{"database": "metadata", "table": "run_metadata", "is_view": false, "human_description_en": "where experiment.library_source = \"TRANSCRIPTOMIC\", experiment.platform = \"BGISEQ\" and tissue_curation_coarse = \"Nervous System\"", "rows": [[30691, "SRR28270998", "SRX23880961", "SRS20704477", "SRP494117", "PRJNA1085662", "Roxithromycin exposure induces motoneuron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells", "PRJNA1085662", "Other", "Roxithromycin ROX  a commonly used macrolide antibiotic  is extensively employed in human medicine and livestock industries. Due to its structural stability and resistance to biological degradation  ROX persists as a resilient environmental contaminant  detectable in aquatic ecosystems and food products. However  our understanding of the potential health risks to humans from continuous ROX exposure remains limited. In this study  we used the zebrafish as a vertebrate model to explore the potential developmental toxicity of early ROX exposure  particularly focusing on its effects on locomotor functionality and motoneuron development. Early exposure to ROX induces marked developmental toxicity in zebrafish embryos  significantly reducing hatch rates  body lengths  and increased malformation rates. Moreover  ROX exposure adversely affected the locomotive capacity of zebrafish embryos  and observations in transgenic zebrafish Tghb9:eGFP revealed axonal loss in motor neurons  evident through reduced or irregular axonal lengths. Concurrently  abnormal apoptosis in ROX exposed zebrafish embryos intensified alongside the upregulation of apoptosis related genes bax  bcl2  caspase 3a. Single cell sequencing further disclosed substantial effects of ROX on genes involved in the differentiation of motor neuron progenitor cells ngn1  olig2  axon development cd82a  mbpa  plp1b  sema5a  and neuroimmunity aplnrb  aplnra in zebrafish larvae. Furthermore  the motor neuron defects induced by ROX can be rescued by administering ngn1 agonist. In summary  ROX exposure leads to early life abnormalities in zebrafish motor neurons and locomotor behavior by hindering the differentiation of motor neuron progenitor cells and inducing abnormal apoptosis.", null, null, null, null, "WT", null, "strain:not provided|isolate:not provided|breed:not provided|cultivar:not provided|ecotype:not provided|age:not provided|dev stage:not provided|collection date:not provided|geo loc name:not provided|sex:not provided|tissue:Cerebrum|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Roxithromycin exposure induces mot1uron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells", "DANIO", "DANIO", "Illumina Second Generation Sequencing", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA_oligo_dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP494117", null, null, "WT_S1_L001_I1_001.fastq.gz", "fastq", 7991376264.0, 998922033.0, "WT S1 L001 I1 001.fastq.gz", "0:8", "A:2573734851;C:1426474966;G:1492966198;T:2498173074;N:27175", 8, null, null, null, 2573734851, 1426474966, 1492966198, 2498173074, 27175, "SRX23880961", "SRS20704477", "SRA1820072", "shantou university|Neurobiology Center", "shantou university", 1, 0.0, null, 0.0, null, 1.0, null, null, null, 8, null, "T", null, "under 1.2% mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "sc_generic", "single_cell_generic", "generic-scrnaseq-only", null, "China", "2024-03-11", "Undetermined", "Multi-stage", "Brain", "Nervous System"], [55972, "SRR10895875", "SRX7564604", "SRS6001805", "SRP241982", "PRJNA599026", "Project of basal ray finned fishes", "PRJNA599026", "Other", "The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish  their body structure and behavior remain highly similar to that of the tetrapods. 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Although they belong to fish  their body structure and behavior remain highly similar to that of the tetrapods. 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Although they belong to fish  their body structure and behavior remain highly similar to that of the tetrapods. 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Although they belong to fish  their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates  we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.", null, "pubmed:33545088;pubmed:12470943", null, null, "Zebrafish 009", null, "strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Spinal cord|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : adult", "CL100103178 L01 6", "CL100103178 L01 6", null, null, null, "RNA-Seq", "TRANSCRIPTOMIC", "RANDOM", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP241982", null, null, "CL100103178_L01_564_1.fq.gz CL100103178_L01_564_2.fq.gz", "fastq fastq", 7468499200.0, 74684992.0, "CL100103178 L01 564 1.fq.gz", "0:100 1:100", "A:2052720985;C:1649448011;G:1690698471;T:2068073830;N:7557903", 100, 100, null, null, 2052720985, 1649448011, 1690698471, 2068073830, 7557903, "SRX7564601", "SRS6001805", "SRA1026516", "BGI|BGI-Research", "BGI", 1, 0.90905, null, 0.10883, null, 0.69578, null, 0.54193, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-01-15", "Adult", "Adult", "Spinal Cord", "Nervous System"], [55976, "SRR10895881", "SRX7564598", "SRS6001805", "SRP241982", "PRJNA599026", "Project of basal ray finned fishes", "PRJNA599026", "Other", "The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish  their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates  we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.", null, "pubmed:33545088;pubmed:12470943", null, null, "Zebrafish 009", null, "strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Spinal cord|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : adult", "CL100103178 L01 5", "CL100103178 L01 5", null, null, null, "RNA-Seq", "TRANSCRIPTOMIC", "RANDOM", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP241982", null, null, "CL100103178_L01_561_1.fq.gz CL100103178_L01_561_2.fq.gz", "fastq fastq", 9173572800.0, 91735728.0, "CL100103178 L01 561 1.fq.gz", "0:100 1:100", "A:2527132650;C:2020739240;G:2066720461;T:2548747865;N:10232584", 100, 100, null, null, 2527132650, 2020739240, 2066720461, 2548747865, 10232584, "SRX7564598", "SRS6001805", "SRA1026516", "BGI|BGI-Research", "BGI", 1, 0.91539, null, 0.11063, null, 0.71427, null, 0.48162, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-01-15", "Adult", "Adult", "Spinal Cord", "Nervous System"], [55992, "SRR10895898", "SRX7564581", "SRS6001800", "SRP241982", "PRJNA599026", "Project of basal ray finned fishes", "PRJNA599026", "Other", "The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish  their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates  we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.", null, "pubmed:33545088;pubmed:12470943", null, null, "Zebrafish 005", null, "strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : adult", "CL100103858 L01 10", "CL100103858 L01 10", null, null, null, "RNA-Seq", "TRANSCRIPTOMIC", "RANDOM", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP241982", null, null, "CL100103858_L01_513_1.fq.gz CL100103858_L01_513_2.fq.gz", "fastq fastq", 9129585000.0, 91295850.0, "CL100103858 L01 513 1.fq.gz", "0:100 1:100", "A:2497450580;C:2015129450;G:2071393661;T:2529809771;N:15801538", 100, 100, null, null, 2497450580, 2015129450, 2071393661, 2529809771, 15801538, "SRX7564581", "SRS6001800", "SRA1026516", "BGI|BGI-Research", "BGI", 1, 0.93396, null, 0.13, null, 0.71431, null, 0.54518, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-01-15", "Adult", "Adult", "Brain", "Nervous System"], [55993, "SRR10895899", "SRX7564580", "SRS6001800", "SRP241982", "PRJNA599026", "Project of basal ray finned fishes", "PRJNA599026", "Other", "The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish  their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates  we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.", null, "pubmed:33545088;pubmed:12470943", null, null, "Zebrafish 005", null, "strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : adult", "CL100103858 L01 9", "CL100103858 L01 9", null, null, null, "RNA-Seq", "TRANSCRIPTOMIC", "RANDOM", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP241982", null, null, "CL100103858_L01_509_2.fq.gz CL100103858_L01_509_1.fq.gz", "fastq fastq", 9063446600.0, 90634466.0, "CL100103858 L01 509 1.fq.gz", "0:100 1:100", "A:2470522817;C:2005905195;G:2066552125;T:2504876588;N:15589875", 100, 100, null, null, 2470522817, 2005905195, 2066552125, 2504876588, 15589875, "SRX7564580", "SRS6001800", "SRA1026516", "BGI|BGI-Research", "BGI", 1, 0.9334, null, 