{"database": "metadata", "table": "run_metadata", "is_view": false, "human_description_en": "where experiment.library_selection = \"PolyA\", experiment.library_strategy = \"RNA-Seq\" and tissue_curation_coarse = \"Digestive System\"", "rows": [[29575, "SRR27387418", "SRX23063709", "SRS20023731", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Combined Intestine", "combined intestine 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:combined intestine replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T8 6", "T8 6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A54_1.fastq.gz A54_2.fastq.gz", "fastq fastq", 8459790000.0, 28199300.0, "A54 1.fastq.gz", "0:150 1:150", "A:2287135948;C:1957145280;G:1959338891;T:2256075943;N:93938", 150, 150, null, null, 2287135948, 1957145280, 1959338891, 2256075943, 93938, "SRX23063709", "SRS20023731", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92583, 0.92422, 0.06345, 0.06263, 0.75718, 0.75757, 0.52145, 0.5361, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29576, "SRR27387419", "SRX23063708", "SRS20023730", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Combined Intestine", "combined intestine 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:combined intestine replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T8 5", "T8 5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A53_1.fastq.gz A53_2.fastq.gz", "fastq fastq", 8302022700.0, 27673409.0, "A53 1.fastq.gz", "0:150 1:150", "A:2241277601;C:1925048164;G:1920142999;T:2215462687;N:91249", 150, 150, null, null, 2241277601, 1925048164, 1920142999, 2215462687, 91249, "SRX23063708", "SRS20023730", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92711, 0.92566, 0.06314, 0.06353, 0.75221, 0.75219, 0.541, 0.53579, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29577, "SRR27387420", "SRX23063707", "SRS20023729", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Combined Intestine", "combined intestine 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:combined intestine replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T8 4", "T8 4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A49_1.fastq.gz A49_2.fastq.gz", "fastq fastq", 6939976800.0, 23133256.0, "A49 1.fastq.gz", "0:150 1:150", "A:1895013575;C:1589528661;G:1585890890;T:1869466351;N:77323", 150, 150, null, null, 1895013575, 1589528661, 1585890890, 1869466351, 77323, "SRX23063707", "SRS20023729", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92632, 0.92542, 0.06323, 0.06265, 0.75588, 0.75722, 0.55002, 0.55324, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29578, "SRR27387421", "SRX23063706", "SRS20023728", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Combined Intestine", "combined intestine 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:combined intestine replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T8 3", "T8 3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A44_1.fastq.gz A44_2.fastq.gz", "fastq fastq", 9116379900.0, 30387933.0, "A44 1.fastq.gz", "0:150 1:150", "A:2462347514;C:2113718621;G:2112401730;T:2427812186;N:99849", 150, 150, null, null, 2462347514, 2113718621, 2112401730, 2427812186, 99849, "SRX23063706", "SRS20023728", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.93154, 0.92882, 0.06321, 0.06277, 0.75499, 0.75519, 0.54224, 0.542, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29579, "SRR27387422", "SRX23063705", "SRS20023727", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Combined Intestine", "combined intestine 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:combined intestine replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T8 2", "T8 2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A43_1.fastq.gz A43_2.fastq.gz", "fastq fastq", 7681997100.0, 25606657.0, "A43 1.fastq.gz", "0:150 1:150", "A:2098281007;C:1758609887;G:1757658923;T:2067364339;N:82944", 150, 150, null, null, 2098281007, 1758609887, 1757658923, 2067364339, 82944, "SRX23063705", "SRS20023727", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92257, 0.92131, 0.07154, 0.07125, 0.74769, 0.74712, 0.52352, 0.51843, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29580, "SRR27387423", "SRX23063704", "SRS20023726", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Combined Intestine", "combined intestine 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:combined intestine replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T8 1", "T8 1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A29_1.fastq.gz A29_2.fastq.gz", "fastq fastq", 8869294500.0, 29564315.0, "A29 1.fastq.gz", "0:150 1:150", "A:2411657291;C:2043119196;G:2038118093;T:2376336869;N:63051", 150, 150, null, null, 2411657291, 2043119196, 2038118093, 2376336869, 63051, "SRX23063704", "SRS20023726", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.9293, 0.93157, 0.06846, 0.06859, 0.75138, 0.75209, 0.54348, 0.54178, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29582, "SRR27387425", "SRX23063702", "SRS20023724", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Nanoplastics Intestine", "nps intestine 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:nps intestine replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T7 5", "T7 5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A51_1.fastq.gz A51_2.fastq.gz", "fastq fastq", 8229865500.0, 27432885.0, "A51 1.fastq.gz", "0:150 1:150", "A:2239224965;C:1891494000;G:1890511233;T:2208544358;N:90944", 150, 150, null, null, 2239224965, 1891494000, 1890511233, 2208544358, 90944, "SRX23063702", "SRS20023724", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.9282, 0.92676, 0.06786, 0.06815, 0.74566, 0.74673, 0.54961, 0.55067, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29583, "SRR27387426", "SRX23063701", "SRS20023723", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Nanoplastics Intestine", "nps intestine 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:nps intestine replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T7 4", "T7 4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A50_1.fastq.gz A50_2.fastq.gz", "fastq fastq", 8549274300.0, 28497581.0, "A50 1.fastq.gz", "0:150 1:150", "A:2321938070;C:1971518879;G:1967040023;T:2288683614;N:93714", 150, 150, null, null, 2321938070, 1971518879, 1967040023, 2288683614, 93714, "SRX23063701", "SRS20023723", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.93231, 0.93126, 0.06361, 0.06304, 0.7527, 0.75211, 0.48289, 0.48336, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29584, "SRR27387427", "SRX23063700", "SRS20023722", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Nanoplastics Intestine", "nps intestine 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:nps intestine replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T7 3", "T7 3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A48_1.fastq.gz A48_2.fastq.gz", "fastq fastq", 8065026000.0, 26883420.0, "A48 1.fastq.gz", "0:150 1:150", "A:2177870889;C:1870003683;G:1870725132;T:2146337507;N:88789", 150, 150, null, null, 2177870889, 1870003683, 1870725132, 2146337507, 88789, "SRX23063700", "SRS20023722", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92891, 0.92753, 0.05842, 0.05778, 0.71991, 0.72009, 0.51653, 0.51675, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29585, "SRR27387428", "SRX23063699", "SRS20023721", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Nanoplastics Intestine", "nps intestine 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:nps intestine replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T7 2", "T7 2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A42_1.fastq.gz A42_2.fastq.gz", "fastq fastq", 8391356700.0, 27971189.0, "A42 1.fastq.gz", "0:150 1:150", "A:2247673277;C:1962692430;G:1966871884;T:2214026582;N:92527", 