metadata: run_metadata: 25 rows where experiment.library_layout = "SINGLE", experiment.library_selection = "Oligo-dT" and experiment.platform = "BGISEQ"

25 rows where experiment.library_layout = "SINGLE", experiment.library_selection = "Oligo-dT" and experiment.platform = "BGISEQ"

descending

Link	rowid ▼	run.accession	experiment.accession	sample.accession	study.accession	bioproject	study.title	study.alias	study.type	study.abstract	sample.alias	sample.attributes	experiment.title	experiment.alias	experiment.library_name	experiment.design_description	experiment.library_strategy	experiment.library_source	experiment.library_selection	experiment.library_layout	experiment.platform	experiment.instrument_model	experiment.study_ref	run.attributes	run.filename	run.semantic_name	run.total_bases	run.total_spots	run.alias	run.read_lengths	run.base_counts	run.r1_length	run.r2_length	run.Acount	run.Ccount	run.Gcount	run.Tcount	run.Ncount	run.experiment	run.pool_member	submission.accession	submission.srasource	submission.bioprojectsource	seqdetective.n_mates	seqdetective.mapping_rate.mate1	seqdetective.nofeature_rate.mate1	seqdetective.sparsity.mate1	seqdetective.pos_strand_rate.mate1	seqdetective.readlen.mate1	seqdetective.judgement.mate1	seqdetective.judgement.reason	platform_family	instrument_generation	read_bias	selection_class	prep_kit	sc_or_bulk	tech_class	technology	submission.bioprojectsource.country	earliest_date	devstage_curation	devstage_curation_coarse	tissue_curation	tissue_curation_coarse
57271	57271	SRR12577970	SRX9064853	SRS7314026	SRP279881	PRJNA612371	Danio rerio strain:TU Raw sequence reads	PRJNA612371	Whole Genome Sequencing	Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.	Ctrl 3 zebrafish	strain:TU\|isolate:not collected\|breed:not collected\|cultivar:not collected\|ecotype:not collected\|age:2dpf\|dev stage:not collected\|sex:not applicable\|tissue:head\|geo loc name:China:Shanghai\|sample type:model organism\|replicate:replicate=biological replicate 6'\|BioSampleModel:Model organism or animal	Ctrl 3 zebrafish	Ctrl 3 zebrafish	Ctrl 3 zebrafish	transcriptome	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP279881		Ctrl_3_1.fq.gz	fastq	1061227250.0	21224545.0	Ctrl 3 1.fq.gz	0:50	A:286099732;C:241244619;G:246876865;T:287006034;N:0	50		286099732	241244619	246876865	287006034	0	SRX9064853	SRS7314026	SRA1120721	Shanghai University of Traditional Chinese Medicine\|Longhua Hospital	Shanghai University of Traditional Chinese Medicine	1	0.94563	0.10453	0.70552	0.46655	50	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2020-09-03	Hatching	Embryo	Head	Nervous System
57272	57272	SRR12577971	SRX9064852	SRS7314025	SRP279881	PRJNA612371	Danio rerio strain:TU Raw sequence reads	PRJNA612371	Whole Genome Sequencing	Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.	Ctrl 2 zebrafish	strain:TU\|isolate:not collected\|breed:not collected\|cultivar:not collected\|ecotype:not collected\|age:2dpf\|dev stage:not collected\|sex:not applicable\|tissue:head\|geo loc name:China:Shanghai\|sample type:model organism\|replicate:replicate=biological replicate 5 prime\|BioSampleModel:Model organism or animal	Ctrl 2 zebrafish	Ctrl 2 zebrafish	Ctrl 2 zebrafish	transcriptome	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP279881		Ctrl_2_1.fq.gz	fastq	1058116700.0	21162334.0	Ctrl 2 1.fq.gz	0:50	A:287223905;C:238707750;G:244987559;T:287197486;N:0	50		287223905	238707750	244987559	287197486	0	SRX9064852	SRS7314025	SRA1120721	Shanghai University of Traditional Chinese Medicine\|Longhua Hospital	Shanghai University of Traditional Chinese Medicine	1	0.94534	0.11174	0.70104	0.47946	50	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2020-09-03	Hatching	Embryo	Head	Nervous System