0.13676, null, 0.71614, null, 0.54289, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-01-15", "Adult", "Adult", "Brain", "Nervous System"], [55994, "SRR10895900", "SRX7564579", "SRS6001800", "SRP241982", "PRJNA599026", "Project of basal ray finned fishes", "PRJNA599026", "Other", "The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish  their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates  we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.", null, "pubmed:33545088;pubmed:12470943", null, null, "Zebrafish 005", null, "strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : adult", "CL100103858 L01 8", "CL100103858 L01 8", null, null, null, "RNA-Seq", "TRANSCRIPTOMIC", "RANDOM", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP241982", null, null, "CL100103858_L01_510_1.fq.gz CL100103858_L01_510_2.fq.gz", "fastq fastq", 10414313800.0, 104143138.0, "CL100103858 L01 510 1.fq.gz", "0:100 1:100", "A:2858166440;C:2289999240;G:2356174514;T:2892047112;N:17926494", 100, 100, null, null, 2858166440, 2289999240, 2356174514, 2892047112, 17926494, "SRX7564579", "SRS6001800", "SRA1026516", "BGI|BGI-Research", "BGI", 1, 0.93036, null, 0.13448, null, 0.71045, null, 0.53846, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-01-15", "Adult", "Adult", "Brain", "Nervous System"], [55995, "SRR10895901", "SRX7564578", "SRS6001800", "SRP241982", "PRJNA599026", "Project of basal ray finned fishes", "PRJNA599026", "Other", "The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish  their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates  we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.", null, "pubmed:33545088;pubmed:12470943", null, null, "Zebrafish 005", null, "strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : adult", "CL100103858 L01 7", "CL100103858 L01 7", null, null, null, "RNA-Seq", "TRANSCRIPTOMIC", "RANDOM", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP241982", null, null, "CL100103858_L01_511_2.fq.gz CL100103858_L01_511_1.fq.gz", "fastq fastq", 10057553400.0, 100575534.0, "CL100103858 L01 511 1.fq.gz", "0:100 1:100", "A:2762495630;C:2212266487;G:2274060113;T:2791456239;N:17274931", 100, 100, null, null, 2762495630, 2212266487, 2274060113, 2791456239, 17274931, "SRX7564578", "SRS6001800", "SRA1026516", "BGI|BGI-Research", "BGI", 1, 0.93578, null, 0.11695, null, 0.72005, null, 0.51093, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-01-15", "Adult", "Adult", "Brain", "Nervous System"], [55996, "SRR10895903", "SRX7564576", "SRS6001800", "SRP241982", "PRJNA599026", "Project of basal ray finned fishes", "PRJNA599026", "Other", "The project is to study the oldest fish lineages in the ray finned fishes. Although they belong to fish  their body structure and behavior remain highly similar to that of the tetrapods. Through comparative genome analysis with living vertebrates  we provides insights into the molecular basis of terrestrial adaptation of basal ray finned fishes.", null, "pubmed:33545088;pubmed:12470943", null, null, "Zebrafish 005", null, "strain:not collected|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:not collected|dev stage:Adult|sex:not determined|tissue:Brain|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : adult", "CL100103858 L01 6", "CL100103858 L01 6", null, null, null, "RNA-Seq", "TRANSCRIPTOMIC", "RANDOM", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP241982", null, null, "CL100103858_L01_512_1.fq.gz CL100103858_L01_512_2.fq.gz", "fastq fastq", 8575207600.0, 85752076.0, "CL100103858 L01 512 1.fq.gz", "0:100 1:100", "A:2340755177;C:1898089765;G:1951995517;T:2369794410;N:14572731", 100, 100, null, null, 2340755177, 1898089765, 1951995517, 2369794410, 14572731, "SRX7564576", "SRS6001800", "SRA1026516", "BGI|BGI-Research", "BGI", 1, 0.93429, null, 0.12481, null, 0.71384, null, 0.52278, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-01-15", "Adult", "Adult", "Brain", "Nervous System"], [57271, "SRR12577970", "SRX9064853", "SRS7314026", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ctrl 3 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 6'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ctrl 3 zebrafish", "Ctrl 3 zebrafish", "Ctrl 3 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ctrl_3_1.fq.gz", "fastq", 1061227250.0, 21224545.0, "Ctrl 3 1.fq.gz", "0:50", "A:286099732;C:241244619;G:246876865;T:287006034;N:0", 50, null, null, null, 286099732, 241244619, 246876865, 287006034, 0, "SRX9064853", "SRS7314026", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94563, null, 0.10453, null, 0.70552, null, 0.46655, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57272, "SRR12577971", "SRX9064852", "SRS7314025", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ctrl 2 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 5 prime|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ctrl 2 zebrafish", "Ctrl 2 zebrafish", "Ctrl 2 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ctrl_2_1.fq.gz", "fastq", 1058116700.0, 21162334.0, "Ctrl 2 1.fq.gz", "0:50", "A:287223905;C:238707750;G:244987559;T:287197486;N:0", 50, null, null, null, 287223905, 238707750, 244987559, 287197486, 0, "SRX9064852", "SRS7314025", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94534, null, 0.11174, null, 0.70104, null, 0.47946, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57273, "SRR12577972", "SRX9064851", "SRS7314024", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ctrl 1 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 4'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ctrl 1 zebrafish", "Ctrl 1 zebrafish", "Ctrl 1 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ctrl_1_1.fq.gz", "fastq", 1065919600.0, 21318392.0, "Ctrl 1 1.fq.gz", "0:50", "A:295920720;C:242146677;G:242962633;T:284889570;N:0", 50, null, null, null, 295920720, 242146677, 242962633, 284889570, 0, "SRX9064851", "SRS7314024", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94228, null, 0.15007, null, 0.68028, null, 0.46845, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57274, "SRR12577973", "SRX9064850", "SRS7314023", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator STS 3 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 3 prime|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator STS 3 zebrafish", "Ator STS 3 zebrafish", "Ator STS 3 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_STS_3_1.fq.gz", "fastq", 1059717350.0, 21194347.0, "Ator STS 3 1.fq.gz", "0:50", "A:287279590;C:239708340;G:245740313;T:286989107;N:0", 50, null, null, null, 287279590, 239708340, 245740313, 286989107, 0, "SRX9064850", "SRS7314023", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94345, null, 0.10458, null, 0.69686, null, 0.4755, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57275, "SRR12577974", "SRX9064849", "SRS7314022", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator STS 2 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 2'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator STS 2 zebrafish", "Ator STS 2 zebrafish", "Ator STS 2 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_STS_2_1.fq.gz", "fastq", 1057950250.0, 21159005.0, "Ator STS 2 1.fq.gz", "0:50", "A:286256354;C:238832868;G:244078781;T:288782247;N:0", 50, null, null, null, 286256354, 238832868, 244078781, 288782247, 0, "SRX9064849", "SRS7314022", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94307, null, 0.10974, null, 0.69631, null, 0.4703, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57276, "SRR12577975", "SRX9064848", "SRS7314021", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator STS 1 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 1'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator STS 1 zebrafish", "Ator STS 1 zebrafish", "Ator STS 1 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_STS_1_1.fq.gz", "fastq", 1070136700.0, 21402734.0, "Ator STS 1 1.fq.gz", "0:50", "A:297601042;C:243837062;G:243583907;T:285114689;N:0", 50, null, null, null, 297601042, 243837062, 243583907, 285114689, 0, "SRX9064848", "SRS7314021", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94665, null, 0.12219, null, 0.67953, null, 0.46393, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57277, "SRR12577976", "SRX9064847", "SRS7314020", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator 3 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 3 prime|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator 3 zebrafish", "Ator 3 zebrafish", "Ator 3 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_3_1.fq.gz", "fastq", 1058031900.0, 