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sequencing", "S TOXR1832:S 96hpf 250 Par1 UHEI e", null, "TempO Seq library", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "SINGLE", "ILLUMINA", "Illumina HiSeq 2500", null, "ERP136288", "Illumina HiSeq 2500 sequencing", "ENA FIRST PUBLIC:2024 03 15|ENA LAST UPDATE:2024 03 15", "S_96hpf_250_Par1_UHEI.fastq.gz", "fastq", 96150100.0, 1923002.0, "S TOXR1832:S 96hpf 250 Par1 UHEI r", "0:50", "A:20310305;C:25128686;G:22290025;T:28408131;N:12953", 50, null, null, null, 20310305, 25128686, 22290025, 28408131, 12953, "ERX8812322", "ERS10998389", "ERA10091710", "EMBL EBI", "EMBL EBI", null, null, null, null, null, null, null, null, null, null, null, "B", null, "usable mapping rate", "illumina", "hiseq_era", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "United Kingdom", "2022-03-15", "Larval", "Larval", "Cell Line", "Cell Line"], [10645, "ERR9269912", "ERX8812309", "ERS10998375", "ERP136288", "PRJEB51641", "CS2 UHEI DART 96 120h raw data EUT053", "S-TOXR1832", "Transcriptome Analysis", null, "ENA FIRST PUBLIC:2024 03 15|ENA LAST UPDATE:2024 03 15", null, null, null, "SAMEA13395721", "University of Heidelberg", "Compound:VPA|Concentration:100.0 \u00b5M|ENA first public:2024 03 15|Exposure time:120 hpf|External Id:SAMEA13395721|Gender:null|INSDC center name:University of Heidelberg|INSDC last update:2022 03 15T10:53:12Z|INSDC status:public|Submitter Id:S TOXR1832:S 120hpf VPA100 UHEI|Treatment:repeated dose|Treatment scheme:daily|broker name:EU ToxRisk DCC|cell line:null|common name:zebrafish|sample name:S TOXR1832:S 120hpf VPA100 UHEI|scientific name:Danio rerio", null, null, null, null, null, null, null, null, "Illumina HiSeq 2500 sequencing", "S TOXR1832:S 120hpf VPA100 UHEI e", null, "TempO Seq library", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "SINGLE", "ILLUMINA", "Illumina HiSeq 2500", null, "ERP136288", "Illumina HiSeq 2500 sequencing", "ENA FIRST PUBLIC:2024 03 15|ENA LAST UPDATE:2024 03 15", "S_120hpf_VPA100_UHEI.fastq.gz", "fastq", 89459950.0, 1789199.0, "S TOXR1832:S 120hpf VPA100 UHEI r", "0:50", "A:18937857;C:23260429;G:20527346;T:26722200;N:12118", 50, null, null, null, 18937857, 23260429, 20527346, 26722200, 12118, "ERX8812309", "ERS10998375", "ERA10091710", "EMBL EBI", "EMBL EBI", null, null, null, null, null, null, null, null, null, null, null, "B", null, "usable mapping rate", "illumina", "hiseq_era", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "United Kingdom", "2022-03-15", "Larval", "Larval", "Cell Line", "Cell Line"], [10648, "ERR9269921", "ERX8812318", "ERS10998384", "ERP136288", "PRJEB51641", "CS2 UHEI DART 96 120h raw data EUT053", "S-TOXR1832", "Transcriptome Analysis", null, "ENA FIRST PUBLIC:2024 03 15|ENA LAST UPDATE:2024 03 15", null, null, null, "SAMEA13395730", "University of Heidelberg", "Compound:VPA|Concentration:2.0 \u00b5M|ENA first public:2024 03 15|Exposure time:120 hpf|External Id:SAMEA13395730|Gender:null|INSDC center name:University of Heidelberg|INSDC last update:2022 03 15T10:53:12Z|INSDC status:public|Submitter Id:S TOXR1832:S 120hpf VPA2 UHEI|Treatment:repeated dose|Treatment scheme:daily|broker name:EU ToxRisk DCC|cell line:null|common name:zebrafish|sample name:S TOXR1832:S 120hpf VPA2 UHEI|scientific name:Danio rerio", null, null, null, null, null, null, null, null, "Illumina HiSeq 2500 sequencing", "S TOXR1832:S 120hpf VPA2 UHEI e", null, "TempO Seq library", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "SINGLE", "ILLUMINA", "Illumina HiSeq 2500", null, "ERP136288", "Illumina HiSeq 2500 sequencing", "ENA FIRST PUBLIC:2024 03 15|ENA LAST UPDATE:2024 03 15", "S_120hpf_VPA2_UHEI.fastq.gz", "fastq", 67771050.0, 1355421.0, "S TOXR1832:S 120hpf VPA2 UHEI r", "0:50", "A:14454221;C:17723386;G:15909234;T:19674975;N:9234", 50, null, null, null, 14454221, 17723386, 15909234, 19674975, 9234, "ERX8812318", "ERS10998384", "ERA10091710", "EMBL EBI", "EMBL EBI", null, null, null, null, null, null, null, null, null, null, null, "B", null, "usable mapping rate", "illumina", "hiseq_era", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "United Kingdom", "2022-03-15", "Larval", "Larval", "Cell