1520587242 1541238550 1813478908 0 SRX24268112 SRS21034392     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31829 31829 SRR28700416 SRX24268111 SRS21034391 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         EC 2   isolate:EC2|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 2|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish EC 2 EC 2 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     EC_2_1.fq.gz EC_2_2.fq.gz fastq fastq 6702179400.0 22340598.0 EC 2 1.fq.gz 0:150 1:150 A:1816692261;C:1527379142;G:1547365810;T:1810742187;N:0 150 150     1816692261 1527379142 1547365810 1810742187 0 SRX24268111 SRS21034391     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31830 31830 SRR28700417 SRX24268110 SRS21034390 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         EC 1   isolate:EC1|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 1|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish EC 1 EC 1 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     EC_1_1.fq.gz EC_1_2.fq.gz fastq fastq 6686053500.0 22286845.0 EC 1 1.fq.gz 0:150 1:150 A:1812022780;C:1524359858;G:1544847441;T:1804823421;N:0 150 150     1812022780 1524359858 1544847441 1804823421 0 SRX24268110 SRS21034390     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31831 31831 SRR28700418 SRX24268109 SRS21034388 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         Control 4   isolate:con4|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 4|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish Control 4 Control 4 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     Control_4_1.fq.gz Control_4_2.fq.gz fastq fastq 6669700500.0 22232335.0 Control 4 1.fq.gz 0:150 1:150 A:1804178265;C:1523547469;G:1543839484;T:1798135282;N:0 150 150     1804178265 1523547469 1543839484 1798135282 0 SRX24268109 SRS21034388     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31832 31832 SRR28700419 SRX24268108 SRS21034387 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         Control 3   isolate:con3|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 3|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish Control 3 Control 3 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     Control_3_1.fq.gz Control_3_2.fq.gz fastq fastq 6683518800.0 22278396.0 Control 3 1.fq.gz 0:150 1:150 A:1808495506;C:1525725204;G:1545930043;T:1803368047;N:0 150 150     1808495506 1525725204 1545930043 1803368047 0 SRX24268108 SRS21034387     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31833 31833 SRR28700420 SRX24268107 SRS21034386 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         PN 4   isolate:PN4|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 4|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish PN 4 PN 4 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     PN_4_1.fq.gz PN_4_2.fq.gz fastq fastq 6649316100.0 22164387.0 PN 4 1.fq.gz 0:150 1:150 A:1809816121;C:1508072480;G:1528272654;T:1803154845;N:0 150 150     1809816121 1508072480 1528272654 1803154845 0 SRX24268107 SRS21034386     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31834 31834 SRR28700421 SRX24268106 SRS21034389 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         PN 3   isolate:PN3|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 3|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish PN 3 PN 3 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     PN_3_1.fq.gz PN_3_2.fq.gz fastq fastq 6616113900.0 22053713.0 PN 3 1.fq.gz 0:150 1:150 A:1802283686;C:1499008018;G:1519150002;T:1795672194;N:0 150 150     1802283686 1499008018 1519150002 1795672194 0 SRX24268106 SRS21034389     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31835 31835 SRR28700422 SRX24268105 SRS21034385 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         Control 2   isolate:con2|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 2|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish Control 2 Control 2 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     Control_2_1.fq.gz Control_2_2.fq.gz fastq fastq 6701719200.0 22339064.0 Control 2 1.fq.gz 0:150 1:150 A:1812352260;C:1531672703;G:1551377072;T:1806317165;N:0 150 150     1812352260 1531672703 1551377072 1806317165 0 SRX24268105 SRS21034385     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
31836 31836 SRR28700423 SRX24268104 SRS21034384 SRP501894 PRJNA1100624 Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis PRJNA1100624 Other Research indicates that Epimedin C EC an active compound in Epimedium offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization increases bone mass and improves bone density thus mitigating bone tissue damage caused by prednisolone. Additionally EC impacts key signaling pathways related to bone development such as osteoclast differentiation estrogen MAPK insulin resistance PPAR and AMPK pathways. This study highlights EC's role in bone health and its promising osteoprotective effects presenting it as a viable cost effective treatment for GIOP.         Control 1   isolate:con1|age:9dpf|collection date:2023 07 13|geo loc name:China:Hubei Xiangyang|sex:not collected|tissue:animal sample|replicate:replicate = biological replicate 1|BioSampleModel:Model organism or animal                 RNA Seq of zebrafish Control 1 Control 1 Total RNA undergoes mRNA enrichment reverse transcription adapter ligation PCR amplification and circularization into a single stranded DNA library.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP501894     Control_1_1.fq.gz Control_1_2.fq.gz fastq fastq 6720214500.0 22400715.0 Control 1 1.fq.gz 0:150 1:150 A:1814883015;C:1537948710;G:1559376116;T:1808006659;N:0 150 150     1814883015 1537948710 1559376116 1808006659 0 SRX24268104 SRS21034384     Xiangyang No.1 People's Hospital, Hubei University of Medicine                       B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2024-04-15 Larval Larval Undetermined Undetermined
55643 55643 SRR10604044 SRX7283593 SRS5777402 SRP235014 PRJNA594101 Danio rerio Transcriptome PRJNA594101 Other Danio rerio Transcriptome post cGAS and STING knockout         stko2   strain:not collected|isolate:sting knockout 2|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal                 RNA Seq of zebraish larvae sting knockout 2 sting knockout 2 RNA seq     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP235014     stko2_1.fastq.gz stko2_2.fastq.gz fastq fastq 10635609300.0 70904062.0 stko2 1.fastq.gz 0:150 1:150 A:2864931942;C:2450585568;G:2436540783;T:2882828480;N:722527 150 150     2864931942 2450585568 2436540783 2882828480 722527 SRX7283593 SRS5777402 SRA1007465 Shantou university medical college|Neuroscience Center Shantou university medical college 1 0.93079   0.07849   0.70301   0.47872   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2019-12-08 Larval Larval Undetermined Undetermined
55644 55644 SRR10604045 SRX7283592 SRS5777401 SRP235014 PRJNA594101 Danio rerio Transcriptome PRJNA594101 Other Danio rerio Transcriptome post cGAS and STING knockout         stko1   strain:not collected|isolate:sting knockout 1|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal                 RNA Seq of zebraish larvae sting knockout 1 sting knockout 1 RNA seq     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP235014     stko1_1.fastq.gz stko1_2.fastq.gz fastq fastq 10453959000.0 69693060.0 stko1 1.fastq.gz 0:150 1:150 A:2823253748;C:2400078679;G:2379662427;T:2850274552;N:689594 150 150     2823253748 2400078679 2379662427 2850274552 689594 SRX7283592 SRS5777401 SRA1007465 Shantou university medical college|Neuroscience Center Shantou university medical college 1 0.92736   0.08475   0.69822   0.47233   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2019-12-08 Larval Larval Undetermined Undetermined
55645 55645 SRR10604046 SRX7283591 SRS5777400 SRP235014 PRJNA594101 Danio rerio Transcriptome PRJNA594101 Other Danio rerio Transcriptome post cGAS and STING knockout         cgko2   strain:not collected|isolate:cgas knockout 2|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal                 RNA Seq of zebraish larvae cgas knockout 2 cgas knockout 2 RNA seq     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP235014     cgko2_1.fastq.gz cgko2_2.fastq.gz fastq fastq 10462236900.0 69748246.0 cgko2 1.fastq.gz 0:150 1:150 A:2836737922;C:2388112649;G:2370425883;T:2866326601;N:633845 150 150     2836737922 2388112649 2370425883 2866326601 633845 SRX7283591 SRS5777400 SRA1007465 Shantou university medical college|Neuroscience Center Shantou university medical college 1 0.93603   0.10606   0.67765   0.46153   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2019-12-08 Larval Larval Undetermined Undetermined
55646 55646 SRR10604047 SRX7283590 SRS5777399 SRP235014 PRJNA594101 Danio rerio Transcriptome PRJNA594101 Other Danio rerio Transcriptome post cGAS and STING knockout         cgko1   strain:not collected|isolate:cgas knockout 1|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal                 RNA Seq of zebraish larvae cgas knockout 1 cgas knockout 1 RNA seq     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP235014     cgko1_2.fastq.gz cgko1_1.fastq.gz fastq fastq 10498495500.0 69989970.0 cgko1 1.fastq.gz 0:150 1:150 A:2845684832;C:2398817161;G:2379300746;T:2874108573;N:584188 150 150     2845684832 2398817161 2379300746 2874108573 584188 SRX7283590 SRS5777399 SRA1007465 Shantou university medical college|Neuroscience Center Shantou university medical college 1 0.93684   0.10589   0.67933   0.48363   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2019-12-08 Larval Larval Undetermined Undetermined
