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80 rows where experiment.library_layout = "PAIRED", experiment.platform = "BGISEQ" and tissue_curation_coarse = "Nervous System"

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experiment.library_selection 4

tissue_curation 2

experiment.library_source 2

tissue_curation_coarse 1

  • Nervous System · 80 ✖

technology 1

experiment.platform 1

  • BGISEQ · 80 ✖

experiment.library_strategy 1

experiment.library_layout 1

  • PAIRED · 80 ✖

devstage_curation_coarse 1

devstage_curation 1

Link rowid ▼ run.accession experiment.accession sample.accession study.accession bioproject study.title study.alias study.type study.abstract study.attributes study.PMIDs sample.description sample.title sample.alias sample.centername sample.attributes GEOsample.title GEOsample.dataprocessing GEOsample.source GEOsample.treatmentprotocol GEOsample.extractprotocol GEOsample.growthprotocol GEOsample.characteristics GEOsample.accession experiment.title experiment.alias experiment.library_name experiment.design_description experiment.library_construction_protocol experiment.attributes experiment.library_strategy experiment.library_source experiment.library_selection experiment.library_layout experiment.platform experiment.instrument_model experiment.spot_descriptor experiment.study_ref run.title run.attributes run.filename run.semantic_name run.total_bases run.total_spots run.alias run.read_lengths run.base_counts run.r1_length run.r2_length run.r3_length run.r4_length run.Acount run.Ccount run.Gcount run.Tcount run.Ncount run.experiment run.pool_member submission.accession submission.srasource submission.bioprojectsource seqdetective.n_mates seqdetective.mapping_rate.mate1 seqdetective.mapping_rate.mate2 seqdetective.nofeature_rate.mate1 seqdetective.nofeature_rate.mate2 seqdetective.sparsity.mate1 seqdetective.sparsity.mate2 seqdetective.pos_strand_rate.mate1 seqdetective.pos_strand_rate.mate2 seqdetective.readlen.mate1 seqdetective.readlen.mate2 seqdetective.judgement.mate1 seqdetective.judgement.mate2 seqdetective.judgement.reason platform_family instrument_generation read_bias selection_class prep_kit sc_or_bulk tech_class technology tech_variant submission.bioprojectsource.country earliest_date devstage_curation devstage_curation_coarse tissue_curation tissue_curation_coarse
35865 35865 SRR33094447 SRX28358130 SRS24687221 SRP578075 PRJNA1249535 P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy PRJNA1249535 Other Single cell transcriptome sequencing provides high resolution transcriptome data on the molecular mechanisms by which Tau P301S mediates Alzheimer's disease like pathological changes in zebrafish providing unique insights into the pathogenesis of Tau pathology mediated cell to cell interactions in AD.     TauP301S 4   TauP301S 4   breed:zebrafish|age:4 month|collection date:2024 05 18|geo loc name:China:Shantou|sex:not determined|tissue:brain|BioSampleModel:Model organism or animal                 P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy TauP301S 4 TauP301S 4 tissue     RNA-Seq TRANSCRIPTOMIC SINGLE CELL PolyA PAIRED BGISEQ BGISEQ-500   SRP578075     AD4_S1_L001_R1_001.fastq.gz AD4_S1_L001_R2_001.fastq.gz fastq fastq 129145897746.0 427635423.0 AD4 S1 L001 R1 001.fastq.gz 0:151 1:151 A:37870495722;C:24917123133;G:22536537853;T:43764941649;N:56799389 151 151     37870495722 24917123133 22536537853 43764941649 56799389 SRX28358130 SRS24687221 SRA2110625 Shantou university medical college|Neuroscience Center Shantou university medical college                       T B mate1 technical by mapping diff bgi bgi unknown poly_a unknown sc unknown unknown   China 2025-04-13 Adult Adult Brain Nervous System
35866 35866 SRR33094448 SRX28358129 SRS24687220 SRP578075 PRJNA1249535 P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy PRJNA1249535 Other Single cell transcriptome sequencing provides high resolution transcriptome data on the molecular mechanisms by which Tau P301S mediates Alzheimer's disease like pathological changes in zebrafish providing unique insights into the pathogenesis of Tau pathology mediated cell to cell interactions in AD.     TauP301S 3   TauP301S 3   breed:zebrafish|age:4 month|collection date:2024 05 17|geo loc name:China:Shantou|sex:not determined|tissue:brain|BioSampleModel:Model organism or animal                 P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy TauP301S 3 TauP301S 3 tissue     RNA-Seq TRANSCRIPTOMIC SINGLE CELL PolyA PAIRED BGISEQ BGISEQ-500   SRP578075     AD3_S1_L001_R1_001.fastq.gz AD3_S1_L001_R2_001.fastq.gz fastq fastq 130723873718.0 432860509.0 AD3 S1 L001 R1 001.fastq.gz 0:151 1:151 A:38509426012;C:25238065771;G:22586405501;T:44332442791;N:57533643 151 151     38509426012 25238065771 22586405501 44332442791 57533643 SRX28358129 SRS24687220 SRA2110625 Shantou university medical college|Neuroscience Center Shantou university medical college                       T B mate1 technical by mapping diff bgi bgi unknown poly_a unknown sc unknown unknown   China 2025-04-13 Adult Adult Brain Nervous System
35867 35867 SRR33094449 SRX28358128 SRS24687219 SRP578075 PRJNA1249535 P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy PRJNA1249535 Other Single cell transcriptome sequencing provides high resolution transcriptome data on the molecular mechanisms by which Tau P301S mediates Alzheimer's disease like pathological changes in zebrafish providing unique insights into the pathogenesis of Tau pathology mediated cell to cell interactions in AD.     TauP301S 2   TauP301S 2   breed:zebrafish|age:4 month|collection date:2024 05 16|geo loc name:China:Shantou|sex:not determined|tissue:brain|BioSampleModel:Model organism or animal                 P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy TauP301S 2 TauP301S 2 tissue     RNA-Seq TRANSCRIPTOMIC SINGLE CELL PolyA PAIRED BGISEQ BGISEQ-500   SRP578075     AD2_S1_L001_R1_001.fastq.gz AD2_S1_L001_R2_001.fastq.gz fastq fastq 130145208498.0 430944399.0 AD2 S1 L001 R1 001.fastq.gz 0:151 1:151 A:37802929660;C:22980541562;G:20982421471;T:48304142442;N:75173363 151 151     37802929660 22980541562 20982421471 48304142442 75173363 SRX28358128 SRS24687219 SRA2110625 Shantou university medical college|Neuroscience Center Shantou university medical college                       T B mate1 technical by mapping diff bgi bgi unknown poly_a unknown sc unknown unknown   China 2025-04-13 Adult Adult Brain Nervous System
35868 35868 SRR33094450 SRX28358127 SRS24687218 SRP578075 PRJNA1249535 P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy PRJNA1249535 Other Single cell transcriptome sequencing provides high resolution transcriptome data on the molecular mechanisms by which Tau P301S mediates Alzheimer's disease like pathological changes in zebrafish providing unique insights into the pathogenesis of Tau pathology mediated cell to cell interactions in AD.     TauP301S 1   TauP301S 1   breed:zebrafish|age:4 month|collection date:2024 05 15|geo loc name:China:Shantou|sex:not determined|tissue:brain|BioSampleModel:Model organism or animal                 P301S Mutant Tau Driven Zebrafish Platform Enables Systematic Identification of Pharmacological GSK3B Inhibitors with Anti Neurodegenerative Efficacy TauP301S 1 TauP301S 1 tissue     RNA-Seq TRANSCRIPTOMIC SINGLE CELL PolyA PAIRED BGISEQ BGISEQ-500   SRP578075     AD1_S1_L001_R1_001.fastq.gz AD1_S1_L001_R2_001.fastq.gz fastq fastq 151897861402.0 502973051.0 AD1 S1 L001 R1 001.fastq.gz 0:151 1:151 A:44290580650;C:26864167508;G:24611898618;T:56043760812;N:87453814 151 151     44290580650 26864167508 24611898618 56043760812 87453814 SRX28358127 SRS24687218 SRA2110625 Shantou university medical college|Neuroscience Center Shantou university medical college                       T B mate1 technical by mapping diff bgi bgi unknown poly_a unknown sc unknown unknown   China 2025-04-13 Adult Adult Brain Nervous System
55972 55972 SRR10895875 SRX7564604 SRS6001805 SRP241982 PRJNA599026 Project of basal ray finned fishes PRJNA599026 Other The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.   pubmed:33545088;pubmed:12470943     Zebrafish 009   strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Spinal cord|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : adult CL100103178 L01 9 CL100103178 L01 9       RNA-Seq TRANSCRIPTOMIC RANDOM PAIRED BGISEQ BGISEQ-500   SRP241982     CL100103178_L01_567_1.fq.gz CL100103178_L01_567_2.fq.gz fastq fastq 7926659000.0 79266590.0 CL100103178 L01 567 1.fq.gz 0:100 1:100 A:2177233520;C:1750763335;G:1793690428;T:2195598681;N:9373036 100 100     2177233520 1750763335 1793690428 2195598681 9373036 SRX7564604 SRS6001805 SRA1026516 BGI|BGI-Research BGI 1 0.90731   0.11069   0.70548   0.53521   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   China 2020-01-15 Adult Adult Spinal Cord Nervous System
55973 55973 SRR10895876 SRX7564603 SRS6001805 SRP241982 PRJNA599026 Project of basal ray finned fishes PRJNA599026 Other The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.   pubmed:33545088;pubmed:12470943     Zebrafish 009   strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Spinal cord|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : adult CL100103178 L01 8 CL100103178 L01 8       RNA-Seq TRANSCRIPTOMIC RANDOM PAIRED BGISEQ BGISEQ-500   SRP241982     CL100103178_L01_563_1.fq.gz CL100103178_L01_563_2.fq.gz fastq fastq 9981278800.0 99812788.0 CL100103178 L01 563 1.fq.gz 0:100 1:100 A:2753622693;C:2192952746;G:2243702494;T:2779006876;N:11993991 100 100     2753622693 2192952746 2243702494 2779006876 11993991 SRX7564603 SRS6001805 SRA1026516 BGI|BGI-Research BGI 1 0.90715   0.11372   0.71467   0.5089   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   China 2020-01-15 Adult Adult Spinal Cord Nervous System
