metadata: run_metadata: 15 rows where experiment.library_layout = "SINGLE", experiment.library_selection = "Oligo-dT" and tissue

15 rows where experiment.library_layout = "SINGLE", experiment.library_selection = "Oligo-dT" and tissue_curation = "Blood"

descending

Link	rowid ▼	run.accession	experiment.accession	sample.accession	study.accession	bioproject	study.title	study.alias	study.type	study.abstract	sample.title	sample.alias	sample.attributes	experiment.title	experiment.alias	experiment.library_name	experiment.design_description	experiment.library_strategy	experiment.library_source	experiment.library_selection	experiment.library_layout	experiment.platform	experiment.instrument_model	experiment.study_ref	run.filename	run.semantic_name	run.total_bases	run.total_spots	run.alias	run.read_lengths	run.base_counts	run.r1_length	run.r2_length	run.Acount	run.Ccount	run.Gcount	run.Tcount	run.Ncount	run.experiment	run.pool_member	submission.accession	submission.srasource	submission.bioprojectsource	seqdetective.n_mates	seqdetective.mapping_rate.mate1	seqdetective.nofeature_rate.mate1	seqdetective.sparsity.mate1	seqdetective.pos_strand_rate.mate1	seqdetective.readlen.mate1	seqdetective.judgement.mate1	seqdetective.judgement.reason	platform_family	instrument_generation	read_bias	selection_class	prep_kit	sc_or_bulk	tech_class	technology	submission.bioprojectsource.country	earliest_date	devstage_curation	devstage_curation_coarse	tissue_curation	tissue_curation_coarse
25304	25304	SRR25793376	SRX21515638	SRS18742880	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes miR 144 adult	miR 144 adult	isolate:miR 144 mutant\|age:Adult\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes miR 144 mutant Danio rerio ADULT replicate 1	144 1 adult blood	144 1 adult blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-144AL1_S10.fastq	fastq	781435052.0	17368946.0	DC 144AL1 S10.fastq	0:44.99	A:207445570;C:148430622;G:177122903;T:245179579;N:3256378	44		207445570	148430622	177122903	245179579	3256378	SRX21515638	SRS18742880	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.8759	0.28126	0.95051	0.47905	22	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Adult	Adult	Blood	Hematopoietic System
25305	25305	SRR25793377	SRX21515637	SRS18742882	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes Wild type adult	WT adult	isolate:Wildtype\|age:Adult\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes Wild type Danio rerio ADULT replicate 3	WT3 adult blood	WT3 adult blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-WTA3_S6.fastq	fastq	601997398.0	17290043.0	DC WTA3 S6.fastq	0:34.82	A:136034449;C:142779447;G:177204517;T:134955264;N:11023721	34		136034449	142779447	177204517	134955264	11023721	SRX21515637	SRS18742882	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.32909	0.08525	0.95288	0.60214	22	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Adult	Adult	Blood	Hematopoietic System
25306	25306	SRR25793378	SRX21515636	SRS18742882	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes Wild type adult	WT adult	isolate:Wildtype\|age:Adult\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes Wild type Danio rerio ADULT replicate 2	WT2 adult blood	WT2 adult blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-WTA2_S5.fastq	fastq	669871903.0	17381581.0	DC WTA2 S5.fastq	0:38.54	A:169704437;C:140964096;G:160484620;T:189596855;N:9121895	38		169704437	140964096	160484620	189596855	9121895	SRX21515636	SRS18742882	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.69865	0.19099	0.93432	0.47502	68	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Adult	Adult	Blood	Hematopoietic System
