{"database": "metadata", "table": "run_metadata", "is_view": false, "human_description_en": "where experiment.library_layout = \"SINGLE\", experiment.library_selection = \"PolyA\" and tissue_curation_coarse = \"Digestive System\"", "rows": [[62742, "SRR13360748", "SRX9785053", "SRS7972286", "SRP300470", "PRJNA689790", "Elucidating the effects of microbe derived glucans on the gut microbiota and the immune system of zebrafish", "PRJNA689790", "Other", "We present a holistic picture of soybean induced changes in the intestine of juvenile zebrafish and the effect of yeast beta glucan through a transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. 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Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "control", "control2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:controlCZ replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "CZ2", "CZ2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "cz2_S2_R1_001.fastq", "fastq", 2207708116.0, 29048791.0, "cz2 S2 R1 001.fastq", "0:76 1:0", "A:614048827;C:488071931;G:474165427;T:631372646;N:49285", 76, 0, null, null, 614048827, 488071931, 474165427, 631372646, 49285, "SRX9785043", "SRS7972276", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.93271, null, 0.12538, null, 0.71733, null, 0.53166, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [62753, "SRR13360759", "SRX9785042", "SRS7972275", "SRP300470", "PRJNA689790", "Elucidating the effects of microbe derived glucans on the gut microbiota and the immune system of zebrafish", "PRJNA689790", "Other", "We present a holistic picture of soybean induced changes in the intestine of juvenile zebrafish and the effect of yeast beta glucan through a transcriptomic approach. Dietary soybean altered the expression of specific GTP binding genes which are known to initiate inflammatory responses in the intestinal tissue. The intestinal barrier function appears to be affected by the modulation of mucin genes and genes linked to junction proteins. Furthermore  the inclusion of soybean meal affected metabolic genes that are related to oxidative stress and genes related to lipid metabolism  namely arl4ca and elovl6 in the intestinal tissue. Genes that counter inflammation were also upregulated in the soybean fed group. Our study also explains the plausible effect of yeast beta glucan on the intestinal barrier through regulation of immune responses and autophagy  and strengthening of the mucosal barrier. Our findings indicate a subdued inflammation in juvenile zebrafish fed soybean meal and a strengthened mucosal barrier in the fish fed yeast beta glucan.", null, null, null, "control", "control1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:50 days|dev stage:Juvenile|sex:not applicable|tissue:intestine|collected by:Saima Nord University|collection date:2019 11|treatment:controlCZ replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish larvae", "CZ1", "CZ1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP300470", null, null, "cz1_S1_R1_001.fastq.gz", "fastq", 2264115696.0, 29790996.0, "cz1 S1 R1 001.fastq.gz", "0:76 1:0", "A:619936364;C:496981021;G:501038961;T:646109550;N:49800", 76, 0, null, null, 619936364, 496981021, 501038961, 646109550, 49800, "SRX9785042", "SRS7972275", "SRA1180489", "Nord University|Faculty of Bioscience", "Nord University", 1, 0.93737, null, 0.1307, null, 0.73003, null, 0.55416, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-01-05", "Juvenile", "Juvenile", "Gut", "Digestive System"], [66094, "SRR15910149", "SRX12200592", "SRS10176883", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "High cholesterol", "high 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:cholesterolHC replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "HC4", "HC4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "high_5_S5_R1_001.fastq.gz", "fastq", 1878287660.0, 24877927.0, "high 5 S5 R1 001.fastq.gz", "0:75.50 1:0", "A:476823620;C:439449647;G:429501262;T:532480837;N:32294", 75, 0, null, null, 476823620, 439449647, 429501262, 532480837, 32294, "SRX12200592", "SRS10176883", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94553, null, 0.08147, null, 0.74582, null, 0.53024, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66095, "SRR15910150", "SRX12200591", "SRS10176881", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "High cholesterol", "high 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:cholesterolHC replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "HC3", "HC3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "high_4_S4_R1_001.fastq.gz", "fastq", 1888383069.0, 25020396.0, "high 4 S4 R1 001.fastq.gz", "0:75.47 1:0", "A:503511674;C:424269464;G:408669727;T:551898358;N:33846", 75, 0, null, null, 503511674, 424269464, 408669727, 551898358, 