55974 55974 SRR10895877 SRX7564602 SRS6001805 SRP241982 PRJNA599026 Project of basal ray finned fishes PRJNA599026 Other The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.   pubmed:33545088;pubmed:12470943     Zebrafish 009   strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Spinal cord|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : adult CL100103178 L01 7 CL100103178 L01 7       RNA-Seq TRANSCRIPTOMIC RANDOM PAIRED BGISEQ BGISEQ-500   SRP241982     CL100103178_L01_562_1.fq.gz CL100103178_L01_562_2.fq.gz fastq fastq 8857552800.0 88575528.0 CL100103178 L01 562 1.fq.gz 0:100 1:100 A:2418167382;C:1969456035;G:2015821568;T:2442764114;N:11343701 100 100     2418167382 1969456035 2015821568 2442764114 11343701 SRX7564602 SRS6001805 SRA1026516 BGI|BGI-Research BGI 1 0.90895   0.10978   0.71336   0.50272   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   China 2020-01-15 Adult Adult Spinal Cord Nervous System
55975 55975 SRR10895878 SRX7564601 SRS6001805 SRP241982 PRJNA599026 Project of basal ray finned fishes PRJNA599026 Other The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.   pubmed:33545088;pubmed:12470943     Zebrafish 009   strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Spinal cord|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : adult CL100103178 L01 6 CL100103178 L01 6       RNA-Seq TRANSCRIPTOMIC RANDOM PAIRED BGISEQ BGISEQ-500   SRP241982     CL100103178_L01_564_1.fq.gz CL100103178_L01_564_2.fq.gz fastq fastq 7468499200.0 74684992.0 CL100103178 L01 564 1.fq.gz 0:100 1:100 A:2052720985;C:1649448011;G:1690698471;T:2068073830;N:7557903 100 100     2052720985 1649448011 1690698471 2068073830 7557903 SRX7564601 SRS6001805 SRA1026516 BGI|BGI-Research BGI 1 0.90905   0.10883   0.69578   0.54193   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   China 2020-01-15 Adult Adult Spinal Cord Nervous System
55976 55976 SRR10895881 SRX7564598 SRS6001805 SRP241982 PRJNA599026 Project of basal ray finned fishes PRJNA599026 Other The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.   pubmed:33545088;pubmed:12470943     Zebrafish 009   strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Spinal cord|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : adult CL100103178 L01 5 CL100103178 L01 5       RNA-Seq TRANSCRIPTOMIC RANDOM PAIRED BGISEQ BGISEQ-500   SRP241982     CL100103178_L01_561_1.fq.gz CL100103178_L01_561_2.fq.gz fastq fastq 9173572800.0 91735728.0 CL100103178 L01 561 1.fq.gz 0:100 1:100 A:2527132650;C:2020739240;G:2066720461;T:2548747865;N:10232584 100 100     2527132650 2020739240 2066720461 2548747865 10232584 SRX7564598 SRS6001805 SRA1026516 BGI|BGI-Research BGI 1 0.91539   0.11063   0.71427   0.48162   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   China 2020-01-15 Adult Adult Spinal Cord Nervous System
55992 55992 SRR10895898 SRX7564581 SRS6001800 SRP241982 PRJNA599026 Project of basal ray finned fishes PRJNA599026 Other The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.   pubmed:33545088;pubmed:12470943     Zebrafish 005   strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : adult CL100103858 L01 10 CL100103858 L01 10       RNA-Seq TRANSCRIPTOMIC RANDOM PAIRED BGISEQ BGISEQ-500   SRP241982     CL100103858_L01_513_1.fq.gz CL100103858_L01_513_2.fq.gz fastq fastq 9129585000.0 91295850.0 CL100103858 L01 513 1.fq.gz 0:100 1:100 A:2497450580;C:2015129450;G:2071393661;T:2529809771;N:15801538 100 100     2497450580 2015129450 2071393661 2529809771 15801538 SRX7564581 SRS6001800 SRA1026516 BGI|BGI-Research BGI 1 0.93396   0.13   0.71431   0.54518   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   China 2020-01-15 Adult Adult Brain Nervous System
55993 55993 SRR10895899 SRX7564580 SRS6001800 SRP241982 PRJNA599026 Project of basal ray finned fishes PRJNA599026 Other The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.   pubmed:33545088;pubmed:12470943     Zebrafish 005   strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : adult CL100103858 L01 9 CL100103858 L01 9       RNA-Seq TRANSCRIPTOMIC RANDOM PAIRED BGISEQ BGISEQ-500   SRP241982     CL100103858_L01_509_2.fq.gz CL100103858_L01_509_1.fq.gz fastq fastq 9063446600.0 90634466.0 CL100103858 L01 509 1.fq.gz 0:100 1:100 A:2470522817;C:2005905195;G:2066552125;T:2504876588;N:15589875 100 100     2470522817 2005905195 2066552125 2504876588 15589875 SRX7564580 SRS6001800 SRA1026516 BGI|BGI-Research BGI 1 0.9334   0.13676   0.71614   0.54289   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   China 2020-01-15 Adult Adult Brain Nervous System
55994 55994 SRR10895900 SRX7564579 SRS6001800 SRP241982 PRJNA599026 Project of basal ray finned fishes PRJNA599026 Other The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.   pubmed:33545088;pubmed:12470943     Zebrafish 005   strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : adult CL100103858 L01 8 CL100103858 L01 8       RNA-Seq TRANSCRIPTOMIC RANDOM PAIRED BGISEQ BGISEQ-500   SRP241982     CL100103858_L01_510_1.fq.gz CL100103858_L01_510_2.fq.gz fastq fastq 10414313800.0 104143138.0 CL100103858 L01 510 1.fq.gz 0:100 1:100 A:2858166440;C:2289999240;G:2356174514;T:2892047112;N:17926494 100 100     2858166440 2289999240 2356174514 2892047112 17926494 SRX7564579 SRS6001800 SRA1026516 BGI|BGI-Research BGI 1 0.93036   0.13448   0.71045   0.53846   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   China 2020-01-15 Adult Adult Brain Nervous System
55995 55995 SRR10895901 SRX7564578 SRS6001800 SRP241982 PRJNA599026 Project of basal ray finned fishes PRJNA599026 Other The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.   pubmed:33545088;pubmed:12470943     Zebrafish 005   strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : adult CL100103858 L01 7 CL100103858 L01 7       RNA-Seq TRANSCRIPTOMIC RANDOM PAIRED BGISEQ BGISEQ-500   SRP241982     CL100103858_L01_511_2.fq.gz CL100103858_L01_511_1.fq.gz fastq fastq 10057553400.0 100575534.0 CL100103858 L01 511 1.fq.gz 0:100 1:100 A:2762495630;C:2212266487;G:2274060113;T:2791456239;N:17274931 100 100     2762495630 2212266487 2274060113 2791456239 17274931 SRX7564578 SRS6001800 SRA1026516 BGI|BGI-Research BGI 1 0.93578   0.11695   0.72005   0.51093   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   China 2020-01-15 Adult Adult Brain Nervous System
55996 55996 SRR10895903 SRX7564576 SRS6001800 SRP241982 PRJNA599026 Project of basal ray finned fishes PRJNA599026 Other The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.   pubmed:33545088;pubmed:12470943     Zebrafish 005   strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio : adult CL100103858 L01 6 CL100103858 L01 6       RNA-Seq TRANSCRIPTOMIC RANDOM PAIRED BGISEQ BGISEQ-500   SRP241982     CL100103858_L01_512_1.fq.gz CL100103858_L01_512_2.fq.gz fastq fastq 8575207600.0 85752076.0 CL100103858 L01 512 1.fq.gz 0:100 1:100 A:2340755177;C:1898089765;G:1951995517;T:2369794410;N:14572731 100 100     2340755177 1898089765 1951995517 2369794410 14572731 SRX7564576 SRS6001800 SRA1026516 BGI|BGI-Research BGI 1 0.93429   0.12481   0.71384   0.52278   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   China 2020-01-15 Adult Adult Brain Nervous System
60203 60203 SRR12173066 SRX8687829 SRS6966493 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   100B GSM4661929   source name:SCA12|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male 100B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA12   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M GSM4661929 GSM4661929: 100B; Danio rerio; RNA Seq GSM4661929   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661929 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     100B_2.fq 100B_1.fq fastq fastq 4300755000.0 43007550.0 GSM4661929 r1 0:100 1:100 A:1195013481;C:933832983;G:962461499;T:1209447037;N:0 100 100     1195013481 933832983 962461499 1209447037 0 SRX8687829 SRS6966493 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91912   0.15522   0.71829   0.50865   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60204 60204 SRR12173065 SRX8687828 SRS6966492 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   99B GSM4661928   source name:SCA10|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male 99B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA10   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M GSM4661928 GSM4661928: 99B; Danio rerio; RNA Seq GSM4661928   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661928 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     99B_2.fq 99B_1.fq fastq fastq 4953251000.0 49532510.0 GSM4661928 r1 0:100 1:100 A:1415039103;C:1040525484;G:1060332314;T:1437354099;N:0 100 100     1415039103 1040525484 1060332314 1437354099 0 SRX8687828 SRS6966492 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91619   0.16544   0.71922   0.51996   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60205 60205 SRR12173064 SRX8687827 SRS6966491 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   121B GSM4661927   source name:SCA14|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male 121B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA14   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M GSM4661927 GSM4661927: 121B; Danio rerio; RNA Seq GSM4661927   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661927 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     121B_1.fq 121B_2.fq fastq fastq 4482694600.0 44826946.0 GSM4661927 r1 0:100 1:100 A:1292365837;C:920169200;G:950296696;T:1319862867;N:0 100 100     1292365837 920169200 950296696 1319862867 0 SRX8687827 SRS6966491 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90277   0.17799   0.72295   0.51987   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60206 60206 SRR12173063 SRX8687826 SRS6966490 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   97B GSM4661926   source name:SCA5|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male 97B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA5   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M GSM4661926 GSM4661926: 97B; Danio rerio; RNA Seq GSM4661926   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661926 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     97B_1.fq 97B_2.fq fastq fastq 5178357000.0 51783570.0 GSM4661926 r1 0:100 1:100 A:1442148425;C:1119935128;G:1149243236;T:1467030211;N:0 100 100     1442148425 1119935128 1149243236 1467030211 0 SRX8687826 SRS6966490 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91869   0.1619   0.71047   0.50907   