Line", "Cell Line"], [30692, "SRR29655998", "SRX25159999", "SRS21850513", "SRP494129", "PRJNA1085664", "Human norovirus replicates in macrophages migrating to intestinal tissues and changes their transcriptional profile", "GSE261163", "Transcriptome Analysis", "Human noroviruses HuNoVs are a major cause of diarrheal disease  yet critical aspects of their biology  including cellular tropism  remain unclear. While research traditionally focused on the intestinal epithelium  the hypothesis that HuNoV infects macrophages has been recurrently discussed and is investigated here by a zebrafish larval model. Our study reveals that HuNoV capsid proteins and double stranded RNA colocalize within intestinal macrophages of infected zebrafish larvae  while the negative strand RNA intermediate was detected within FACS sorted macrophages. Flow cytometry confirms viral replication within these macrophages  constituting 9% of HuNoV?s host cells. Single cell RNA sequencing reaffirms their role in viral replication  as all three open reading frames were mapped to individual macrophages. Yet  macrophages were not required for productive infection given the limited changes in viral loads upon their absence. Identifying macrophages as host cells prompts a reevaluation of their role in HuNoV pathogenesis  offering new directions for understanding and controlling this infection. Overall design: Intestines of uninfected and HuNoV infected zebrafish larvae were dissected and subjected to the preparation of a single cell suspension that was analyzed using scRNAseq. Subsequently  an additional sample was analyzed on FACS sorted macrophages of HuNoV infected zebrafish larvae.", null, "pubmed:39584740", null, "GC145382 HuNoV infected  replicate 1  scRNAseq", "GSM8370069", null, "tissue:Tg mpeg:mCherry|cell line:Tg mpeg:mCherry|cell type:120 hpf|infection:HuNoV infected|geo loc name:missing|collection date:missing", "GC145382 HuNoV infected  replicate 1  scRNAseq", "Cell Ranger v3.0 10X Genomics  Pleasanton  California  USA was used for single cell analysis to demultiplex raw base call files from Illumina sequencing and to align reads to both the zebrafish reference genome Ensembl GRCz11.106 and the HuNoV reference genome Genbank JX459908.1. Cell Ranger output matrices were analyzed using the Seurat R package version 3.1 in RStudio. Assembly: hg38 Supplementary files format and content: Count Matrix Cell Ranger", "Tg mpeg:mCherry", null, "Intestinal tissues were manually dissected and subjected to dissociation using 1mg/mL collagenase  40 \u00b5g/mL proteinase K  0.25% trypsin for 40 min at 37\u00b0C. Cells were resuspended in 0.04% BSA and live cells were selected via Optiprep density gradient according to the manufacterer's protocol. The single cell suspensions were immediately subjected to the 10X Genomics Chromium Controller with Chromium Single Cell 3\u2032 Library & Gel Bead Kit v3.1. Libraries were constructed according to 10X Genomics Chromium Single Cell 3\u2019Library & Gel Bead Kit v3 protocol.", null, "cell line:Tg mpeg:mCherry|cell type:120 hpf|infection:HuNoV infected", "GSM8370069", "GSM8370069: GC145382 HuNoV infected  replicate 1  scRNAseq; Danio rerio; RNA Seq", "GSM8370069 r1", "GSM8370069", "1", "Intestinal tissues were manually dissected and subjected to dissociation using 1mg/mL collagenase  40 \u00b5g/mL proteinase K  0.25% trypsin for 40 min at 37\u00b0C. Cells were resuspended in 0.04% BSA and live cells were selected via Optiprep density gradient according to the manufacterer's protocol. The single cell suspensions were immediately subjected to the 10X Genomics Chromium Controller with Chromium Single Cell 3\u2032 Library & Gel Bead Kit v3.1. Libraries were constructed according to 10X Genomics Chromium Single Cell three primeLibrary & Gel Bead Kit v3 protocol.", null, "RNA-Seq", "TRANSCRIPTOMIC SINGLE CELL", "cDNA", "PAIRED", "ILLUMINA", "Illumina NovaSeq 6000", null, "SRP494129", null, null, "GC145382_SI-GA-B1_S1_L001_R1_001.fastq.gz GC145382_SI-GA-B1_S1_L001_R2_001.fastq.gz", "fastq fastq", 5781664526.0, 48997157.0, "GSM8370069 r1", "0:28 1:90", "A:1659071356;C:1268706433;G:1342749232;T:1510681009;N:456496", 