57273	57273	SRR12577972	SRX9064851	SRS7314024	SRP279881	PRJNA612371	Danio rerio strain:TU Raw sequence reads	PRJNA612371	Whole Genome Sequencing	Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.	Ctrl 1 zebrafish	strain:TU\|isolate:not collected\|breed:not collected\|cultivar:not collected\|ecotype:not collected\|age:2dpf\|dev stage:not collected\|sex:not applicable\|tissue:head\|geo loc name:China:Shanghai\|sample type:model organism\|replicate:replicate=biological replicate 4'\|BioSampleModel:Model organism or animal	Ctrl 1 zebrafish	Ctrl 1 zebrafish	Ctrl 1 zebrafish	transcriptome	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP279881		Ctrl_1_1.fq.gz	fastq	1065919600.0	21318392.0	Ctrl 1 1.fq.gz	0:50	A:295920720;C:242146677;G:242962633;T:284889570;N:0	50		295920720	242146677	242962633	284889570	0	SRX9064851	SRS7314024	SRA1120721	Shanghai University of Traditional Chinese Medicine\|Longhua Hospital	Shanghai University of Traditional Chinese Medicine	1	0.94228	0.15007	0.68028	0.46845	50	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2020-09-03	Hatching	Embryo	Head	Nervous System
57274	57274	SRR12577973	SRX9064850	SRS7314023	SRP279881	PRJNA612371	Danio rerio strain:TU Raw sequence reads	PRJNA612371	Whole Genome Sequencing	Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.	Ator STS 3 zebrafish	strain:TU\|isolate:not collected\|breed:not collected\|cultivar:not collected\|ecotype:not collected\|age:2dpf\|dev stage:not collected\|sex:not applicable\|tissue:head\|geo loc name:China:Shanghai\|sample type:model organism\|replicate:replicate=biological replicate 3 prime\|BioSampleModel:Model organism or animal	Ator STS 3 zebrafish	Ator STS 3 zebrafish	Ator STS 3 zebrafish	transcriptome	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP279881		Ator_STS_3_1.fq.gz	fastq	1059717350.0	21194347.0	Ator STS 3 1.fq.gz	0:50	A:287279590;C:239708340;G:245740313;T:286989107;N:0	50		287279590	239708340	245740313	286989107	0	SRX9064850	SRS7314023	SRA1120721	Shanghai University of Traditional Chinese Medicine\|Longhua Hospital	Shanghai University of Traditional Chinese Medicine	1	0.94345	0.10458	0.69686	0.4755	50	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2020-09-03	Hatching	Embryo	Head	Nervous System
57275	57275	SRR12577974	SRX9064849	SRS7314022	SRP279881	PRJNA612371	Danio rerio strain:TU Raw sequence reads	PRJNA612371	Whole Genome Sequencing	Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.	Ator STS 2 zebrafish	strain:TU\|isolate:not collected\|breed:not collected\|cultivar:not collected\|ecotype:not collected\|age:2dpf\|dev stage:not collected\|sex:not applicable\|tissue:head\|geo loc name:China:Shanghai\|sample type:model organism\|replicate:replicate=biological replicate 2'\|BioSampleModel:Model organism or animal	Ator STS 2 zebrafish	Ator STS 2 zebrafish	Ator STS 2 zebrafish	transcriptome	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP279881		Ator_STS_2_1.fq.gz	fastq	1057950250.0	21159005.0	Ator STS 2 1.fq.gz	0:50	A:286256354;C:238832868;G:244078781;T:288782247;N:0	50		286256354	238832868	244078781	288782247	0	SRX9064849	SRS7314022	SRA1120721	Shanghai University of Traditional Chinese Medicine\|Longhua Hospital	Shanghai University of Traditional Chinese Medicine	1	0.94307	0.10974	0.69631	0.4703	50	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2020-09-03	Hatching	Embryo	Head	Nervous System
57276	57276	SRR12577975	SRX9064848	SRS7314021	SRP279881	PRJNA612371	Danio rerio strain:TU Raw sequence reads	PRJNA612371	Whole Genome Sequencing	Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.	Ator STS 1 zebrafish	strain:TU\|isolate:not collected\|breed:not collected\|cultivar:not collected\|ecotype:not collected\|age:2dpf\|dev stage:not collected\|sex:not applicable\|tissue:head\|geo loc name:China:Shanghai\|sample type:model organism\|replicate:replicate=biological replicate 1'\|BioSampleModel:Model organism or animal	Ator STS 1 zebrafish	Ator STS 1 zebrafish	Ator STS 1 zebrafish	transcriptome	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP279881		Ator_STS_1_1.fq.gz	fastq	1070136700.0	21402734.0	Ator STS 1 1.fq.gz	0:50	A:297601042;C:243837062;G:243583907;T:285114689;N:0	50		297601042	243837062	243583907	285114689	0	SRX9064848	SRS7314021	SRA1120721	Shanghai University of Traditional Chinese Medicine\|Longhua Hospital	Shanghai University of Traditional Chinese Medicine	1	0.94665	0.12219	0.67953	0.46393	50	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2020-09-03	Hatching	Embryo	Head	Nervous System