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60207 60207 SRR12173062 SRX8687825 SRS6966489 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   80B GSM4661925   source name:SCA8|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female 80B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA8   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F GSM4661925 GSM4661925: 80B; Danio rerio; RNA Seq GSM4661925   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661925 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     80B_1.fq 80B_2.fq fastq fastq 4927736800.0 49277368.0 GSM4661925 r1 0:100 1:100 A:1384189069;C:1048151377;G:1079300714;T:1416095640;N:0 100 100     1384189069 1048151377 1079300714 1416095640 0 SRX8687825 SRS6966489 SRA1096323 GEO UMR MARBEC, INRAE 1 0.9104   0.17333   0.71102   0.50853   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60208 60208 SRR12173061 SRX8687824 SRS6966488 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   79B GSM4661924   source name:SCA7|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female 79B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA7   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F GSM4661924 GSM4661924: 79B; Danio rerio; RNA Seq GSM4661924   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661924 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     79B_1.fq 79B_2.fq fastq fastq 5158717400.0 51587174.0 GSM4661924 r1 0:100 1:100 A:1423369091;C:1127803059;G:1156903341;T:1450641909;N:0 100 100     1423369091 1127803059 1156903341 1450641909 0 SRX8687824 SRS6966488 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91578   0.15498   0.70841   0.50875   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60209 60209 SRR12173060 SRX8687823 SRS6966487 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   78B GSM4661923   source name:SCA6|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female 78B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA6   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F GSM4661923 GSM4661923: 78B; Danio rerio; RNA Seq GSM4661923   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661923 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     78B_2.fq 78B_1.fq fastq fastq 4080284000.0 40802840.0 GSM4661923 r1 0:100 1:100 A:1146760011;C:872005355;G:893480498;T:1168038136;N:0 100 100     1146760011 872005355 893480498 1168038136 0 SRX8687823 SRS6966487 SRA1096323 GEO UMR MARBEC, INRAE 1 0.89506   0.16061   0.7147   0.51109   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60210 60210 SRR12173059 SRX8687822 SRS6966486 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   77B GSM4661922   source name:SCA4|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female 77B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA4   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F GSM4661922 GSM4661922: 77B; Danio rerio; RNA Seq GSM4661922   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661922 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     77B_1.fq 77B_2.fq fastq fastq 5053965200.0 50539652.0 GSM4661922 r1 0:100 1:100 A:1432899891;C:1065155546;G:1092749323;T:1463160440;N:0 100 100     1432899891 1065155546 1092749323 1463160440 0 SRX8687822 SRS6966486 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90965   0.17028   0.71259   0.51804   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60211 60211 SRR12173058 SRX8687821 SRS6966485 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   95B GSM4661921   source name:PH8|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male 95B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH8   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M GSM4661921 GSM4661921: 95B; Danio rerio; RNA Seq GSM4661921   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661921 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     95B_2.fq 95B_1.fq fastq fastq 4984910800.0 49849108.0 GSM4661921 r1 0:100 1:100 A:1404088729;C:1063272664;G:1094657988;T:1422891419;N:0 100 100     1404088729 1063272664 1094657988 1422891419 0 SRX8687821 SRS6966485 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91574   0.16729   0.71776   0.51526   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60212 60212 SRR12173057 SRX8687820 SRS6966484 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   94B GSM4661920   source name:PH7|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male 94B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH7   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M GSM4661920 GSM4661920: 94B; Danio rerio; RNA Seq GSM4661920   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661920 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     94B_2.fq 94B_1.fq fastq fastq 4973104000.0 49731040.0 GSM4661920 r1 0:100 1:100 A:1403074698;C:1055981307;G:1089110444;T:1424937551;N:0 100 100     1403074698 1055981307 1089110444 1424937551 0 SRX8687820 SRS6966484 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91432   0.16183   0.72001   0.51323   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60213 60213 SRR12173056 SRX8687819 SRS6966483 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   93B GSM4661919   source name:PH6|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male 93B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH6   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M GSM4661919 GSM4661919: 93B; Danio rerio; RNA Seq GSM4661919   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661919 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     93B_2.fq 93B_1.fq fastq fastq 4896774400.0 48967744.0 GSM4661919 r1 0:100 1:100 A:1403923710;C:1011507726;G:1048273729;T:1433069235;N:0 100 100     1403923710 1011507726 1048273729 1433069235 0 SRX8687819 SRS6966483 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91124   0.1598   0.72247   0.54532   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60214 60214 SRR12173055 SRX8687818 SRS6966482 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   92B GSM4661918   source name:PH4|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male 92B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH4   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M GSM4661918 GSM4661918: 92B; Danio rerio; RNA Seq GSM4661918   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661918 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     92B_1.fq 92B_2.fq fastq fastq 5153962600.0 51539626.0 GSM4661918 r1 0:100 1:100 A:1429538166;C:1118723084;G:1151444792;T:1454256558;N:0 100 100     1429538166 1118723084 1151444792 1454256558 0 SRX8687818 SRS6966482 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91817   0.15904   0.71088   0.51009   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60215 60215 SRR12173054 SRX8687817 SRS6966481 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   75B GSM4661917   source name:PH10|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female 75B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH10   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F GSM4661917 GSM4661917: 75B; Danio rerio; RNA Seq GSM4661917   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661917 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     75B_1.fq 75B_2.fq fastq fastq 4868261600.0 48682616.0 GSM4661917 r1 0:100 1:100 A:1376009816;C:1028298503;G:1057930129;T:1406023152;N:0 100 100     1376009816 1028298503 1057930129 1406023152 0 SRX8687817 SRS6966481 SRA1096323 GEO UMR MARBEC, INRAE 1 0.9126   0.1697   0.71638   0.50591   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60216 60216 SRR12173053 SRX8687816 SRS6966480 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   74B GSM4661916   source name:PH9|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female 74B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH9   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F GSM4661916 GSM4661916: 74B; Danio rerio; RNA Seq GSM4661916   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661916 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     74B_1.fq 74B_2.fq fastq fastq 5179173200.0 51791732.0 GSM4661916 r1 0:100 1:100 A:1449133916;C:1117631254;G:1139937410;T:1472470620;N:0 100 100     1449133916 1117631254 1139937410 1472470620 0 SRX8687816 SRS6966480 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91222   0.16046   0.71029   0.50076   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60217 60217 SRR12173052 SRX8687815 SRS6966479 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   72B GSM4661915   source name:PH2|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female 72B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH2   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F GSM4661915 GSM4661915: 72B; Danio rerio; RNA Seq GSM4661915   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661915 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     72B_1.fq 72B_2.fq fastq fastq 5878512600.0 58785126.0 GSM4661915 r1 0:100 1:100 A:1639773073;C:1271766251;G:1298391071;T:1668582205;N:0 100 100     1639773073 1271766251 1298391071 1668582205 0 SRX8687815 SRS6966479 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91084   0.16615   0.70713   0.5033   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60218 60218 SRR12173051 SRX8687814 SRS6966478 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   71B GSM4661914   source name:PH1|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female 71B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH1   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F GSM4661914 GSM4661914: 71B; Danio rerio; RNA Seq GSM4661914   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661914 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     71B_1.fq 71B_2.fq fastq fastq 2921419400.0 29214194.0 GSM4661914 r1 0:100 1:100 A:838032642;C:606973028;G:618918524;T:857495206;N:0 100 100     838032642 606973028 618918524 857495206 0 SRX8687814 SRS6966478 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90765   0.17712   0.71015   0.48691   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60219 