{"database": "metadata", "table": "run_metadata", "is_view": false, "human_description_en": "where experiment.library_selection = \"Oligo-dT\", experiment.platform = \"BGISEQ\" and tissue_curation_coarse = \"Undetermined\"", "rows": [[31825, "SRR28700412", "SRX24268115", "SRS21034395", "SRP501894", "PRJNA1100624", "Functions of Epimedin C in a zebrafish model of glucocorticoid induced osteoporosis", "PRJNA1100624", "Other", "Research indicates that Epimedin C EC  an active compound in Epimedium  offers a potential treatment for glucocorticoid induced osteoporosis GIOP. Studies on zebrafish larvae revealed that EC treatment enhances bone mineralization  increases bone mass  and improves bone density  thus mitigating bone tissue damage caused by prednisolone. Additionally  EC impacts key signaling pathways related to bone development  such as osteoclast differentiation  estrogen  MAPK  insulin resistance  PPAR  and AMPK pathways. 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null, "2con", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:2 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio :control group", "con 2", "con 2", "96hpf zebrafish larvae control group", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP346547", null, "loader:fastq load.py", "con_2_2.fq", "fastq", 3324287550.0, 22161917.0, "con 2 2.fq.gz", "0:150", "A:848766265;C:812477645;G:798995610;T:864040426;N:7604", 150, null, null, null, 848766265, 812477645, 798995610, 864040426, 7604, "SRX13156584", "SRS11088488", "SRA1329868", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.95546, null, 0.03524, null, 0.70027, null, 0.48649, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-22", "Larval", "Larval", "Undetermined", "Undetermined"], [66973, "SRR16965152", "SRX13156583", "SRS11088487", "SRP346547", "PRJNA780808", "transcriptomics of carbendazim and enrofloxacin on zebrafish embryos", "PRJNA780808", "Other", "reveal a interaction between ENF and CAR on metabolic regulation during development", null, null, null, null, "1con", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:1 96hpf|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio :control group", "con 1", "con 1", "96hpf zebrafish larvae control group", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP346547", null, "loader:fastq load.py", "con_1_1.fq", "fastq", 3330724500.0, 22204830.0, "con 1 1.fq.gz", "0:150", "A:896812508;C:762246067;G:774062043;T:897597946;N:5936", 150, null, null, null, 896812508, 762246067, 774062043, 897597946, 5936, "SRX13156583", "SRS11088487", "SRA1329868", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.94926, null, 0.08711, null, 0.66789, null, 0.48628, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-22", "Larval", "Larval", "Undetermined", "Undetermined"], [66974, "SRR16959538", "SRX13151074", "SRS11083380", "SRP346418", "PRJNA780940", "transcriptomics of difenoconazole and dimethomorph on zebrafish embryos", "PRJNA780940", "Other", "Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.", null, null, null, null, "1+mix", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:10 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : mixture group", "mix 1", "mix 1", "The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP346418", null, null, "mix1_3_2.fq.gz mix1_1_1.fq.gz", "fastq fastq", 6639699600.0, 44264664.0, "mix1 1 1.fq.gz", "0:150 1:150", "A:1738687157;C:1575344731;G:1569683716;T:1755974708;N:9288", 150, 150, null, null, 1738687157, 1575344731, 1569683716, 1755974708, 9288, "SRX13151074", "SRS11083380", "SRA1330365", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.95161, null, 0.05697, null, 0.6817, null, 0.48485, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-16", "Larval", "Larval", "Undetermined", "Undetermined"], [66975, "SRR16959539", "SRX13151073", "SRS11083379", "SRP346418", "PRJNA780940", "transcriptomics of difenoconazole and dimethomorph on zebrafish embryos", "PRJNA780940", "Other", "Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.", null, null, null, null, "2dim", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:8 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : dimethomorph group", "dim 2", "dim 2", "The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP346418", null, null, "dim_2_1.fq.gz", "fastq", 3344257500.0, 22295050.0, "dim 2 1.fq.gz", "0:150 1:0", "A:895700119;C:767415749;G:784994320;T:896143585;N:3727", 150, 0, null, null, 895700119, 767415749, 784994320, 896143585, 3727, "SRX13151073", "SRS11083379", "SRA1330365", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.9497, null, 0.08418, null, 0.66352, null, 0.49341, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-16", "Larval", "Larval", "Undetermined", "Undetermined"], [66976, "SRR16959540", "SRX13151072", "SRS11083378", "SRP346418", "PRJNA780940", "transcriptomics