33846, "SRX12200591", "SRS10176881", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93958, null, 0.1137, null, 0.74472, null, 0.52962, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66096, "SRR15910151", "SRX12200590", "SRS10176882", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "High cholesterol", "high 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:cholesterolHC replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "HC2", "HC2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "high_3_S6_R1_001.fastq.gz", "fastq", 2337788390.0, 31029913.0, "high 3 S6 R1 001.fastq.gz", "0:75.34 1:0", "A:586705132;C:555534330;G:547485592;T:645264200;N:2799136", 75, 0, null, null, 586705132, 555534330, 547485592, 645264200, 2799136, "SRX12200590", "SRS10176882", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94651, null, 0.08395, null, 0.67872, null, 0.51496, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66097, "SRR15910152", "SRX12200589", "SRS10176880", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "High cholesterol", "high 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:cholesterolHC replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "HC1", "HC1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "high_1_S4_R1_001.fastq.gz", "fastq", 2390465384.0, 31789893.0, "high 1 S4 R1 001.fastq.gz", "0:75.20 1:0", "A:599574460;C:559752099;G:546456599;T:677639257;N:7042969", 75, 0, null, null, 599574460, 559752099, 546456599, 677639257, 7042969, "SRX12200589", "SRS10176880", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94326, null, 0.09122, null, 0.73892, null, 0.52413, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66098, "SRR15910153", "SRX12200588", "SRS10176878", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC6", "LC6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_6_S3_R1_001.fastq.gz", "fastq", 1915028032.0, 25430699.0, "control 6 S3 R1 001.fastq.gz", "0:75.30 1:0", "A:502285547;C:435337245;G:424726824;T:549290123;N:3388293", 75, 0, null, null, 502285547, 435337245, 424726824, 549290123, 3388293, "SRX12200588", "SRS10176878", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.92666, null, 0.1269, null, 0.74968, null, 0.54447, null, 73, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66099, "SRR15910154", "SRX12200587", "SRS10176877", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC5", "LC5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_5_S2_R1_001.fastq.gz", "fastq", 2327013759.0, 30824465.0, "control 5 S2 R1 001.fastq.gz", "0:75.49 1:0", "A:590955916;C:541856449;G:529786509;T:664374176;N:40709", 75, 0, null, null, 590955916, 541856449, 529786509, 664374176, 40709, "SRX12200587", "SRS10176877", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94087, null, 0.09604, null, 0.74489, null, 0.53048, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66100, "SRR15910155", "SRX12200586", "SRS10176879", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC4", "LC4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_4_S1_R1_001.fastq.gz", "fastq", 1559648966.0, 20660136.0, "control 4 S1 R1 001.fastq.gz", "0:75.49 1:0", "A:398086562;C:359082782;G:356015350;T:446436847;N:27425", 75, 0, null, null, 398086562, 359082782, 356015350, 446436847, 27425, "SRX12200586", "SRS10176879", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93707, null, 0.10017, null, 0.73464, null, 0.52715, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66101, "SRR15910156", "SRX12200585", "SRS10176876", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS6", "SS6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_6_S15_R1_001.fastq.gz", "fastq", 2431012086.0, 32275098.0, "sim 6 S15 R1 001.fastq.gz", "0:75.32 1:0", "A:647191218;C:551606901;G:529110857;T:703050921;N:52189", 75, 0, null, null, 647191218, 551606901, 529110857, 703050921, 52189, "SRX12200585", "SRS10176876", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93331, null, 0.1165, null, 0.75268, null, 0.52753, null, 74, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66102, "SRR15910157", "SRX12200584", "SRS10176875", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS5", "SS5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_5_S14_R1_001.fastq.gz", "fastq", 1902101028.0, 25201273.0, "sim 5 S14 R1 001.fastq.gz", "0:75.48 1:0", "A:482206150;C:442300454;G:433280346;T:544280250;N:33828", 75, 0, null, null, 482206150, 442300454, 433280346, 544280250, 33828, "SRX12200584", "SRS10176875", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93441, null, 0.09457, null, 0.72431, null, 0.53047, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66103, "SRR15910158", "SRX12200583", "SRS10176874", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS4", "SS4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_4_S13_R1_001.fastq.gz", "fastq", 