25307	25307	SRR25793379	SRX21515635	SRS18742882	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes Wild type adult	WT adult	isolate:Wildtype\|age:Adult\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes Wild type Danio rerio ADULT replicate 1	WT1 adult blood	WT1 adult blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-WTA1_S4.fastq	fastq	824193699.0	17465379.0	DC WTA1 S4.fastq	0:47.19	A:209553199;C:169966117;G:194322860;T:244145525;N:6205998	47		209553199	169966117	194322860	244145525	6205998	SRX21515635	SRS18742882	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.76241	0.25975	0.94619	0.50211	66	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Adult	Adult	Blood	Hematopoietic System
25308	25308	SRR25793380	SRX21515634	SRS18742881	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes miR 144 embryo	miR 144 embryo	isolate:miR 144 mutant\|age:Embryo\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes miR 144 mutant Danio rerio 2 dpf replicate 3	144 3 embryo blood	144 3 embryo blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-144EL3_S18.fastq	fastq	687309797.0	17039739.0	DC 144EL3 S18.fastq	0:40.34	A:159186558;C:130452893;G:155820002;T:181676510;N:60173834	40		159186558	130452893	155820002	181676510	60173834	SRX21515634	SRS18742881	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.52966	0.16941	0.97615	0.58418	61	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Hatching	Embryo	Blood	Hematopoietic System
25309	25309	SRR25793381	SRX21515633	SRS18742881	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes miR 144 embryo	miR 144 embryo	isolate:miR 144 mutant\|age:Embryo\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes miR 144 mutant Danio rerio 2 dpf replicate 2	144 2 embryo blood	144 2 embryo blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-144EL2_S17.fastq	fastq	495318731.0	14459195.0	DC 144EL2 S17.fastq	0:34.26	A:110392869;C:106378418;G:128881687;T:107956679;N:41709078	34		110392869	106378418	128881687	107956679	41709078	SRX21515633	SRS18742881	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.32147	0.04496	0.97569	0.58512	31	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Hatching	Embryo	Blood	Hematopoietic System
25310	25310	SRR25793382	SRX21515632	SRS18742881	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes miR 144 embryo	miR 144 embryo	isolate:miR 144 mutant\|age:Embryo\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes miR 144 mutant Danio rerio 2 dpf replicate 1	144 1 embryo blood	144 1 embryo blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-144EL1_S16.fastq	fastq	974854100.0	20079553.0	DC 144EL1 S16.fastq	0:48.55	A:233861010;C:192987350;G:215192262;T:269960344;N:62853134	48		233861010	192987350	215192262	269960344	62853134	SRX21515632	SRS18742881	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.77953	0.18084	0.90905	0.74157	75	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Hatching	Embryo	Blood	Hematopoietic System
25311	25311	SRR25793383	SRX21515631	SRS18742879	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes Wild type embryo	WT embryo	isolate:Wildtype\|age:Embryo\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes Wild type Danio rerio 2 dpf replicate 3	WT3 embryo blood	WT3 embryo blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-WTE3_S15.fastq	fastq	657139116.0	15618072.0	DC WTE3 S15.fastq	0:42.08	A:154495614;C:122942896;G:147719345;T:179403193;N:52578068	42		154495614	122942896	147719345	179403193	52578068	SRX21515631	SRS18742879	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.56358	0.19381	0.96757	0.6115	76	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Hatching	Embryo	Blood	Hematopoietic System
25312	25312	SRR25793384	SRX21515630	SRS18742880	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes miR 144 adult	miR 144 adult	isolate:miR 144 mutant\|age:Adult\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes miR 144 mutant Danio rerio ADULT replicate 3	144 3 adult blood	144 3 adult blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-144AL3_S12.fastq	fastq	498938612.0	14861511.0	DC 144AL3 S12.fastq	0:33.57	A:137243823;C:96735877;G:109220779;T:152042235;N:3695898	33		137243823	96735877	109220779	152042235	3695898	SRX21515630	SRS18742880	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.82213	0.16617	0.95053	0.46386	22	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Adult	Adult	Blood	Hematopoietic System