21160638.0, "Ator 3 1.fq.gz", "0:50", "A:285399527;C:239993172;G:245571467;T:287067734;N:0", 50, null, null, null, 285399527, 239993172, 245571467, 287067734, 0, "SRX9064847", "SRS7314020", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94536, null, 0.11052, null, 0.6957, null, 0.48195, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57278, "SRR12577977", "SRX9064846", "SRS7314019", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator 2 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 2'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator 2 zebrafish", "Ator 2 zebrafish", "Ator 2 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_2_1.fq.gz", "fastq", 1059618400.0, 21192368.0, "Ator 2 1.fq.gz", "0:50", "A:283429136;C:243023053;G:248904818;T:284261393;N:0", 50, null, null, null, 283429136, 243023053, 248904818, 284261393, 0, "SRX9064846", "SRS7314019", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94743, null, 0.09493, null, 0.70218, null, 0.475, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57279, "SRR12577978", "SRX9064845", "SRS7314018", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator 1 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 1'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator 1 zebrafish", "Ator 1 zebrafish", "Ator 1 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_1_1.fq.gz", "fastq", 1075695950.0, 21513919.0, "Ator 1 1.fq.gz", "0:50", "A:297768036;C:244470267;G:243768925;T:289688722;N:0", 50, null, null, null, 297768036, 244470267, 243768925, 289688722, 0, "SRX9064845", "SRS7314018", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94468, null, 0.13183, null, 0.68363, null, 0.46288, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [60203, "SRR12173066", "SRX8687829", "SRS6966493", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "100B", "GSM4661929", null, "source name:SCA12|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male", "100B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA12", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M", "GSM4661929", "GSM4661929: 100B; Danio rerio; RNA Seq", "GSM4661929", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661929", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "100B_2.fq 100B_1.fq", "fastq fastq", 4300755000.0, 43007550.0, "GSM4661929 r1", "0:100 1:100", "A:1195013481;C:933832983;G:962461499;T:1209447037;N:0", 100, 100, null, null, 1195013481, 933832983, 962461499, 1209447037, 0, "SRX8687829", "SRS6966493", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91912, null, 0.15522, null, 0.71829, null, 0.50865, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60204, "SRR12173065", "SRX8687828", "SRS6966492", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "99B", "GSM4661928", null, "source name:SCA10|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male", "99B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA10", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M", "GSM4661928", "GSM4661928: 99B; Danio rerio; RNA Seq", "GSM4661928", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661928", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "99B_2.fq 99B_1.fq", "fastq fastq", 4953251000.0, 49532510.0, "GSM4661928 r1", "0:100 1:100", "A:1415039103;C:1040525484;G:1060332314;T:1437354099;N:0", 100, 100, null, null, 1415039103, 1040525484, 1060332314, 1437354099, 0, "SRX8687828", "SRS6966492", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91619, null, 0.16544, null, 0.71922, null, 0.51996, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60205, "SRR12173064", "SRX8687827", "SRS6966491", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "121B", "GSM4661927", null, "source name:SCA14|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male", "121B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA14", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M", "GSM4661927", "GSM4661927: 121B; Danio rerio; RNA Seq", "GSM4661927", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661927", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "121B_1.fq 121B_2.fq", "fastq fastq", 4482694600.0, 44826946.0, "GSM4661927 r1", "0:100 1:100", "A:1292365837;C:920169200;G:950296696;T:1319862867;N:0", 100, 100, null, null, 1292365837, 920169200, 950296696, 1319862867, 0, "SRX8687827", "SRS6966491", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90277, null, 0.17799, null, 0.72295, null, 0.51987, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60206, "SRR12173063", "SRX8687826", "SRS6966490", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "97B", "GSM4661926", null, "source name:SCA5|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male", "97B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA5", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M", "GSM4661926", "GSM4661926: 97B; Danio rerio; RNA Seq", "GSM4661926", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661926", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "97B_1.fq 97B_2.fq", "fastq fastq", 5178357000.0, 51783570.0, "GSM4661926 r1", "0:100 1:100", "A:1442148425;C:1119935128;G:1149243236;T:1467030211;N:0", 100, 100, null, null, 1442148425, 1119935128, 1149243236, 1467030211, 0, "SRX8687826", "SRS6966490", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91869, null, 0.1619, null, 0.71047, null, 0.50907, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60207, "SRR12173062", "SRX8687825", "SRS6966489", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "80B", "GSM4661925", null, "source name:SCA8|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female", "80B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA8", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F", "GSM4661925", "GSM4661925: 80B; Danio rerio; RNA Seq", "GSM4661925", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661925", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "80B_1.fq 80B_2.fq", "fastq fastq", 4927736800.0, 49277368.0, "GSM4661925 r1", "0:100 1:100", "A:1384189069;C:1048151377;G:1079300714;T:1416095640;N:0", 100, 100, null, null, 1384189069, 1048151377, 1079300714, 1416095640, 0, "SRX8687825", "SRS6966489", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.9104, null, 0.17333, null, 0.71102, null, 0.50853, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60208, "SRR12173061", "SRX8687824", "SRS6966488", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "79B", "GSM4661924", null, "source name:SCA7|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female", "79B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA7", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F", "GSM4661924", "GSM4661924: 79B; Danio rerio; RNA Seq", "GSM4661924", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661924", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "79B_1.fq 79B_2.fq", "fastq fastq", 5158717400.0, 51587174.0, "GSM4661924 r1", "0:100 1:100", "A:1423369091;C:1127803059;G:1156903341;T:1450641909;N:0", 100, 100, null, null, 1423369091, 1127803059, 1156903341, 1450641909, 0, "SRX8687824", "SRS6966488", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91578, null, 0.15498, null, 0.70841, null, 0.50875, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60209, "SRR12173060", "SRX8687823", "SRS6966487", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "78B", "GSM4661923", null, "source name:SCA6|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female", "78B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA6", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F", "GSM4661923", "GSM4661923: 78B; Danio rerio; RNA Seq", "GSM4661923", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661923", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "78B_2.fq 78B_1.fq", "fastq fastq", 4080284000.0, 40802840.0, "GSM4661923 r1", "0:100 1:100", "A:1146760011;C:872005355;G:893480498;T:1168038136;N:0", 100, 100, null, null, 1146760011, 872005355, 893480498, 1168038136, 0, "SRX8687823", "SRS6966487", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.89506, null, 0.16061, null, 0.7147, null, 0.51109, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60210, "SRR12173059", "SRX8687822", "SRS6966486", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "77B", "GSM4661922", null, "source name:SCA4|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female", "77B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA4", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F", "GSM4661922", "GSM4661922: 77B; Danio rerio; RNA