55647 55647 SRR10604048 SRX7283589 SRS5777398 SRP235014 PRJNA594101 Danio rerio Transcriptome PRJNA594101 Other Danio rerio Transcriptome post cGAS and STING knockout         wt2   strain:not collected|isolate:normal 2|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal                 RNA Seq of zebraish larvae wt normal 2 wt normal 2 RNA seq     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP235014     wt2_1.fastq.gz wt2_2.fastq.gz fastq fastq 10660916400.0 71072776.0 wt2 1.fastq.gz 0:150 1:150 A:2906473511;C:2417423798;G:2405111864;T:2931146507;N:760720 150 150     2906473511 2417423798 2405111864 2931146507 760720 SRX7283589 SRS5777398 SRA1007465 Shantou university medical college|Neuroscience Center Shantou university medical college 1 0.94167   0.11781   0.66831   0.4757   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2019-12-08 Larval Larval Undetermined Undetermined
55648 55648 SRR10604049 SRX7283588 SRS5777397 SRP235014 PRJNA594101 Danio rerio Transcriptome PRJNA594101 Other Danio rerio Transcriptome post cGAS and STING knockout         wt1   strain:not collected|isolate:normal 1|breed:not applicable|cultivar:not applicable|ecotype:not applicable|age:7 days|dev stage:larvae|sex:not applicable|tissue:larvae|biomaterial provider:Yang xiaojun|BioSampleModel:Model organism or animal                 RNA Seq of zebraish larvae wt nomal 1 wt nomal 1 RNA seq     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP235014     wt1_1.fastq.gz wt1_2.fastq.gz fastq fastq 10599804000.0 70665360.0 wt1 1.fastq.gz 0:150 1:150 A:2896989124;C:2397285811;G:2382705623;T:2922067937;N:755505 150 150     2896989124 2397285811 2382705623 2922067937 755505 SRX7283588 SRS5777397 SRA1007465 Shantou university medical college|Neuroscience Center Shantou university medical college 1 0.93947   0.11723   0.67203   0.45826   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2019-12-08 Larval Larval Undetermined Undetermined
57271 57271 SRR12577970 SRX9064853 SRS7314026 SRP279881 PRJNA612371 Danio rerio strain:TU Raw sequence reads PRJNA612371 Whole Genome Sequencing Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.         Ctrl 3 zebrafish   strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 6'|BioSampleModel:Model organism or animal                 Ctrl 3 zebrafish Ctrl 3 zebrafish Ctrl 3 zebrafish transcriptome     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP279881     Ctrl_3_1.fq.gz fastq 1061227250.0 21224545.0 Ctrl 3 1.fq.gz 0:50 A:286099732;C:241244619;G:246876865;T:287006034;N:0 50       286099732 241244619 246876865 287006034 0 SRX9064853 SRS7314026 SRA1120721 Shanghai University of Traditional Chinese Medicine|Longhua Hospital Shanghai University of Traditional Chinese Medicine 1 0.94563   0.10453   0.70552   0.46655   50   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2020-09-03 Hatching Embryo Head Nervous System
57272 57272 SRR12577971 SRX9064852 SRS7314025 SRP279881 PRJNA612371 Danio rerio strain:TU Raw sequence reads PRJNA612371 Whole Genome Sequencing Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.         Ctrl 2 zebrafish   strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 5 prime|BioSampleModel:Model organism or animal                 Ctrl 2 zebrafish Ctrl 2 zebrafish Ctrl 2 zebrafish transcriptome     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP279881     Ctrl_2_1.fq.gz fastq 1058116700.0 21162334.0 Ctrl 2 1.fq.gz 0:50 A:287223905;C:238707750;G:244987559;T:287197486;N:0 50       287223905 238707750 244987559 287197486 0 SRX9064852 SRS7314025 SRA1120721 Shanghai University of Traditional Chinese Medicine|Longhua Hospital Shanghai University of Traditional Chinese Medicine 1 0.94534   0.11174   0.70104   0.47946   50   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2020-09-03 Hatching Embryo Head Nervous System
57273 57273 SRR12577972 SRX9064851 SRS7314024 SRP279881 PRJNA612371 Danio rerio strain:TU Raw sequence reads PRJNA612371 Whole Genome Sequencing Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.         Ctrl 1 zebrafish   strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 4'|BioSampleModel:Model organism or animal                 Ctrl 1 zebrafish Ctrl 1 zebrafish Ctrl 1 zebrafish transcriptome     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP279881     Ctrl_1_1.fq.gz fastq 1065919600.0 21318392.0 Ctrl 1 1.fq.gz 0:50 A:295920720;C:242146677;G:242962633;T:284889570;N:0 50       295920720 242146677 242962633 284889570 0 SRX9064851 SRS7314024 SRA1120721 Shanghai University of Traditional Chinese Medicine|Longhua Hospital Shanghai University of Traditional Chinese Medicine 1 0.94228   0.15007   0.68028   0.46845   50   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2020-09-03 Hatching Embryo Head Nervous System
57274 57274 SRR12577973 SRX9064850 SRS7314023 SRP279881 PRJNA612371 Danio rerio strain:TU Raw sequence reads PRJNA612371 Whole Genome Sequencing Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.         Ator STS 3 zebrafish   strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 3 prime|BioSampleModel:Model organism or animal                 Ator STS 3 zebrafish Ator STS 3 zebrafish Ator STS 3 zebrafish transcriptome     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP279881     Ator_STS_3_1.fq.gz fastq 1059717350.0 21194347.0 Ator STS 3 1.fq.gz 0:50 A:287279590;C:239708340;G:245740313;T:286989107;N:0 50       287279590 239708340 245740313 286989107 0 SRX9064850 SRS7314023 SRA1120721 Shanghai University of Traditional Chinese Medicine|Longhua Hospital Shanghai University of Traditional Chinese Medicine 1 0.94345   0.10458   0.69686   0.4755   50   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2020-09-03 Hatching Embryo Head Nervous System
57275 57275 SRR12577974 SRX9064849 SRS7314022 SRP279881 PRJNA612371 Danio rerio strain:TU Raw sequence reads PRJNA612371 Whole Genome Sequencing Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.         Ator STS 2 zebrafish   strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 2'|BioSampleModel:Model organism or animal                 Ator STS 2 zebrafish Ator STS 2 zebrafish Ator STS 2 zebrafish transcriptome     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP279881     Ator_STS_2_1.fq.gz fastq 1057950250.0 21159005.0 Ator STS 2 1.fq.gz 0:50 A:286256354;C:238832868;G:244078781;T:288782247;N:0 50       286256354 238832868 244078781 288782247 0 SRX9064849 SRS7314022 SRA1120721 Shanghai University of Traditional Chinese Medicine|Longhua Hospital Shanghai University of Traditional Chinese Medicine 1 0.94307   0.10974   0.69631   0.4703   50   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2020-09-03 Hatching Embryo Head Nervous System
57276 57276 SRR12577975 SRX9064848 SRS7314021 SRP279881 PRJNA612371 Danio rerio strain:TU Raw sequence reads PRJNA612371 Whole Genome Sequencing Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.         Ator STS 1 zebrafish   strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 1'|BioSampleModel:Model organism or animal                 Ator STS 1 zebrafish Ator STS 1 zebrafish Ator STS 1 zebrafish transcriptome     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP279881     Ator_STS_1_1.fq.gz fastq 1070136700.0 21402734.0 Ator STS 1 1.fq.gz 0:50 A:297601042;C:243837062;G:243583907;T:285114689;N:0 50       297601042 243837062 243583907 285114689 0 SRX9064848 SRS7314021 SRA1120721 Shanghai University of Traditional Chinese Medicine|Longhua Hospital Shanghai University of Traditional Chinese Medicine 1 0.94665   0.12219   0.67953   0.46393   50   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2020-09-03 Hatching Embryo Head Nervous System
57277 57277 SRR12577976 SRX9064847 SRS7314020 SRP279881 PRJNA612371 Danio rerio strain:TU Raw sequence reads PRJNA612371 Whole Genome Sequencing Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.         Ator 3 zebrafish   strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 3 prime|BioSampleModel:Model organism or animal                 Ator 3 zebrafish Ator 3 zebrafish Ator 3 zebrafish transcriptome     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP279881     Ator_3_1.fq.gz fastq 1058031900.0 21160638.0 Ator 3 1.fq.gz 0:50 A:285399527;C:239993172;G:245571467;T:287067734;N:0 50       285399527 239993172 245571467 287067734 0 SRX9064847 SRS7314020 SRA1120721 Shanghai University of Traditional Chinese Medicine|Longhua Hospital Shanghai University of Traditional Chinese Medicine 1 0.94536   0.11052   0.6957   0.48195   50   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2020-09-03 Hatching Embryo Head Nervous System
57278 57278 SRR12577977 SRX9064846 SRS7314019 SRP279881 PRJNA612371 Danio rerio strain:TU Raw sequence reads PRJNA612371 Whole Genome Sequencing Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.         Ator 2 zebrafish   strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 2'|BioSampleModel:Model organism or animal                 Ator 2 zebrafish Ator 2 zebrafish Ator 2 zebrafish transcriptome     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP279881     Ator_2_1.fq.gz fastq 1059618400.0 21192368.0 Ator 2 1.fq.gz 0:50 A:283429136;C:243023053;G:248904818;T:284261393;N:0 50       283429136 243023053 248904818 284261393 0 SRX9064846 SRS7314019 SRA1120721 Shanghai University of Traditional Chinese Medicine|Longhua Hospital Shanghai University of Traditional Chinese Medicine 1 0.94743   0.09493   0.70218   0.475   50   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2020-09-03 Hatching Embryo Head Nervous System
57279 57279 SRR12577978 SRX9064845 SRS7314018 SRP279881 PRJNA612371 Danio rerio strain:TU Raw sequence reads PRJNA612371 Whole Genome Sequencing Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.         Ator 1 zebrafish   strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 1'|BioSampleModel:Model organism or animal                 Ator 1 zebrafish Ator 1 zebrafish Ator 1 zebrafish transcriptome     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP279881     Ator_1_1.fq.gz fastq 1075695950.0 21513919.0 Ator 1 1.fq.gz 0:50 A:297768036;C:244470267;G:243768925;T:289688722;N:0 50       297768036 244470267 243768925 289688722 0 SRX9064845 SRS7314018 SRA1120721 Shanghai University of Traditional Chinese Medicine|Longhua Hospital Shanghai University of Traditional Chinese Medicine 1 0.94468   0.13183   0.68363   0.46288   50   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2020-09-03 Hatching Embryo Head Nervous System