25313	25313	SRR25793385	SRX21515629	SRS18742880	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes miR 144 adult	miR 144 adult	isolate:miR 144 mutant\|age:Adult\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes miR 144 mutant Danio rerio ADULT replicate 2	144 2 adult blood	144 2 adult blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-144AL2_S11.fastq	fastq	497890134.0	10636306.0	DC 144AL2 S11.fastq	0:46.81	A:134598214;C:94036725;G:109501897;T:158719603;N:1033695	46		134598214	94036725	109501897	158719603	1033695	SRX21515629	SRS18742880	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.88496	0.29132	0.96002	0.53343	22	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Adult	Adult	Blood	Hematopoietic System
25314	25314	SRR25793386	SRX21515628	SRS18742879	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes Wild type embryo	WT embryo	isolate:Wildtype\|age:Embryo\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes Wild type Danio rerio 2 dpf replicate 2	WT2 embryo blood	WT2 embryo blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-WTE2_S14.fastq	fastq	250958009.0	9755304.0	DC WTE2 S14.fastq	0:25.73	A:43225839;C:41823862;G:54150092;T:43159724;N:68598492	25		43225839	41823862	54150092	43159724	68598492	SRX21515628	SRS18742879	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.34114	0.05466	0.96664	0.54625	47	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Hatching	Embryo	Blood	Hematopoietic System
25315	25315	SRR25793387	SRX21515627	SRS18742879	SRP457465	PRJNA1010662	The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.	PRJNA1010662	Other	Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.	RNA seq Erythrocytes Wild type embryo	WT embryo	isolate:Wildtype\|age:Embryo\|collection date:N/A\|geo loc name:N/A\|sex:mixed\|tissue:Blood\|BioSampleModel:Model organism or animal	Quant seq Erythrocytes Wild type Danio rerio 2 dpf replicate 1	WT1 embryo blood	WT1 embryo blood	Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	Illumina NovaSeq 6000	SRP457465	DC-WTE1_S13.fastq	fastq	816518564.0	19556325.0	DC WTE1 S13.fastq	0:41.75	A:187091550;C:151287428;G:179967901;T:221475884;N:76695801	41		187091550	151287428	179967901	221475884	76695801	SRX21515627	SRS18742879	SRA1701831	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.61681	0.1874	0.95101	0.56879	29	B	usable mapping rate	illumina	novaseq_era	3prime	poly_a	lexogen	bulk	unknown	unknown	United Kingdom	2023-08-30	Hatching	Embryo	Blood	Hematopoietic System
55536	55536	SRR10532692	SRX7216663	SRS5719129	SRP233258	PRJNA591815	Ago2 dependent processing allows miR 451 to evade the global microRNA turnover elicited during erythropoiesis	PRJNA591815	Other	MicroRNAs are sequentially processed by two RNAse III enzymes Drosha and Dicer. miR 451 is the only known miRNA whose processing bypasses Dicer and instead relies on the slicer activity of Argonaute 2 Ago2. MiR 451 is highly conserved in vertebrates and regulates erythrocyte maturation where it becomes the most abundant miRNA. However the basis for the non canonical biogenesis of miR 451 is unclear. In this study we tested the hypothesis that miR 144 represses Dicer in a negative feedback loop during erythropoiesis and enhances miR 451 biogenesis. Loss of miR 144 mediated Dicer repression in zebrafish embryos and human cells leads to increased canonical miRNA production and impaired miR 451 maturation.		