57277	57277	SRR12577976	SRX9064847	SRS7314020	SRP279881	PRJNA612371	Danio rerio strain:TU Raw sequence reads	PRJNA612371	Whole Genome Sequencing	Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.	Ator 3 zebrafish	strain:TU\|isolate:not collected\|breed:not collected\|cultivar:not collected\|ecotype:not collected\|age:2dpf\|dev stage:not collected\|sex:not applicable\|tissue:head\|geo loc name:China:Shanghai\|sample type:model organism\|replicate:replicate=biological replicate 3 prime\|BioSampleModel:Model organism or animal	Ator 3 zebrafish	Ator 3 zebrafish	Ator 3 zebrafish	transcriptome	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP279881		Ator_3_1.fq.gz	fastq	1058031900.0	21160638.0	Ator 3 1.fq.gz	0:50	A:285399527;C:239993172;G:245571467;T:287067734;N:0	50		285399527	239993172	245571467	287067734	0	SRX9064847	SRS7314020	SRA1120721	Shanghai University of Traditional Chinese Medicine\|Longhua Hospital	Shanghai University of Traditional Chinese Medicine	1	0.94536	0.11052	0.6957	0.48195	50	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2020-09-03	Hatching	Embryo	Head	Nervous System
57278	57278	SRR12577977	SRX9064846	SRS7314019	SRP279881	PRJNA612371	Danio rerio strain:TU Raw sequence reads	PRJNA612371	Whole Genome Sequencing	Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.	Ator 2 zebrafish	strain:TU\|isolate:not collected\|breed:not collected\|cultivar:not collected\|ecotype:not collected\|age:2dpf\|dev stage:not collected\|sex:not applicable\|tissue:head\|geo loc name:China:Shanghai\|sample type:model organism\|replicate:replicate=biological replicate 2'\|BioSampleModel:Model organism or animal	Ator 2 zebrafish	Ator 2 zebrafish	Ator 2 zebrafish	transcriptome	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP279881		Ator_2_1.fq.gz	fastq	1059618400.0	21192368.0	Ator 2 1.fq.gz	0:50	A:283429136;C:243023053;G:248904818;T:284261393;N:0	50		283429136	243023053	248904818	284261393	0	SRX9064846	SRS7314019	SRA1120721	Shanghai University of Traditional Chinese Medicine\|Longhua Hospital	Shanghai University of Traditional Chinese Medicine	1	0.94743	0.09493	0.70218	0.475	50	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2020-09-03	Hatching	Embryo	Head	Nervous System
57279	57279	SRR12577978	SRX9064845	SRS7314018	SRP279881	PRJNA612371	Danio rerio strain:TU Raw sequence reads	PRJNA612371	Whole Genome Sequencing	Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area although the underlying mechanism was not fully elucidated. Therefore in the present study we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology and further clarify its underlying molecular mechanisms on HIF 1 and its regulators i.e. the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin carbonic anhydrase Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.	Ator 1 zebrafish	strain:TU\|isolate:not collected\|breed:not collected\|cultivar:not collected\|ecotype:not collected\|age:2dpf\|dev stage:not collected\|sex:not applicable\|tissue:head\|geo loc name:China:Shanghai\|sample type:model organism\|replicate:replicate=biological replicate 1'\|BioSampleModel:Model organism or animal	Ator 1 zebrafish	Ator 1 zebrafish	Ator 1 zebrafish	transcriptome	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP279881		Ator_1_1.fq.gz	fastq	1075695950.0	21513919.0	Ator 1 1.fq.gz	0:50	A:297768036;C:244470267;G:243768925;T:289688722;N:0	50		297768036	244470267	243768925	289688722	0	SRX9064845	SRS7314018	SRA1120721	Shanghai University of Traditional Chinese Medicine\|Longhua Hospital	Shanghai University of Traditional Chinese Medicine	1	0.94468	0.13183	0.68363	0.46288	50	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2020-09-03	Hatching	Embryo	Head	Nervous System
66964	66964	SRR16965143	SRX13156592	SRS11088496	SRP346547	PRJNA780808	transcriptomics of carbendazim and enrofloxacin on zebrafish embryos	PRJNA780808	Other	reveal a interaction between ENF and CAR on metabolic regulation during development	1mix	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:10 96hpf\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio :mixture group	mix 1	mix 1	96hpf zebrafish larvae mixture group	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346547		mix2_1_2.fq.gz	fastq	3313823250.0	22092155.0	mix2 1 2.fq.gz	0:0 1:150	A:895726357;C:763402657;G:745765587;T:908922686;N:5963	0	150	895726357	763402657	745765587	908922686	5963	SRX13156592	SRS11088496	SRA1329868	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.93604	0.10794	0.65587	0.47956	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-17	Larval	Larval	Undetermined	Undetermined
