{"database": "metadata", "table": "run_metadata", "rows": [[67047, "SRR17017809", "SRX13207900", "SRS11133995", "SRP347444", "PRJNA782975", "Accumulation of Acetaldehyde in aldh2.1 /  Zebrafish Causes Increased Retinal Angiogenesis and Impaired Glucose Homeostasis", "GSE189416", "Transcriptome Analysis", "In conclusion  the data have identified acetaldehyde as the preferred substrate for Aldh2.1's detoxification ability. In zebrafish acetaldehyde induces impaired glucose metabolism by blocking gene expression of glucokinase and glucose 6 phosphatase. Moreover  Stress activated protein Kinases JNK and p38 MAPK were activated by elevated endogenous acetaldehyde leading to increased angiogenesis and vasodilatory effects in aldh2.1 /  zebrafish mutants. Overall design: Characterization of aldh2.1 knockout zebrafish mutants regarding effects on reactive metabolite detoxification  metabolomics  genomics and organ health   especially vascular health.", null, "pubmed:35114580", null, "Aldh 2.1 +/+ WT la5", "GSM5701228", null, "source name:whole larvae|developmental stage:larvae 120hpf|tissue:whole larvae|genotype:WT", "Aldh 2.1 +/+ WT la5", "trimmed with trim galore version 0.6.4. Parameters:   length 26   phred33 Get raw counts with kallisto quant version 0.4.6. TPM abundance estimates  generated with kallisto quant 0.4.6 Genome build: GRCz11 Supplementary files format and content: TPM abundance estimates and raw counts generated with kallisto.", "whole larvae", null, "Embryo / larvae samples were anaesthetized with 0.0003 % tricaine at 120 hpf  collected and snap frozen in liquid nitrogen in a clutch of 50. RNA libraries were prepared for sequencing using standard BGISeq 500 protocols", "Embryos / larvae were held and raised in egg water at 28.5 \u00b0C for 120 hours with no extra treatment.", "developmental stage:larvae 120hpf|tissue:whole larvae|genotype:WT", "GSM5701228", "GSM5701228: Aldh 2.1 +/+ WT la5; Danio rerio; RNA Seq", "GSM5701228 r1", "GSM5701228", "1", "Embryo / larvae samples were anaesthetized with 0.0003 % tricaine at 120 hpf  collected and snap frozen in liquid nitrogen in a clutch of 50. 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