Seq", "GSM4661922", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661922", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "77B_1.fq 77B_2.fq", "fastq fastq", 5053965200.0, 50539652.0, "GSM4661922 r1", "0:100 1:100", "A:1432899891;C:1065155546;G:1092749323;T:1463160440;N:0", 100, 100, null, null, 1432899891, 1065155546, 1092749323, 1463160440, 0, "SRX8687822", "SRS6966486", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90965, null, 0.17028, null, 0.71259, null, 0.51804, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60211, "SRR12173058", "SRX8687821", "SRS6966485", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "95B", "GSM4661921", null, "source name:PH8|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male", "95B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH8", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M", "GSM4661921", "GSM4661921: 95B; Danio rerio; RNA Seq", "GSM4661921", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661921", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "95B_2.fq 95B_1.fq", "fastq fastq", 4984910800.0, 49849108.0, "GSM4661921 r1", "0:100 1:100", "A:1404088729;C:1063272664;G:1094657988;T:1422891419;N:0", 100, 100, null, null, 1404088729, 1063272664, 1094657988, 1422891419, 0, "SRX8687821", "SRS6966485", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91574, null, 0.16729, null, 0.71776, null, 0.51526, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60212, "SRR12173057", "SRX8687820", "SRS6966484", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "94B", "GSM4661920", null, "source name:PH7|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male", "94B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH7", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M", "GSM4661920", "GSM4661920: 94B; Danio rerio; RNA Seq", "GSM4661920", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661920", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "94B_2.fq 94B_1.fq", "fastq fastq", 4973104000.0, 49731040.0, "GSM4661920 r1", "0:100 1:100", "A:1403074698;C:1055981307;G:1089110444;T:1424937551;N:0", 100, 100, null, null, 1403074698, 1055981307, 1089110444, 1424937551, 0, "SRX8687820", "SRS6966484", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91432, null, 0.16183, null, 0.72001, null, 0.51323, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60213, "SRR12173056", "SRX8687819", "SRS6966483", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "93B", "GSM4661919", null, "source name:PH6|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male", "93B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH6", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M", "GSM4661919", "GSM4661919: 93B; Danio rerio; RNA Seq", "GSM4661919", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661919", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "93B_2.fq 93B_1.fq", "fastq fastq", 4896774400.0, 48967744.0, "GSM4661919 r1", "0:100 1:100", "A:1403923710;C:1011507726;G:1048273729;T:1433069235;N:0", 100, 100, null, null, 1403923710, 1011507726, 1048273729, 1433069235, 0, "SRX8687819", "SRS6966483", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91124, null, 0.1598, null, 0.72247, null, 0.54532, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60214, "SRR12173055", "SRX8687818", "SRS6966482", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "92B", "GSM4661918", null, "source name:PH4|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:male", "92B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH4", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:M", "GSM4661918", "GSM4661918: 92B; Danio rerio; RNA Seq", "GSM4661918", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661918", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "92B_1.fq 92B_2.fq", "fastq fastq", 5153962600.0, 51539626.0, "GSM4661918 r1", "0:100 1:100", "A:1429538166;C:1118723084;G:1151444792;T:1454256558;N:0", 100, 100, null, null, 1429538166, 1118723084, 1151444792, 1454256558, 0, "SRX8687818", "SRS6966482", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91817, null, 0.15904, null, 0.71088, null, 0.51009, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60215, "SRR12173054", "SRX8687817", "SRS6966481", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "75B", "GSM4661917", null, "source name:PH10|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female", "75B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH10", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F", "GSM4661917", "GSM4661917: 75B; Danio rerio; RNA Seq", "GSM4661917", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661917", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "75B_1.fq 75B_2.fq", "fastq fastq", 4868261600.0, 48682616.0, "GSM4661917 r1", "0:100 1:100", "A:1376009816;C:1028298503;G:1057930129;T:1406023152;N:0", 100, 100, null, null, 1376009816, 1028298503, 1057930129, 1406023152, 0, "SRX8687817", "SRS6966481", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.9126, null, 0.1697, null, 0.71638, null, 0.50591, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60216, "SRR12173053", "SRX8687816", "SRS6966480", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "74B", "GSM4661916", null, "source name:PH9|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female", "74B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH9", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F", "GSM4661916", "GSM4661916: 74B; Danio rerio; RNA Seq", "GSM4661916", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661916", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "74B_1.fq 74B_2.fq", "fastq fastq", 5179173200.0, 51791732.0, "GSM4661916 r1", "0:100 1:100", "A:1449133916;C:1117631254;G:1139937410;T:1472470620;N:0", 100, 100, null, null, 1449133916, 1117631254, 1139937410, 1472470620, 0, "SRX8687816", "SRS6966480", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91222, null, 0.16046, null, 0.71029, null, 0.50076, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60217, "SRR12173052", "SRX8687815", "SRS6966479", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "72B", "GSM4661915", null, "source name:PH2|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female", "72B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH2", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F", "GSM4661915", "GSM4661915: 72B; Danio rerio; RNA Seq", "GSM4661915", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661915", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "72B_1.fq 72B_2.fq", "fastq fastq", 5878512600.0, 58785126.0, "GSM4661915 r1", "0:100 1:100", "A:1639773073;C:1271766251;G:1298391071;T:1668582205;N:0", 100, 100, null, null, 1639773073, 1271766251, 1298391071, 1668582205, 0, "SRX8687815", "SRS6966479", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91084, null, 0.16615, null, 0.70713, null, 0.5033, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60218, "SRR12173051", "SRX8687814", "SRS6966478", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "71B", "GSM4661914", null, "source name:PH1|tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:female", "71B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH1", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F1|Sex:F", "GSM4661914", "GSM4661914: 71B; Danio rerio; RNA Seq", "GSM4661914", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661914", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "71B_1.fq 71B_2.fq", "fastq fastq", 2921419400.0, 29214194.0, "GSM4661914 r1", "0:100 1:100", "A:838032642;C:606973028;G:618918524;T:857495206;N:0", 100, 100, null, null, 838032642, 606973028, 618918524, 857495206, 0, "SRX8687814", "SRS6966478", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90765, null, 0.17712, null, 0.71015, null, 0.48691, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60219, "SRR12173050", "SRX8687813", "SRS6966477", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "173B", "GSM4661913", null, "source name:SCA10|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male", "173B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA10", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M", "GSM4661913", "GSM4661913: 173B; Danio rerio; RNA Seq", "GSM4661913", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661913", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB44-68_1.fq.gz V300016697_L3_DKRT190808OligoTB44-68_2.fq.gz", "fastq fastq", 4933950400.0, 49339504.0, "GSM4661913 r1", "0:100 1:100", "A:1477278267;C:971417805;G:982397108;T:1502857220;N:0", 100, 100, null, null, 1477278267, 971417805, 982397108, 1502857220, 