60219 SRR12173050 SRX8687813 SRS6966477 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   173B GSM4661913   source name:SCA10|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male 173B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA10   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M GSM4661913 GSM4661913: 173B; Danio rerio; RNA Seq GSM4661913   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661913 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB44-68_1.fq.gz V300016697_L3_DKRT190808OligoTB44-68_2.fq.gz fastq fastq 4933950400.0 49339504.0 GSM4661913 r1 0:100 1:100 A:1477278267;C:971417805;G:982397108;T:1502857220;N:0 100 100     1477278267 971417805 982397108 1502857220 0 SRX8687813 SRS6966477 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90094   0.26419   0.73066   0.51886   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60220 60220 SRR12173049 SRX8687812 SRS6966476 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   172B GSM4661912   source name:SCA7|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male 172B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA7   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M GSM4661912 GSM4661912: 172B; Danio rerio; RNA Seq GSM4661912   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661912 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB43-67_1.fq.gz V300016697_L3_DKRT190808OligoTB43-67_2.fq.gz fastq fastq 4916317800.0 49163178.0 GSM4661912 r1 0:100 1:100 A:1456100891;C:983643530;G:996293468;T:1480279911;N:0 100 100     1456100891 983643530 996293468 1480279911 0 SRX8687812 SRS6966476 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90484   0.24497   0.72563   0.51605   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60221 60221 SRR12173048 SRX8687811 SRS6966475 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   171B GSM4661911   source name:SCA5|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male 171B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA5   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M GSM4661911 GSM4661911: 171B; Danio rerio; RNA Seq GSM4661911   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661911 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB42-66_1.fq.gz V300016697_L3_DKRT190808OligoTB42-66_2.fq.gz fastq fastq 4935261800.0 49352618.0 GSM4661911 r1 0:100 1:100 A:1445056643;C:1003559733;G:1015728708;T:1470916716;N:0 100 100     1445056643 1003559733 1015728708 1470916716 0 SRX8687811 SRS6966475 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90817   0.23047   0.72086   0.5134   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60222 60222 SRR12173047 SRX8687810 SRS6966474 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   170B GSM4661910   source name:SCA3|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male 170B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA3   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M GSM4661910 GSM4661910: 170B; Danio rerio; RNA Seq GSM4661910   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661910 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB41-65_1.fq.gz V300016697_L3_DKRT190808OligoTB41-65_2.fq.gz fastq fastq 4925193600.0 49251936.0 GSM4661910 r1 0:100 1:100 A:1463488890;C:982336799;G:993110731;T:1486257180;N:0 100 100     1463488890 982336799 993110731 1486257180 0 SRX8687810 SRS6966474 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90727   0.24322   0.72659   0.52026   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60223 60223 SRR12173046 SRX8687809 SRS6966473 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   168B GSM4661909   source name:SCA9|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female 168B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA9   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F GSM4661909 GSM4661909: 168B; Danio rerio; RNA Seq GSM4661909   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661909 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB40-64_1.fq.gz V300016697_L3_DKRT190808OligoTB40-64_2.fq.gz fastq fastq 4921204600.0 49212046.0 GSM4661909 r1 0:100 1:100 A:1472696868;C:970527278;G:980479163;T:1497501291;N:0 100 100     1472696868 970527278 980479163 1497501291 0 SRX8687809 SRS6966473 SRA1096323 GEO UMR MARBEC, INRAE 1 0.89853   0.26909   0.72934   0.50679   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60224 60224 SRR12173045 SRX8687808 SRS6966472 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   167B GSM4661908   source name:SCA8|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female 167B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA8   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F GSM4661908 GSM4661908: 167B; Danio rerio; RNA Seq GSM4661908   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661908 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB39-63_1.fq.gz V300016697_L3_DKRT190808OligoTB39-63_2.fq.gz fastq fastq 4929648000.0 49296480.0 GSM4661908 r1 0:100 1:100 A:1444571687;C:1001131050;G:1014059660;T:1469885603;N:0 100 100     1444571687 1001131050 1014059660 1469885603 0 SRX8687808 SRS6966472 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90469   0.23511   0.71644   0.50939   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60225 60225 SRR12173044 SRX8687807 SRS6966471 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   166B GSM4661907   source name:SCA6|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female 166B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA6   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F GSM4661907 GSM4661907: 166B; Danio rerio; RNA Seq GSM4661907   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661907 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB38-62_1.fq.gz V300016697_L3_DKRT190808OligoTB38-62_2.fq.gz fastq fastq 4934480200.0 49344802.0 GSM4661907 r1 0:100 1:100 A:1465270023;C:983677716;G:995361912;T:1490170549;N:0 100 100     1465270023 983677716 995361912 1490170549 0 SRX8687807 SRS6966471 SRA1096323 GEO UMR MARBEC, INRAE 1 0.89941   0.25615   0.72127   0.50512   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60226 60226 SRR12173043 SRX8687806 SRS6966470 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   165B GSM4661906   source name:SCA4|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female 165B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA4   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F GSM4661906 GSM4661906: 165B; Danio rerio; RNA Seq GSM4661906   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661906 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB37-61_1.fq.gz V300016697_L3_DKRT190808OligoTB37-61_2.fq.gz fastq fastq 4919775200.0 49197752.0 GSM4661906 r1 0:100 1:100 A:1439207243;C:1003073787;G:1015357028;T:1462137142;N:0 100 100     1439207243 1003073787 1015357028 1462137142 0 SRX8687806 SRS6966470 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90664   0.23232   0.71652   0.49875   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60227 60227 SRR12173042 SRX8687805 SRS6966469 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   163B GSM4661905   source name:PH9|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male 163B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH9   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M GSM4661905 GSM4661905: 163B; Danio rerio; RNA Seq GSM4661905   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661905 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB36-60_1.fq.gz V300016697_L3_DKRT190808OligoTB36-60_2.fq.gz fastq fastq 4916788400.0 49167884.0 GSM4661905 r1 0:100 1:100 A:1450695371;C:989044062;G:1001626000;T:1475422967;N:0 100 100     1450695371 989044062 1001626000 1475422967 0 SRX8687805 SRS6966469 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90357   0.24123   0.72023   0.50955   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60228 60228 SRR12173041 SRX8687804 SRS6966468 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   161B GSM4661904   source name:PH6|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male 161B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH6   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M GSM4661904 GSM4661904: 161B; Danio rerio; RNA Seq GSM4661904   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661904 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB35-59_1.fq.gz V300016697_L3_DKRT190808OligoTB35-59_2.fq.gz fastq fastq 4926157600.0 49261576.0 GSM4661904 r1 0:100 1:100 A:1467853995;C:977298660;G:990198306;T:1490806639;N:0 100 100     1467853995 977298660 990198306 1490806639 0 SRX8687804 SRS6966468 SRA1096323 GEO UMR MARBEC, INRAE 1 0.9013   0.25482   0.72912   0.51654   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60229 60229 SRR12173040 SRX8687803 SRS6966467 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   160B GSM4661903   source name:PH12|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male 160B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH12   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M GSM4661903 GSM4661903: 160B; Danio rerio; RNA Seq GSM4661903   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661903 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB34-58_1.fq.gz V300016697_L3_DKRT190808OligoTB34-58_2.fq.gz fastq fastq 4937891400.0 49378914.0 GSM4661903 r1 0:100 1:100 A:1466862905;C:983988502;G:997702772;T:1489337221;N:0 100 100     1466862905 983988502 997702772 1489337221 0 SRX8687803 SRS6966467 SRA1096323 GEO UMR MARBEC, INRAE 1 0.8994   0.2581   0.72906   0.51649   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60230 60230 SRR12173039 SRX8687802 SRS6966466 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   159B GSM4661902   source name:PH11|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male 159B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH11   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M GSM4661902 GSM4661902: 159B; Danio rerio; RNA Seq GSM4661902   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661902 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB33-57_1.fq.gz