65944 65944 SRR15700565 SRX11996477 SRS10003992 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   R01   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain R01 R01 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     R01_1.fq.gz R01_2.fq.gz fastq fastq 6781182900.0 45207886.0 R01 1.fq.gz 0:150 1:150 A:1988991157;C:1393829563;G:1402027963;T:1996312981;N:21236 150 150     1988991157 1393829563 1402027963 1996312981 21236 SRX11996477 SRS10003992 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91278   0.20165   0.71054   0.54354   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65945 65945 SRR15700566 SRX11996476 SRS10003991 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EH3   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EH3 EH3 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EH3_1.fq.gz EH3_2.fq.gz fastq fastq 6798939900.0 45326266.0 EH3 1.fq.gz 0:150 1:150 A:1958992563;C:1429773625;G:1441958341;T:1968192397;N:22974 150 150     1958992563 1429773625 1441958341 1968192397 22974 SRX11996476 SRS10003991 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91681   0.18245   0.7083   0.5369   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65946 65946 SRR15700567 SRX11996475 SRS10003990 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EH2   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EH2 EH2 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EH2_1.fq.gz EH2_2.fq.gz fastq fastq 6792825900.0 45285506.0 EH2 1.fq.gz 0:150 1:150 A:1958355652;C:1427389031;G:1440081079;T:1966978334;N:21804 150 150     1958355652 1427389031 1440081079 1966978334 21804 SRX11996475 SRS10003990 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91907   0.17888   0.70575   0.54118   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65947 65947 SRR15700568 SRX11996474 SRS10003989 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EH1   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EH1 EH1 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EH1_1.fq.gz EH1_2.fq.gz fastq fastq 6723154200.0 44821028.0 EH1 1.fq.gz 0:150 1:150 A:1939940725;C:1412087358;G:1424339686;T:1946764075;N:22356 150 150     1939940725 1412087358 1424339686 1946764075 22356 SRX11996474 SRS10003989 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91848   0.1756   0.71293   0.54795   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65948 65948 SRR15700569 SRX11996473 SRS10003988 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EL3   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EL3 EL3 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EL3_1.fq.gz EL3_2.fq.gz fastq fastq 6756746700.0 45044978.0 EL3 1.fq.gz 0:150 1:150 A:1958754520;C:1411572406;G:1418753117;T:1967647023;N:19634 150 150     1958754520 1411572406 1418753117 1967647023 19634 SRX11996473 SRS10003988 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91873   0.18319   0.71027   0.55277   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65949 65949 SRR15700570 SRX11996472 SRS10003987 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EL2   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EL2 EL2 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EL2_1.fq.gz EL2_2.fq.gz fastq fastq 6811200600.0 45408004.0 EL2 1.fq.gz 0:150 1:150 A:1961542081;C:1433135536;G:1446857456;T:1969644200;N:21327 150 150     1961542081 1433135536 1446857456 1969644200 21327 SRX11996472 SRS10003987 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91853   0.17639   0.71076   0.54175   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65950 65950 SRR15700571 SRX11996471 SRS10003986 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EL1   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EL1 EL1 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EL1_1.fq.gz EL1_2.fq.gz fastq fastq 6764302200.0 45095348.0 EL1 1.fq.gz 0:150 1:150 A:1943560425;C:1428175041;G:1441358638;T:1951185256;N:22840 150 150     1943560425 1428175041 1441358638 1951185256 22840 SRX11996471 SRS10003986 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91885   0.17456   0.71423   0.53356   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65951 65951 SRR15700572 SRX11996470 SRS10003985 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   E03   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain E03 E03 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     E03_1.fq.gz E03_2.fq.gz fastq fastq 6762334500.0 45082230.0 E03 1.fq.gz 0:150 1:150 A:1941432663;C:1429093210;G:1444693949;T:1947091388;N:23290 150 150     1941432663 1429093210 1444693949 1947091388 23290 SRX11996470 SRS10003985 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91902   0.17577   0.71413   0.54672   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65952 65952 SRR15700573 SRX11996469 SRS10003984 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RH3   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RH3 RH3 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RH3_1.fq.gz RH3_2.fq.gz fastq fastq 6620159400.0 44134396.0 RH3 1.fq.gz 0:150 1:150 A:1906961918;C:1396128146;G:1402603611;T:1914452217;N:13508 150 150     1906961918 1396128146 1402603611 1914452217 13508 SRX11996469 SRS10003984 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91596   0.18007   0.70307   0.53072   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65953 65953 SRR15700574 SRX11996468 SRS10003983 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RH2   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RH2 RH2 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RH2_1.fq.gz RH2_2.fq.gz fastq fastq 6779957400.0 45199716.0 RH2 1.fq.gz 0:150 1:150 A:1943750299;C:1436936087;G:1447253724;T:1952003667;N:13623 150 150     1943750299 1436936087 1447253724 1952003667 13623 SRX11996468 SRS10003983 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91806   0.17416   0.70364   0.53449   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65954 65954 SRR15700575 SRX11996467 SRS10003982 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RH1   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RH1 RH1 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RH1_1.fq.gz RH1_2.fq.gz fastq fastq 6803711400.0 45358076.0 RH1 1.fq.gz 0:150 1:150 A:1919109429;C:1472916047;G:1485344758;T:1926327627;N:13539 150 150     1919109429 1472916047 1485344758 1926327627 13539 SRX11996467 SRS10003982 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.92595   0.14064   0.71392   0.5508   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65955 65955 SRR15700576 SRX11996466 SRS10003981 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RL3   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RL3 RL3 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RL3_1.fq.gz RL3_2.fq.gz fastq fastq 6775779300.0 45171862.0 RL3 1.fq.gz 0:150 1:150 A:1977555439;C:1404514814;G:1412262159;T:1981432811;N:14077 150 150     1977555439 1404514814 1412262159 1981432811 14077 SRX11996466 SRS10003981 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91883   0.1833   0.71638   0.55343   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65956 65956 SRR15700577 SRX11996465 SRS10003979 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RL2   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RL2 RL2 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RL2_1.fq.gz RL2_2.fq.gz fastq fastq 6716301900.0 44775346.0 RL2 1.fq.gz 0:150 1:150 A:1959165761;C:1392977724;G:1400724963;T:1963418595;N:14857 150 150     1959165761 1392977724 1400724963 1963418595 14857 SRX11996465 SRS10003979 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.92114   0.18164   0.7217   0.55665   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65957 65957 SRR15700578 SRX11996464 SRS10003980 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RL1   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RL1 RL1 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RL1_1.fq.gz RL1_2.fq.gz fastq fastq 6632905200.0 44219368.0 RL1 1.fq.gz 0:150 1:150 A:1930258593;C:1379056686;G:1391344096;T:1932223405;N:22420 150 150     1930258593 1379056686 1391344096 1932223405 22420 SRX11996464 SRS10003980 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91966   0.18087   0.72121   0.5664   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65958 65958 SRR15700579 SRX11996463 SRS10003978 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   R03   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain R03 R03 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     R03_1.fq.gz R03_2.fq.gz fastq fastq 6574600200.0 43830668.0 R03 1.fq.gz 0:150 1:150 A:1940343461;C:1342685356;G:1350150434;T:1941399481;N:21468 150 150     1940343461 1342685356 1350150434 1941399481 21468 SRX11996463 SRS10003978 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91867   0.19479   0.72707   0.57885   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65959 65959 SRR15700580 SRX11996462 SRS10003977 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   R02   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain R02 R02 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     R02_1.fq.gz R02_2.fq.gz fastq fastq 6399007800.0 42660052.0 R02 1.fq.gz 0:150 1:150 A:1884110766;C:1308008993;G:1315054545;T:1891764364;N:69132 150 150     1884110766 1308008993 1315054545 1891764364 69132 SRX11996462 SRS10003977 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91477   0.19859   0.72417   0.55394   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65960 65960 SRR15700581 SRX11996461 SRS10003976 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   E02   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain E02 E02 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     E02_1.fq.gz E02_2.fq.gz fastq fastq 6588207000.0 43921380.0 E02 1.fq.gz 0:150 1:150 A:1905685715;C:1379753621;G:1389708827;T:1913038146;N:20691 150 150     1905685715 1379753621 1389708827 1913038146 20691 SRX11996461 SRS10003976 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91596   0.18027   0.70903   0.54349   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65961 