28, 90, null, null, 1659071356, 1268706433, 1342749232, 1510681009, 456496, "SRX25159999", "SRS21850513", "SRA1913292", "Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Rega Institute", "Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Rega Institute", null, null, null, null, null, null, null, null, null, null, null, "T", "B", "sc-like readlen", "illumina", "novaseq_era", "unknown", "cdna_unspecified", "unknown", "sc", "single_cell_droplet", "10x", null, "Belgium", "2024-06-30", "Larval", "Larval", "Cell Line", "Cell Line"], [30693, "SRR29655999", "SRX25159999", "SRS21850513", "SRP494129", "PRJNA1085664", "Human norovirus replicates in macrophages migrating to intestinal tissues and changes their transcriptional profile", "GSE261163", "Transcriptome Analysis", "Human noroviruses HuNoVs are a major cause of diarrheal disease  yet critical aspects of their biology  including cellular tropism  remain unclear. While research traditionally focused on the intestinal epithelium  the hypothesis that HuNoV infects macrophages has been recurrently discussed and is investigated here by a zebrafish larval model. Our study reveals that HuNoV capsid proteins and double stranded RNA colocalize within intestinal macrophages of infected zebrafish larvae  while the negative strand RNA intermediate was detected within FACS sorted macrophages. Flow cytometry confirms viral replication within these macrophages  constituting 9% of HuNoV?s host cells. Single cell RNA sequencing reaffirms their role in viral replication  as all three open reading frames were mapped to individual macrophages. Yet  macrophages were not required for productive infection given the limited changes in viral loads upon their absence. Identifying macrophages as host cells prompts a reevaluation of their role in HuNoV pathogenesis  offering new directions for understanding and controlling this infection. Overall design: Intestines of uninfected and HuNoV infected zebrafish larvae were dissected and subjected to the preparation of a single cell suspension that was analyzed using scRNAseq. Subsequently  an additional sample was analyzed on FACS sorted macrophages of HuNoV infected zebrafish larvae.", null, "pubmed:39584740", null, "GC145382 HuNoV infected  replicate 1  scRNAseq", "GSM8370069", null, "tissue:Tg mpeg:mCherry|cell line:Tg mpeg:mCherry|cell type:120 hpf|infection:HuNoV infected|geo loc name:missing|collection date:missing", "GC145382 HuNoV infected  replicate 1  scRNAseq", "Cell Ranger v3.0 10X Genomics  Pleasanton  California  USA was used for single cell analysis to demultiplex raw base call files from Illumina sequencing and to align reads to both the zebrafish reference genome Ensembl GRCz11.106 and the HuNoV reference genome Genbank JX459908.1. Cell Ranger output matrices were analyzed using the Seurat R package version 3.1 in RStudio. Assembly: hg38 Supplementary files format and content: Count Matrix Cell Ranger", "Tg mpeg:mCherry", null, "Intestinal tissues were manually dissected and subjected to dissociation using 1mg/mL collagenase  40 \u00b5g/mL proteinase K  0.25% trypsin for 40 min at 37\u00b0C. Cells were resuspended in 0.04% BSA and live cells were selected via Optiprep density gradient according to the manufacterer's protocol. The single cell suspensions were immediately subjected to the 10X Genomics Chromium Controller with Chromium Single Cell 3\u2032 Library & Gel Bead Kit v3.1. Libraries were constructed according to 10X Genomics Chromium Single Cell 3\u2019Library & Gel Bead Kit v3 protocol.", null, "cell line:Tg mpeg:mCherry|cell type:120 hpf|infection:HuNoV infected", "GSM8370069", "GSM8370069: GC145382 HuNoV infected  replicate 1  scRNAseq; Danio rerio; RNA Seq", "GSM8370069 r1", "GSM8370069", "1", "Intestinal tissues were manually dissected and subjected to dissociation using 1mg/mL collagenase  40 \u00b5g/mL proteinase K  0.25% trypsin for 40 min at 37\u00b0C. Cells were resuspended in 0.04% BSA and live cells were selected via Optiprep density gradient according to the manufacterer's protocol. The single cell suspensions were immediately subjected to the 10X Genomics