150, 150, null, null, 2247673277, 1962692430, 1966871884, 2214026582, 92527, "SRX23063699", "SRS20023721", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.93153, 0.93045, 0.05902, 0.05934, 0.75424, 0.75546, 0.548, 0.54354, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29586, "SRR27387429", "SRX23063698", "SRS20023720", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Nanoplastics Intestine", "nps intestine 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:nps intestine replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T7 1", "T7 1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A31_1.fastq.gz A31_2.fastq.gz", "fastq fastq", 8236557000.0, 27455190.0, "A31 1.fastq.gz", "0:150 1:150", "A:2204148101;C:1929010419;G:1925723147;T:2177582914;N:92419", 150, 150, null, null, 2204148101, 1929010419, 1925723147, 2177582914, 92419, "SRX23063698", "SRS20023720", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.93739, 0.93581, 0.06216, 0.06176, 0.75057, 0.75049, 0.54176, 0.53414, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29587, "SRR27387430", "SRX23063697", "SRS20023719", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "6PPDQ Intestine", "6ppdq intestine 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:6ppdq intestine replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T6 6", "T6 6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A56_1.fastq.gz A56_2.fastq.gz", "fastq fastq", 6435464400.0, 21451548.0, "A56 1.fastq.gz", "0:150 1:150", "A:1748400934;C:1486171533;G:1481023797;T:1719795546;N:72590", 150, 150, null, null, 1748400934, 1486171533, 1481023797, 1719795546, 72590, "SRX23063697", "SRS20023719", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92722, 0.92559, 0.0729, 0.07288, 0.74288, 0.74343, 0.53587, 0.52589, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29588, "SRR27387431", "SRX23063696", "SRS20023718", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "6PPDQ Intestine", "6ppdq intestine 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:6ppdq intestine replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T6 5", "T6 5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A40_1.fastq.gz A40_2.fastq.gz", "fastq fastq", 8749914000.0, 29166380.0, "A40 1.fastq.gz", "0:150 1:150", "A:2338416402;C:2051360445;G:2055480569;T:2304561447;N:95137", 150, 150, null, null, 2338416402, 2051360445, 2055480569, 2304561447, 95137, "SRX23063696", "SRS20023718", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.94523, 0.9504, 0.03896, 0.03887, 0.80661, 0.80728, 0.46402, 0.45996, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29589, "SRR27387432", "SRX23063695", "SRS20023717", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "6PPDQ Intestine", "6ppdq intestine 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:6ppdq intestine replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T6 4", "T6 4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A39_1.fastq.gz A39_2.fastq.gz", "fastq fastq", 8140938300.0, 27136461.0, "A39 1.fastq.gz", "0:150 1:150", "A:2198617601;C:1888830697;G:1887283102;T:2166117857;N:89043", 150, 150, null, null, 2198617601, 1888830697, 1887283102, 2166117857, 89043, "SRX23063695", "SRS20023717", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92636, 0.92532, 0.05883, 0.0588, 0.71689, 0.71593, 0.52397, 0.5214, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29590, "SRR27387433", "SRX23063694", "SRS20023716", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "6PPDQ Intestine", "6ppdq intestine 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:6ppdq intestine replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T6 3", "T6 3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A35_1.fastq.gz A35_2.fastq.gz", "fastq fastq", 6912319200.0, 23041064.0, "A35 1.fastq.gz", "0:150 1:150", "A:1895216825;C:1576630157;G:1574441195;T:1865953455;N:77568", 150, 150, null, null, 1895216825, 1576630157, 1574441195, 1865953455, 77568, "SRX23063694", "SRS20023716", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92983, 0.92816, 0.072, 0.07173, 0.76601, 0.76615, 0.55997, 0.55562, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29591, "SRR27387434", "SRX23063693", "SRS20023715", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "6PPDQ Intestine", "6ppdq intestine 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:6ppdq intestine replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T6 2", "T6 2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A34_1.fastq.gz A34_2.fastq.gz", "fastq fastq", 7279802100.0, 24266007.0, "A34 1.fastq.gz", "0:150 1:150", "A:1989158951;C:1663891494;G:1668311413;T:1958359476;N:80766", 150, 150, null, null, 1989158951, 1663891494, 1668311413, 1958359476, 80766, "SRX23063693", "SRS20023715", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92923, 0.92655, 0.06821, 0.068, 0.74042, 0.74128, 0.54366, 0.54276, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29593, "SRR27387436", "SRX23063691", "SRS20023713", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "6PPDQ Intestine", "6ppdq intestine 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:6ppdq intestine replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T6 1", "T6 1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A30_1.fastq.gz A30_2.fastq.gz", "fastq fastq", 7219947600.0, 24066492.0, "A30 1.fastq.gz", "0:150 1:150", "A:1901354175;C:1717600917;G:1716606554;T:1884305293;N:80661", 150, 150, null, null, 1901354175, 1717600917, 1716606554, 1884305293, 80661, "SRX23063691", "SRS20023713", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.93375, 0.93214, 0.05513, 0.05567, 0.74759, 0.74698, 0.5475, 0.54855, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29594, "SRR27387437", "SRX23063690", "SRS20023712", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Control Intestine", "control intestine 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:control intestine replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T5 6", "T5 6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A46_1.fastq.gz A46_2.fastq.gz", "fastq fastq", 8509361100.0, 28364537.0, "A46 1.fastq.gz", "0:150 1:150", "A:2341600956;C:1932495972;G:1930461855;T:2304710926;N:91391", 150, 150, null, null, 2341600956, 1932495972, 1930461855, 2304710926, 91391, "SRX23063690", "SRS20023712", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92542, 0.92408, 0.07033, 0.06986, 0.77234, 0.77199, 0.55246, 0.55942, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29595, "SRR27387438", "SRX23063689", "SRS20023711", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Control Intestine", "control intestine 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:control intestine replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T5 5", "T5 5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A45_1.fastq.gz A45_2.fastq.gz", "fastq fastq", 7856294100.0, 26187647.0, "A45 1.fastq.gz", "0:150 1:150", "A:2129077180;C:1813666476;G:1813868805;T:2099595491;N:86148", 150, 150, null, null, 2129077180, 1813666476, 1813868805, 2099595491, 86148, "SRX23063689", "SRS20023711", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.93087, 0.92866, 0.06398, 0.06358, 0.75481, 0.75597, 0.55424, 0.55289, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29596, "SRR27387439", "SRX23063688", "SRS20023710", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Control Intestine", "control intestine 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:control intestine replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T5 4", "T5 4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A38_1.fastq.gz A38_2.fastq.gz", "fastq fastq", 8039208600.0, 26797362.0, "A38 1.fastq.gz", "0:150 1:150", "A:2201215819;C:1836215616;G:1833348507;T:2168337651;N:91007", 