65961 SRR15700582 SRX11996460 SRS10003975 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   E01   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain E01 E01 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     E01_1.fq.gz E01_2.fq.gz fastq fastq 6766213800.0 45108092.0 E01 1.fq.gz 0:150 1:150 A:1963125745;C:1410900205;G:1420069949;T:1972096961;N:20940 150 150     1963125745 1410900205 1420069949 1972096961 20940 SRX11996460 SRS10003975 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91884   0.18555   0.71585   0.5455   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65984 65984 SRR15859821 SRX12150937 SRS10130028 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     levonorgestrel treatment at high concentration treatment LNG H 1 AN   strain:not collected2|isolate:whole fish13|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 1'|BioSampleModel:Model organism or animal                 LNG H 1 BM BM zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     50_1_R1.clean.fq.gz 50_1_R2.clean.fq.gz fastq fastq 6850889266.0 22893917.0 50 1 R1.clean.fq.gz 0:149.83 1:149.42 A:1908972876;C:1556853849;G:1559240564;T:1825804841;N:17136 149 149     1908972876 1556853849 1559240564 1825804841 17136 SRX12150937 SRS10130028 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.93957 0.92386 0.09467 0.08944 0.66582 0.67142 0.50349 0.499 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65985 65985 SRR15859822 SRX12150936 SRS10130027 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     levonorgestrel treatment at low concentration treatment LNG L 4 M   strain:not collected2|isolate:whole fish12|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 4'|BioSampleModel:Model organism or animal                 LNG L 4 BL BL zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     5_4_R1.clean.fq.gz 5_4_R2.clean.fq.gz fastq fastq 6757301758.0 22579367.0 5 4 R1.clean.fq.gz 0:149.83 1:149.44 A:1886236851;C:1526321374;G:1529138861;T:1815587663;N:17009 149 149     1886236851 1526321374 1529138861 1815587663 17009 SRX12150936 SRS10130027 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.93955 0.92322 0.09955 0.0937 0.66612 0.67056 0.4936 0.50296 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65986 65986 SRR15859823 SRX12150935 SRS10130026 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     levonorgestrel treatment at low concentration treatment LNG L 3 AL   strain:not collected2|isolate:whole fish11|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 3 prime|BioSampleModel:Model organism or animal                 LNG L 3 BK BK zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     5_3_R1.clean.fq.gz 5_3_R2.clean.fq.gz fastq fastq 6942028867.0 23178890.0 5 3 R1.clean.fq.gz 0:149.82 1:149.68 A:1895507796;C:1573477638;G:1599422601;T:1873160988;N:459844 149 149     1895507796 1573477638 1599422601 1873160988 459844 SRX12150935 SRS10130026 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.92261 0.9213 0.10308 0.10394 0.67298 0.67677 0.50615 0.5026 150 145 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65987 65987 SRR15859824 SRX12150934 SRS10130025 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Solvent control SC2 AC   strain:not collected2|isolate:whole fish2|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 2'|BioSampleModel:Model organism or animal                 SC2 BB BB zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     SC_2_R1.clean.fq.gz SC_2_R2.clean.fq.gz fastq fastq 6847074418.0 22905359.0 SC 2 R1.clean.fq.gz 0:149.58 1:149.35 A:1835075664;C:1586631096;G:1607651961;T:1817247855;N:467842 149 149     1835075664 1586631096 1607651961 1817247855 467842 SRX12150934 SRS10130025 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.93172 0.93195 0.07691 0.0771 0.67265 0.67665 0.48862 0.49579 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65988 65988 SRR15859825 SRX12150933 SRS10130024 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Solvent control SC1 AB   strain:not collected2|isolate:whole fish1|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 1'|BioSampleModel:Model organism or animal                 SC1 BA BA zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     SC_1_R1.clean.fq.gz SC_1_R2.clean.fq.gz fastq fastq 7101595814.0 23743270.0 SC 1 R1.clean.fq.gz 0:149.65 1:149.45 A:1888007422;C:1656304946;G:1683234514;T:1873563589;N:485343 149 149     1888007422 1656304946 1683234514 1873563589 485343 SRX12150933 SRS10130024 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.93193 0.93408 0.08101 0.08156 0.6744 0.67785 0.49761 0.49038 150 149 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65989 65989 SRR15859826 SRX12150932 SRS10130023 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     levonorgestrel treatment at low concentration treatment LNG L 2 AK   strain:not collected2|isolate:whole fish10|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 2'|BioSampleModel:Model organism or animal                 LNG L 2 BJ BJ zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     5_2_R1.clean.fq.gz 5_2_R2.clean.fq.gz fastq fastq 6978116268.0 23316955.0 5 2 R1.clean.fq.gz 0:149.72 1:149.55 A:1877413088;C:1609547451;G:1632121199;T:1858563731;N:470799 149 149     1877413088 1609547451 1632121199 1858563731 470799 SRX12150932 SRS10130023 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.93086 0.93049 0.08702 0.08712 0.68357 0.68844 0.49793 0.48668 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65990 65990 SRR15859827 SRX12150931 SRS10130022 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     levonorgestrel treatment at low concentration treatment LNG L 1 AJ   strain:not collected2|isolate:whole fish9|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 1'|BioSampleModel:Model organism or animal                 LNG L 1 BI BI zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     5_1_R1.clean.fq.gz 5_1_R2.clean.fq.gz fastq fastq 6306082896.0 21075245.0 5 1 R1.clean.fq.gz 0:149.70 1:149.52 A:1679788198;C:1469939151;G:1489873755;T:1666053801;N:427991 149 149     1679788198 1469939151 1489873755 1666053801 427991 SRX12150931 SRS10130022 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.93145 0.93206 0.08123 0.08188 0.67951 0.68432 0.48499 0.48763 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65991 65991 SRR15859828 SRX12150930 SRS10130021 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     dydrogesterone treatment DDG 4 AI   strain:not collected2|isolate:whole fish8|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 4'|BioSampleModel:Model organism or animal                 DDG 4 BH BH zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_4_R1.clean.fq.gz 100_4_R2.clean.fq.gz fastq fastq 7014679884.0 23437449.0 100 4 R1.clean.fq.gz 0:149.72 1:149.57 A:1882114669;C:1625037935;G:1641102139;T:1865959279;N:465862 149 149     1882114669 1625037935 1641102139 1865959279 465862 SRX12150930 SRS10130021 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.93236 0.93264 0.08797 0.08919 0.67574 0.67965 0.50279 0.495 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65992 65992 SRR15859829 SRX12150929 SRS10130019 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     dydrogesterone treatment DDG 3 AH   strain:not collected2|isolate:whole fish7|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 3 prime|BioSampleModel:Model organism or animal                 DDG 3 BG BG zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_3_R1.clean.fq.gz 100_3_R2.clean.fq.gz fastq fastq 7000790030.0 23371313.0 100 3 R1.clean.fq.gz 0:149.83 1:149.72 A:1906942833;C:1592634521;G:1609492258;T:1891245267;N:475151 149 149     1906942833 1592634521 1609492258 1891245267 475151 SRX12150929 SRS10130019 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.92801 0.92781 0.09747 0.09744 0.66517 0.66776 0.50246 0.49531 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65993 65993 SRR15859830 SRX12150928 SRS10130020 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     dydrogesterone treatment DDG 2 AG   strain:not collected2|isolate:whole fish6|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 2'|BioSampleModel:Model organism or animal                 DDG 2 BF BF zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_2_R1.clean.fq.gz 100_2_R2.clean.fq.gz fastq fastq 7075813310.0 23625836.0 100 2 R1.clean.fq.gz 0:149.82 1:149.68 A:1918796036;C:1619755625;G:1637664383;T:1899135516;N:461750 149 149     1918796036 1619755625 1637664383 1899135516 461750 SRX12150928 SRS10130020 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.92935 0.92868 0.08886 0.08912 0.65717 0.6621 0.4843 0.49415 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65994 65994 SRR15859831 SRX12150927 SRS10130018 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     dydrogesterone treatment DDG 1 AF   strain:not collected2|isolate:whole fish5|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 1'|BioSampleModel:Model organism or animal                 DDG 1 BE BE zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_1_R1.clean.fq.gz 100_1_R2.clean.fq.gz fastq fastq 6740898004.0 22511996.0 100 1 R1.clean.fq.gz 0:149.79 1:149.65 A:1828418830;C:1542362815;G:1564205385;T:1805464983;N:445991 149 149     1828418830 1542362815 1564205385 1805464983 445991 SRX12150927 SRS10130018 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.92893 0.92836 0.08577 0.08614 0.67639 0.68077 0.48573 0.49544 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65995 65995 SRR15859832 SRX12150926 SRS10130016 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Solvent control SC4 AE   strain:not collected2|isolate:whole fish4|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 4'|BioSampleModel:Model organism or animal                 SC4 BD BD zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     SC_4_R1.clean.fq.gz SC_4_R2.clean.fq.gz fastq fastq 6051468288.0 20209797.0 SC 4 R1.clean.fq.gz 0:149.80 1:149.63 A:1652651735;C:1373191643;G:1392749062;T:1632474997;N:400851 149 149     1652651735 1373191643 1392749062 1632474997 400851 SRX12150926 SRS10130016 