V300016697_L3_DKRT190808OligoTB33-57_2.fq.gz fastq fastq 4912693200.0 49126932.0 GSM4661902 r1 0:100 1:100 A:1466260254;C:970920251;G:984105331;T:1491407364;N:0 100 100     1466260254 970920251 984105331 1491407364 0 SRX8687802 SRS6966466 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90041   0.25314   0.73381   0.53543   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60231 60231 SRR12173038 SRX8687801 SRS6966465 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   158B GSM4661901   source name:PH16|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female 158B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH16   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F GSM4661901 GSM4661901: 158B; Danio rerio; RNA Seq GSM4661901   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661901 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB32-56_1.fq.gz V300016697_L3_DKRT190808OligoTB32-56_2.fq.gz fastq fastq 4945853000.0 49458530.0 GSM4661901 r1 0:100 1:100 A:1483522148;C:971739399;G:982030279;T:1508561174;N:0 100 100     1483522148 971739399 982030279 1508561174 0 SRX8687801 SRS6966465 SRA1096323 GEO UMR MARBEC, INRAE 1 0.89835   0.26809   0.73036   0.51167   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60232 60232 SRR12173037 SRX8687800 SRS6966464 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   157B GSM4661900   source name:PH5|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female 157B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH5   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F GSM4661900 GSM4661900: 157B; Danio rerio; RNA Seq GSM4661900   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661900 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L3_DKRT190808OligoTB31-55_2.fq.gz V300016697_L3_DKRT190808OligoTB31-55_1.fq.gz fastq fastq 4930661000.0 49306610.0 GSM4661900 r1 0:100 1:100 A:1479111656;C:968782080;G:980526976;T:1502240288;N:0 100 100     1479111656 968782080 980526976 1502240288 0 SRX8687800 SRS6966464 SRA1096323 GEO UMR MARBEC, INRAE 1 0.8997   0.26769   0.72894   0.52069   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60233 60233 SRR12173036 SRX8687799 SRS6966463 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   156B GSM4661899   source name:PH4|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female 156B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH4   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F GSM4661899 GSM4661899: 156B; Danio rerio; RNA Seq GSM4661899   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661899 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L2_DKRT190808OligoTB30-54_1.fq.gz V300016697_L2_DKRT190808OligoTB30-54_2.fq.gz fastq fastq 5008041200.0 50080412.0 GSM4661899 r1 0:100 1:100 A:1499313897;C:986298102;G:997520882;T:1524908319;N:0 100 100     1499313897 986298102 997520882 1524908319 0 SRX8687799 SRS6966463 SRA1096323 GEO UMR MARBEC, INRAE 1 0.89791   0.26891   0.72782   0.50905   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60234 60234 SRR12173035 SRX8687798 SRS6966462 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   155B GSM4661898   source name:PH3|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female 155B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH3   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F GSM4661898 GSM4661898: 155B; Danio rerio; RNA Seq GSM4661898   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661898 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L2_DKRT190808OligoTB29-53_1.fq.gz V300016697_L2_DKRT190808OligoTB29-53_2.fq.gz fastq fastq 5012833000.0 50128330.0 GSM4661898 r1 0:100 1:100 A:1498301491;C:989903310;G:1001505041;T:1523123158;N:0 100 100     1498301491 989903310 1001505041 1523123158 0 SRX8687798 SRS6966462 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90134   0.26756   0.72535   0.49696   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60235 60235 SRR12173034 SRX8687797 SRS6966461 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   40B GSM4661897   source name:SCA17|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male 40B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA17   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M GSM4661897 GSM4661897: 40B; Danio rerio; RNA Seq GSM4661897   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661897 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L2_DKRT190808OligoTB28-52_1.fq.gz V300016697_L2_DKRT190808OligoTB28-52_2.fq.gz fastq fastq 5024116600.0 50241166.0 GSM4661897 r1 0:100 1:100 A:1477107167;C:1016848490;G:1027973874;T:1502187069;N:0 100 100     1477107167 1016848490 1027973874 1502187069 0 SRX8687797 SRS6966461 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90915   0.22952   0.71658   0.49092   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60236 60236 SRR12173033 SRX8687796 SRS6966460 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   38B GSM4661896   source name:SCA10|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male 38B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA10   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M GSM4661896 GSM4661896: 38B; Danio rerio; RNA Seq GSM4661896   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661896 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L2_DKRT190808OligoTB27-51_1.fq.gz V300016697_L2_DKRT190808OligoTB27-51_2.fq.gz fastq fastq 5008056600.0 50080566.0 GSM4661896 r1 0:100 1:100 A:1461495870;C:1022836043;G:1036957625;T:1486767062;N:0 100 100     1461495870 1022836043 1036957625 1486767062 0 SRX8687796 SRS6966460 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91105   0.21297   0.71419   0.51046   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60237 60237 SRR12173032 SRX8687795 SRS6966459 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   37B GSM4661895   source name:SCA6|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male 37B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA6   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M GSM4661895 GSM4661895: 37B; Danio rerio; RNA Seq GSM4661895   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661895 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L2_DKRT190808OligoTB26-50_1.fq.gz V300016697_L2_DKRT190808OligoTB26-50_2.fq.gz fastq fastq 4970945000.0 49709450.0 GSM4661895 r1 0:100 1:100 A:1452650065;C:1013500708;G:1027205899;T:1477588328;N:0 100 100     1452650065 1013500708 1027205899 1477588328 0 SRX8687795 SRS6966459 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91153   0.21127   0.71567   0.51669   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60238 60238 SRR12173031 SRX8687794 SRS6966458 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   36B GSM4661894   source name:SCA2|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male 36B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA2   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M GSM4661894 GSM4661894: 36B; Danio rerio; RNA Seq GSM4661894   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661894 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L2_DKRT190808OligoTB25-49_2.fq.gz V300016697_L2_DKRT190808OligoTB25-49_1.fq.gz fastq fastq 4965885400.0 49658854.0 GSM4661894 r1 0:100 1:100 A:1447470026;C:1015061012;G:1029974741;T:1473379621;N:0 100 100     1447470026 1015061012 1029974741 1473379621 0 SRX8687794 SRS6966458 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91108   0.21513   0.71816   0.50811   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60239 60239 SRR12173030 SRX8687793 SRS6966457 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   35B GSM4661893   source name:SCA18|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female 35B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA18   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F GSM4661893 GSM4661893: 35B; Danio rerio; RNA Seq GSM4661893   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661893 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB24-32_2.fq.gz V300016697_L4_DKRT190808OligoTB24-32_1.fq.gz fastq fastq 5015053400.0 50150534.0 GSM4661893 r1 0:100 1:100 A:1457835767;C:1029178424;G:1044039825;T:1483999384;N:0 100 100     1457835767 1029178424 1044039825 1483999384 0 SRX8687793 SRS6966457 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90833   0.21925   0.71672   0.50097   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60240 60240 SRR12173029 SRX8687792 SRS6966456 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   34B GSM4661892   source name:SCA16|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female 34B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA16   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F GSM4661892 GSM4661892: 34B; Danio rerio; RNA Seq GSM4661892   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661892 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB23-31_1.fq.gz V300016697_L4_DKRT190808OligoTB23-31_2.fq.gz fastq fastq 4986700200.0 49867002.0 GSM4661892 r1 0:100 1:100 A:1462869969;C:1011992988;G:1024320004;T:1487517239;N:0 100 100     1462869969 1011992988 1024320004 1487517239 0 SRX8687792 SRS6966456 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90718   0.22544   0.71342   0.5072   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60241 60241 SRR12173028 SRX8687791 SRS6966455 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   33B GSM4661891   source name:SCA15|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female 33B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA15   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F GSM4661891 GSM4661891: 33B; Danio rerio; RNA Seq GSM4661891   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661891 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB22-30_1.fq.gz V300016697_L4_DKRT190808OligoTB22-30_2.fq.gz fastq fastq 5002163800.0 50021638.0 GSM4661891 r1 0:100 1:100 A:1458240783;C:1023254938;G:1035393042;T:1485275037;N:0 100 100     1458240783 1023254938 1035393042 1485275037 0 SRX8687791 SRS6966455 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90922   0.2217   