150, 150, null, null, 2201215819, 1836215616, 1833348507, 2168337651, 91007, "SRX23063688", "SRS20023710", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.9219, 0.91957, 0.0702, 0.06947, 0.76343, 0.76493, 0.55355, 0.54863, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29597, "SRR27387440", "SRX23063687", "SRS20023709", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Control Intestine", "control intestine 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:control intestine replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T5 3", "T5 3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A37_1.fastq.gz A37_2.fastq.gz", "fastq fastq", 8253642600.0, 27512142.0, "A37 1.fastq.gz", "0:150 1:150", "A:2254958000;C:1889478281;G:1886099650;T:2223014303;N:92366", 150, 150, null, null, 2254958000, 1889478281, 1886099650, 2223014303, 92366, "SRX23063687", "SRS20023709", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92632, 0.92477, 0.06268, 0.06279, 0.76719, 0.76682, 0.53773, 0.53566, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29598, "SRR27387441", "SRX23063686", "SRS20023708", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Control Intestine", "control intestine 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:control intestine replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T5 2", "T5 2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A33_1.fastq.gz A33_2.fastq.gz", "fastq fastq", 8276959500.0, 27589865.0, "A33 1.fastq.gz", "0:150 1:150", "A:2244800716;C:1909951370;G:1909130637;T:2212988991;N:87786", 150, 150, null, null, 2244800716, 1909951370, 1909130637, 2212988991, 87786, "SRX23063686", "SRS20023708", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.93248, 0.93089, 0.06402, 0.06475, 0.701, 0.7012, 0.53585, 0.53722, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [29599, "SRR27387442", "SRX23063685", "SRS20023707", "SRP480720", "PRJNA1059246", "Mixture toxicity of 6PPD quinone and polystyrene nanoplastics in zebrafish", "PRJNA1059246", "Other", "Tyre wear particles are the second largest source of microplastics in the ocean following abrasion of synthetic fibres. In addition to the particles themselves  TWPs contain many harmful chemicals  including 6PPD. This chemical reacts with atmospheric ozone and forms the toxic compound 6PPD quinone  which poses a danger to aquatic life. There is a knowledge gap in understanding risks associated with thecombined toxicity of nanoplastics and 6PPDq. The present study aimed to investigate the toxicity of NPs and 6PPDq on adult zebrafish. However  we found significant hyperlocomotion in zebrafish exposed to 6PPDq and this effect was even more substantial post co exposure with PSNPs. The more pronounced toxic response in coexposed zebrafish was also observed at the transcriptomic level. KEGG pathways analysis identified mitochondrial dysfunction in the intestine and metabolic disturbances in the liver. These results highlight the significance of mixture toxicity when studying the effects of NPs and associated chemicals like 6PPDq.", null, null, null, "Control Intestine", "control intestine 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:16 weeks|dev stage:adult|sex:male|tissue:intestine|biomaterial provider:not applicable|birth date:not applicable|birth location:not applicable|breeding history:not applicable|breeding method:not applicable|cell line:not applicable|cell subtype:not applicable|cell type:not applicable|collected by:Shubham Varshney|collection date:2023 06|culture collection:not applicable|death date:not applicable|disease:not applicable|disease stg:not applicable|genotype:not applicable|geo loc name:not applicable|growth protocol:not applicable|health state:not applicable|isolation source:not applicable|lat lon:not applicable|phenotype:not applicable|sample type:not applicable|specimen voucher:not applicable|store cond:not applicable|stud book number:not applicable|treatment:control intestine replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "T5 1", "T5 1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "NextSeq 550", null, "SRP480720", null, null, "A32_1.fastq.gz A32_2.fastq.gz", "fastq fastq", 7955418900.0, 26518063.0, "A32 1.fastq.gz", "0:150 1:150", "A:2236485440;C:1768380410;G:1765867470;T:2184596828;N:88752", 150, 150, null, null, 2236485440, 1768380410, 1765867470, 2184596828, 88752, "SRX23063685", "SRS20023707", "SRA1777576", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 2, 0.92662, 0.92301, 0.071, 0.07061, 0.75207, 0.75158, 0.53095, 0.54507, 150, 150, "B", "B", "biological fallback assumption", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2023-12-30", "Adult", "Adult", "Gut", "Digestive System"], [55951, "SRR10827995", "SRX7501389", "SRS5942789", "SRP239446", "PRJNA598916", "Zebrafish intestinal gene expression", "PRJNA598916", "Other", "An analysis of zebrafish intestinal gene expression", null, null, null, null, "ZR011", null, "strain:5D|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:not applicable|dev stage:Adult|sex:male|tissue:whole intestine|replicate:replicate10|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio: adult 5D intestine", "ZR011", "ZR011", "Illumina Paired end sequencing", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 4000", null, "SRP239446", null, null, "lane9-ZR011_S00_L009_R2_001.fastq.gz lane9-ZR011_S00_L009_R1_001.fastq.gz", "fastq fastq", 9665147298.0, 32003799.0, "lane9 ZR011 S00 L009 R1 001.fastq.gz", "0:151 1:151", 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transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. 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Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. 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Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. 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Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "soybean", "soybean3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:soybeanCP replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "CP3", "CP3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "cp3_S6_R1_001.fastq.gz", "fastq", 2648220684.0, 34845009.0, "cp3 S6 R1 001.fastq.gz", "0:76 1:0", "A:697194378;C:597685138;G:585283565;T:767999519;N:58084", 76, 0, null, null, 697194378, 597685138, 585283565, 767999519, 58084, "SRX9785050", "SRS7972283", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.93629, null, 0.1048, null, 0.7349, null, 0.54364, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [62746, "SRR13360752", "SRX9785049", "SRS7972282", "SRP300470", "PRJNA689790", "Elucidating the effects of microbe derived glucans on the gut microbiota and the immune system of zebrafish", "PRJNA689790", "Other", "We present a holistic picture of soybean induced changes in the intestine of juvenile zebrafish and the effect of yeast beta glucan through a transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "soybean", "soybean2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:soybeanCP replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "CP2", "CP2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "cp2_S5_R1_001.fastq.gz", "fastq", 2339410872.0, 30781722.0, "cp2 S5 R1 001.fastq.gz", "0:76 1:0", "A:620056592;C:539298564;G:520500416;T:659503250;N:52050", 76, 0, null, null, 620056592, 539298564, 520500416, 659503250, 52050, "SRX9785049", "SRS7972282", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.93909, null, 0.0916, null, 0.70942, null, 0.51709, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [62747, "SRR13360753", "SRX9785048", "SRS7972281", "SRP300470", "PRJNA689790", "Elucidating the effects of microbe derived glucans on the gut microbiota and the immune system of