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.92672 0.92501 0.09038 0.09121 0.66259 0.66565 0.49636 0.49698 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65996 65996 SRR15859833 SRX12150925 SRS10130017 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Levonorgestrel at high concentration and dydrogesterone mixturestreatment DDG+LNG H 1 AY   strain:not collected2|isolate:whole fish24|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 4'|BioSampleModel:Model organism or animal                 DDG+LNG H 1 BX BX zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_50_4_R1.clean.fq.gz 100_50_4_R2.clean.fq.gz fastq fastq 6861007764.0 22938186.0 100 50 4 R1.clean.fq.gz 0:149.76 1:149.35 A:1881600852;C:1578987219;G:1582313999;T:1818088269;N:17425 149 149     1881600852 1578987219 1582313999 1818088269 17425 SRX12150925 SRS10130017 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.93777 0.92424 0.09796 0.0931 0.66182 0.66746 0.49608 0.49787 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65997 65997 SRR15859834 SRX12150924 SRS10130015 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Levonorgestrel at high concentration and dydrogesterone mixtures treatment DDG+LNG H 1 AX   strain:not collected2|isolate:whole fish23|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 3 prime|BioSampleModel:Model organism or animal                 DDG+LNG H 1 BW BW zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_50_3_R1.clean.fq.gz 100_50_3_R2.clean.fq.gz fastq fastq 6448167527.0 21546554.0 100 50 3 R1.clean.fq.gz 0:149.84 1:149.43 A:1776900923;C:1483436670;G:1478517308;T:1709296399;N:16227 149 149     1776900923 1483436670 1478517308 1709296399 16227 SRX12150924 SRS10130015 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.94114 0.92751 0.08812 0.0842 0.66557 0.67052 0.49525 0.49796 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65998 65998 SRR15859835 SRX12150923 SRS10130014 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Levonorgestrel at high concentration and dydrogesterone mixtures treatment DDG+LNG H 1 AW   strain:not collected2|isolate:whole fish22|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 2'|BioSampleModel:Model organism or animal                 DDG+LNG H 1 BV BV zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_50_2_R1.clean.fq.gz 100_50_2_R2.clean.fq.gz fastq fastq 6097050612.0 20374795.0 100 50 2 R1.clean.fq.gz 0:149.83 1:149.42 A:1697937652;C:1387399999;G:1387536896;T:1624160680;N:15385 149 149     1697937652 1387399999 1387536896 1624160680 15385 SRX12150923 SRS10130014 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.93921 0.92457 0.09156 0.08703 0.677 0.68268 0.51381 0.51338 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
65999 65999 SRR15859836 SRX12150922 SRS10130013 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Levonorgestrel at high concentration and dydrogesterone mixtures treatment DDG+LNG H 1 AV   strain:not collected2|isolate:whole fish21|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 1'|BioSampleModel:Model organism or animal                 DDG+LNG H 1 BU BU zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_50_1_R1.clean.fq.gz 100_50_1_R2.clean.fq.gz fastq fastq 6200464490.0 20718210.0 100 50 1 R1.clean.fq.gz 0:149.84 1:149.44 A:1722773998;C:1411958803;G:1410364088;T:1655351787;N:15814 149 149     1722773998 1411958803 1410364088 1655351787 15814 SRX12150922 SRS10130013 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.94019 0.92317 0.09428 0.08799 0.66192 0.66813 0.50339 0.50384 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
66000 66000 SRR15859837 SRX12150921 SRS10130012 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Solvent control SC3 AD   strain:not collected2|isolate:whole fish3|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 3 prime|BioSampleModel:Model organism or animal                 SC3 BC BC zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     SC_3_R1.clean.fq.gz SC_3_R2.clean.fq.gz fastq fastq 6744019219.0 22522868.0 SC 3 R1.clean.fq.gz 0:149.81 1:149.62 A:1832736009;C:1540439892;G:1560536404;T:1809859936;N:446978 149 149     1832736009 1540439892 1560536404 1809859936 446978 SRX12150921 SRS10130012 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.92908 0.92831 0.08407 0.08413 0.66748 0.67332 0.49151 0.50363 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
66001 66001 SRR15859838 SRX12150920 SRS10130011 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Levonorgestrel at low concentration and dydrogesterone mixtures treatment DDG+LNG L 4 AU   strain:not collected2|isolate:whole fish20|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 4'|BioSampleModel:Model organism or animal                 DDG+LNG L 4 BT BT zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_5_4_R1.clean.fq.gz 100_5_4_R2.clean.fq.gz fastq fastq 6698715338.0 22386760.0 100 5 4 R1.clean.fq.gz 0:149.82 1:149.41 A:1854944489;C:1532319316;G:1533554376;T:1777880466;N:16691 149 149     1854944489 1532319316 1533554376 1777880466 16691 SRX12150920 SRS10130011 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.93948 0.92423 0.09198 0.08752 0.66967 0.67513 0.49914 0.49616 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
66002 66002 SRR15859839 SRX12150919 SRS10130010 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Levonorgestrel at low concentration and dydrogesterone mixtures treatment DDG+LNG L 3 AT   strain:not collected2|isolate:whole fish19|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 3 prime|BioSampleModel:Model organism or animal                 DDG+LNG L 3 BS BS zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_5_3_R1.clean.fq.gz 100_5_3_R2.clean.fq.gz fastq fastq 6731263096.0 22494392.0 100 5 3 R1.clean.fq.gz 0:149.82 1:149.42 A:1853865687;C:1546635036;G:1549005691;T:1781740007;N:16675 149 149     1853865687 1546635036 1549005691 1781740007 16675 SRX12150919 SRS10130010 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.94161 0.92699 0.09368 0.08881 0.67146 0.67671 0.49075 0.4916 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
66003 66003 SRR15859840 SRX12150918 SRS10130009 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Levonorgestrel at low concentration and dydrogesterone mixtures treatment DDG+LNG L 2 AS   strain:not collected2|isolate:whole fish18|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 2'|BioSampleModel:Model organism or animal                 DDG+LNG L 2 BR BR zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_5_2_R1.clean.fq.gz 100_5_2_R2.clean.fq.gz fastq fastq 6856677730.0 22942302.0 100 5 2 R1.clean.fq.gz 0:149.63 1:149.23 A:1861833177;C:1593702006;G:1601437245;T:1799688067;N:17235 149 149     1861833177 1593702006 1601437245 1799688067 17235 SRX12150918 SRS10130009 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.94226 0.93085 0.08471 0.08039 0.67677 0.68191 0.48927 0.47969 150 148 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
66004 66004 SRR15859841 SRX12150917 SRS10130007 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     Levonorgestrel at low concentration and dydrogesterone mixtures treatment DDG+LNG L 1 AR   strain:not collected2|isolate:whole fish17|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 1'|BioSampleModel:Model organism or animal                 DDG+LNG L 1 BQ BQ zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     100_5_1_R1.clean.fq.gz 100_5_1_R2.clean.fq.gz fastq fastq 6734596961.0 22519168.0 100 5 1 R1.clean.fq.gz 0:149.72 1:149.34 A:1835515639;C:1562058332;G:1561380426;T:1775625709;N:16855 149 149     1835515639 1562058332 1561380426 1775625709 16855 SRX12150917 SRS10130007 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.94108 0.92768 0.09123 0.08716 0.66967 0.6747 0.50584 0.50347 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
66005 66005 SRR15859842 SRX12150916 SRS10130006 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     levonorgestrel treatment at high concentration treatment LNG H 4 AQ   strain:not collected2|isolate:whole fish16|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 4'|BioSampleModel:Model organism or animal                 LNG H 4 BP BP zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     50_4_R1.clean.fq.gz 50_4_R2.clean.fq.gz fastq fastq 7033955938.0 23502039.0 50 4 R1.clean.fq.gz 0:149.84 1:149.46 A:1939982949;C:1612770444;G:1610988374;T:1870196531;N:17640 149 149     1939982949 1612770444 1610988374 1870196531 17640 SRX12150916 SRS10130006 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.94099 0.92749 0.09644 0.09215 0.67261 0.67838 0.49766 0.49584 150 149 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
66006 66006 SRR15859843 SRX12150915 SRS10130008 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     levonorgestrel treatment at high concentration treatment LNG H 3 AP   strain:not collected2|isolate:whole fish15|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 3 prime|BioSampleModel:Model organism or animal                 LNG H 3 BO BO zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     50_3_R1.clean.fq.gz 50_3_R2.clean.fq.gz fastq fastq 5819952570.0 19444342.0 50 3 R1.clean.fq.gz 0:149.86 1:149.46 A:1615559082;C:1328350353;G:1325535770;T:1550492661;N:14704 149 149     1615559082 1328350353 1325535770 1550492661 14704 SRX12150915 SRS10130008 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.9397 0.92495 0.09375 0.08838 0.669 0.67338 0.50535 0.5146 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