of difenoconazole and dimethomorph on zebrafish embryos", "PRJNA780940", "Other", "Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.", null, null, null, null, "1dim", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:7 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : dimethomorph group", "dim 1", "dim 1", "The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP346418", null, null, "dim_1_1.fq.gz", "fastq", 3318812250.0, 22125415.0, "dim 1 1.fq.gz", "0:150 1:0", "A:908481293;C:742787936;G:755930542;T:911608821;N:3658", 150, 0, null, null, 908481293, 742787936, 755930542, 911608821, 3658, "SRX13151072", "SRS11083378", "SRA1330365", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.94211, null, 0.11824, null, 0.65344, null, 0.47716, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-16", "Larval", "Larval", "Undetermined", "Undetermined"], [66977, "SRR16959541", "SRX13151071", "SRS11083377", "SRP346418", "PRJNA780940", "transcriptomics of difenoconazole and dimethomorph on zebrafish embryos", "PRJNA780940", "Other", "Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.", null, null, null, null, "3dif", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:6 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : difenoconazole group", "dif 3", "dif 3", "The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP346418", null, null, "dif_3_1.fq.gz", "fastq", 3318453000.0, 22123020.0, "dif 3 1.fq.gz", "0:150 1:0", "A:893975607;C:758489621;G:772391705;T:893592335;N:3732", 150, 0, null, null, 893975607, 758489621, 772391705, 893592335, 3732, "SRX13151071", "SRS11083377", "SRA1330365", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.94838, null, 0.08393, null, 0.66543, null, 0.4818, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-16", "Larval", "Larval", "Undetermined", "Undetermined"], [66978, "SRR16959542", "SRX13151070", "SRS11083376", "SRP346418", "PRJNA780940", "transcriptomics of difenoconazole and dimethomorph on zebrafish embryos", "PRJNA780940", "Other", "Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.", null, null, null, null, "2dif", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:5 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : difenoconazole group", "dif 2", "dif 2", "The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP346418", null, null, "dif_2_2.fq.gz", "fastq", 3304972350.0, 22033149.0, "dif 2 2.fq.gz", "0:0 1:150", "A:890456734;C:764917766;G:744757536;T:904833787;N:6527", 0, 150, null, null, 890456734, 764917766, 744757536, 904833787, 6527, "SRX13151070", "SRS11083376", "SRA1330365", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.93514, null, 0.107, null, 0.6633, null, 0.47599, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-16", "Larval", "Larval", "Undetermined", "Undetermined"], [66979, "SRR16959543", "SRX13151069", "SRS11083375", "SRP346418", "PRJNA780940", "transcriptomics of difenoconazole and dimethomorph on zebrafish embryos", "PRJNA780940", "Other", "Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.", null, null, null, null, "1dif", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:4 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : difenoconazole group", "dif 1", "dif 1", "The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP346418", null, null, "dif_1_1.fq.gz", "fastq", 3295443900.0, 21969626.0, "dif 1 1.fq.gz", "0:150 1:0", "A:887936493;C:751636494;G:765508757;T:890358629;N:3527", 150, 0, null, null, 887936493, 751636494, 765508757, 890358629, 3527, "SRX13151069", "SRS11083375", "SRA1330365", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.94623, null, 0.09138, null, 0.66478, null, 0.4828, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-16", "Larval", "Larval", "Undetermined", "Undetermined"], [66980, "SRR16959544", "SRX13151068", "SRS11083374", "SRP346418", "PRJNA780940", "transcriptomics of difenoconazole and dimethomorph on zebrafish embryos", "PRJNA780940", "Other", "Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.", null, null, null, null, "3+con", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:3 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : control group", "con 3", "con 3", "The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP346418", null, null, "con_3_1.fq.gz", "fastq", 3306406800.0, 22042712.0, "con 3 1.fq.gz", "0:150 1:0", "A:872740236;C:773482184;G:788334419;T:871846539;N:3422", 150, 0, null, null, 872740236, 773482184, 788334419, 871846539, 3422, "SRX13151068", "SRS11083374", "SRA1330365", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.95458, null, 0.06103, null, 0.67409, null, 0.48439, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-16", "Larval", "Larval", "Undetermined", "Undetermined"], [66981, "SRR16959545", "SRX13151067", "SRS11083373", "SRP346418", "PRJNA780940", "transcriptomics of difenoconazole