zebrafish", "PRJNA689790", "Other", "We present a holistic picture of soybean induced changes in the intestine of juvenile zebrafish and the effect of yeast beta glucan through a transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "soybean", "soybean1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:soybeanCP replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "CP1", "CP1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "cp1_S4_R1_001.fastq.gz", "fastq", 2271445592.0, 29887442.0, "cp1 S4 R1 001.fastq.gz", "0:76 1:0", "A:620595380;C:508382666;G:499686333;T:642731924;N:49289", 76, 0, null, null, 620595380, 508382666, 499686333, 642731924, 49289, "SRX9785048", "SRS7972281", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.93497, null, 0.1129, null, 0.71127, null, 0.50787, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [62748, "SRR13360754", "SRX9785047", "SRS7972280", "SRP300470", "PRJNA689790", "Elucidating the effects of microbe derived glucans on the gut microbiota and the immune system of zebrafish", "PRJNA689790", "Other", "We present a holistic picture of soybean induced changes in the intestine of juvenile zebrafish and the effect of yeast beta glucan through a transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "control", "control4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:controlCZ replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "CZ4", "CZ4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "cz4_S1_R1_001.fastq.gz", "fastq", 2772612848.0, 36481748.0, "cz4 S1 R1 001.fastq.gz", "0:76 1:0", "A:753409223;C:625962831;G:590503241;T:802690640;N:46913", 76, 0, null, null, 753409223, 625962831, 590503241, 802690640, 46913, "SRX9785047", "SRS7972280", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.92942, null, 0.15362, null, 0.62889, null, 0.51867, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [62749, "SRR13360755", "SRX9785046", "SRS7972279", "SRP300470", "PRJNA689790", "Elucidating the effects of microbe derived glucans on the gut microbiota and the immune system of zebrafish", "PRJNA689790", "Other", "We present a holistic picture of soybean induced changes in the intestine of juvenile zebrafish and the effect of yeast beta glucan through a transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "control", "control3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:controlCZ replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "CZ3", "CZ3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "cz3_S3_R1_001.fastq.gz", "fastq", 2424287672.0, 31898522.0, "cz3 S3 R1 001.fastq.gz", "0:76 1:0", "A:629966430;C:571438897;G:558947157;T:663881953;N:53235", 76, 0, null, null, 629966430, 571438897, 558947157, 663881953, 53235, "SRX9785046", "SRS7972279", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.94199, null, 0.04836, null, 0.72218, null, 0.48478, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [62750, "SRR13360756", "SRX9785045", "SRS7972278", "SRP300470", "PRJNA689790", "Elucidating the effects of microbe derived glucans on the gut microbiota and the immune system of zebrafish", "PRJNA689790", "Other", "We present a holistic picture of soybean induced changes in the intestine of juvenile zebrafish and the effect of yeast beta glucan through a transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "macrogard", "macrogard4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:macrogardPM replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "PM4", "PM4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "pm4_S7_R1_001.fastq.gz", "fastq", 2901513560.0, 38177810.0, "pm4 S7 R1 001.fastq.gz", "0:76 1:0", "A:737189471;C:698799076;G:664901115;T:800575145;N:48753", 76, 0, null, null, 737189471, 698799076, 664901115, 800575145, 48753, "SRX9785045", "SRS7972278", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.95173, null, 0.04367, null, 0.74089, null, 0.50116, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [62751, "SRR13360757", "SRX9785044", "SRS7972277", "SRP300470", "PRJNA689790", "Elucidating the effects of microbe derived glucans on the gut microbiota and the immune system of zebrafish", "PRJNA689790", "Other", "We present a holistic picture of soybean induced changes in the intestine of juvenile zebrafish and the effect of yeast beta glucan through a transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "macrogard", "macrogard3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:macrogardPM replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "PM3", "PM3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "pm3_S9_R1_001.fastq.gz", "fastq", 3148390744.0, 41426194.0, "pm3 S9 R1 001.fastq.gz", "0:76 1:0", "A:834545372;C:725073648;G:704241250;T:884462724;N:67750", 76, 0, null, null, 834545372, 725073648, 704241250, 884462724, 67750, "SRX9785044", "SRS7972277", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.94256, null, 0.09248, null, 0.72099, null, 0.52303, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [62752, "SRR13360758", "SRX9785043", "SRS7972276", "SRP300470", "PRJNA689790", "Elucidating the effects of microbe derived glucans on the gut microbiota and the immune system of zebrafish", "PRJNA689790", "Other", "We present a holistic picture of soybean induced changes in the intestine of juvenile zebrafish and the effect of yeast beta glucan through a transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "control", "control2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:controlCZ replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "CZ2", "CZ2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "cz2_S2_R1_001.fastq", "fastq", 2207708116.0, 29048791.0, "cz2 S2 R1 001.fastq", "0:76 1:0", "A:614048827;C:488071931;G:474165427;T:631372646;N:49285", 76, 0, null, null, 614048827, 488071931, 474165427, 631372646, 49285, "SRX9785043", "SRS7972276", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.93271, null, 0.12538, null, 0.71733, null, 0.53166, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [62753, "SRR13360759", "SRX9785042", "SRS7972275", "SRP300470", "PRJNA689790", "Elucidating the effects of microbe derived glucans on the gut microbiota and the immune system of zebrafish", "PRJNA689790", "Other", "We present a holistic picture of soybean induced changes in the intestine of juvenile zebrafish and the effect of yeast beta glucan through a transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "control", "control1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:controlCZ replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "CZ1", "CZ1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "cz1_S1_R1_001.fastq.gz", "fastq", 2264115696.0, 29790996.0, "cz1 S1 R1 001.fastq.gz", "0:76 1:0", "A:619936364;C:496981021;G:501038961;T:646109550;N:49800", 76, 0, null, null, 619936364, 496981021, 501038961, 646109550, 49800, "SRX9785042", "SRS7972275", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.93737, null, 0.1307, null, 0.73003, null, 0.55416, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [66094, "SRR15910149", "SRX12200592", "SRS10176883", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "High cholesterol", "high 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:cholesterolHC replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "HC4", "HC4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "high_5_S5_R1_001.fastq.gz", "fastq", 1878287660.0, 24877927.0, "high 5 S5 R1 001.fastq.gz", "0:75.50 1:0", "A:476823620;C:439449647;G:429501262;T:532480837;N:32294", 75, 0, null, null, 476823620, 439449647, 429501262, 532480837, 32294, "SRX12200592", "SRS10176883", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94553, null, 0.08147, null, 0.74582, null, 0.53024, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66095, "SRR15910150", "SRX12200591", "SRS10176881", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "High cholesterol", "high 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:cholesterolHC replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "HC3", "HC3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "high_4_S4_R1_001.fastq.gz", "fastq", 1888383069.0, 25020396.0, "high 4 S4 R1 001.fastq.gz", "0:75.47 1:0", "A:503511674;C:424269464;G:408669727;T:551898358;N:33846", 75, 0, null, null, 503511674, 424269464, 408669727, 551898358, 33846, "SRX12200591", "SRS10176881", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93958, null, 0.1137, null, 0.74472, null, 0.52962, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66096, "SRR15910151", "SRX12200590", "SRS10176882", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "High cholesterol", "high 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:cholesterolHC replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "HC2", "HC2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "high_3_S6_R1_001.fastq.gz", "fastq", 2337788390.0, 31029913.0, "high 3 S6 R1 001.fastq.gz", "0:75.34 1:0", "A:586705132;C:555534330;G:547485592;T:645264200;N:2799136", 75, 0, null, null, 586705132, 555534330, 547485592, 645264200, 2799136, "SRX12200590", "SRS10176882", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94651, null, 0.08395, null, 0.67872, null, 0.51496, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66097, "SRR15910152", "SRX12200589", "SRS10176880", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "High cholesterol", "high 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:cholesterolHC replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "HC1", "HC1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "high_1_S4_R1_001.fastq.gz", "fastq", 2390465384.0, 31789893.0, "high 1 S4 R1 001.fastq.gz", "0:75.20 1:0", "A:599574460;C:559752099;G:546456599;T:677639257;N:7042969", 75, 0, null, null, 599574460, 559752099, 546456599, 677639257, 7042969, "SRX12200589", "SRS10176880", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94326, null, 0.09122, null, 0.73892, null, 0.52413, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66098, "SRR15910153", "SRX12200588", "SRS10176878", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC6", "LC6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_6_S3_R1_001.fastq.gz", "fastq", 1915028032.0, 25430699.0, "control 6 S3 R1 001.fastq.gz", "0:75.30 1:0", "A:502285547;C:435337245;G:424726824;T:549290123;N:3388293", 75, 0, null, null, 502285547, 435337245, 424726824, 549290123, 3388293, "SRX12200588", "SRS10176878", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.92666, null, 0.1269, null, 0.74968, null, 0.54447, null, 73, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66099, "SRR15910154", "SRX12200587", "SRS10176877", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC5", "LC5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_5_S2_R1_001.fastq.gz", "fastq", 2327013759.0, 30824465.0, "control 5 S2 R1 001.fastq.gz", "0:75.49 1:0", "A:590955916;C:541856449;G:529786509;T:664374176;N:40709", 75, 0, null, null, 590955916, 541856449, 529786509, 664374176, 40709, "SRX12200587", "SRS10176877", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94087, null, 0.09604, null, 0.74489, null, 0.53048, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66100, "SRR15910155", "SRX12200586", "SRS10176879", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC4", "LC4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_4_S1_R1_001.fastq.gz", "fastq", 1559648966.0, 20660136.0, "control 4 S1 R1 001.fastq.gz", "0:75.49 1:0", "A:398086562;C:359082782;G:356015350;T:446436847;N:27425", 75, 0, null, null, 398086562, 359082782, 356015350, 446436847, 27425, "SRX12200586", "SRS10176879", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93707, null, 0.10017, null, 0.73464, null, 0.52715, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66101, "SRR15910156", "SRX12200585", "SRS10176876", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS6", "SS6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_6_S15_R1_001.fastq.gz", "fastq", 2431012086.0, 32275098.0, "sim 6 S15 R1 001.fastq.gz", "0:75.32 1:0", "A:647191218;C:551606901;G:529110857;T:703050921;N:52189", 75, 0, null, null, 647191218, 551606901, 529110857, 703050921, 52189, "SRX12200585", "SRS10176876", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93331, null, 0.1165, null, 0.75268, null, 0.52753, null, 74, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66102, "SRR15910157", "SRX12200584", "SRS10176875", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS5", "SS5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_5_S14_R1_001.fastq.gz", "fastq", 1902101028.0, 25201273.0, "sim 5 S14 R1 001.fastq.gz", "0:75.48 1:0", "A:482206150;C:442300454;G:433280346;T:544280250;N:33828", 75, 0, null, null, 482206150, 442300454, 433280346, 544280250, 33828, "SRX12200584", "SRS10176875", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93441, null, 0.09457, null, 0.72431, null, 0.53047, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66103, "SRR15910158", "SRX12200583", "SRS10176874", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS4", "SS4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_4_S13_R1_001.fastq.gz", "fastq", 1887931329.0, 25021534.0, "sim 4 S13 R1 001.fastq.gz", "0:75.45 1:0", "A:483691629;C:436592360;G:424733601;T:542880751;N:32988", 75, 0, null, null, 483691629, 436592360, 424733601, 542880751, 32988, "SRX12200583", "SRS10176874", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.92435, null, 0.09393, null, 0.76039, null, 0.54018, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66104, "SRR15910159", "SRX12200582", "SRS10176873", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS3", "SS3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_3_S15_R1_001.fastq.gz", "fastq", 2278093448.0, 30193199.0, "sim 3 S15 R1 001.fastq.gz", "0:75.45 1:0", "A:575276152;C:529447047;G:521207330;T:650819961;N:1342958", 75, 0, null, null, 575276152, 529447047, 521207330, 650819961, 1342958, "SRX12200582", "SRS10176873", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94093, null, 0.087, null, 0.73876, null, 0.53488, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66105, "SRR15910160", "SRX12200581", "SRS10176872", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS2", "SS2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_2_S14_R1_001.fastq.gz", "fastq", 2543469673.0, 33741391.0, "sim 2 S14 R1 001.fastq.gz", "0:75.38 1:0", "A:667279341;C:584937962;G:562098766;T:726456492;N:2697112", 75, 0, null, null, 667279341, 584937962, 562098766, 726456492, 2697112, "SRX12200581", "SRS10176872", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93369, null, 0.11515, null, 0.72283, null, 0.51172, null, 74, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66106, "SRR15910161", "SRX12200580", "SRS10176871", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS1", "SS1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_1_S13_R1_001.fastq.gz", "fastq", 1663748041.0, 22080724.0, "sim 1 S13 R1 001.fastq.gz", "0:75.35 1:0", "A:424766717;C:386318148;G:378172921;T:472190364;N:2299891", 75, 0, null, null, 424766717, 386318148, 378172921, 472190364, 2299891, "SRX12200580", "SRS10176871", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93979, null, 0.08815, null, 0.74194, null, 0.52705, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66107, "SRR15910162", "SRX12200579", "SRS10176870", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG6", "OG6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_6_S12_R1_001.fastq.gz", "fastq", 1950238266.0, 25861117.0, "oat 6 S12 R1 001.fastq.gz", "0:75.41 1:0", "A:502273927;C:456918053;G:438368291;T:552640342;N:37653", 