66007 66007 SRR15859844 SRX12150914 SRS10130005 SRP336743 PRJNA760976 Danio rerio strain:AB Transcriptome or Gene expression PRJNA760976 Transcriptome Analysis we investigated the effects of progestins on gonadal differentiation and sex determination in zebrafish     levonorgestrel treatment at high concentration treatment LNG H 2 AO   strain:not collected2|isolate:whole fish14|breed:not collected|cultivar:not applicable3|ecotype:not applicable4|age:4 weeks|dev stage:not applicable5|sex:missing|tissue:whole fish|replicate:'replicate = biological replicate 2'|BioSampleModel:Model organism or animal                 LNG H 2 BN BN zebraifsh exposure     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP336743     50_2_R1.clean.fq.gz 50_2_R2.clean.fq.gz fastq fastq 5888497480.0 19673249.0 50 2 R1.clean.fq.gz 0:149.84 1:149.47 A:1638307115;C:1337036459;G:1335389572;T:1577749137;N:15197 149 149     1638307115 1337036459 1335389572 1577749137 15197 SRX12150914 SRS10130005 SRA1291484 South China Normal University|School of Environment South China Normal University 2 0.9395 0.92471 0.09382 0.08964 0.66785 0.67144 0.50388 0.5077 150 150 B B biological fallback assumption bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-12 Larval Larval Whole Organism All anatomical structures
66964 66964 SRR16965143 SRX13156592 SRS11088496 SRP346547 PRJNA780808 transcriptomics of carbendazim and enrofloxacin on zebrafish embryos PRJNA780808 Other reveal a interaction between ENF and CAR on metabolic regulation during development         1mix   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:10 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio :mixture group mix 1 mix 1 96hpf zebrafish larvae mixture group     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346547     mix2_1_2.fq.gz fastq 3313823250.0 22092155.0 mix2 1 2.fq.gz 0:0 1:150 A:895726357;C:763402657;G:745765587;T:908922686;N:5963 0 150     895726357 763402657 745765587 908922686 5963 SRX13156592 SRS11088496 SRA1329868 China Agricultural University|College of animal science and technology China Agricultural University 1 0.93604   0.10794   0.65587   0.47956   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-17 Larval Larval Undetermined Undetermined
66965 66965 SRR16965144 SRX13156591 SRS11088495 SRP346547 PRJNA780808 transcriptomics of carbendazim and enrofloxacin on zebrafish embryos PRJNA780808 Other reveal a interaction between ENF and CAR on metabolic regulation during development         3enf   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:9 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio :enrofloxacin group enf 3 enf 3 96hpf zebrafish larvae enrofloxacin group     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346547     enf_3.fq.gz fastq 3304972350.0 22033149.0 enf 3.fq.gz 0:150 1:0 A:899427202;C:745999066;G:759917309;T:899625137;N:3636 150 0     899427202 745999066 759917309 899625137 3636 SRX13156591 SRS11088495 SRA1329868 China Agricultural University|College of animal science and technology China Agricultural University 1 0.94353   0.10795   0.66212   0.47773   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-17 Larval Larval Undetermined Undetermined
66966 66966 SRR16965145 SRX13156590 SRS11088493 SRP346547 PRJNA780808 transcriptomics of carbendazim and enrofloxacin on zebrafish embryos PRJNA780808 Other reveal a interaction between ENF and CAR on metabolic regulation during development         1enf   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:7 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio :enrofloxacin group enf 1 enf 1 96hpf zebrafish larvae enrofloxacin group     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP346547     enf_1.fq.gz enf_2.fq.gz fastq fastq 6652389300.0 44349262.0 enf 1.fq.gz 0:150 1:150 A:1759651033;C:1563446116;G:1556912596;T:1772370048;N:9507 150 150     1759651033 1563446116 1556912596 1772370048 9507 SRX13156590 SRS11088493 SRA1329868 China Agricultural University|College of animal science and technology China Agricultural University 1 0.94992   0.06316   0.66979   0.48987   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-17 Larval Larval Undetermined Undetermined
66967 66967 SRR16965146 SRX13156589 SRS11088492 SRP346547 PRJNA780808 transcriptomics of carbendazim and enrofloxacin on zebrafish embryos PRJNA780808 Other reveal a interaction between ENF and CAR on metabolic regulation during development         3car   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:6 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio :carbendazim group car 3 car 3 96hpf zebrafish larvae carbendazim group     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346547     car_3_1.fq.gz fastq 3335622150.0 22237481.0 car 3 1.fq.gz 0:150 1:0 A:853229671;C:807433601;G:820478265;T:854475092;N:5521 150 0     853229671 807433601 820478265 854475092 5521 SRX13156589 SRS11088492 SRA1329868 China Agricultural University|College of animal science and technology China Agricultural University 1 0.96567   0.03093   0.70997   0.47751   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-17 Larval Larval Undetermined Undetermined
66968 66968 SRR16965147 SRX13156588 SRS11088494 SRP346547 PRJNA780808 transcriptomics of carbendazim and enrofloxacin on zebrafish embryos PRJNA780808 Other reveal a interaction between ENF and CAR on metabolic regulation during development         1car   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:4 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio :carbendazim group car 1 car 1 96hpf zebrafish larvae carbendazim group     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346547     car_1_1.fq.gz fastq 3378056400.0 22520376.0 car 1 1.fq.gz 0:150 1:0 A:886009175;C:795203398;G:809447342;T:887390300;N:6185 150 0     886009175 795203398 809447342 887390300 6185 SRX13156588 SRS11088494 SRA1329868 China Agricultural University|College of animal science and technology China Agricultural University 1 0.95701   0.05956   0.67836   0.4884   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-17 Larval Larval Undetermined Undetermined
66969 66969 SRR16965148 SRX13156587 SRS11088491 SRP346547 PRJNA780808 transcriptomics of carbendazim and enrofloxacin on zebrafish embryos PRJNA780808 Other reveal a interaction between ENF and CAR on metabolic regulation during development         3con   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:3 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio :control group con 3 con 3 96hpf zebrafish larvae control group     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346547     con_3_2.fq.gz fastq 3359054500.0 33590545.0 con 3 2.fq.gz 0:100 1:0 A:914533337;C:755914202;G:773676246;T:914930715;N:0 100 0     914533337 755914202 773676246 914930715 0 SRX13156587 SRS11088491 SRA1329868 China Agricultural University|College of animal science and technology China Agricultural University 1 0.95076   0.10478   0.65646   0.49594   100   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-17 Larval Larval Undetermined Undetermined
66970 66970 SRR16965149 SRX13156586 SRS11088489 SRP346547 PRJNA780808 transcriptomics of carbendazim and enrofloxacin on zebrafish embryos PRJNA780808 Other reveal a interaction between ENF and CAR on metabolic regulation during development         3mix   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:12 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio :mixture group mix 3 mix 3 96hpf zebrafish larvae mixture group     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346547     mix2_3_1.fq.gz fastq 3362094000.0 33620940.0 mix2 3 1.fq.gz 0:100 1:0 A:916124379;C:755910593;G:768246534;T:921812494;N:0 100 0     916124379 755910593 768246534 921812494 0 SRX13156586 SRS11088489 SRA1329868 China Agricultural University|College of animal science and technology China Agricultural University 1 0.94894   0.10416   0.65342   0.49475   100   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-17 Larval Larval Undetermined Undetermined
66971 66971 SRR16965150 SRX13156585 SRS11088490 SRP346547 PRJNA780808 transcriptomics of carbendazim and enrofloxacin on zebrafish embryos PRJNA780808 Other reveal a interaction between ENF and CAR on metabolic regulation during development         2mix   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:11 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio :mixture group mix 2 mix 2 96hpf zebrafish larvae mixture group     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP346547     car_2_2.fq.gz mix2_2_1.fq.gz fastq fastq 6669719100.0 44464794.0 car 2 2.fq.gz 0:150 1:150 A:1815824677;C:1515086864;G:1506360115;T:1832433148;N:14296 150 150     1815824677 1515086864 1506360115 1832433148 14296 SRX13156585 SRS11088490 SRA1329868 China Agricultural University|College of animal science and technology China Agricultural University 1 0.93884   0.11657   0.65527   0.48114   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-17 Larval Larval Undetermined Undetermined
66972 66972 SRR16965151 SRX13156584 SRS11088488 SRP346547 PRJNA780808 transcriptomics of carbendazim and enrofloxacin on zebrafish embryos PRJNA780808 Other reveal a interaction between ENF and CAR on metabolic regulation during development         2con   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:2 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio :control group con 2 con 2 96hpf zebrafish larvae control group     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346547   loader:fastq load.py con_2_2.fq fastq 3324287550.0 22161917.0 con 2 2.fq.gz 0:150 A:848766265;C:812477645;G:798995610;T:864040426;N:7604 150       848766265 812477645 798995610 864040426 7604 SRX13156584 SRS11088488 SRA1329868 China Agricultural University|College of animal science and technology China Agricultural University 1 0.95546   0.03524   0.70027   0.48649   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-22 Larval Larval Undetermined Undetermined
66973 66973 SRR16965152 SRX13156583 SRS11088487 SRP346547 PRJNA780808 transcriptomics of carbendazim and enrofloxacin on zebrafish embryos PRJNA780808 Other reveal a interaction between ENF and CAR on metabolic regulation during development         1con   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:1 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio :control group con 1 con 1 96hpf zebrafish larvae control group     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346547   loader:fastq load.py con_1_1.fq fastq 3330724500.0 22204830.0 con 1 1.fq.gz 0:150 A:896812508;C:762246067;G:774062043;T:897597946;N:5936 150       896812508 762246067 774062043 897597946 5936 SRX13156583 SRS11088487 SRA1329868 China Agricultural University|College of animal science and technology China Agricultural University 1 0.94926   0.08711   0.66789   0.48628   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-22 Larval Larval Undetermined Undetermined