miR 451 mutant	isolate:Lab reared\|age:2 days\|sex:not applicable\|tissue:peripheral blood\|genotype:miR 451 / \|phenotype:wild type\|treatment:n1\|BioSampleModel:Model organism or animal	Transcriptomic profiling of peripheral blood from 2 dpf zebrafish embryos	mRNA Mut miR 451	mRNA Mut miR 451	mRNA libraries were cloned from polyA+ RNA isolated from peripheral blood of 2 dpf WT and mutant zebrafish embryos according to Illumina TruSeq protocol. Libraries were cloned and sequenced at Boston University Microarray and Sequencing core.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	NextSeq 500	SRP233258	mRNA-miR-451.fastq.gz	fastq	7904410367.0	104613601.0	mRNA miR 451.fastq.gz	0:75.56 1:0	A:1795110678;C:2004074141;G:2113982350;T:1989843693;N:1399505	75	0	1795110678	2004074141	2113982350	1989843693	1399505	SRX7216663	SRS5719129	SRA1002853	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.97314	0.03847	0.81744	0.4673	75	B	usable mapping rate	illumina	nextseq	unknown	poly_a	trueseq	bulk	unknown	unknown	United Kingdom	2019-11-26	Hatching	Embryo	Blood	Hematopoietic System
55537	55537	SRR10532693	SRX7216662	SRS5719128	SRP233258	PRJNA591815	Ago2 dependent processing allows miR 451 to evade the global microRNA turnover elicited during erythropoiesis	PRJNA591815	Other	MicroRNAs are sequentially processed by two RNAse III enzymes Drosha and Dicer. miR 451 is the only known miRNA whose processing bypasses Dicer and instead relies on the slicer activity of Argonaute 2 Ago2. MiR 451 is highly conserved in vertebrates and regulates erythrocyte maturation where it becomes the most abundant miRNA. However the basis for the non canonical biogenesis of miR 451 is unclear. In this study we tested the hypothesis that miR 144 represses Dicer in a negative feedback loop during erythropoiesis and enhances miR 451 biogenesis. Loss of miR 144 mediated Dicer repression in zebrafish embryos and human cells leads to increased canonical miRNA production and impaired miR 451 maturation.		miR 144 mutant	isolate:Lab reared\|age:2 days\|sex:not applicable\|tissue:peripheral blood\|genotype:miR 144 / \|phenotype:wild type\|treatment:n1\|BioSampleModel:Model organism or animal	Transcriptomic profiling of peripheral blood from 2 dpf zebrafish embryos	mRNA Mut miR 144	mRNA Mut miR 144	mRNA libraries were cloned from polyA+ RNA isolated from peripheral blood of 2 dpf WT and mutant zebrafish embryos according to Illumina TruSeq protocol. Libraries were cloned and sequenced at Boston University Microarray and Sequencing core.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	NextSeq 500	SRP233258	mRNA-miR-144.fastq.gz	fastq	21666521349.0	286736059.0	mRNA miR 144.fastq.gz	0:75.56 1:0	A:4937891523;C:5429635867;G:5884853915;T:5410789187;N:3350857	75	0	4937891523	5429635867	5884853915	5410789187	3350857	SRX7216662	SRS5719128	SRA1002853	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.97729	0.02379	0.84102	0.45517	76	B	usable mapping rate	illumina	nextseq	unknown	poly_a	trueseq	bulk	unknown	unknown	United Kingdom	2019-11-26	Hatching	Embryo	Blood	Hematopoietic System
55538	55538	SRR10532694	SRX7216661	SRS5719127	SRP233258	PRJNA591815	Ago2 dependent processing allows miR 451 to evade the global microRNA turnover elicited during erythropoiesis	PRJNA591815	Other	MicroRNAs are sequentially processed by two RNAse III enzymes Drosha and Dicer. miR 451 is the only known miRNA whose processing bypasses Dicer and instead relies on the slicer activity of Argonaute 2 Ago2. MiR 451 is highly conserved in vertebrates and regulates erythrocyte maturation where it becomes the most abundant miRNA. However the basis for the non canonical biogenesis of miR 451 is unclear. In this study we tested the hypothesis that miR 144 represses Dicer in a negative feedback loop during erythropoiesis and enhances miR 451 biogenesis. Loss of miR 144 mediated Dicer repression in zebrafish embryos and human cells leads to increased canonical miRNA production and impaired miR 451 maturation.		