75, 0, null, null, 502273927, 456918053, 438368291, 552640342, 37653, "SRX12200579", "SRS10176870", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93318, null, 0.08879, null, 0.74901, null, 0.54257, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66108, "SRR15910163", "SRX12200578", "SRS10176869", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG5", "OG5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_5_S11_R1_001.fastq.gz", "fastq", 1818990592.0, 24148417.0, "oat 5 S11 R1 001.fastq.gz", "0:75.33 1:0", "A:460795176;C:423681740;G:415715028;T:516509914;N:2288734", 75, 0, null, null, 460795176, 423681740, 415715028, 516509914, 2288734, "SRX12200578", "SRS10176869", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93555, null, 0.09413, null, 0.73732, null, 0.54828, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66109, "SRR15910164", "SRX12200577", "SRS10176868", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG4", "OG4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_4_S10_R1_001.fastq.gz", "fastq", 1734135458.0, 22972939.0, "oat 4 S10 R1 001.fastq.gz", "0:75.49 1:0", "A:444047928;C:402248080;G:393083056;T:494726063;N:30331", 75, 0, null, null, 444047928, 402248080, 393083056, 494726063, 30331, "SRX12200577", "SRS10176868", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93619, null, 0.09257, null, 0.75635, null, 0.54807, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66110, "SRR15910165", "SRX12200576", "SRS10176867", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC3", "LC3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_3_S3_R1_001.fastq.gz", "fastq", 2544827138.0, 33810050.0, "control 3 S3 R1 001.fastq.gz", "0:75.27 1:0", "A:649235065;C:587469807;G:574700155;T:728104191;N:5317920", 75, 0, null, null, 649235065, 587469807, 574700155, 728104191, 5317920, "SRX12200576", "SRS10176867", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93445, null, 0.09084, null, 0.75471, null, 0.53891, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66111, "SRR15910166", "SRX12200575", "SRS10176866", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG3", "OG3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_3_S12_R1_001.fastq.gz", "fastq", 2676109047.0, 35499063.0, "oat 3 S12 R1 001.fastq.gz", "0:75.39 1:0", "A:668562223;C:624794464;G:608983398;T:770847910;N:2921052", 75, 0, null, null, 668562223, 624794464, 608983398, 770847910, 2921052, "SRX12200575", "SRS10176866", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.95624, null, 0.07731, null, 0.78368, null, 0.5561, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66112, "SRR15910167", "SRX12200574", "SRS10176865", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG2", "OG2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_2_S11_R1_001.fastq.gz", "fastq", 1920714201.0, 25464331.0, "oat 2 S11 R1 001.fastq.gz", "0:75.43 1:0", "A:489513738;C:448024192;G:438816907;T:542892434;N:1466930", 75, 0, null, null, 489513738, 448024192, 438816907, 542892434, 1466930, "SRX12200574", "SRS10176865", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94472, null, 0.08495, null, 0.73766, null, 0.54149, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66113, "SRR15910168", "SRX12200573", "SRS10176864", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG1", "OG1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_1_S10_R1_001.fastq.gz", "fastq", 2171014631.0, 28803940.0, "oat 1 S10 R1 001.fastq.gz", "0:75.37 1:0", "A:550611852;C:504793219;G:494893735;T:618143286;N:2572539", 75, 0, null, null, 550611852, 504793219, 494893735, 618143286, 2572539, "SRX12200573", "SRS10176864", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94056, null, 0.089, null, 0.74142, null, 0.53823, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66114, "SRR15910169", "SRX12200572", "SRS10176863", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG6", "AG6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_6_S12_R1_001.fastq.gz", "fastq", 2098747142.0, 27807858.0, "alga 6 S12 R1 001.fastq.gz", "0:75.47 1:0", "A:534561461;C:494167859;G:489052359;T:580927807;N:37656", 75, 0, null, null, 534561461, 494167859, 489052359, 580927807, 37656, "SRX12200572", "SRS10176863", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94831, null, 0.08427, null, 0.73292, null, 0.52842, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66115, "SRR15910170", "SRX12200571", "SRS10176862", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG5", "AG5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_5_S11_R1_001.fastq.gz", "fastq", 1763481116.0, 23363097.0, "alga 5 S11 R1 001.fastq.gz", "0:75.48 1:0", "A:447338889;C:412970655;G:414050708;T:489089552;N:31312", 75, 0, null, null, 447338889, 412970655, 414050708, 489089552, 31312, "SRX12200571", "SRS10176862", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94349, null, 0.08062, null, 0.739, null, 0.52999, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66116, "SRR15910171", "SRX12200570", "SRS10176861", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG4", "AG4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_4_S10_R1_001.fastq.gz", "fastq", 1879826054.0, 24897114.0, "alga 4 S10 R1 001.fastq.gz", "0:75.50 1:0", "A:470066955;C:443235235;G:435473614;T:531017855;N:32395", 75, 0, null, null, 470066955, 443235235, 435473614, 531017855, 32395, "SRX12200570", "SRS10176861", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94546, null, 0.09326, null, 0.65845, null, 0.52459, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66117, "SRR15910172", "SRX12200569", "SRS10176858", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG3", "AG3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_3_S12_R1_001.fastq.gz", "fastq", 2171152050.0, 28804773.0, "alga 3 S12 R1 001.fastq.gz", "0:75.37 1:0", "A:577878327;C:486896436;G:474333381;T:629132016;N:2911890", 75, 0, null, null, 577878327, 486896436, 474333381, 629132016, 2911890, "SRX12200569", "SRS10176858", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.9263, null, 0.13343, null, 0.74308, null, 0.54791, null, 74, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66118, "SRR15910173", "SRX12200568", "SRS10176857", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG2", "AG2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_2_S11_R1_001.fastq.gz", "fastq", 2667876981.0, 35347747.0, "alga 2 S11 R1 001.fastq.gz", "0:75.48 1:0", "A:608681566;C:714247949;G:658536241;T:684669115;N:1742110", 75, 0, null, null, 608681566, 714247949, 658536241, 684669115, 1742110, "SRX12200568", "SRS10176857", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.9577, null, 0.13465, null, 0.77425, null, 0.60177, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66119, "SRR15910174", "SRX12200567", "SRS10176859", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG1", "AG1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_1_S10_R_001.fastq.gz", "fastq", 2947209259.0, 39094391.0, "alga 1 S10 R 001.fastq.gz", "0:75.39 1:0", "A:769302900;C:671912702;G:657628697;T:845634633;N:2730327", 75, 0, null, null, 769302900, 671912702, 657628697, 845634633, 2730327, "SRX12200567", "SRS10176859", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93867, null, 0.08991, null, 0.74272, null, 0.53283, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66120, "SRR15910175", "SRX12200566", "SRS10176855", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "High cholesterol", "high 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:cholesterolHC replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "HC5", "HC5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "high_6_S6_R1_001.fastq.gz", "fastq", 1822201784.0, 24137941.0, "high 6 S6 R1 001.fastq.gz", "0:75.49 1:0", "A:461483337;C:426648920;G:419516035;T:514521907;N:31585", 