66974 66974 SRR16959538 SRX13151074 SRS11083380 SRP346418 PRJNA780940 transcriptomics of difenoconazole and dimethomorph on zebrafish embryos PRJNA780940 Other Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.         1+mix   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:10 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : mixture group mix 1 mix 1 The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP346418     mix1_3_2.fq.gz mix1_1_1.fq.gz fastq fastq 6639699600.0 44264664.0 mix1 1 1.fq.gz 0:150 1:150 A:1738687157;C:1575344731;G:1569683716;T:1755974708;N:9288 150 150     1738687157 1575344731 1569683716 1755974708 9288 SRX13151074 SRS11083380 SRA1330365 China Agricultural University|College of animal science and technology China Agricultural University 1 0.95161   0.05697   0.6817   0.48485   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-16 Larval Larval Undetermined Undetermined
66975 66975 SRR16959539 SRX13151073 SRS11083379 SRP346418 PRJNA780940 transcriptomics of difenoconazole and dimethomorph on zebrafish embryos PRJNA780940 Other Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.         2dim   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:8 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : dimethomorph group dim 2 dim 2 The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346418     dim_2_1.fq.gz fastq 3344257500.0 22295050.0 dim 2 1.fq.gz 0:150 1:0 A:895700119;C:767415749;G:784994320;T:896143585;N:3727 150 0     895700119 767415749 784994320 896143585 3727 SRX13151073 SRS11083379 SRA1330365 China Agricultural University|College of animal science and technology China Agricultural University 1 0.9497   0.08418   0.66352   0.49341   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-16 Larval Larval Undetermined Undetermined
66976 66976 SRR16959540 SRX13151072 SRS11083378 SRP346418 PRJNA780940 transcriptomics of difenoconazole and dimethomorph on zebrafish embryos PRJNA780940 Other Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.         1dim   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:7 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : dimethomorph group dim 1 dim 1 The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346418     dim_1_1.fq.gz fastq 3318812250.0 22125415.0 dim 1 1.fq.gz 0:150 1:0 A:908481293;C:742787936;G:755930542;T:911608821;N:3658 150 0     908481293 742787936 755930542 911608821 3658 SRX13151072 SRS11083378 SRA1330365 China Agricultural University|College of animal science and technology China Agricultural University 1 0.94211   0.11824   0.65344   0.47716   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-16 Larval Larval Undetermined Undetermined
66977 66977 SRR16959541 SRX13151071 SRS11083377 SRP346418 PRJNA780940 transcriptomics of difenoconazole and dimethomorph on zebrafish embryos PRJNA780940 Other Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.         3dif   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:6 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : difenoconazole group dif 3 dif 3 The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346418     dif_3_1.fq.gz fastq 3318453000.0 22123020.0 dif 3 1.fq.gz 0:150 1:0 A:893975607;C:758489621;G:772391705;T:893592335;N:3732 150 0     893975607 758489621 772391705 893592335 3732 SRX13151071 SRS11083377 SRA1330365 China Agricultural University|College of animal science and technology China Agricultural University 1 0.94838   0.08393   0.66543   0.4818   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-16 Larval Larval Undetermined Undetermined
66978 66978 SRR16959542 SRX13151070 SRS11083376 SRP346418 PRJNA780940 transcriptomics of difenoconazole and dimethomorph on zebrafish embryos PRJNA780940 Other Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.         2dif   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:5 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : difenoconazole group dif 2 dif 2 The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346418     dif_2_2.fq.gz fastq 3304972350.0 22033149.0 dif 2 2.fq.gz 0:0 1:150 A:890456734;C:764917766;G:744757536;T:904833787;N:6527 0 150     890456734 764917766 744757536 904833787 6527 SRX13151070 SRS11083376 SRA1330365 China Agricultural University|College of animal science and technology China Agricultural University 1 0.93514   0.107   0.6633   0.47599   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-16 Larval Larval Undetermined Undetermined
66979 66979 SRR16959543 SRX13151069 SRS11083375 SRP346418 PRJNA780940 transcriptomics of difenoconazole and dimethomorph on zebrafish embryos PRJNA780940 Other Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.         1dif   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:4 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : difenoconazole group dif 1 dif 1 The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346418     dif_1_1.fq.gz fastq 3295443900.0 21969626.0 dif 1 1.fq.gz 0:150 1:0 A:887936493;C:751636494;G:765508757;T:890358629;N:3527 150 0     887936493 751636494 765508757 890358629 3527 SRX13151069 SRS11083375 SRA1330365 China Agricultural University|College of animal science and technology China Agricultural University 1 0.94623   0.09138   0.66478   0.4828   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-16 Larval Larval Undetermined Undetermined
66980 66980 SRR16959544 SRX13151068 SRS11083374 SRP346418 PRJNA780940 transcriptomics of difenoconazole and dimethomorph on zebrafish embryos PRJNA780940 Other Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.         3+con   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:3 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : control group con 3 con 3 The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346418     con_3_1.fq.gz fastq 3306406800.0 22042712.0 con 3 1.fq.gz 0:150 1:0 A:872740236;C:773482184;G:788334419;T:871846539;N:3422 150 0     872740236 773482184 788334419 871846539 3422 SRX13151068 SRS11083374 SRA1330365 China Agricultural University|College of animal science and technology China Agricultural University 1 0.95458   0.06103   0.67409   0.48439   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-16 Larval Larval Undetermined Undetermined
66981 66981 SRR16959545 SRX13151067 SRS11083373 SRP346418 PRJNA780940 transcriptomics of difenoconazole and dimethomorph on zebrafish embryos PRJNA780940 Other Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.         2+mix   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:11 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : mixture group mix 2 mix 2 The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP346418     mix1_2_1.fq.gz dim_3_2.fq.gz fastq fastq 6589866900.0 43932446.0 dim 3 2.fq.gz 0:150 1:150 A:1782755416;C:1508342477;G:1501934674;T:1796820276;N:14057 150 150     1782755416 1508342477 1501934674 1796820276 14057 SRX13151067 SRS11083373 SRA1330365 China Agricultural University|College of animal science and technology China Agricultural University 1 0.93861   0.10685   0.66393   0.47194   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-16 Larval Larval Undetermined Undetermined
66982 66982 SRR16959546 SRX13151066 SRS11083372 SRP346418 PRJNA780940 transcriptomics of difenoconazole and dimethomorph on zebrafish embryos PRJNA780940 Other Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.         2+con   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:2 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : control group con 2 con 2 The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346418     con_2_2.fq.gz fastq 3324287550.0 22161917.0 con 2 2.fq.gz 0:0 1:150 A:848766265;C:812477645;G:798995610;T:864040426;N:7604 0 150     848766265 812477645 798995610 864040426 7604 SRX13151066 SRS11083372 SRA1330365 China Agricultural University|College of animal science and technology China Agricultural University 1 0.95548   0.03524   0.70021   0.4867   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-16 Larval Larval Undetermined Undetermined
66983 66983 SRR16959547 SRX13151065 SRS11083371 SRP346418 PRJNA780940 transcriptomics of difenoconazole and dimethomorph on zebrafish embryos PRJNA780940 Other Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.         1+con   strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:1 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : control group con 1 con 1 The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.     RNA-Seq TRANSCRIPTOMIC Oligo-dT SINGLE BGISEQ BGISEQ-500   SRP346418     con_1_1.fq.gz fastq 3330724500.0 22204830.0 con 1 1.fq.gz 0:150 1:0 A:896812508;C:762246067;G:774062043;T:897597946;N:5936 150 0     896812508 762246067 774062043 897597946 5936 SRX13151065 SRS11083371 SRA1330365 China Agricultural University|College of animal science and technology China Agricultural University 1 0.94925   0.08711   0.66772   0.48635   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-11-16 Larval Larval Undetermined Undetermined
67884 67884 SRR17868935 SRX14028691 SRS11864778 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         C4 1   strain:danio rerio AgNPs4|breed:zebrafish10|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 4 1 AG 4 1 AG 4 1 treatment7     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     C4-1_1.fq.gz C4-1_2.fq.gz fastq fastq 6830916900.0 45539446.0 C4 1 1.fq.gz 0:150 1:150 A:2011586443;C:1405775454;G:1388504965;T:2024992696;N:57342 150 150     2011586443 1405775454 1388504965 2024992696 57342 SRX14028691 SRS11864778 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.92344   0.21929   0.71043   0.46315   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures
67885 67885 SRR17868936 SRX14028690 SRS11864777 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         C2 3   strain:danio rerio AgNPs2|breed:zebrafish9|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 2 3 AG 2 3 AG 2 3 treatment6     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     C2-3_1.fq.gz C2-3_2.fq.gz fastq fastq 6782959200.0 45219728.0 C2 3 1.fq.gz 0:150 1:150 A:1949560199;C:1443524899;G:1428814233;T:1960921903;N:137966 150 150     1949560199 1443524899 1428814233 1960921903 137966 SRX14028690 SRS11864777 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.93181   0.17739   0.6927   0.50528   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures
67886 67886 SRR17868937 SRX14028689 SRS11864776 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         C2 2   strain:danio rerio AgNPs2|breed:zebrafish8|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 2 2 AG 2 2 AG 2 2 treatment5     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     C2-2_1.fq.gz C2-2_2.fq.gz fastq fastq 6817863300.0 45452422.0 C2 2 1.fq.gz 0:150 1:150 A:1964890519;C:1446826412;G:1428708103;T:1977297439;N:140827 150 150     1964890519 1446826412 1428708103 1977297439 140827 SRX14028689 SRS11864776 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.93045   0.17846   0.69116   0.48565   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures
67887 67887 SRR17868938 SRX14028688 SRS11864774 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         C2 1   strain:danio rerio AgNPs2|breed:zebrafish7|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 2 1 AG 2 1 AG 2 1 treatment4     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     C2-1_1.fq.gz C2-1_2.fq.gz fastq fastq 6795911700.0 45306078.0 C2 1 1.fq.gz 0:150 1:150 A:1910936263;C:1486390531;G:1471463982;T:1927036309;N:84615 150 150     1910936263 1486390531 1471463982 1927036309 84615 SRX14028688 SRS11864774 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.93638   0.14847   0.6814   0.46864   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures
67888 67888 SRR17868939 SRX14028687 SRS11864775 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         C1 3   strain:danio rerio AgNPs1|breed:zebrafish6|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 1 3 AG 1 3 AG 1 3 treatment3     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     C1-3_1.fq.gz C1-3_2.fq.gz fastq fastq 6788960100.0 45259734.0 C1 3 1.fq.gz 0:150 1:150 A:1883226902;C:1511814926;G:1492397960;T:1901504019;N:16293 150 150     1883226902 1511814926 1492397960 1901504019 16293 SRX14028687 SRS11864775 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.94253   0.12673   0.67623   0.49289   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures
67889 67889 SRR17868940 SRX14028686 SRS11864773 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         C1 2   strain:danio rerio AgNPs1|breed:zebrafish5|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 1 2 AG 1 2 AG 1 2 treatment2     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     C1-2_1.fq.gz C1-2_2.fq.gz fastq fastq 6781043100.0 45206954.0 C1 2 1.fq.gz 0:150 1:150 A:1890710017;C:1500221789;G:1482973456;T:1907121929;N:15909 150 150     1890710017 1500221789 1482973456 1907121929 15909 SRX14028686 SRS11864773 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.93834   0.13288   0.67777   0.49269   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures
67890 67890 SRR17868941 SRX14028685 SRS11864772 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         C1 1   strain:danio rerio AgNPs1|breed:zebrafish4|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 1 1 AG 1 1 AG 1 1 treatment1     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     C1-1_1.fq.gz C1-1_2.fq.gz fastq fastq 6760511100.0 45070074.0 C1 1 1.fq.gz 0:150 1:150 A:1875451292;C:1504527737;G:1489983693;T:1890505493;N:42885 150 150     1875451292 1504527737 1489983693 1890505493 42885 SRX14028685 SRS11864772 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.94039   0.1298   0.68071   0.49309   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures
67891 67891 SRR17868942 SRX14028684 SRS11864771 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         WT3   strain:danio rerio con3|breed:zebrafish3|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 0 3 WT 0 3 WT 0 3 control3     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     WT3_1.fq.gz WT3_2.fq.gz fastq fastq 6735369300.0 44902462.0 WT3 1.fq.gz 0:150 1:150 A:1853105410;C:1513363689;G:1496503080;T:1872187115;N:210006 150 150     1853105410 1513363689 1496503080 1872187115 210006 SRX14028684 SRS11864771 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.94653   0.11174   0.69116   0.49069   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures
67892 67892 SRR17868943 SRX14028683 SRS11864768 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         C4 3   strain:danio rerio AgNPs4|breed:zebrafish12|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 4 3 AG 4 3 AG 4 3 treatment9     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     C4-3_1.fq.gz C4-3_2.fq.gz fastq fastq 7066801800.0 47112012.0 C4 3 1.fq.gz 0:150 1:150 A:2079705050;C:1456973666;G:1436564156;T:2093467396;N:91532 150 150     2079705050 1456973666 1436564156 2093467396 91532 SRX14028683 SRS11864768 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.92264   0.21457   0.70236   0.52765   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures
67893 67893 SRR17868944 SRX14028682 SRS11864769 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         C4 2   strain:danio rerio AgNPs4|breed:zebrafish11|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 4 2 AG 4 2 AG 4 2 treatment8     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     C4-2_1.fq.gz C4-2_2.fq.gz fastq fastq 6813742200.0 45424948.0 C4 2 1.fq.gz 0:150 1:150 A:1969847243;C:1438590202;G:1418612399;T:1986677730;N:14626 150 150     1969847243 1438590202 1418612399 1986677730 14626 SRX14028682 SRS11864769 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.92909   0.18109   0.69029   0.50538   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures
67894 67894 SRR17868945 SRX14028681 SRS11864770 SRP358022 PRJNA793391 Effects of acute exposure to nano silver on zebrafish larvae PRJNA793391 Other Sliver nanoparticles AgNPs are widely used for industry agriculture and medicals which potentially result in adverse effects for human health and aquatic environment. In this present study we investigated the illumine high throughput RNA sequencing revealed the transcriptome profiling of zebrafish larvae post AgNPs treatment for 72 h.         WT2   strain:danio rerio con2|breed:zebrafish2|age:3 day|sex:pooled male and female|tissue:fish|BioSampleModel:Model organism or animal                 DANIO RERIO 0 2 WT 0 2 WT 0 2 control2     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP358022     WT2_1.fq.gz WT2_2.fq.gz fastq fastq 6760866900.0 45072446.0 WT2 1.fq.gz 0:150 1:150 A:1893259201;C:1485992528;G:1471666738;T:1909709705;N:238728 150 150     1893259201 1485992528 1471666738 1909709705 238728 SRX14028681 SRS11864770 SRA1350965 Center for Neuroscience|Shantou university Center for Neuroscience 1 0.94132   0.13956   0.68596   0.48309   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   United States 2022-02-03 Larval Larval Whole Organism All anatomical structures

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CREATE TABLE run_metadata("run.accession" VARCHAR, "experiment.accession" VARCHAR, "sample.accession" VARCHAR, "study.accession" VARCHAR, bioproject VARCHAR, "study.title" VARCHAR, "study.alias" VARCHAR, "study.type" VARCHAR, "study.abstract" VARCHAR, "study.attributes" VARCHAR, "study.PMIDs" VARCHAR, "sample.description" VARCHAR, "sample.title" VARCHAR, "sample.alias" VARCHAR, "sample.centername" VARCHAR, "sample.attributes" VARCHAR, "GEOsample.title" VARCHAR, "GEOsample.dataprocessing" VARCHAR, "GEOsample.source" VARCHAR, "GEOsample.treatmentprotocol" VARCHAR, "GEOsample.extractprotocol" VARCHAR, "GEOsample.growthprotocol" VARCHAR, "GEOsample.characteristics" VARCHAR, "GEOsample.accession" VARCHAR, "experiment.title" VARCHAR, "experiment.alias" VARCHAR, "experiment.library_name" VARCHAR, "experiment.design_description" VARCHAR, "experiment.library_construction_protocol" VARCHAR, "experiment.attributes" VARCHAR, "experiment.library_strategy" VARCHAR, "experiment.library_source" VARCHAR, "experiment.library_selection" VARCHAR, "experiment.library_layout" VARCHAR, "experiment.platform" VARCHAR, "experiment.instrument_model" VARCHAR, "experiment.spot_descriptor" VARCHAR, "experiment.study_ref" VARCHAR, "run.title" VARCHAR, "run.attributes" VARCHAR, "run.filename" VARCHAR, "run.semantic_name" VARCHAR, "run.total_bases" DOUBLE, "run.total_spots" DOUBLE, "run.alias" VARCHAR, "run.read_lengths" VARCHAR, "run.base_counts" VARCHAR, "run.r1_length" BIGINT, "run.r2_length" BIGINT, "run.r3_length" BIGINT, "run.r4_length" BIGINT, "run.Acount" BIGINT, "run.Ccount" BIGINT, "run.Gcount" BIGINT, "run.Tcount" BIGINT, "run.Ncount" BIGINT, "run.experiment" VARCHAR, "run.pool_member" VARCHAR, "submission.accession" VARCHAR, "submission.srasource" VARCHAR, "submission.bioprojectsource" VARCHAR, "seqdetective.n_mates" BIGINT, "seqdetective.mapping_rate.mate1" DOUBLE, "seqdetective.mapping_rate.mate2" DOUBLE, "seqdetective.nofeature_rate.mate1" DOUBLE, "seqdetective.nofeature_rate.mate2" DOUBLE, "seqdetective.sparsity.mate1" DOUBLE, "seqdetective.sparsity.mate2" DOUBLE, "seqdetective.pos_strand_rate.mate1" DOUBLE, "seqdetective.pos_strand_rate.mate2" DOUBLE, "seqdetective.readlen.mate1" BIGINT, "seqdetective.readlen.mate2" BIGINT, "seqdetective.judgement.mate1" VARCHAR, "seqdetective.judgement.mate2" VARCHAR, "seqdetective.judgement.reason" VARCHAR, platform_family VARCHAR, instrument_generation VARCHAR, read_bias VARCHAR, selection_class VARCHAR, prep_kit VARCHAR, sc_or_bulk VARCHAR, tech_class VARCHAR, technology VARCHAR, tech_variant VARCHAR, "submission.bioprojectsource.country" VARCHAR, earliest_date DATE, devstage_curation VARCHAR, devstage_curation_coarse VARCHAR, tissue_curation VARCHAR, tissue_curation_coarse VARCHAR);;
CREATE INDEX idx_run_bioproject ON run_metadata(bioproject);;
CREATE INDEX idx_run_run_accession ON run_metadata("run.accession");;