1887931329.0, 25021534.0, "sim 4 S13 R1 001.fastq.gz", "0:75.45 1:0", "A:483691629;C:436592360;G:424733601;T:542880751;N:32988", 75, 0, null, null, 483691629, 436592360, 424733601, 542880751, 32988, "SRX12200583", "SRS10176874", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.92435, null, 0.09393, null, 0.76039, null, 0.54018, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66104, "SRR15910159", "SRX12200582", "SRS10176873", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS3", "SS3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_3_S15_R1_001.fastq.gz", "fastq", 2278093448.0, 30193199.0, "sim 3 S15 R1 001.fastq.gz", "0:75.45 1:0", "A:575276152;C:529447047;G:521207330;T:650819961;N:1342958", 75, 0, null, null, 575276152, 529447047, 521207330, 650819961, 1342958, "SRX12200582", "SRS10176873", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94093, null, 0.087, null, 0.73876, null, 0.53488, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66105, "SRR15910160", "SRX12200581", "SRS10176872", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS2", "SS2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_2_S14_R1_001.fastq.gz", "fastq", 2543469673.0, 33741391.0, "sim 2 S14 R1 001.fastq.gz", "0:75.38 1:0", "A:667279341;C:584937962;G:562098766;T:726456492;N:2697112", 75, 0, null, null, 667279341, 584937962, 562098766, 726456492, 2697112, "SRX12200581", "SRS10176872", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93369, null, 0.11515, null, 0.72283, null, 0.51172, null, 74, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66106, "SRR15910161", "SRX12200580", "SRS10176871", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Simvastatin", "simvastatin 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:simvastatinSS replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "SS1", "SS1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "sim_1_S13_R1_001.fastq.gz", "fastq", 1663748041.0, 22080724.0, "sim 1 S13 R1 001.fastq.gz", "0:75.35 1:0", "A:424766717;C:386318148;G:378172921;T:472190364;N:2299891", 75, 0, null, null, 424766717, 386318148, 378172921, 472190364, 2299891, "SRX12200580", "SRS10176871", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93979, null, 0.08815, null, 0.74194, null, 0.52705, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66107, "SRR15910162", "SRX12200579", "SRS10176870", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG6", "OG6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_6_S12_R1_001.fastq.gz", "fastq", 1950238266.0, 25861117.0, "oat 6 S12 R1 001.fastq.gz", "0:75.41 1:0", "A:502273927;C:456918053;G:438368291;T:552640342;N:37653", 75, 0, null, null, 502273927, 456918053, 438368291, 552640342, 37653, "SRX12200579", "SRS10176870", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93318, null, 0.08879, null, 0.74901, null, 0.54257, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66108, "SRR15910163", "SRX12200578", "SRS10176869", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG5", "OG5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_5_S11_R1_001.fastq.gz", "fastq", 1818990592.0, 24148417.0, "oat 5 S11 R1 001.fastq.gz", "0:75.33 1:0", "A:460795176;C:423681740;G:415715028;T:516509914;N:2288734", 75, 0, null, null, 460795176, 423681740, 415715028, 516509914, 2288734, "SRX12200578", "SRS10176869", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93555, null, 0.09413, null, 0.73732, null, 0.54828, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66109, "SRR15910164", "SRX12200577", "SRS10176868", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG4", "OG4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_4_S10_R1_001.fastq.gz", "fastq", 1734135458.0, 22972939.0, "oat 4 S10 R1 001.fastq.gz", "0:75.49 1:0", "A:444047928;C:402248080;G:393083056;T:494726063;N:30331", 75, 0, null, null, 444047928, 402248080, 393083056, 494726063, 30331, "SRX12200577", "SRS10176868", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93619, null, 0.09257, null, 0.75635, null, 0.54807, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66110, "SRR15910165", "SRX12200576", "SRS10176867", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC3", "LC3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_3_S3_R1_001.fastq.gz", "fastq", 2544827138.0, 33810050.0, "control 3 S3 R1 001.fastq.gz", "0:75.27 1:0", "A:649235065;C:587469807;G:574700155;T:728104191;N:5317920", 75, 0, null, null, 649235065, 587469807, 574700155, 728104191, 5317920, "SRX12200576", "SRS10176867", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93445, null, 0.09084, null, 0.75471, null, 0.53891, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66111, "SRR15910166", "SRX12200575", "SRS10176866", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG3", "OG3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_3_S12_R1_001.fastq.gz", "fastq", 