Chromium Controller with Chromium Single Cell 3\u2032 Library & Gel Bead Kit v3.1. Libraries were constructed according to 10X Genomics Chromium Single Cell three primeLibrary & Gel Bead Kit v3 protocol.", null, "RNA-Seq", "TRANSCRIPTOMIC SINGLE CELL", "cDNA", "PAIRED", "ILLUMINA", "Illumina NovaSeq 6000", null, "SRP494129", null, null, "GC145382_SI-GA-B1_S1_L002_R1_001.fastq.gz GC145382_SI-GA-B1_S1_L002_R2_001.fastq.gz", "fastq fastq", 6046508328.0, 51241596.0, "GSM8370069 r2", "0:28 1:90", "A:1731027394;C:1330440539;G:1408717533;T:1575870623;N:452239", 28, 90, null, null, 1731027394, 1330440539, 1408717533, 1575870623, 452239, "SRX25159999", "SRS21850513", "SRA1913292", "Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Rega Institute", "Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Rega Institute", null, null, null, null, null, null, null, null, null, null, null, "T", "B", "sc-like readlen", "illumina", "novaseq_era", "unknown", "cdna_unspecified", "unknown", "sc", "single_cell_droplet", "10x", null, "Belgium", "2024-06-30", "Larval", "Larval", "Cell Line", "Cell Line"], [32865, "SRR29488925", "SRX24999628", "SRS21700588", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "DKO5", "GSM8343040", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:DKO|geo loc name:missing|collection date:missing", "DKO5", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:DKO", "GSM8343040", "GSM8343040: DKO5; Danio rerio; RNA Seq", "GSM8343040 r1", "GSM8343040", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "DKO5_1.fq.gz DKO5_2.fq.gz", "fastq fastq", 4813408600.0, 24067043.0, "GSM8343040 r1", "0:100 1:100", "A:1302917202;C:1105312585;G:1123058369;T:1282120444;N:0", 100, 100, null, null, 1302917202, 1105312585, 1123058369, 1282120444, 0, "SRX24999628", "SRS21700588", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32866, "SRR29488926", "SRX24999627", "SRS21700587", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "DKO4", "GSM8343039", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:DKO|geo loc name:missing|collection date:missing", "DKO4", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:DKO", "GSM8343039", "GSM8343039: DKO4; Danio rerio; RNA Seq", "GSM8343039 r1", "GSM8343039", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "DKO4_1.fq.gz DKO4_2.fq.gz", "fastq fastq", 4825860200.0, 24129301.0, "GSM8343039 r1", "0:100 1:100", "A:1303584214;C:1108617528;G:1131675283;T:1281983175;N:0", 100, 100, null, null, 1303584214, 1108617528, 1131675283, 1281983175, 0, "SRX24999627", "SRS21700587", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32867, "SRR29488927", "SRX24999626", "SRS21700586", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "DKO3", "GSM8343038", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:DKO|geo loc name:missing|collection date:missing", "DKO3", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:DKO", "GSM8343038", "GSM8343038: DKO3; Danio rerio; RNA Seq", "GSM8343038 r1", "GSM8343038", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "DKO3_1.fq.gz DKO3_2.fq.gz", "fastq fastq", 4806754400.0, 24033772.0, "GSM8343038 r1", "0:100 1:100", "A:1289902978;C:1113397086;G:1131727783;T:1271726553;N:0", 100, 100, null, null, 1289902978, 1113397086, 1131727783, 1271726553, 0, "SRX24999626", "SRS21700586", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32868, "SRR29488928", "SRX24999625", "SRS21700585", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "DKO2", "GSM8343037", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:DKO|geo loc name:missing|collection date:missing", "DKO2", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:DKO", "GSM8343037", "GSM8343037: DKO2; Danio rerio; RNA Seq", "GSM8343037 r1", "GSM8343037", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "DKO2_1.fq.gz DKO2_2.fq.gz", "fastq fastq", 4805757800.0, 24028789.0, "GSM8343037 r1", "0:100 1:100", "A:1299804990;C:1103101159;G:1124220106;T:1278631545;N:0", 100, 100, null, null, 1299804990, 1103101159, 1124220106, 1278631545, 0, "SRX24999625", "SRS21700585", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32869, "SRR29488929", "SRX24999624", "SRS21700584", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "DKO1", "GSM8343036", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:DKO|geo