75, 0, null, null, 461483337, 426648920, 419516035, 514521907, 31585, "SRX12200566", "SRS10176855", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94209, null, 0.09014, null, 0.74468, null, 0.50897, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66121, "SRR15910176", "SRX12200565", "SRS10176860", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC2", "LC2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_2_S2_R1_001.fastq.gz", "fastq", 2450938234.0, 32590616.0, "control 2 S2 R1 001.fastq.gz", "0:75.20 1:0", "A:628466312;C:568472904;G:556931536;T:689980376;N:7087106", 75, 0, null, null, 628466312, 568472904, 556931536, 689980376, 7087106, "SRX12200565", "SRS10176860", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93782, null, 0.10577, null, 0.73699, null, 0.52, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66122, "SRR15910177", "SRX12200564", "SRS10176856", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC1", "LC1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_1_S1_R1_001.fastq.gz", "fastq", 2784628452.0, 37009570.0, "control 1 S1 R1 001.fastq.gz", "0:75.24 1:0", "A:700349148;C:654385631;G:634389883;T:789658848;N:5844942", 75, 0, null, null, 700349148, 654385631, 634389883, 789658848, 5844942, "SRX12200564", "SRS10176856", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.9386, null, 0.08609, null, 0.73829, null, 0.53049, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [68333, "SRR17714676", "SRX13877733", "SRS11747906", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. In addition  to clarify the splenic phenotype of the Syngnathidaes  the transcriptomic profiles of the S. biaculeatus spleens and the H. erectus small white organ were also sampled and sequenced.", null, null, null, null, "KO in 4", null, "strain:AB type|isolate:knockout|breed:KO in 4|age:3 month|dev stage:NA|sex:NA|tissue:intestine|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "KO in 4", "KO in 4", "RNA seq", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP356388", null, "loader:fastq load.py", "Daniorerio_KO-in-4_good_1.fq.gz Daniorerio_KO-in-4_good_2.fq.gz", "fastq fastq", 8086373448.0, 27114595.0, "Daniorerio KO in 4 good 1.fq.gz", "0:149.11 1:149.11", "A:2114635166;C:1908498639;G:1940373806;T:2122462453;N:403384", 149, 149, null, null, 2114635166, 1908498639, 1940373806, 2122462453, 403384, "SRX13877733", "SRS11747906", "SRA1360632", "South China Sea Institute of Oceanology|CAS Key Laboratory of Tropical Marine Bio-Resource", "South China Sea Institute of Oceanology", 2, 0.93003, 0.92992, 0.06176, 0.06188, 0.70163, 0.70429, 0.48922, 0.48903, 150, 150, "B", "B", "biological fallback assumption", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2022-01-27", "Adult", "Adult", "Gut", "Digestive System"], [68334, "SRR17714677", "SRX13877732", "SRS11747905", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. In addition  to clarify the splenic phenotype of the Syngnathidaes  the transcriptomic profiles of the S. biaculeatus spleens and the H. erectus small white organ were also sampled and sequenced.", null, null, null, null, "KO in 3", null, "strain:AB type|isolate:knockout|breed:KO in 3|age:3 month|dev stage:NA|sex:NA|tissue:intestine|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "KO in 3", "KO in 3", "RNA seq", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP356388", null, "loader:fastq load.py", "Daniorerio_KO-in-3_good_1.fq.gz Daniorerio_KO-in-3_good_2.fq.gz", "fastq fastq", 7347019970.0, 24569878.0, "Daniorerio KO in 3 good 1.fq.gz", "0:149.51 1:149.51", "A:1946037694;C:1706069195;G:1743974411;T:1950573440;N:365230", 149, 149, null, null, 1946037694, 1706069195, 1743974411, 1950573440, 365230, "SRX13877732", "SRS11747905", "SRA1360632", "South China Sea Institute of Oceanology|CAS Key Laboratory of Tropical Marine Bio-Resource", "South China Sea Institute of Oceanology", 2, 0.92803, 0.92694, 0.07821, 0.07735, 0.73367, 0.73438, 0.51472, 0.52472, 150, 150, "B", "B", "biological fallback assumption", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2022-01-27", "Adult", "Adult", "Gut", "Digestive System"], [68335, "SRR17714678", "SRX13877731", "SRS11747903", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. In addition  to clarify the splenic phenotype of the Syngnathidaes  the transcriptomic profiles of the S. biaculeatus spleens and the H. erectus small white organ were also sampled and sequenced.", null, null, null, null, "KO in 2", null, "strain:AB type|isolate:knockout|breed:KO in 2|age:3 month|dev stage:NA|sex:NA|tissue:intestine|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "KO in 2", "KO in 2", "RNA seq", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP356388", null, "loader:fastq load.py", "Daniorerio_KO-in-2_good_1.fq.gz Daniorerio_KO-in-2_good_2.fq.gz", "fastq fastq", 8301032318.0, 27790678.0, "Daniorerio KO in 2 good 1.fq.gz", "0:149.35 1:149.35", "A:2179637699;C:1945190004;G:1982782844;T:2193010761;N:411010", 149, 149, null, null, 2179637699, 1945190004, 1982782844, 2193010761, 411010, "SRX13877731", "SRS11747903", "SRA1360632", "South China Sea Institute of Oceanology|CAS Key Laboratory of Tropical Marine Bio-Resource", "South China Sea Institute of Oceanology", 2, 0.94456, 0.9438, 0.04849, 0.04881, 0.77191, 0.77333, 0.36067, 0.3652, 150, 150, "B", "B", "biological fallback assumption", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2022-01-27", "Adult", "Adult", "Gut", "Digestive System"], [68344, "SRR17714687", "SRX13877722", "SRS11747895", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. In addition  to clarify the splenic phenotype of the Syngnathidaes  the transcriptomic profiles of the S. biaculeatus spleens and the H. erectus small white organ were also sampled and sequenced.", null, null, null, null, "KO in 1", null, "strain:AB type|isolate:knockout|breed:KO in 1|age:3 month|dev stage:NA|sex:NA|tissue:intestine|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "KO in 1", "KO in 1", "RNA seq", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP356388", null, "loader:fastq load.py", "Daniorerio_KO-in-1_good_1.fq.gz Daniorerio_KO-in-1_good_2.fq.gz", "fastq fastq", 7827900066.0, 26180712.0, "Daniorerio KO in 1 good 1.fq.gz", "0:149.50 1:149.50", "A:2080601651;C:1809785147;G:1846482300;T:2090643065;N:387903", 149, 149, null, null, 2080601651, 1809785147, 1846482300, 2090643065, 387903, "SRX13877722", "SRS11747895", "SRA1360632", "South China Sea Institute of Oceanology|CAS Key Laboratory of Tropical Marine Bio-Resource", "South China Sea Institute of Oceanology", 2, 0.92406, 0.92332, 0.08136, 0.08064, 0.72596, 0.72541, 0.51544, 0.52064, 150, 150, "B", "B", "biological fallback assumption", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2022-01-27", "Adult", "Adult", "Gut", "Digestive System"], [68345, "SRR17714688", "SRX13877721", "SRS11747893", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. In addition  to clarify the splenic phenotype of the Syngnathidaes  the transcriptomic profiles of the S. biaculeatus spleens and the H. erectus small white organ were also sampled and sequenced.", null, null, null, null, "WT in 7", null, "strain:AB type|isolate:wild type|breed:WT in 7|age:3 month|dev stage:NA|sex:NA|tissue:intestine|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "WT in 7", "WT in 7", "RNA seq", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP356388", null, "loader:fastq load.py", "Daniorerio_WT-in-7_good_1.fq.gz Daniorerio_WT-in-7_good_2.fq.gz", "fastq fastq", 6525605248.0, 21813313.0, "Daniorerio WT in 7 good 1.fq.gz", "0:149.58 1:149.58", "A:1779067091;C:1469759022;G:1500273479;T:1776177556;N:328100", 149, 149, null, null, 1779067091, 1469759022, 1500273479, 1776177556, 328100, "SRX13877721", "SRS11747893", "SRA1360632", "South China