and dimethomorph on zebrafish embryos", "PRJNA780940", "Other", "Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.", null, null, null, null, "2+mix", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:11 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : mixture group", "mix 2", "mix 2", "The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "PAIRED", "BGISEQ", "BGISEQ-500", null, "SRP346418", null, null, "mix1_2_1.fq.gz dim_3_2.fq.gz", "fastq fastq", 6589866900.0, 43932446.0, "dim 3 2.fq.gz", "0:150 1:150", "A:1782755416;C:1508342477;G:1501934674;T:1796820276;N:14057", 150, 150, null, null, 1782755416, 1508342477, 1501934674, 1796820276, 14057, "SRX13151067", "SRS11083373", "SRA1330365", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.93861, null, 0.10685, null, 0.66393, null, 0.47194, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-16", "Larval", "Larval", "Undetermined", "Undetermined"], [66982, "SRR16959546", "SRX13151066", "SRS11083372", "SRP346418", "PRJNA780940", "transcriptomics of difenoconazole and dimethomorph on zebrafish embryos", "PRJNA780940", "Other", "Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.", null, null, null, null, "2+con", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:2 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : control group", "con 2", "con 2", "The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP346418", null, null, "con_2_2.fq.gz", "fastq", 3324287550.0, 22161917.0, "con 2 2.fq.gz", "0:0 1:150", "A:848766265;C:812477645;G:798995610;T:864040426;N:7604", 0, 150, null, null, 848766265, 812477645, 798995610, 864040426, 7604, "SRX13151066", "SRS11083372", "SRA1330365", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.95548, null, 0.03524, null, 0.70021, null, 0.4867, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-16", "Larval", "Larval", "Undetermined", "Undetermined"], [66983, "SRR16959547", "SRX13151065", "SRS11083371", "SRP346418", "PRJNA780940", "transcriptomics of difenoconazole and dimethomorph on zebrafish embryos", "PRJNA780940", "Other", "Difenoconazole DIF and dimethomorph DIM are widely used pesticides frequently detected together in environmental samples  so the deleterious effects of combined exposure warrant detailed examination. In this study  the individual and combined effects of DIM and DIF on conventional developmental parameters hatch rate  deformity rate  lethality and gene expression were measured in embryonic zebrafish. Both DIF and DIM interfered with normal zebrafish embryo development  and the most sensitive toxicity index for both was 96 hpf deformity rate BMDL10 values of 0.30 and 1.10 mg/L  respectively. The combination of DIF and DIM had mainly synergistic deleterious effects on 96 hpf deformity and mortality rates. Transcriptome analysis showed that these compounds markedly downregulated expression of mcm family genes  cdk1  and cdc20  thereby potentially disrupting DNA replication and cell cycle progression. Enhanced surveillance for this pesticide combination is recommended as simultaneous environmental exposure may be substantially more harmful than exposure to either compound alone.", null, null, null, null, "1+con", null, "strain:Tu|isolate:N/A|breed:N/A|cultivar:N/A|ecotype:N/A|age:1 96h|dev stage:larvae|sex:male and female|tissue:larvae|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of Danio rerio : control group", "con 1", "con 1", "The final library was amplified with phi29 to make DNA nanoballs DNB  with more than 300 copies of one molecular.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP346418", null, null, "con_1_1.fq.gz", "fastq", 3330724500.0, 22204830.0, "con 1 1.fq.gz", "0:150 1:0", "A:896812508;C:762246067;G:774062043;T:897597946;N:5936", 150, 0, null, null, 896812508, 762246067, 774062043, 897597946, 5936, "SRX13151065", "SRS11083371", "SRA1330365", "China Agricultural University|College of animal science and technology", "China Agricultural University", 1, 0.94925, null, 0.08711, null, 0.66772, null, 0.48635, null, 150, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2021-11-16", "Larval", "Larval", "Undetermined", "Undetermined"]], "truncated": false, "filtered_table_rows_count": 38, "expanded_columns": [], "expandable_columns": [], "columns": ["rowid", "run.accession", "experiment.accession", "sample.accession", "study.accession", "bioproject", "study.title", "study.alias", "study.type", "study.abstract", "study.attributes", "study.PMIDs", "sample.description", "sample.title", "sample.alias", "sample.centername", "sample.attributes", "GEOsample.title", "GEOsample.dataprocessing", "GEOsample.source", "GEOsample.treatmentprotocol", "GEOsample.extractprotocol", "GEOsample.growthprotocol", "GEOsample.characteristics", "GEOsample.accession", "experiment.title", 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