66965	66965	SRR16965144	SRX13156591	SRS11088495	SRP346547	PRJNA780808	transcriptomics of carbendazim and enrofloxacin on zebrafish embryos	PRJNA780808	Other	reveal a interaction between ENF and CAR on metabolic regulation during development	3enf	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:9 96hpf\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio :enrofloxacin group	enf 3	enf 3	96hpf zebrafish larvae enrofloxacin group	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346547		enf_3.fq.gz	fastq	3304972350.0	22033149.0	enf 3.fq.gz	0:150 1:0	A:899427202;C:745999066;G:759917309;T:899625137;N:3636	150	0	899427202	745999066	759917309	899625137	3636	SRX13156591	SRS11088495	SRA1329868	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.94353	0.10795	0.66212	0.47773	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-17	Larval	Larval	Undetermined	Undetermined
66967	66967	SRR16965146	SRX13156589	SRS11088492	SRP346547	PRJNA780808	transcriptomics of carbendazim and enrofloxacin on zebrafish embryos	PRJNA780808	Other	reveal a interaction between ENF and CAR on metabolic regulation during development	3car	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:6 96hpf\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio :carbendazim group	car 3	car 3	96hpf zebrafish larvae carbendazim group	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346547		car_3_1.fq.gz	fastq	3335622150.0	22237481.0	car 3 1.fq.gz	0:150 1:0	A:853229671;C:807433601;G:820478265;T:854475092;N:5521	150	0	853229671	807433601	820478265	854475092	5521	SRX13156589	SRS11088492	SRA1329868	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.96567	0.03093	0.70997	0.47751	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-17	Larval	Larval	Undetermined	Undetermined
66968	66968	SRR16965147	SRX13156588	SRS11088494	SRP346547	PRJNA780808	transcriptomics of carbendazim and enrofloxacin on zebrafish embryos	PRJNA780808	Other	reveal a interaction between ENF and CAR on metabolic regulation during development	1car	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:4 96hpf\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio :carbendazim group	car 1	car 1	96hpf zebrafish larvae carbendazim group	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346547		car_1_1.fq.gz	fastq	3378056400.0	22520376.0	car 1 1.fq.gz	0:150 1:0	A:886009175;C:795203398;G:809447342;T:887390300;N:6185	150	0	886009175	795203398	809447342	887390300	6185	SRX13156588	SRS11088494	SRA1329868	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.95701	0.05956	0.67836	0.4884	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-17	Larval	Larval	Undetermined	Undetermined
66969	66969	SRR16965148	SRX13156587	SRS11088491	SRP346547	PRJNA780808	transcriptomics of carbendazim and enrofloxacin on zebrafish embryos	PRJNA780808	Other	reveal a interaction between ENF and CAR on metabolic regulation during development	3con	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:3 96hpf\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio :control group	con 3	con 3	96hpf zebrafish larvae control group	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346547		con_3_2.fq.gz	fastq	3359054500.0	33590545.0	con 3 2.fq.gz	0:100 1:0	A:914533337;C:755914202;G:773676246;T:914930715;N:0	100	0	914533337	755914202	773676246	914930715	0	SRX13156587	SRS11088491	SRA1329868	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.95076	0.10478	0.65646	0.49594	100	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-17	Larval	Larval	Undetermined	Undetermined