0.7097   0.51063   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60242 60242 SRR12173027 SRX8687790 SRS6966454 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   32B GSM4661890   source name:SCA14|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female 32B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. SCA14   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F GSM4661890 GSM4661890: 32B; Danio rerio; RNA Seq GSM4661890   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661890 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB21-29_1.fq.gz V300016697_L4_DKRT190808OligoTB21-29_2.fq.gz fastq fastq 5004918600.0 50049186.0 GSM4661890 r1 0:100 1:100 A:1478882760;C:1005298319;G:1018268859;T:1502468662;N:0 100 100     1478882760 1005298319 1018268859 1502468662 0 SRX8687790 SRS6966454 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90266   0.24047   0.71997   0.50514   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60243 60243 SRR12173026 SRX8687789 SRS6966453 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   30B GSM4661889   source name:PH22|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male 30B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH22   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M GSM4661889 GSM4661889: 30B; Danio rerio; RNA Seq GSM4661889   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661889 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB20-28_2.fq.gz V300016697_L4_DKRT190808OligoTB20-28_1.fq.gz fastq fastq 5004549600.0 50045496.0 GSM4661889 r1 0:100 1:100 A:1464234691;C:1019451110;G:1029365798;T:1491498001;N:0 100 100     1464234691 1019451110 1029365798 1491498001 0 SRX8687789 SRS6966453 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90749   0.21628   0.71784   0.51498   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60244 60244 SRR12173025 SRX8687788 SRS6966452 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   29B GSM4661888   source name:PH19|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male 29B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH19   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M GSM4661888 GSM4661888: 29B; Danio rerio; RNA Seq GSM4661888   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661888 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB19-27_1.fq.gz V300016697_L4_DKRT190808OligoTB19-27_2.fq.gz fastq fastq 5002749400.0 50027494.0 GSM4661888 r1 0:100 1:100 A:1467188892;C:1015426772;G:1028344254;T:1491789482;N:0 100 100     1467188892 1015426772 1028344254 1491789482 0 SRX8687788 SRS6966452 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90801   0.22987   0.71823   0.50663   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60245 60245 SRR12173024 SRX8687787 SRS6966451 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   28B GSM4661887   source name:PH17|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male 28B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH17   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M GSM4661887 GSM4661887: 28B; Danio rerio; RNA Seq GSM4661887   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661887 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB18-26_2.fq.gz V300016697_L4_DKRT190808OligoTB18-26_1.fq.gz fastq fastq 5006123800.0 50061238.0 GSM4661887 r1 0:100 1:100 A:1456441519;C:1027857948;G:1041287742;T:1480536591;N:0 100 100     1456441519 1027857948 1041287742 1480536591 0 SRX8687787 SRS6966451 SRA1096323 GEO UMR MARBEC, INRAE 1 0.91262   0.21085   0.71662   0.51982   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60246 60246 SRR12173023 SRX8687786 SRS6966450 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   26B GSM4661886   source name:PH12|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male 26B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH12   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M GSM4661886 GSM4661886: 26B; Danio rerio; RNA Seq GSM4661886   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661886 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB17-25_1.fq.gz V300016697_L4_DKRT190808OligoTB17-25_2.fq.gz fastq fastq 5009606600.0 50096066.0 GSM4661886 r1 0:100 1:100 A:1500013398;C:985021902;G:996549130;T:1528022170;N:0 100 100     1500013398 985021902 996549130 1528022170 0 SRX8687786 SRS6966450 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90128   0.25532   0.73359   0.52879   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60247 60247 SRR12173022 SRX8687785 SRS6966449 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   25B GSM4661885   source name:PH16|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female 25B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH16   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F GSM4661885 GSM4661885: 25B; Danio rerio; RNA Seq GSM4661885   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661885 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB16-24_1.fq.gz V300016697_L4_DKRT190808OligoTB16-24_2.fq.gz fastq fastq 5015052800.0 50150528.0 GSM4661885 r1 0:100 1:100 A:1465175690;C:1021710593;G:1034828694;T:1493337823;N:0 100 100     1465175690 1021710593 1034828694 1493337823 0 SRX8687785 SRS6966449 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90728   0.22634   0.71486   0.50164   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60248 60248 SRR12173021 SRX8687784 SRS6966448 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   24B GSM4661884   source name:PH15|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female 24B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH15   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F GSM4661884 GSM4661884: 24B; Danio rerio; RNA Seq GSM4661884   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661884 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB15-23_1.fq.gz V300016697_L4_DKRT190808OligoTB15-23_2.fq.gz fastq fastq 5007208200.0 50072082.0 GSM4661884 r1 0:100 1:100 A:1467951978;C:1015424803;G:1028177858;T:1495653561;N:0 100 100     1467951978 1015424803 1028177858 1495653561 0 SRX8687784 SRS6966448 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90528   0.23927   0.71555   0.50336   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60249 60249 SRR12173020 SRX8687783 SRS6966447 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   21B GSM4661883   source name:PH9|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female 21B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH9   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F GSM4661883 GSM4661883: 21B; Danio rerio; RNA Seq GSM4661883   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661883 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB14-22_1.fq.gz V300016697_L4_DKRT190808OligoTB14-22_2.fq.gz fastq fastq 5024734000.0 50247340.0 GSM4661883 r1 0:100 1:100 A:1486766175;C:1007118234;G:1018199457;T:1512650134;N:0 100 100     1486766175 1007118234 1018199457 1512650134 0 SRX8687783 SRS6966447 SRA1096323 GEO UMR MARBEC, INRAE 1 0.89909   0.24852   0.7249   0.5102   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
60250 60250 SRR12173019 SRX8687782 SRS6966446 SRP270926 PRJNA644883 Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L GSE154020 Transcriptome Analysis In the present study zebrafish were exposed to permethrin during early life and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0 genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0 F1 and F2 generations 4 replicates treatment 4 replicates control for each sex and each generation   pubmed:33752003   22B GSM4661882   source name:PH10|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female 22B Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized. PH10   Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol   tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F GSM4661882 GSM4661882: 22B; Danio rerio; RNA Seq GSM4661882   1 Fish were euthanized brains were dissected and flash frozen in liquid nitrogen and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol GEO Accession:GSM4661882 RNA-Seq TRANSCRIPTOMIC cDNA PAIRED BGISEQ BGISEQ-500   SRP270926     V300016697_L4_DKRT190808OligoTB13-21_1.fq.gz V300016697_L4_DKRT190808OligoTB13-21_2.fq.gz fastq fastq 5016105600.0 50161056.0 GSM4661882 r1 0:100 1:100 A:1470011990;C:1017729527;G:1032133240;T:1496230843;N:0 100 100     1470011990 1017729527 1032133240 1496230843 0 SRX8687782 SRS6966446 SRA1096323 GEO UMR MARBEC, INRAE 1 0.90507   0.24172   0.71459   0.50712   100   B   usable mapping rate bgi bgi unknown random_priming unknown bulk unknown unknown   France 2020-07-08 Adult Adult Brain Nervous System