0, "SRX8687813", "SRS6966477", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90094, null, 0.26419, null, 0.73066, null, 0.51886, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60220, "SRR12173049", "SRX8687812", "SRS6966476", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "172B", "GSM4661912", null, "source name:SCA7|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male", "172B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA7", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M", "GSM4661912", "GSM4661912: 172B; Danio rerio; RNA Seq", "GSM4661912", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661912", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB43-67_1.fq.gz V300016697_L3_DKRT190808OligoTB43-67_2.fq.gz", "fastq fastq", 4916317800.0, 49163178.0, "GSM4661912 r1", "0:100 1:100", "A:1456100891;C:983643530;G:996293468;T:1480279911;N:0", 100, 100, null, null, 1456100891, 983643530, 996293468, 1480279911, 0, "SRX8687812", "SRS6966476", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90484, null, 0.24497, null, 0.72563, null, 0.51605, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60221, "SRR12173048", "SRX8687811", "SRS6966475", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "171B", "GSM4661911", null, "source name:SCA5|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male", "171B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA5", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M", "GSM4661911", "GSM4661911: 171B; Danio rerio; RNA Seq", "GSM4661911", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661911", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB42-66_1.fq.gz V300016697_L3_DKRT190808OligoTB42-66_2.fq.gz", "fastq fastq", 4935261800.0, 49352618.0, "GSM4661911 r1", "0:100 1:100", "A:1445056643;C:1003559733;G:1015728708;T:1470916716;N:0", 100, 100, null, null, 1445056643, 1003559733, 1015728708, 1470916716, 0, "SRX8687811", "SRS6966475", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90817, null, 0.23047, null, 0.72086, null, 0.5134, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60222, "SRR12173047", "SRX8687810", "SRS6966474", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "170B", "GSM4661910", null, "source name:SCA3|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male", "170B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA3", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M", "GSM4661910", "GSM4661910: 170B; Danio rerio; RNA Seq", "GSM4661910", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661910", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB41-65_1.fq.gz V300016697_L3_DKRT190808OligoTB41-65_2.fq.gz", "fastq fastq", 4925193600.0, 49251936.0, "GSM4661910 r1", "0:100 1:100", "A:1463488890;C:982336799;G:993110731;T:1486257180;N:0", 100, 100, null, null, 1463488890, 982336799, 993110731, 1486257180, 0, "SRX8687810", "SRS6966474", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90727, null, 0.24322, null, 0.72659, null, 0.52026, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60223, "SRR12173046", "SRX8687809", "SRS6966473", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "168B", "GSM4661909", null, "source name:SCA9|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female", "168B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA9", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F", "GSM4661909", "GSM4661909: 168B; Danio rerio; RNA Seq", "GSM4661909", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661909", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB40-64_1.fq.gz V300016697_L3_DKRT190808OligoTB40-64_2.fq.gz", "fastq fastq", 4921204600.0, 49212046.0, "GSM4661909 r1", "0:100 1:100", "A:1472696868;C:970527278;G:980479163;T:1497501291;N:0", 100, 100, null, null, 1472696868, 970527278, 980479163, 1497501291, 0, "SRX8687809", "SRS6966473", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.89853, null, 0.26909, null, 0.72934, null, 0.50679, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60224, "SRR12173045", "SRX8687808", "SRS6966472", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "167B", "GSM4661908", null, "source name:SCA8|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female", "167B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA8", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F", "GSM4661908", "GSM4661908: 167B; Danio rerio; RNA Seq", "GSM4661908", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661908", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB39-63_1.fq.gz V300016697_L3_DKRT190808OligoTB39-63_2.fq.gz", "fastq fastq", 4929648000.0, 49296480.0, "GSM4661908 r1", "0:100 1:100", "A:1444571687;C:1001131050;G:1014059660;T:1469885603;N:0", 100, 100, null, null, 1444571687, 1001131050, 1014059660, 1469885603, 0, "SRX8687808", "SRS6966472", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90469, null, 0.23511, null, 0.71644, null, 0.50939, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60225, "SRR12173044", "SRX8687807", "SRS6966471", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "166B", "GSM4661907", null, "source name:SCA6|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female", "166B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA6", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F", "GSM4661907", "GSM4661907: 166B; Danio rerio; RNA Seq", "GSM4661907", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661907", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB38-62_1.fq.gz V300016697_L3_DKRT190808OligoTB38-62_2.fq.gz", "fastq fastq", 4934480200.0, 49344802.0, "GSM4661907 r1", "0:100 1:100", "A:1465270023;C:983677716;G:995361912;T:1490170549;N:0", 100, 100, null, null, 1465270023, 983677716, 995361912, 1490170549, 0, "SRX8687807", "SRS6966471", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.89941, null, 0.25615, null, 0.72127, null, 0.50512, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60226, "SRR12173043", "SRX8687806", "SRS6966470", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "165B", "GSM4661906", null, "source name:SCA4|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female", "165B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA4", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F", "GSM4661906", "GSM4661906: 165B; Danio rerio; RNA Seq", "GSM4661906", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661906", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB37-61_1.fq.gz V300016697_L3_DKRT190808OligoTB37-61_2.fq.gz", "fastq fastq", 4919775200.0, 49197752.0, "GSM4661906 r1", "0:100 1:100", "A:1439207243;C:1003073787;G:1015357028;T:1462137142;N:0", 100, 100, null, null, 1439207243, 1003073787, 1015357028, 1462137142, 0, "SRX8687806", "SRS6966470", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90664, null, 0.23232, null, 0.71652, null, 0.49875, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60227, "SRR12173042", "SRX8687805", "SRS6966469", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "163B", "GSM4661905", null, "source name:PH9|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male", "163B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH9", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M", "GSM4661905", "GSM4661905: 163B; Danio rerio; RNA Seq", "GSM4661905", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661905", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB36-60_1.fq.gz V300016697_L3_DKRT190808OligoTB36-60_2.fq.gz", "fastq fastq", 4916788400.0, 49167884.0, "GSM4661905 r1", "0:100 1:100", "A:1450695371;C:989044062;G:1001626000;T:1475422967;N:0", 100, 100, null, null, 1450695371, 989044062, 1001626000, 1475422967, 0, "SRX8687805", "SRS6966469", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90357, null, 0.24123, null, 0.72023, null, 0.50955, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60228, "SRR12173041", "SRX8687804", "SRS6966468", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "161B", "GSM4661904", null, "source name:PH6|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male", "161B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH6", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M", "GSM4661904", "GSM4661904: 161B; Danio rerio; RNA Seq", "GSM4661904", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661904", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB35-59_1.fq.gz V300016697_L3_DKRT190808OligoTB35-59_2.fq.gz", "fastq fastq", 4926157600.0, 49261576.0, "GSM4661904 r1", "0:100 1:100", "A:1467853995;C:977298660;G:990198306;T:1490806639;N:0", 100, 100, null, null, 1467853995, 977298660, 990198306, 