66970	66970	SRR16965149	SRX13156586	SRS11088489	SRP346547	PRJNA780808	transcriptomics of carbendazim and enrofloxacin on zebrafish embryos	PRJNA780808	Other	reveal a interaction between ENF and CAR on metabolic regulation during development	3mix	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:12 96hpf\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio :mixture group	mix 3	mix 3	96hpf zebrafish larvae mixture group	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346547		mix2_3_1.fq.gz	fastq	3362094000.0	33620940.0	mix2 3 1.fq.gz	0:100 1:0	A:916124379;C:755910593;G:768246534;T:921812494;N:0	100	0	916124379	755910593	768246534	921812494	0	SRX13156586	SRS11088489	SRA1329868	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.94894	0.10416	0.65342	0.49475	100	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-17	Larval	Larval	Undetermined	Undetermined
66972	66972	SRR16965151	SRX13156584	SRS11088488	SRP346547	PRJNA780808	transcriptomics of carbendazim and enrofloxacin on zebrafish embryos	PRJNA780808	Other	reveal a interaction between ENF and CAR on metabolic regulation during development	2con	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:2 96hpf\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio :control group	con 2	con 2	96hpf zebrafish larvae control group	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346547	loader:fastq load.py	con_2_2.fq	fastq	3324287550.0	22161917.0	con 2 2.fq.gz	0:150	A:848766265;C:812477645;G:798995610;T:864040426;N:7604	150		848766265	812477645	798995610	864040426	7604	SRX13156584	SRS11088488	SRA1329868	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.95546	0.03524	0.70027	0.48649	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-22	Larval	Larval	Undetermined	Undetermined
66973	66973	SRR16965152	SRX13156583	SRS11088487	SRP346547	PRJNA780808	transcriptomics of carbendazim and enrofloxacin on zebrafish embryos	PRJNA780808	Other	reveal a interaction between ENF and CAR on metabolic regulation during development	1con	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:1 96hpf\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio :control group	con 1	con 1	96hpf zebrafish larvae control group	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346547	loader:fastq load.py	con_1_1.fq	fastq	3330724500.0	22204830.0	con 1 1.fq.gz	0:150	A:896812508;C:762246067;G:774062043;T:897597946;N:5936	150		896812508	762246067	774062043	897597946	5936	SRX13156583	SRS11088487	SRA1329868	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.94926	0.08711	0.66789	0.48628	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-22	Larval	Larval	Undetermined	Undetermined
66975	66975	SRR16959539	SRX13151073	SRS11083379	SRP346418	PRJNA780940	transcriptomics of difenoconazole and dimethomorph on zebrafish embryos	PRJNA780940	Other	Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.	2dim	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:8 96h\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio : dimethomorph group	dim 2	dim 2	The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346418		dim_2_1.fq.gz	fastq	3344257500.0	22295050.0	dim 2 1.fq.gz	0:150 1:0	A:895700119;C:767415749;G:784994320;T:896143585;N:3727	150	0	895700119	767415749	784994320	896143585	3727	SRX13151073	SRS11083379	SRA1330365	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.9497	0.08418	0.66352	0.49341	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-16	Larval	Larval	Undetermined	Undetermined
66976	66976	SRR16959540	SRX13151072	SRS11083378	SRP346418	PRJNA780940	transcriptomics of difenoconazole and dimethomorph on zebrafish embryos	PRJNA780940	Other	Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.	1dim	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:7 96h\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio : dimethomorph group	dim 1	dim 1	The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346418		dim_1_1.fq.gz	fastq	3318812250.0	22125415.0	dim 1 1.fq.gz	0:150 1:0	A:908481293;C:742787936;G:755930542;T:911608821;N:3658	150	0	908481293	742787936	755930542	911608821	3658	SRX13151072	SRS11083378	SRA1330365	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.94211	0.11824	0.65344	0.47716	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-16	Larval	Larval	Undetermined	Undetermined