loc name:missing|collection date:missing", "DKO1", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:DKO", "GSM8343036", "GSM8343036: DKO1; Danio rerio; RNA Seq", "GSM8343036 r1", "GSM8343036", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "DKO1_1.fq.gz DKO1_2.fq.gz", "fastq fastq", 4819172400.0, 24095862.0, "GSM8343036 r1", "0:100 1:100", "A:1296017748;C:1112321357;G:1133115185;T:1277718110;N:0", 100, 100, null, null, 1296017748, 1112321357, 1133115185, 1277718110, 0, "SRX24999624", "SRS21700584", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32870, "SRR29488930", "SRX24999623", "SRS21700583", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "GLO1KO5", "GSM8343035", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:GLO1KO|geo loc name:missing|collection date:missing", "GLO1KO5", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:GLO1KO", "GSM8343035", "GSM8343035: GLO1KO5; Danio rerio; RNA Seq", "GSM8343035 r1", "GSM8343035", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "GLO1KO5_1.fq.gz GLO1KO5_2.fq.gz", "fastq fastq", 4813614800.0, 24068074.0, "GSM8343035 r1", "0:100 1:100", "A:1289774342;C:1116099072;G:1136080400;T:1271660986;N:0", 100, 100, null, null, 1289774342, 1116099072, 1136080400, 1271660986, 0, "SRX24999623", "SRS21700583", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32871, "SRR29488931", "SRX24999622", "SRS21700582", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "GLO1KO4", "GSM8343034", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:GLO1KO|geo loc name:missing|collection date:missing", "GLO1KO4", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:GLO1KO", "GSM8343034", "GSM8343034: GLO1KO4; Danio rerio; RNA Seq", "GSM8343034 r1", "GSM8343034", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "GLO1KO4_1.fq.gz GLO1KO4_2.fq.gz", "fastq fastq", 4805954200.0, 24029771.0, "GSM8343034 r1", "0:100 1:100", "A:1288997011;C:1113616764;G:1132409574;T:1270930851;N:0", 100, 100, null, null, 1288997011, 1113616764, 1132409574, 1270930851, 0, "SRX24999622", "SRS21700582", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32872, "SRR29488932", "SRX24999621", "SRS21700581", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "GLO1KO3", "GSM8343033", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:GLO1KO|geo loc name:missing|collection date:missing", "GLO1KO3", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:GLO1KO", "GSM8343033", "GSM8343033: GLO1KO3; Danio rerio; RNA Seq", "GSM8343033 r1", "GSM8343033", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "GLO1KO3_1.fq.gz GLO1KO3_2.fq.gz", "fastq fastq", 4817965600.0, 24089828.0, "GSM8343033 r1", "0:100 1:100", "A:1290593290;C:1118086028;G:1134064137;T:1275222145;N:0", 100, 100, null, null, 1290593290, 1118086028, 1134064137, 1275222145, 0, "SRX24999621", "SRS21700581", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32873, "SRR29488933", "SRX24999620", "SRS21700580", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "GLO1KO2", "GSM8343032", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:GLO1KO|geo loc name:missing|collection date:missing", "GLO1KO2", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:GLO1KO", "GSM8343032", "GSM8343032: GLO1KO2; Danio rerio; RNA Seq", "GSM8343032 r1", "GSM8343032", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "GLO1KO2_1.fq.gz GLO1KO2_2.fq.gz", "fastq fastq", 4805999000.0, 24029995.0, "GSM8343032 r1", "0:100 1:100", "A:1293609489;C:1109265811;G:1128786421;T:1274337279;N:0", 100, 100, null, null, 1293609489, 1109265811, 1128786421, 1274337279, 0, "SRX24999620", "SRS21700580", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32874, "SRR29488934", "SRX24999619", "SRS21700579", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "GLO1KO1", "GSM8343031", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:GLO1KO|geo loc name:missing|collection date:missing", "GLO1KO1", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:GLO1KO", "GSM8343031", "GSM8343031: GLO1KO1; Danio rerio; RNA Seq", "GSM8343031 