65944 65944 SRR15700565 SRX11996477 SRS10003992 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   R01   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain R01 R01 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     R01_1.fq.gz R01_2.fq.gz fastq fastq 6781182900.0 45207886.0 R01 1.fq.gz 0:150 1:150 A:1988991157;C:1393829563;G:1402027963;T:1996312981;N:21236 150 150     1988991157 1393829563 1402027963 1996312981 21236 SRX11996477 SRS10003992 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91278   0.20165   0.71054   0.54354   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65945 65945 SRR15700566 SRX11996476 SRS10003991 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EH3   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EH3 EH3 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EH3_1.fq.gz EH3_2.fq.gz fastq fastq 6798939900.0 45326266.0 EH3 1.fq.gz 0:150 1:150 A:1958992563;C:1429773625;G:1441958341;T:1968192397;N:22974 150 150     1958992563 1429773625 1441958341 1968192397 22974 SRX11996476 SRS10003991 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91681   0.18245   0.7083   0.5369   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65946 65946 SRR15700567 SRX11996475 SRS10003990 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EH2   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EH2 EH2 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EH2_1.fq.gz EH2_2.fq.gz fastq fastq 6792825900.0 45285506.0 EH2 1.fq.gz 0:150 1:150 A:1958355652;C:1427389031;G:1440081079;T:1966978334;N:21804 150 150     1958355652 1427389031 1440081079 1966978334 21804 SRX11996475 SRS10003990 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91907   0.17888   0.70575   0.54118   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65947 65947 SRR15700568 SRX11996474 SRS10003989 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EH1   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EH1 EH1 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EH1_1.fq.gz EH1_2.fq.gz fastq fastq 6723154200.0 44821028.0 EH1 1.fq.gz 0:150 1:150 A:1939940725;C:1412087358;G:1424339686;T:1946764075;N:22356 150 150     1939940725 1412087358 1424339686 1946764075 22356 SRX11996474 SRS10003989 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91848   0.1756   0.71293   0.54795   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65948 65948 SRR15700569 SRX11996473 SRS10003988 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EL3   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EL3 EL3 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EL3_1.fq.gz EL3_2.fq.gz fastq fastq 6756746700.0 45044978.0 EL3 1.fq.gz 0:150 1:150 A:1958754520;C:1411572406;G:1418753117;T:1967647023;N:19634 150 150     1958754520 1411572406 1418753117 1967647023 19634 SRX11996473 SRS10003988 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91873   0.18319   0.71027   0.55277   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65949 65949 SRR15700570 SRX11996472 SRS10003987 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EL2   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EL2 EL2 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EL2_1.fq.gz EL2_2.fq.gz fastq fastq 6811200600.0 45408004.0 EL2 1.fq.gz 0:150 1:150 A:1961542081;C:1433135536;G:1446857456;T:1969644200;N:21327 150 150     1961542081 1433135536 1446857456 1969644200 21327 SRX11996472 SRS10003987 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91853   0.17639   0.71076   0.54175   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65950 65950 SRR15700571 SRX11996471 SRS10003986 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   EL1   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain EL1 EL1 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     EL1_1.fq.gz EL1_2.fq.gz fastq fastq 6764302200.0 45095348.0 EL1 1.fq.gz 0:150 1:150 A:1943560425;C:1428175041;G:1441358638;T:1951185256;N:22840 150 150     1943560425 1428175041 1441358638 1951185256 22840 SRX11996471 SRS10003986 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91885   0.17456   0.71423   0.53356   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65951 65951 SRR15700572 SRX11996470 SRS10003985 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   E03   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain E03 E03 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     E03_1.fq.gz E03_2.fq.gz fastq fastq 6762334500.0 45082230.0 E03 1.fq.gz 0:150 1:150 A:1941432663;C:1429093210;G:1444693949;T:1947091388;N:23290 150 150     1941432663 1429093210 1444693949 1947091388 23290 SRX11996470 SRS10003985 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91902   0.17577   0.71413   0.54672   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65952 65952 SRR15700573 SRX11996469 SRS10003984 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RH3   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RH3 RH3 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RH3_1.fq.gz RH3_2.fq.gz fastq fastq 6620159400.0 44134396.0 RH3 1.fq.gz 0:150 1:150 A:1906961918;C:1396128146;G:1402603611;T:1914452217;N:13508 150 150     1906961918 1396128146 1402603611 1914452217 13508 SRX11996469 SRS10003984 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91596   0.18007   0.70307   0.53072   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65953 65953 SRR15700574 SRX11996468 SRS10003983 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RH2   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RH2 RH2 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RH2_1.fq.gz RH2_2.fq.gz fastq fastq 6779957400.0 45199716.0 RH2 1.fq.gz 0:150 1:150 A:1943750299;C:1436936087;G:1447253724;T:1952003667;N:13623 150 150     1943750299 1436936087 1447253724 1952003667 13623 SRX11996468 SRS10003983 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91806   0.17416   0.70364   0.53449   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65954 65954 SRR15700575 SRX11996467 SRS10003982 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RH1   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 40.0|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RH1 RH1 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RH1_1.fq.gz RH1_2.fq.gz fastq fastq 6803711400.0 45358076.0 RH1 1.fq.gz 0:150 1:150 A:1919109429;C:1472916047;G:1485344758;T:1926327627;N:13539 150 150     1919109429 1472916047 1485344758 1926327627 13539 SRX11996467 SRS10003982 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.92595   0.14064   0.71392   0.5508   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65955 65955 SRR15700576 SRX11996466 SRS10003981 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RL3   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RL3 RL3 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RL3_1.fq.gz RL3_2.fq.gz fastq fastq 6775779300.0 45171862.0 RL3 1.fq.gz 0:150 1:150 A:1977555439;C:1404514814;G:1412262159;T:1981432811;N:14077 150 150     1977555439 1404514814 1412262159 1981432811 14077 SRX11996466 SRS10003981 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91883   0.1833   0.71638   0.55343   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65956 65956 SRR15700577 SRX11996465 SRS10003979 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RL2   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RL2 RL2 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RL2_1.fq.gz RL2_2.fq.gz fastq fastq 6716301900.0 44775346.0 RL2 1.fq.gz 0:150 1:150 A:1959165761;C:1392977724;G:1400724963;T:1963418595;N:14857 150 150     1959165761 1392977724 1400724963 1963418595 14857 SRX11996465 SRS10003979 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.92114   0.18164   0.7217   0.55665   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65957 65957 SRR15700578 SRX11996464 SRS10003980 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   RL1   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 2.5|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain RL1 RL1 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     RL1_1.fq.gz RL1_2.fq.gz fastq fastq 6632905200.0 44219368.0 RL1 1.fq.gz 0:150 1:150 A:1930258593;C:1379056686;G:1391344096;T:1932223405;N:22420 150 150     1930258593 1379056686 1391344096 1932223405 22420 SRX11996464 SRS10003980 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91966   0.18087   0.72121   0.5664   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65958 65958 SRR15700579 SRX11996463 SRS10003978 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   R03   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 3|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain R03 R03 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     R03_1.fq.gz R03_2.fq.gz fastq fastq 6574600200.0 43830668.0 R03 1.fq.gz 0:150 1:150 A:1940343461;C:1342685356;G:1350150434;T:1941399481;N:21468 150 150     1940343461 1342685356 1350150434 1941399481 21468 SRX11996463 SRS10003978 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91867   0.19479   0.72707   0.57885   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65959 65959 SRR15700580 SRX11996462 SRS10003977 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 21 DAY RECOVERY   R02   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:control|SAMPLING TIME:END OF 21 DAY RECOVERY|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain R02 R02 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     R02_1.fq.gz R02_2.fq.gz fastq fastq 6399007800.0 42660052.0 R02 1.fq.gz 0:150 1:150 A:1884110766;C:1308008993;G:1315054545;T:1891764364;N:69132 150 150     1884110766 1308008993 1315054545 1891764364 69132 SRX11996462 SRS10003977 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91477   0.19859   0.72417   0.55394   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65960 65960 SRR15700581 SRX11996461 SRS10003976 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   E02   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain E02 E02 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     E02_1.fq.gz E02_2.fq.gz fastq fastq 6588207000.0 43921380.0 E02 1.fq.gz 0:150 1:150 A:1905685715;C:1379753621;G:1389708827;T:1913038146;N:20691 150 150     1905685715 1379753621 1389708827 1913038146 20691 SRX11996461 SRS10003976 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91596   0.18027   0.70903   0.54349   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System
65961 65961 SRR15700582 SRX11996460 SRS10003975 SRP335395 PRJNA759881 Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio PRJNA759881 Other Following exposure to Amitriptyline AMI for 7 days E7 zebrafish were transferred into AMI free water to recover for 21 days R21. Brain transcriptional profiles were investigated on E7 and R21.     END OF 7 DAY EXPOSURE   E01   strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:control|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal                 RNA Seq of Danio rerio: adult female brain E01 E01 a standardized procedure at the Beijing Genome Institute     RNA-Seq TRANSCRIPTOMIC Oligo-dT PAIRED BGISEQ BGISEQ-500   SRP335395     E01_1.fq.gz E01_2.fq.gz fastq fastq 6766213800.0 45108092.0 E01 1.fq.gz 0:150 1:150 A:1963125745;C:1410900205;G:1420069949;T:1972096961;N:20940 150 150     1963125745 1410900205 1420069949 1972096961 20940 SRX11996460 SRS10003975 SRA1288076 Jiangsu University|Institute of Environmental Health and Ecological S Jiangsu University 1 0.91884   0.18555   0.71585   0.5455   150   B   usable mapping rate bgi bgi unknown poly_a unknown bulk unknown unknown   China 2021-09-02 Adult Adult Brain Nervous System