66977	66977	SRR16959541	SRX13151071	SRS11083377	SRP346418	PRJNA780940	transcriptomics of difenoconazole and dimethomorph on zebrafish embryos	PRJNA780940	Other	Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.	3dif	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:6 96h\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio : difenoconazole group	dif 3	dif 3	The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346418		dif_3_1.fq.gz	fastq	3318453000.0	22123020.0	dif 3 1.fq.gz	0:150 1:0	A:893975607;C:758489621;G:772391705;T:893592335;N:3732	150	0	893975607	758489621	772391705	893592335	3732	SRX13151071	SRS11083377	SRA1330365	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.94838	0.08393	0.66543	0.4818	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-16	Larval	Larval	Undetermined	Undetermined
66978	66978	SRR16959542	SRX13151070	SRS11083376	SRP346418	PRJNA780940	transcriptomics of difenoconazole and dimethomorph on zebrafish embryos	PRJNA780940	Other	Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.	2dif	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:5 96h\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio : difenoconazole group	dif 2	dif 2	The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346418		dif_2_2.fq.gz	fastq	3304972350.0	22033149.0	dif 2 2.fq.gz	0:0 1:150	A:890456734;C:764917766;G:744757536;T:904833787;N:6527	0	150	890456734	764917766	744757536	904833787	6527	SRX13151070	SRS11083376	SRA1330365	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.93514	0.107	0.6633	0.47599	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-16	Larval	Larval	Undetermined	Undetermined
66979	66979	SRR16959543	SRX13151069	SRS11083375	SRP346418	PRJNA780940	transcriptomics of difenoconazole and dimethomorph on zebrafish embryos	PRJNA780940	Other	Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.	1dif	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:4 96h\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio : difenoconazole group	dif 1	dif 1	The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346418		dif_1_1.fq.gz	fastq	3295443900.0	21969626.0	dif 1 1.fq.gz	0:150 1:0	A:887936493;C:751636494;G:765508757;T:890358629;N:3527	150	0	887936493	751636494	765508757	890358629	3527	SRX13151069	SRS11083375	SRA1330365	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.94623	0.09138	0.66478	0.4828	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-16	Larval	Larval	Undetermined	Undetermined
66980	66980	SRR16959544	SRX13151068	SRS11083374	SRP346418	PRJNA780940	transcriptomics of difenoconazole and dimethomorph on zebrafish embryos	PRJNA780940	Other	Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.	3+con	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:3 96h\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio : control group	con 3	con 3	The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346418		con_3_1.fq.gz	fastq	3306406800.0	22042712.0	con 3 1.fq.gz	0:150 1:0	A:872740236;C:773482184;G:788334419;T:871846539;N:3422	150	0	872740236	773482184	788334419	871846539	3422	SRX13151068	SRS11083374	SRA1330365	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.95458	0.06103	0.67409	0.48439	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-16	Larval	Larval	Undetermined	Undetermined
66982	66982	SRR16959546	SRX13151066	SRS11083372	SRP346418	PRJNA780940	transcriptomics of difenoconazole and dimethomorph on zebrafish embryos	PRJNA780940	Other	Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.	2+con	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:2 96h\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio : control group	con 2	con 2	The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346418		con_2_2.fq.gz	fastq	3324287550.0	22161917.0	con 2 2.fq.gz	0:0 1:150	A:848766265;C:812477645;G:798995610;T:864040426;N:7604	0	150	848766265	812477645	798995610	864040426	7604	SRX13151066	SRS11083372	SRA1330365	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.95548	0.03524	0.70021	0.4867	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-16	Larval	Larval	Undetermined	Undetermined