1490806639, 0, "SRX8687804", "SRS6966468", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.9013, null, 0.25482, null, 0.72912, null, 0.51654, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60229, "SRR12173040", "SRX8687803", "SRS6966467", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "160B", "GSM4661903", null, "source name:PH12|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male", "160B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH12", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M", "GSM4661903", "GSM4661903: 160B; Danio rerio; RNA Seq", "GSM4661903", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661903", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB34-58_1.fq.gz V300016697_L3_DKRT190808OligoTB34-58_2.fq.gz", "fastq fastq", 4937891400.0, 49378914.0, "GSM4661903 r1", "0:100 1:100", "A:1466862905;C:983988502;G:997702772;T:1489337221;N:0", 100, 100, null, null, 1466862905, 983988502, 997702772, 1489337221, 0, "SRX8687803", "SRS6966467", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.8994, null, 0.2581, null, 0.72906, null, 0.51649, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60230, "SRR12173039", "SRX8687802", "SRS6966466", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "159B", "GSM4661902", null, "source name:PH11|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:male", "159B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH11", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:M", "GSM4661902", "GSM4661902: 159B; Danio rerio; RNA Seq", "GSM4661902", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661902", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB33-57_1.fq.gz V300016697_L3_DKRT190808OligoTB33-57_2.fq.gz", "fastq fastq", 4912693200.0, 49126932.0, "GSM4661902 r1", "0:100 1:100", "A:1466260254;C:970920251;G:984105331;T:1491407364;N:0", 100, 100, null, null, 1466260254, 970920251, 984105331, 1491407364, 0, "SRX8687802", "SRS6966466", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90041, null, 0.25314, null, 0.73381, null, 0.53543, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60231, "SRR12173038", "SRX8687801", "SRS6966465", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "158B", "GSM4661901", null, "source name:PH16|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female", "158B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH16", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F", "GSM4661901", "GSM4661901: 158B; Danio rerio; RNA Seq", "GSM4661901", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661901", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB32-56_1.fq.gz V300016697_L3_DKRT190808OligoTB32-56_2.fq.gz", "fastq fastq", 4945853000.0, 49458530.0, "GSM4661901 r1", "0:100 1:100", "A:1483522148;C:971739399;G:982030279;T:1508561174;N:0", 100, 100, null, null, 1483522148, 971739399, 982030279, 1508561174, 0, "SRX8687801", "SRS6966465", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.89835, null, 0.26809, null, 0.73036, null, 0.51167, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60232, "SRR12173037", "SRX8687800", "SRS6966464", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "157B", "GSM4661900", null, "source name:PH5|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female", "157B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH5", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F", "GSM4661900", "GSM4661900: 157B; Danio rerio; RNA Seq", "GSM4661900", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661900", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L3_DKRT190808OligoTB31-55_2.fq.gz V300016697_L3_DKRT190808OligoTB31-55_1.fq.gz", "fastq fastq", 4930661000.0, 49306610.0, "GSM4661900 r1", "0:100 1:100", "A:1479111656;C:968782080;G:980526976;T:1502240288;N:0", 100, 100, null, null, 1479111656, 968782080, 980526976, 1502240288, 0, "SRX8687800", "SRS6966464", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.8997, null, 0.26769, null, 0.72894, null, 0.52069, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60233, "SRR12173036", "SRX8687799", "SRS6966463", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "156B", "GSM4661899", null, "source name:PH4|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female", "156B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH4", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F", "GSM4661899", "GSM4661899: 156B; Danio rerio; RNA Seq", "GSM4661899", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661899", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L2_DKRT190808OligoTB30-54_1.fq.gz V300016697_L2_DKRT190808OligoTB30-54_2.fq.gz", "fastq fastq", 5008041200.0, 50080412.0, "GSM4661899 r1", "0:100 1:100", "A:1499313897;C:986298102;G:997520882;T:1524908319;N:0", 100, 100, null, null, 1499313897, 986298102, 997520882, 1524908319, 0, "SRX8687799", "SRS6966463", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.89791, null, 0.26891, null, 0.72782, null, 0.50905, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60234, "SRR12173035", "SRX8687798", "SRS6966462", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "155B", "GSM4661898", null, "source name:PH3|tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:female", "155B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH3", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F2|Sex:F", "GSM4661898", "GSM4661898: 155B; Danio rerio; RNA Seq", "GSM4661898", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661898", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L2_DKRT190808OligoTB29-53_1.fq.gz V300016697_L2_DKRT190808OligoTB29-53_2.fq.gz", "fastq fastq", 5012833000.0, 50128330.0, "GSM4661898 r1", "0:100 1:100", "A:1498301491;C:989903310;G:1001505041;T:1523123158;N:0", 100, 100, null, null, 1498301491, 989903310, 1001505041, 1523123158, 0, "SRX8687798", "SRS6966462", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90134, null, 0.26756, null, 0.72535, null, 0.49696, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60235, "SRR12173034", "SRX8687797", "SRS6966461", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "40B", "GSM4661897", null, "source name:SCA17|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male", "40B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA17", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M", "GSM4661897", "GSM4661897: 40B; Danio rerio; RNA Seq", "GSM4661897", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661897", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L2_DKRT190808OligoTB28-52_1.fq.gz V300016697_L2_DKRT190808OligoTB28-52_2.fq.gz", "fastq fastq", 5024116600.0, 50241166.0, "GSM4661897 r1", "0:100 1:100", "A:1477107167;C:1016848490;G:1027973874;T:1502187069;N:0", 100, 100, null, null, 1477107167, 1016848490, 1027973874, 1502187069, 0, "SRX8687797", "SRS6966461", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90915, null, 0.22952, null, 0.71658, null, 0.49092, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60236, "SRR12173033", "SRX8687796", "SRS6966460", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "38B", "GSM4661896", null, "source name:SCA10|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male", "38B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA10", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M", "GSM4661896", "GSM4661896: 38B; Danio rerio; RNA Seq", "GSM4661896", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661896", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L2_DKRT190808OligoTB27-51_1.fq.gz V300016697_L2_DKRT190808OligoTB27-51_2.fq.gz", "fastq fastq", 5008056600.0, 50080566.0, "GSM4661896 r1", "0:100 1:100", "A:1461495870;C:1022836043;G:1036957625;T:1486767062;N:0", 100, 100, null, null, 1461495870, 1022836043, 1036957625, 1486767062, 0, "SRX8687796", "SRS6966460", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91105, null, 0.21297, null, 0.71419, null, 0.51046, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60237, "SRR12173032", "SRX8687795", "SRS6966459", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "37B", "GSM4661895", null, "source name:SCA6|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male", "37B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA6", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M", "GSM4661895", "GSM4661895: 37B; Danio rerio; RNA Seq", "GSM4661895", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661895", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L2_DKRT190808OligoTB26-50_1.fq.gz V300016697_L2_DKRT190808OligoTB26-50_2.fq.gz", "fastq fastq", 4970945000.0, 49709450.0, "GSM4661895 