r1", "GSM8343031", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "GLO1KO1_1.fq.gz GLO1KO1_2.fq.gz", "fastq fastq", 4806768400.0, 24033842.0, "GSM8343031 r1", "0:100 1:100", "A:1286467027;C:1115478546;G:1135313631;T:1269509196;N:0", 100, 100, null, null, 1286467027, 1115478546, 1135313631, 1269509196, 0, "SRX24999619", "SRS21700579", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32875, "SRR29488935", "SRX24999618", "SRS21700578", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "ALDH3A1KO5", "GSM8343030", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:ALDH3A1KO|geo loc name:missing|collection date:missing", "ALDH3A1KO5", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:ALDH3A1KO", "GSM8343030", "GSM8343030: ALDH3A1KO5; Danio rerio; RNA Seq", "GSM8343030 r1", "GSM8343030", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "ALDH3A1KO5_1.fq.gz ALDH3A1KO5_2.fq.gz", "fastq fastq", 4811331000.0, 24056655.0, "GSM8343030 r1", "0:100 1:100", "A:1314568654;C:1091419677;G:1111494171;T:1293848498;N:0", 100, 100, null, null, 1314568654, 1091419677, 1111494171, 1293848498, 0, "SRX24999618", "SRS21700578", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32876, "SRR29488936", "SRX24999617", "SRS21700577", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "ALDH3A1KO4", "GSM8343029", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:ALDH3A1KO|geo loc name:missing|collection date:missing", "ALDH3A1KO4", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:ALDH3A1KO", "GSM8343029", "GSM8343029: ALDH3A1KO4; Danio rerio; RNA Seq", "GSM8343029 r1", "GSM8343029", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "ALDH3A1KO4_1.fq.gz ALDH3A1KO4_2.fq.gz", "fastq fastq", 4816993800.0, 24084969.0, "GSM8343029 r1", "0:100 1:100", "A:1320840277;C:1087361823;G:1108886472;T:1299905228;N:0", 100, 100, null, null, 1320840277, 1087361823, 1108886472, 1299905228, 0, "SRX24999617", "SRS21700577", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32877, "SRR29488937", "SRX24999616", "SRS21700576", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "ALDH3A1KO3", "GSM8343028", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:ALDH3A1KO|geo loc name:missing|collection date:missing", "ALDH3A1KO3", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:ALDH3A1KO", "GSM8343028", "GSM8343028: ALDH3A1KO3; Danio rerio; RNA Seq", "GSM8343028 r1", "GSM8343028", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "ALDH3A1KO3_1.fq.gz ALDH3A1KO3_2.fq.gz", "fastq fastq", 4828261200.0, 24141306.0, "GSM8343028 r1", "0:100 1:100", "A:1325980327;C:1088988247;G:1107987702;T:1305304924;N:0", 100, 100, null, null, 1325980327, 1088988247, 1107987702, 1305304924, 0, "SRX24999616", "SRS21700576", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32878, "SRR29488938", "SRX24999615", "SRS21700575", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "ALDH3A1KO2", "GSM8343027", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:ALDH3A1KO|geo loc name:missing|collection date:missing", "ALDH3A1KO2", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:ALDH3A1KO", "GSM8343027", "GSM8343027: ALDH3A1KO2; Danio rerio; RNA Seq", "GSM8343027 r1", "GSM8343027", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "ALDH3A1KO2_1.fq.gz ALDH3A1KO2_2.fq.gz", "fastq fastq", 4806790400.0, 24033952.0, "GSM8343027 r1", "0:100 1:100", "A:1296924744;C:1110667292;G:1117161162;T:1282037202;N:0", 100, 100, null, null, 1296924744, 1110667292, 1117161162, 1282037202, 0, "SRX24999615", "SRS21700575", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32879, "SRR29488939", "SRX24999614", "SRS21700574", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "ALDH3A1KO1", "GSM8343026", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:ALDH3A1KO|geo loc name:missing|collection date:missing", "ALDH3A1KO1", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:ALDH3A1KO", "GSM8343026", "GSM8343026: ALDH3A1KO1; Danio rerio; RNA Seq", "GSM8343026 r1", "GSM8343026", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "ALDH3A1KO1_1.fq.gz ALDH3A1KO1_2.fq.gz", "fastq fastq", 4801013600.0, 24005068.0, "GSM8343026 r1", "0:100 