2676109047.0, 35499063.0, "oat 3 S12 R1 001.fastq.gz", "0:75.39 1:0", "A:668562223;C:624794464;G:608983398;T:770847910;N:2921052", 75, 0, null, null, 668562223, 624794464, 608983398, 770847910, 2921052, "SRX12200575", "SRS10176866", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.95624, null, 0.07731, null, 0.78368, null, 0.5561, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66112, "SRR15910167", "SRX12200574", "SRS10176865", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG2", "OG2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_2_S11_R1_001.fastq.gz", "fastq", 1920714201.0, 25464331.0, "oat 2 S11 R1 001.fastq.gz", "0:75.43 1:0", "A:489513738;C:448024192;G:438816907;T:542892434;N:1466930", 75, 0, null, null, 489513738, 448024192, 438816907, 542892434, 1466930, "SRX12200574", "SRS10176865", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94472, null, 0.08495, null, 0.73766, null, 0.54149, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66113, "SRR15910168", "SRX12200573", "SRS10176864", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Oat glucan", "oat 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:oatglucanOG replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "OG1", "OG1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "oat_1_S10_R1_001.fastq.gz", "fastq", 2171014631.0, 28803940.0, "oat 1 S10 R1 001.fastq.gz", "0:75.37 1:0", "A:550611852;C:504793219;G:494893735;T:618143286;N:2572539", 75, 0, null, null, 550611852, 504793219, 494893735, 618143286, 2572539, "SRX12200573", "SRS10176864", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94056, null, 0.089, null, 0.74142, null, 0.53823, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66114, "SRR15910169", "SRX12200572", "SRS10176863", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 6", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG6", "AG6", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_6_S12_R1_001.fastq.gz", "fastq", 2098747142.0, 27807858.0, "alga 6 S12 R1 001.fastq.gz", "0:75.47 1:0", "A:534561461;C:494167859;G:489052359;T:580927807;N:37656", 75, 0, null, null, 534561461, 494167859, 489052359, 580927807, 37656, "SRX12200572", "SRS10176863", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94831, null, 0.08427, null, 0.73292, null, 0.52842, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66115, "SRR15910170", "SRX12200571", "SRS10176862", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG5", "AG5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_5_S11_R1_001.fastq.gz", "fastq", 1763481116.0, 23363097.0, "alga 5 S11 R1 001.fastq.gz", "0:75.48 1:0", "A:447338889;C:412970655;G:414050708;T:489089552;N:31312", 75, 0, null, null, 447338889, 412970655, 414050708, 489089552, 31312, "SRX12200571", "SRS10176862", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94349, null, 0.08062, null, 0.739, null, 0.52999, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66116, "SRR15910171", "SRX12200570", "SRS10176861", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 4", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG4", "AG4", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_4_S10_R1_001.fastq.gz", "fastq", 1879826054.0, 24897114.0, "alga 4 S10 R1 001.fastq.gz", "0:75.50 1:0", "A:470066955;C:443235235;G:435473614;T:531017855;N:32395", 75, 0, null, null, 470066955, 443235235, 435473614, 531017855, 32395, "SRX12200570", "SRS10176861", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94546, null, 0.09326, null, 0.65845, null, 0.52459, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66117, "SRR15910172", "SRX12200569", "SRS10176858", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 3", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG3", "AG3", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_3_S12_R1_001.fastq.gz", "fastq", 2171152050.0, 28804773.0, "alga 3 S12 R1 001.fastq.gz", "0:75.37 1:0", "A:577878327;C:486896436;G:474333381;T:629132016;N:2911890", 75, 0, null, null, 577878327, 486896436, 474333381, 629132016, 2911890, "SRX12200569", "SRS10176858", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.9263, null, 0.13343, null, 0.74308, null, 0.54791, null, 74, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66118, "SRR15910173", "SRX12200568", "SRS10176857", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG2", "AG2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_2_S11_R1_001.fastq.gz", "fastq", 2667876981.0, 35347747.0, "alga 2 S11 R1 001.fastq.gz", "0:75.48 1:0", "A:608681566;C:714247949;G:658536241;T:684669115;N:1742110", 75, 0, null, null, 608681566, 714247949, 658536241, 684669115, 1742110, "SRX12200568", "SRS10176857", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.9577, null, 0.13465, null, 0.77425, null, 