wild type	isolate:Lab reared\|age:2 days\|sex:not applicable\|tissue:peripheral blood\|genotype:wild type\|phenotype:wild type\|treatment:n1\|BioSampleModel:Model organism or animal	Transcriptomic profiling of peripheral blood from 2 dpf zebrafish embryos	mRNA WT	mRNA WT	mRNA libraries were cloned from polyA+ RNA isolated from peripheral blood of 2 dpf WT and mutant zebrafish embryos according to Illumina TruSeq protocol. Libraries were cloned and sequenced at Boston University Microarray and Sequencing core.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	ILLUMINA	NextSeq 500	SRP233258	mRNA-WT.fastq.gz	fastq	5359234061.0	70925969.0	mRNA WT.fastq.gz	0:75.56 1:0	A:1229417939;C:1341096472;G:1448568683;T:1339375309;N:775658	75	0	1229417939	1341096472	1448568683	1339375309	775658	SRX7216661	SRS5719127	SRA1002853	University of East Anglia\|Biological Sciences	University of East Anglia	1	0.97314	0.02809	0.83179	0.40499	75	B	usable mapping rate	illumina	nextseq	unknown	poly_a	trueseq	bulk	unknown	unknown	United Kingdom	2019-11-26	Hatching	Embryo	Blood	Hematopoietic System

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CREATE TABLE run_metadata("run.accession" VARCHAR, "experiment.accession" VARCHAR, "sample.accession" VARCHAR, "study.accession" VARCHAR, bioproject VARCHAR, "study.title" VARCHAR, "study.alias" VARCHAR, "study.type" VARCHAR, "study.abstract" VARCHAR, "study.attributes" VARCHAR, "study.PMIDs" VARCHAR, "sample.description" VARCHAR, "sample.title" VARCHAR, "sample.alias" VARCHAR, "sample.centername" VARCHAR, "sample.attributes" VARCHAR, "GEOsample.title" VARCHAR, "GEOsample.dataprocessing" VARCHAR, "GEOsample.source" VARCHAR, "GEOsample.treatmentprotocol" VARCHAR, "GEOsample.extractprotocol" VARCHAR, "GEOsample.growthprotocol" VARCHAR, "GEOsample.characteristics" VARCHAR, "GEOsample.accession" VARCHAR, "experiment.title" VARCHAR, "experiment.alias" VARCHAR, "experiment.library_name" VARCHAR, "experiment.design_description" VARCHAR, "experiment.library_construction_protocol" VARCHAR, "experiment.attributes" VARCHAR, "experiment.library_strategy" VARCHAR, "experiment.library_source" VARCHAR, "experiment.library_selection" VARCHAR, "experiment.library_layout" VARCHAR, "experiment.platform" VARCHAR, "experiment.instrument_model" VARCHAR, "experiment.spot_descriptor" VARCHAR, "experiment.study_ref" VARCHAR, "run.title" VARCHAR, "run.attributes" VARCHAR, "run.filename" VARCHAR, "run.semantic_name" VARCHAR, "run.total_bases" DOUBLE, "run.total_spots" DOUBLE, "run.alias" VARCHAR, "run.read_lengths" VARCHAR, "run.base_counts" VARCHAR, "run.r1_length" BIGINT, "run.r2_length" BIGINT, "run.r3_length" BIGINT, "run.r4_length" BIGINT, "run.Acount" BIGINT, "run.Ccount" BIGINT, "run.Gcount" BIGINT, "run.Tcount" BIGINT, "run.Ncount" BIGINT, "run.experiment" VARCHAR, "run.pool_member" VARCHAR, "submission.accession" VARCHAR, "submission.srasource" VARCHAR, "submission.bioprojectsource" VARCHAR, "seqdetective.n_mates" BIGINT, "seqdetective.mapping_rate.mate1" DOUBLE, "seqdetective.mapping_rate.mate2" DOUBLE, "seqdetective.nofeature_rate.mate1" DOUBLE, "seqdetective.nofeature_rate.mate2" DOUBLE, "seqdetective.sparsity.mate1" DOUBLE, "seqdetective.sparsity.mate2" DOUBLE, "seqdetective.pos_strand_rate.mate1" DOUBLE, "seqdetective.pos_strand_rate.mate2" DOUBLE, "seqdetective.readlen.mate1" BIGINT, "seqdetective.readlen.mate2" BIGINT, "seqdetective.judgement.mate1" VARCHAR, "seqdetective.judgement.mate2" VARCHAR, "seqdetective.judgement.reason" VARCHAR, platform_family VARCHAR, instrument_generation VARCHAR, read_bias VARCHAR, selection_class VARCHAR, prep_kit VARCHAR, sc_or_bulk VARCHAR, tech_class VARCHAR, technology VARCHAR, tech_variant VARCHAR, "submission.bioprojectsource.country" VARCHAR, earliest_date DATE, devstage_curation VARCHAR, devstage_curation_coarse VARCHAR, tissue_curation VARCHAR, tissue_curation_coarse VARCHAR);;
CREATE INDEX idx_run_bioproject ON run_metadata(bioproject);;
CREATE INDEX idx_run_run_accession ON run_metadata("run.accession");;