r1", "0:100 1:100", "A:1452650065;C:1013500708;G:1027205899;T:1477588328;N:0", 100, 100, null, null, 1452650065, 1013500708, 1027205899, 1477588328, 0, "SRX8687795", "SRS6966459", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91153, null, 0.21127, null, 0.71567, null, 0.51669, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60238, "SRR12173031", "SRX8687794", "SRS6966458", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "36B", "GSM4661894", null, "source name:SCA2|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male", "36B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA2", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M", "GSM4661894", "GSM4661894: 36B; Danio rerio; RNA Seq", "GSM4661894", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661894", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L2_DKRT190808OligoTB25-49_2.fq.gz V300016697_L2_DKRT190808OligoTB25-49_1.fq.gz", "fastq fastq", 4965885400.0, 49658854.0, "GSM4661894 r1", "0:100 1:100", "A:1447470026;C:1015061012;G:1029974741;T:1473379621;N:0", 100, 100, null, null, 1447470026, 1015061012, 1029974741, 1473379621, 0, "SRX8687794", "SRS6966458", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91108, null, 0.21513, null, 0.71816, null, 0.50811, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60239, "SRR12173030", "SRX8687793", "SRS6966457", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "35B", "GSM4661893", null, "source name:SCA18|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female", "35B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA18", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F", "GSM4661893", "GSM4661893: 35B; Danio rerio; RNA Seq", "GSM4661893", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661893", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB24-32_2.fq.gz V300016697_L4_DKRT190808OligoTB24-32_1.fq.gz", "fastq fastq", 5015053400.0, 50150534.0, "GSM4661893 r1", "0:100 1:100", "A:1457835767;C:1029178424;G:1044039825;T:1483999384;N:0", 100, 100, null, null, 1457835767, 1029178424, 1044039825, 1483999384, 0, "SRX8687793", "SRS6966457", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90833, null, 0.21925, null, 0.71672, null, 0.50097, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60240, "SRR12173029", "SRX8687792", "SRS6966456", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "34B", "GSM4661892", null, "source name:SCA16|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female", "34B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA16", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F", "GSM4661892", "GSM4661892: 34B; Danio rerio; RNA Seq", "GSM4661892", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661892", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB23-31_1.fq.gz V300016697_L4_DKRT190808OligoTB23-31_2.fq.gz", "fastq fastq", 4986700200.0, 49867002.0, "GSM4661892 r1", "0:100 1:100", "A:1462869969;C:1011992988;G:1024320004;T:1487517239;N:0", 100, 100, null, null, 1462869969, 1011992988, 1024320004, 1487517239, 0, "SRX8687792", "SRS6966456", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90718, null, 0.22544, null, 0.71342, null, 0.5072, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60241, "SRR12173028", "SRX8687791", "SRS6966455", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "33B", "GSM4661891", null, "source name:SCA15|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female", "33B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA15", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F", "GSM4661891", "GSM4661891: 33B; Danio rerio; RNA Seq", "GSM4661891", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661891", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB22-30_1.fq.gz V300016697_L4_DKRT190808OligoTB22-30_2.fq.gz", "fastq fastq", 5002163800.0, 50021638.0, "GSM4661891 r1", "0:100 1:100", "A:1458240783;C:1023254938;G:1035393042;T:1485275037;N:0", 100, 100, null, null, 1458240783, 1023254938, 1035393042, 1485275037, 0, "SRX8687791", "SRS6966455", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90922, null, 0.2217, null, 0.7097, null, 0.51063, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60242, "SRR12173027", "SRX8687790", "SRS6966454", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "32B", "GSM4661890", null, "source name:SCA14|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female", "32B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "SCA14", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F", "GSM4661890", "GSM4661890: 32B; Danio rerio; RNA Seq", "GSM4661890", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661890", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB21-29_1.fq.gz V300016697_L4_DKRT190808OligoTB21-29_2.fq.gz", "fastq fastq", 5004918600.0, 50049186.0, "GSM4661890 r1", "0:100 1:100", "A:1478882760;C:1005298319;G:1018268859;T:1502468662;N:0", 100, 100, null, null, 1478882760, 1005298319, 1018268859, 1502468662, 0, "SRX8687790", "SRS6966454", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90266, null, 0.24047, null, 0.71997, null, 0.50514, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60243, "SRR12173026", "SRX8687789", "SRS6966453", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "30B", "GSM4661889", null, "source name:PH22|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male", "30B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH22", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M", "GSM4661889", "GSM4661889: 30B; Danio rerio; RNA Seq", "GSM4661889", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661889", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB20-28_2.fq.gz V300016697_L4_DKRT190808OligoTB20-28_1.fq.gz", "fastq fastq", 5004549600.0, 50045496.0, "GSM4661889 r1", "0:100 1:100", "A:1464234691;C:1019451110;G:1029365798;T:1491498001;N:0", 100, 100, null, null, 1464234691, 1019451110, 1029365798, 1491498001, 0, "SRX8687789", "SRS6966453", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90749, null, 0.21628, null, 0.71784, null, 0.51498, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60244, "SRR12173025", "SRX8687788", "SRS6966452", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "29B", "GSM4661888", null, "source name:PH19|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male", "29B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH19", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M", "GSM4661888", "GSM4661888: 29B; Danio rerio; RNA Seq", "GSM4661888", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661888", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB19-27_1.fq.gz V300016697_L4_DKRT190808OligoTB19-27_2.fq.gz", "fastq fastq", 5002749400.0, 50027494.0, "GSM4661888 r1", "0:100 1:100", "A:1467188892;C:1015426772;G:1028344254;T:1491789482;N:0", 100, 100, null, null, 1467188892, 1015426772, 1028344254, 1491789482, 0, "SRX8687788", "SRS6966452", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90801, null, 0.22987, null, 0.71823, null, 0.50663, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60245, "SRR12173024", "SRX8687787", "SRS6966451", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "28B", "GSM4661887", null, "source name:PH17|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male", "28B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH17", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M", "GSM4661887", "GSM4661887: 28B; Danio rerio; RNA Seq", "GSM4661887", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661887", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB18-26_2.fq.gz V300016697_L4_DKRT190808OligoTB18-26_1.fq.gz", "fastq fastq", 5006123800.0, 50061238.0, "GSM4661887 r1", "0:100 1:100", "A:1456441519;C:1027857948;G:1041287742;T:1480536591;N:0", 100, 100, null, null, 1456441519, 1027857948, 1041287742, 1480536591, 0, "SRX8687787", "SRS6966451", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.91262, null, 0.21085, null, 0.71662, null, 0.51982, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60246, "SRR12173023", "SRX8687786", "SRS6966450", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "26B", "GSM4661886", null, "source name:PH12|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:male", "26B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH12", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:M", "GSM4661886", "GSM4661886: 26B; Danio rerio; RNA Seq", "GSM4661886", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661886", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB17-25_1.fq.gz V300016697_L4_DKRT190808OligoTB17-25_2.fq.gz", "fastq