0.60177, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66119, "SRR15910174", "SRX12200567", "SRS10176859", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Algal glucan", "alga 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:algalglucanAG replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "AG1", "AG1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "alga_1_S10_R_001.fastq.gz", "fastq", 2947209259.0, 39094391.0, "alga 1 S10 R 001.fastq.gz", "0:75.39 1:0", "A:769302900;C:671912702;G:657628697;T:845634633;N:2730327", 75, 0, null, null, 769302900, 671912702, 657628697, 845634633, 2730327, "SRX12200567", "SRS10176859", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93867, null, 0.08991, null, 0.74272, null, 0.53283, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66120, "SRR15910175", "SRX12200566", "SRS10176855", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "High cholesterol", "high 5", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:cholesterolHC replicate5|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "HC5", "HC5", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "high_6_S6_R1_001.fastq.gz", "fastq", 1822201784.0, 24137941.0, "high 6 S6 R1 001.fastq.gz", "0:75.49 1:0", "A:461483337;C:426648920;G:419516035;T:514521907;N:31585", 75, 0, null, null, 461483337, 426648920, 419516035, 514521907, 31585, "SRX12200566", "SRS10176855", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.94209, null, 0.09014, null, 0.74468, null, 0.50897, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66121, "SRR15910176", "SRX12200565", "SRS10176860", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 2", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate2|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC2", "LC2", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_2_S2_R1_001.fastq.gz", "fastq", 2450938234.0, 32590616.0, "control 2 S2 R1 001.fastq.gz", "0:75.20 1:0", "A:628466312;C:568472904;G:556931536;T:689980376;N:7087106", 75, 0, null, null, 628466312, 568472904, 556931536, 689980376, 7087106, "SRX12200565", "SRS10176860", "SRA1295228", "Nord University|Faculty of Biosciences and Aquaculture", "Nord University", 1, 0.93782, null, 0.10577, null, 0.73699, null, 0.52, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Norway", "2021-09-16", "Adult", "Adult", "Gut", "Digestive System"], [66122, "SRR15910177", "SRX12200564", "SRS10176856", "SRP337313", "PRJNA763718", "Management of hypercholesterolemia through dietary beta glucans in a zebrafish model", "PRJNA763718", "Other", "Consumption of lipid rich and highly processed foods can increase the cholesterol content in the blood  leading to unfavourable disease conditions. beta glucans are known to have hypocholesterolemic effect  however  subtle changes in their molecular branching can influence their bioactivity. Therefore  a comparative investigation of the cholesterol lowering potential of dietary beta glucans from oats and a microalga and simvastatin  a well known cholesterol lowering drug  was undertaken employing the zebrafish model of hypercholesterolemia.We conducted a twelve week long feeding experiment employing adult male zebrafish. The fish were allocated to 5 dietary treatments; a control group  a high cholesterol group  two beta glucan groups and a simvastatin group.The intestinal transcriptome of the zebrafish responded to dietary cholesterol  indicating the possible suppression of endogenous cholesterol biosynthesis pathways  dysfunction of both endoplasmic reticulum and mitochondria  and brought about histological changes in the intestine. The two beta glucans and simvastatin significantly mitigated the rise in plasma cholesterol levels  restored the expression of several genes and possibly alleviated the endoplasmic reticulum related effects induced by dietary cholesterol. Oat and microalgal beta glucan feeding induced distinct patterns of gene expression changes  which revealed antagonistic effect of the two beta glucans on fatty acid metabolism  protein catabolic processes and nuclear division in the intestine.", null, null, null, "Control", "control 1", null, "strain:Wild type|isolate:not applicable|breed:not applicable|cultivar:not applicable|ecotype:laboratory|age:70 weeks|dev stage:adult|sex:male|tissue:intestine|collected by:Adnan Hussain Gora|collection date:2020 09|treatment:controlLC replicate1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA Seq of zebrafish", "LC1", "LC1", "PCR enrichment of adaptor ligated DNA", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "PolyA", "SINGLE", "ILLUMINA", "NextSeq 550", null, "SRP337313", null, null, "control_1_S1_R1_001.fastq.gz", "fastq", 2784628452.0, 37009570.0, "control 1 S1 R1 001.fastq.gz", "0:75.24 1:0", 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