66983	66983	SRR16959547	SRX13151065	SRS11083371	SRP346418	PRJNA780940	transcriptomics of difenoconazole and dimethomorph on zebrafish embryos	PRJNA780940	Other	Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples so the deleterious effects of combined exposure warrant detailed examination. In this study the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate deformity rate lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes cdk1 and cdc20 thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.	1+con	strain:Tu\|isolate:N/A\|breed:N/A\|cultivar:N/A\|ecotype:N/A\|age:1 96h\|dev stage:larvae\|sex:male and female\|tissue:larvae\|BioSampleModel:Model organism or animal	RNA Seq of Danio rerio : control group	con 1	con 1	The final library was amplified with phi29 to make DNA nanoballs DNB with more than 300 copies of one molecular.	RNA-Seq	TRANSCRIPTOMIC	Oligo-dT	SINGLE	BGISEQ	BGISEQ-500	SRP346418		con_1_1.fq.gz	fastq	3330724500.0	22204830.0	con 1 1.fq.gz	0:150 1:0	A:896812508;C:762246067;G:774062043;T:897597946;N:5936	150	0	896812508	762246067	774062043	897597946	5936	SRX13151065	SRS11083371	SRA1330365	China Agricultural University\|College of animal science and technology	China Agricultural University	1	0.94925	0.08711	0.66772	0.48635	150	B	usable mapping rate	bgi	bgi	unknown	poly_a	unknown	bulk	unknown	unknown	China	2021-11-16	Larval	Larval	Undetermined	Undetermined

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CREATE TABLE run_metadata("run.accession" VARCHAR, "experiment.accession" VARCHAR, "sample.accession" VARCHAR, "study.accession" VARCHAR, bioproject VARCHAR, "study.title" VARCHAR, "study.alias" VARCHAR, "study.type" VARCHAR, "study.abstract" VARCHAR, "study.attributes" VARCHAR, "study.PMIDs" VARCHAR, "sample.description" VARCHAR, "sample.title" VARCHAR, "sample.alias" VARCHAR, "sample.centername" VARCHAR, "sample.attributes" VARCHAR, "GEOsample.title" VARCHAR, "GEOsample.dataprocessing" VARCHAR, "GEOsample.source" VARCHAR, "GEOsample.treatmentprotocol" VARCHAR, "GEOsample.extractprotocol" VARCHAR, "GEOsample.growthprotocol" VARCHAR, "GEOsample.characteristics" VARCHAR, "GEOsample.accession" VARCHAR, "experiment.title" VARCHAR, "experiment.alias" VARCHAR, "experiment.library_name" VARCHAR, "experiment.design_description" VARCHAR, "experiment.library_construction_protocol" VARCHAR, "experiment.attributes" VARCHAR, "experiment.library_strategy" VARCHAR, "experiment.library_source" VARCHAR, "experiment.library_selection" VARCHAR, "experiment.library_layout" VARCHAR, "experiment.platform" VARCHAR, "experiment.instrument_model" VARCHAR, "experiment.spot_descriptor" VARCHAR, "experiment.study_ref" VARCHAR, "run.title" VARCHAR, "run.attributes" VARCHAR, "run.filename" VARCHAR, "run.semantic_name" VARCHAR, "run.total_bases" DOUBLE, "run.total_spots" DOUBLE, "run.alias" VARCHAR, "run.read_lengths" VARCHAR, "run.base_counts" VARCHAR, "run.r1_length" BIGINT, "run.r2_length" BIGINT, "run.r3_length" BIGINT, "run.r4_length" BIGINT, "run.Acount" BIGINT, "run.Ccount" BIGINT, "run.Gcount" BIGINT, "run.Tcount" BIGINT, "run.Ncount" BIGINT, "run.experiment" VARCHAR, "run.pool_member" VARCHAR, "submission.accession" VARCHAR, "submission.srasource" VARCHAR, "submission.bioprojectsource" VARCHAR, "seqdetective.n_mates" BIGINT, "seqdetective.mapping_rate.mate1" DOUBLE, "seqdetective.mapping_rate.mate2" DOUBLE, "seqdetective.nofeature_rate.mate1" DOUBLE, "seqdetective.nofeature_rate.mate2" DOUBLE, "seqdetective.sparsity.mate1" DOUBLE, "seqdetective.sparsity.mate2" DOUBLE, "seqdetective.pos_strand_rate.mate1" DOUBLE, "seqdetective.pos_strand_rate.mate2" DOUBLE, "seqdetective.readlen.mate1" BIGINT, "seqdetective.readlen.mate2" BIGINT, "seqdetective.judgement.mate1" VARCHAR, "seqdetective.judgement.mate2" VARCHAR, "seqdetective.judgement.reason" VARCHAR, platform_family VARCHAR, instrument_generation VARCHAR, read_bias VARCHAR, selection_class VARCHAR, prep_kit VARCHAR, sc_or_bulk VARCHAR, tech_class VARCHAR, technology VARCHAR, tech_variant VARCHAR, "submission.bioprojectsource.country" VARCHAR, earliest_date DATE, devstage_curation VARCHAR, devstage_curation_coarse VARCHAR, tissue_curation VARCHAR, tissue_curation_coarse VARCHAR);;
CREATE INDEX idx_run_bioproject ON run_metadata(bioproject);;
CREATE INDEX idx_run_run_accession ON run_metadata("run.accession");;