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CREATE TABLE run_metadata("run.accession" VARCHAR, "experiment.accession" VARCHAR, "sample.accession" VARCHAR, "study.accession" VARCHAR, bioproject VARCHAR, "study.title" VARCHAR, "study.alias" VARCHAR, "study.type" VARCHAR, "study.abstract" VARCHAR, "study.attributes" VARCHAR, "study.PMIDs" VARCHAR, "sample.description" VARCHAR, "sample.title" VARCHAR, "sample.alias" VARCHAR, "sample.centername" VARCHAR, "sample.attributes" VARCHAR, "GEOsample.title" VARCHAR, "GEOsample.dataprocessing" VARCHAR, "GEOsample.source" VARCHAR, "GEOsample.treatmentprotocol" VARCHAR, "GEOsample.extractprotocol" VARCHAR, "GEOsample.growthprotocol" VARCHAR, "GEOsample.characteristics" VARCHAR, "GEOsample.accession" VARCHAR, "experiment.title" VARCHAR, "experiment.alias" VARCHAR, "experiment.library_name" VARCHAR, "experiment.design_description" VARCHAR, "experiment.library_construction_protocol" VARCHAR, "experiment.attributes" VARCHAR, "experiment.library_strategy" VARCHAR, "experiment.library_source" VARCHAR, "experiment.library_selection" VARCHAR, "experiment.library_layout" VARCHAR, "experiment.platform" VARCHAR, "experiment.instrument_model" VARCHAR, "experiment.spot_descriptor" VARCHAR, "experiment.study_ref" VARCHAR, "run.title" VARCHAR, "run.attributes" VARCHAR, "run.filename" VARCHAR, "run.semantic_name" VARCHAR, "run.total_bases" DOUBLE, "run.total_spots" DOUBLE, "run.alias" VARCHAR, "run.read_lengths" VARCHAR, "run.base_counts" VARCHAR, "run.r1_length" BIGINT, "run.r2_length" BIGINT, "run.r3_length" BIGINT, "run.r4_length" BIGINT, "run.Acount" BIGINT, "run.Ccount" BIGINT, "run.Gcount" BIGINT, "run.Tcount" BIGINT, "run.Ncount" BIGINT, "run.experiment" VARCHAR, "run.pool_member" VARCHAR, "submission.accession" VARCHAR, "submission.srasource" VARCHAR, "submission.bioprojectsource" VARCHAR, "seqdetective.n_mates" BIGINT, "seqdetective.mapping_rate.mate1" DOUBLE, "seqdetective.mapping_rate.mate2" DOUBLE, "seqdetective.nofeature_rate.mate1" DOUBLE, "seqdetective.nofeature_rate.mate2" DOUBLE, "seqdetective.sparsity.mate1" DOUBLE, "seqdetective.sparsity.mate2" DOUBLE, "seqdetective.pos_strand_rate.mate1" DOUBLE, "seqdetective.pos_strand_rate.mate2" DOUBLE, "seqdetective.readlen.mate1" BIGINT, "seqdetective.readlen.mate2" BIGINT, "seqdetective.judgement.mate1" VARCHAR, "seqdetective.judgement.mate2" VARCHAR, "seqdetective.judgement.reason" VARCHAR, platform_family VARCHAR, instrument_generation VARCHAR, read_bias VARCHAR, selection_class VARCHAR, prep_kit VARCHAR, sc_or_bulk VARCHAR, tech_class VARCHAR, technology VARCHAR, tech_variant VARCHAR, "submission.bioprojectsource.country" VARCHAR, earliest_date DATE, devstage_curation VARCHAR, devstage_curation_coarse VARCHAR, tissue_curation VARCHAR, tissue_curation_coarse VARCHAR);;
CREATE INDEX idx_run_bioproject ON run_metadata(bioproject);;
CREATE INDEX idx_run_run_accession ON run_metadata("run.accession");;