Sea Institute of Oceanology|CAS Key Laboratory of Tropical Marine Bio-Resource", "South China Sea Institute of Oceanology", 2, 0.90976, 0.90971, 0.08435, 0.08468, 0.72709, 0.7289, 0.5376, 0.53733, 150, 150, "B", "B", "biological fallback assumption", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2022-01-27", "Adult", "Adult", "Gut", "Digestive System"], [68346, "SRR17714689", "SRX13877720", "SRS11747894", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. In addition  to clarify the splenic phenotype of the Syngnathidaes  the transcriptomic profiles of the S. biaculeatus spleens and the H. erectus small white organ were also sampled and sequenced.", null, null, null, null, "WT in 4", null, "strain:AB type|isolate:wild type|breed:WT in 4|age:3 month|dev stage:NA|sex:NA|tissue:intestine|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "WT in 4", "WT in 4", "RNA seq", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP356388", null, "loader:fastq load.py", "Daniorerio_WT-in-4_good_1.fq.gz Daniorerio_WT-in-4_good_2.fq.gz", "fastq fastq", 9307471244.0, 31204763.0, "Daniorerio WT in 4 good 1.fq.gz", "0:149.14 1:149.14", "A:2485339643;C:2146056187;G:2184301247;T:2491310160;N:464007", 149, 149, null, null, 2485339643, 2146056187, 2184301247, 2491310160, 464007, "SRX13877720", "SRS11747894", "SRA1360632", "South China Sea Institute of Oceanology|CAS Key Laboratory of Tropical Marine Bio-Resource", "South China Sea Institute of Oceanology", 2, 0.93125, 0.9303, 0.08758, 0.08737, 0.72042, 0.72066, 0.50621, 0.50241, 150, 150, "B", "B", "biological fallback assumption", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2022-01-27", "Adult", "Adult", "Gut", "Digestive System"], [68347, "SRR17714690", "SRX13877719", "SRS11747892", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. In addition  to clarify the splenic phenotype of the Syngnathidaes  the transcriptomic profiles of the S. biaculeatus spleens and the H. erectus small white organ were also sampled and sequenced.", null, null, null, null, "WT in 2", null, "strain:AB type|isolate:wild type|breed:WT in 2|age:3 month|dev stage:NA|sex:NA|tissue:intestine|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "WT in 2", "WT in 2", "RNA seq", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP356388", null, "loader:fastq load.py", "Daniorerio_WT-in-2_good_1.fq.gz Daniorerio_WT-in-2_good_2.fq.gz", "fastq fastq", 7284861540.0, 24415394.0, "Daniorerio WT in 2 good 1.fq.gz", "0:149.19 1:149.19", "A:1956983508;C:1672191117;G:1698929394;T:1956391871;N:365650", 149, 149, null, null, 1956983508, 1672191117, 1698929394, 1956391871, 365650, "SRX13877719", "SRS11747892", "SRA1360632", "South China Sea Institute of Oceanology|CAS Key Laboratory of Tropical Marine Bio-Resource", "South China Sea Institute of Oceanology", 2, 0.92731, 0.92546, 0.09355, 0.09268, 0.73125, 0.7317, 0.53578, 0.51601, 150, 150, "B", "B", "biological fallback assumption", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2022-01-27", "Adult", "Adult", "Gut", "Digestive System"], [68348, "SRR17714691", "SRX13877718", "SRS11747890", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. In addition  to clarify the splenic phenotype of the Syngnathidaes  the transcriptomic profiles of the S. biaculeatus spleens and the H. erectus small white organ were also sampled and sequenced.", null, null, null, null, "WT in 1", null, "strain:AB type|isolate:wild type|breed:WT in 1|age:3 month|dev stage:NA|sex:NA|tissue:intestine|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "WT in 1", "WT in 1", "RNA seq", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP356388", null, "loader:fastq load.py", "Daniorerio_WT-in-1_good_1.fq.gz Daniorerio_WT-in-1_good_2.fq.gz", "fastq fastq", 6846412620.0, 22924105.0, "Daniorerio WT in 1 good 1.fq.gz", "0:149.33 1:149.33", "A:1885463202;C:1523755204;G:1559518207;T:1877335306;N:340701", 149, 149, null, null, 1885463202, 1523755204, 1559518207, 1877335306, 340701, "SRX13877718", "SRS11747890", "SRA1360632", "South China Sea Institute of Oceanology|CAS Key Laboratory of Tropical Marine Bio-Resource", "South China Sea Institute of Oceanology", 2, 0.92598, 0.92418, 0.11749, 0.1172, 0.7124, 0.71287, 0.52007, 0.52208, 150, 150, "B", "B", "biological fallback assumption", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2022-01-27", "Adult", "Adult", "Gut", "Digestive System"], [68362, "SRR17714705", "SRX13877704", "SRS11747876", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. In addition  to clarify the splenic phenotype of the Syngnathidaes  the transcriptomic profiles of the S. biaculeatus spleens and the H. erectus small white organ were also sampled and sequenced.", null, null, null, null, "MU in 4", null, "strain:AB type|isolate:point mutation|breed:MU in 4|age:3 month|dev stage:NA|sex:NA|tissue:intestine|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "MU in 4", "MU in 4", "RNA seq", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP356388", null, "loader:fastq load.py", "Daniorerio_MU-in-4_good_1.fq.gz Daniorerio_MU-in-4_good_2.fq.gz", "fastq fastq", 6981292910.0, 23353513.0, "Daniorerio MU in 4 good 1.fq.gz", "0:149.47 1:149.47", "A:1918651893;C:1556487274;G:1587959315;T:1917844487;N:349941", 149, 149, null, null, 1918651893, 1556487274, 1587959315, 1917844487, 349941, "SRX13877704", "SRS11747876", "SRA1360632", "South China Sea Institute of Oceanology|CAS Key Laboratory of Tropical Marine Bio-Resource", "South China Sea Institute of Oceanology", 2, 0.90619, 0.90539, 0.10392, 0.10257, 0.72581, 0.7262, 0.50279, 0.51648, 115, 115, "B", "B", "biological fallback assumption", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2022-01-27", "Adult", "Adult", "Gut", "Digestive System"], [68363, "SRR17714706", "SRX13877703", "SRS11747877", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. In addition  to clarify the splenic phenotype of the Syngnathidaes  the transcriptomic profiles of the S. biaculeatus spleens and the H. erectus small white organ were also sampled and sequenced.", null, null, null, null, "MU in 3", null, "strain:AB type|isolate:point mutation|breed:MU in 3|age:3 month|dev stage:NA|sex:NA|tissue:intestine|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "MU in 3", "MU in 3", "RNA seq", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "PAIRED", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP356388", null, "loader:fastq load.py", "Daniorerio_MU-in-3_good_1.fq.gz Daniorerio_MU-in-3_good_2.fq.gz", "fastq fastq", 6927732356.0, 23196580.0, "Daniorerio MU in 3 good 1.fq.gz", "0:149.33 1:149.33", "A:1882979804;C:1564547441;G:1599806601;T:1880055787;N:342723", 149, 149, null, null, 1882979804, 1564547441, 1599806601, 1880055787, 342723, "SRX13877703", "SRS11747877", "SRA1360632", "South China Sea Institute of Oceanology|CAS Key Laboratory of Tropical Marine Bio-Resource", "South China Sea Institute of Oceanology", 2, 0.92662, 0.92461, 0.09213, 0.09138, 0.70325, 0.70512, 0.49198, 0.48956, 128, 128, "B", "B", "biological fallback assumption", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2022-01-27", "Adult", "Adult", "Gut", "Digestive System"], [68364, "SRR17714707", "SRX13877702", "SRS11747875", "SRP356388", "PRJNA799842", "RNA seq of CRISPR/Cas9 mediated genome editing zebrafishes; the alligator pipefish spleen and the small white organ of the lined seahorse.", "PRJNA799842", "Other", "To explore the function of the gene in spleen development  we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were caused by a missense mutation in this gene  we generated a point mutation zebrafish line by CRISPR/Cas9 mediated homologous recombination HR. RNA seq of these samples tissues brain  liver  kidney  and intestine were analyzed. 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