fastq", 5009606600.0, 50096066.0, "GSM4661886 r1", "0:100 1:100", "A:1500013398;C:985021902;G:996549130;T:1528022170;N:0", 100, 100, null, null, 1500013398, 985021902, 996549130, 1528022170, 0, "SRX8687786", "SRS6966450", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90128, null, 0.25532, null, 0.73359, null, 0.52879, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60247, "SRR12173022", "SRX8687785", "SRS6966449", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "25B", "GSM4661885", null, "source name:PH16|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female", "25B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH16", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F", "GSM4661885", "GSM4661885: 25B; Danio rerio; RNA Seq", "GSM4661885", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661885", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB16-24_1.fq.gz V300016697_L4_DKRT190808OligoTB16-24_2.fq.gz", "fastq fastq", 5015052800.0, 50150528.0, "GSM4661885 r1", "0:100 1:100", "A:1465175690;C:1021710593;G:1034828694;T:1493337823;N:0", 100, 100, null, null, 1465175690, 1021710593, 1034828694, 1493337823, 0, "SRX8687785", "SRS6966449", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90728, null, 0.22634, null, 0.71486, null, 0.50164, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60248, "SRR12173021", "SRX8687784", "SRS6966448", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "24B", "GSM4661884", null, "source name:PH15|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female", "24B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH15", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F", "GSM4661884", "GSM4661884: 24B; Danio rerio; RNA Seq", "GSM4661884", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661884", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB15-23_1.fq.gz V300016697_L4_DKRT190808OligoTB15-23_2.fq.gz", "fastq fastq", 5007208200.0, 50072082.0, "GSM4661884 r1", "0:100 1:100", "A:1467951978;C:1015424803;G:1028177858;T:1495653561;N:0", 100, 100, null, null, 1467951978, 1015424803, 1028177858, 1495653561, 0, "SRX8687784", "SRS6966448", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.90528, null, 0.23927, null, 0.71555, null, 0.50336, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60249, "SRR12173020", "SRX8687783", "SRS6966447", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "21B", "GSM4661883", null, "source name:PH9|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female", "21B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH9", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F", "GSM4661883", "GSM4661883: 21B; Danio rerio; RNA Seq", "GSM4661883", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", "GEO Accession:GSM4661883", "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP270926", null, null, "V300016697_L4_DKRT190808OligoTB14-22_1.fq.gz V300016697_L4_DKRT190808OligoTB14-22_2.fq.gz", "fastq fastq", 5024734000.0, 50247340.0, "GSM4661883 r1", "0:100 1:100", "A:1486766175;C:1007118234;G:1018199457;T:1512650134;N:0", 100, 100, null, null, 1486766175, 1007118234, 1018199457, 1512650134, 0, "SRX8687783", "SRS6966447", "SRA1096323", "GEO", "UMR MARBEC, INRAE", 1, 0.89909, null, 0.24852, null, 0.7249, null, 0.5102, null, 100, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "random_priming", "unknown", "bulk", "unknown", "unknown", null, "France", "2020-07-08", "Adult", "Adult", "Brain", "Nervous System"], [60250, "SRR12173019", "SRX8687782", "SRS6966446", "SRP270926", "PRJNA644883", "Transcriptomic analyses in brains of exposed F0 zebrafish and their unexposed F1 and F2 offspring post early life exposure to permethrin 10 microg/L", "GSE154020", "Transcriptome Analysis", "In the present study  zebrafish were exposed to permethrin during early life  and F1 and F2 generations were bred unexposed. Permethrin exposed F0 fish showed a hypoactive phenotype at maturity  whereas males from the F1 and F2 generations showed a decrease in anxiety like behavior. Thus  we performed transcriptomic changes to identify underlying molecular mechanisms. They showed limited overlap between sex and generations. In F0  genes and pathways related to glutamatergic synapse activity Gene Ontology and Reactome databases were significantly enriched and may explain the behavioral effects. In F1 and F2 generations  mechanisms are less clear as limited changes which could correlate with behavior were observed in the F1 generation. Overall design: RNA sequencing was performed on males and females from the F0  F1 and F2 generations 4 replicates treatment  4 replicates control for each sex and each generation", null, "pubmed:33752003", null, "22B", "GSM4661882", null, "source name:PH10|tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:female", "22B", "Base calling and prefiltering adaptor removal was performed by BGI STAR 2.7 for alignment of the reads to DanRer11 whole genome with default parameters Counts of reads per gene were obtained with HTSeq v0.11.2 gtf annotation file GRCz11.97 Use of DESeq2 v1.24.0 for differential gene expression analysis Genome build: DanRer11 Supplementary files format and content: csv file including raw counts obtained from htseq unnormalized.", "PH10", null, "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. One microg of total RNA was sent to BGI Europe A/S for pair ended transcriptome sequencing on BGI Seq500 according to BGI standard protocol", null, "tissue:whole brain|age:adult|strain:AB line|generation:F0|Sex:F", "GSM4661882", "GSM4661882: 22B; Danio rerio; RNA Seq", "GSM4661882", null, "1", "Fish were euthanized  brains were dissected and flash frozen in liquid nitrogen  and RNA was extracted using TriPrep extraction kit Macherey Nagel. 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Brain transcriptional profiles were investigated on E7 and R21.", null, null, "END OF 7 DAY EXPOSURE", null, "EH2", null, "strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 2|treatment:AMI 40.0|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio: adult female brain", "EH2", "EH2", "a standardized procedure at the Beijing Genome Institute", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP335395", null, null, "EH2_1.fq.gz EH2_2.fq.gz", "fastq fastq", 6792825900.0, 45285506.0, "EH2 1.fq.gz", "0:150 1:150", "A:1958355652;C:1427389031;G:1440081079;T:1966978334;N:21804", 150, 150, null, null, 1958355652, 1427389031, 1440081079, 1966978334, 21804, "SRX11996475", "SRS10003990", "SRA1288076", "Jiangsu University|Institute of Environmental Health and Ecological S", "Jiangsu University", 1, 0.91907, null, 0.17888, null, 0.70575, null, 0.54118, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-09-02", "Adult", "Adult", "Brain", "Nervous System"], [65947, "SRR15700568", "SRX11996474", "SRS10003989", "SRP335395", "PRJNA759881", "Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio", "PRJNA759881", "Other", "Following exposure to Amitriptyline AMI for 7 days E7  zebrafish were transferred into AMI free water to recover for 21 days R21. 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Brain transcriptional profiles were investigated on E7 and R21.", null, null, "END OF 7 DAY EXPOSURE", null, "EL1", null, "strain:AB|age:4 MONTHS|dev stage:Adult|sex:female|tissue:brain|replicate:replicate = biological replicate 1|treatment:AMI 2.5|SAMPLING TIME:END OF 7 DAY EXPOSURE|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio: adult female brain", "EL1", "EL1", "a standardized procedure at the Beijing Genome Institute", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP335395", null, null, "EL1_1.fq.gz EL1_2.fq.gz", "fastq fastq", 6764302200.0, 45095348.0, "EL1 1.fq.gz", "0:150 1:150", "A:1943560425;C:1428175041;G:1441358638;T:1951185256;N:22840", 150, 150, null, null, 1943560425, 1428175041, 1441358638, 1951185256, 22840, "SRX11996471", "SRS10003986", "SRA1288076", "Jiangsu University|Institute of Environmental Health and Ecological S", "Jiangsu University", 1, 0.91885, null, 0.17456, null, 0.71423, null, 0.53356, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-09-02", "Adult", "Adult", "Brain", "Nervous System"], [65951, "SRR15700572", "SRX11996470", "SRS10003985", "SRP335395", "PRJNA759881", "Persistent Impact of Short term Amitriptyline Exposure on brain Transcriptional Profile of Zebrafish Danio rerio", "PRJNA759881", "Other", "Following exposure to Amitriptyline AMI for 7 days E7  zebrafish were transferred into AMI free water to recover for 21 days R21. 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