1:100", "A:1307355551;C:1094613295;G:1111765622;T:1287279132;N:0", 100, 100, null, null, 1307355551, 1094613295, 1111765622, 1287279132, 0, "SRX24999614", "SRS21700574", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32880, "SRR29488940", "SRX24999613", "SRS21700573", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "WT5", "GSM8343025", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:WT|geo loc name:missing|collection date:missing", "WT5", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:WT", "GSM8343025", "GSM8343025: WT5; Danio rerio; RNA Seq", "GSM8343025 r1", "GSM8343025", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "WT5_1.fq.gz WT5_2.fq.gz", "fastq fastq", 4820580400.0, 24102902.0, "GSM8343025 r1", "0:100 1:100", "A:1288306977;C:1120287477;G:1138943028;T:1273042918;N:0", 100, 100, null, null, 1288306977, 1120287477, 1138943028, 1273042918, 0, "SRX24999613", "SRS21700573", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32881, "SRR29488941", "SRX24999612", "SRS21700572", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "WT4", "GSM8343024", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:WT|geo loc name:missing|collection date:missing", "WT4", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:WT", "GSM8343024", "GSM8343024: WT4; Danio rerio; RNA Seq", "GSM8343024 r1", "GSM8343024", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "WT4_1.fq.gz WT4_2.fq.gz", "fastq fastq", 4821144600.0, 24105723.0, "GSM8343024 r1", "0:100 1:100", "A:1275218149;C:1133748961;G:1151831603;T:1260345887;N:0", 100, 100, null, null, 1275218149, 1133748961, 1151831603, 1260345887, 0, "SRX24999612", "SRS21700572", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32882, "SRR29488942", "SRX24999611", "SRS21700571", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "WT3", "GSM8343023", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:WT|geo loc name:missing|collection date:missing", "WT3", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:WT", "GSM8343023", "GSM8343023: WT3; Danio rerio; RNA Seq", "GSM8343023 r1", "GSM8343023", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "WT3_1.fq.gz WT3_2.fq.gz", "fastq fastq", 4826072600.0, 24130363.0, "GSM8343023 r1", "0:100 1:100", "A:1278424901;C:1132200743;G:1150406212;T:1265040744;N:0", 100, 100, null, null, 1278424901, 1132200743, 1150406212, 1265040744, 0, "SRX24999611", "SRS21700571", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32883, "SRR29488943", "SRX24999610", "SRS21700570", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "WT2", "GSM8343022", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:WT|geo loc name:missing|collection date:missing", "WT2", "Raw sequence data with adapter sequences or low quality sequences was filtered. Filtered reads were aligned to the Zebrafish reference genome GRCz11 Raw counts levels were quantified using FeatureCounts v2.0.3 Assembly: GRCz11 Supplementary files format and content: tab delimited text file includes raw counts for each sample.", "larvae", null, "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:WT", "GSM8343022", "GSM8343022: WT2; Danio rerio; RNA Seq", "GSM8343022 r1", "GSM8343022", "1", "Total RNA was extracted using RNeasy Mini KitQIAGEN  3ug of total RNA was used for the construction of sequencing libraries. RNA libraries for RNA seq were prepared using DNBSEQ Eukaryotic Strand specific mRNA library.", null, "RNA-Seq", "TRANSCRIPTOMIC", "cDNA", "PAIRED", "DNBSEQ", "DNBSEQ-G400", null, "SRP515253", null, null, "WT2_1.fq.gz WT2_2.fq.gz", "fastq fastq", 4801181000.0, 24005905.0, "GSM8343022 r1", "0:100 1:100", "A:1271169177;C:1127438892;G:1145437659;T:1257135272;N:0", 100, 100, null, null, 1271169177, 1127438892, 1145437659, 1257135272, 0, "SRX24999610", "SRS21700570", "SRA1904686", "ECAS", "ECAS", null, null, null, null, null, null, null, null, null, null, null, "B", "B", "biological fallback assumption", "bgi", "bgi", "unknown", "cdna_unspecified", "unknown", "bulk", "unknown", "unknown", null, "Unknown", "2024-06-21", "Larval", "Larval", "Cell Line", "Cell Line"], [32884, "SRR29488944", "SRX24999609", "SRS21700569", "SRP515253", "PRJNA1126644", "Elevated MG H1 in glo1 / aldh3a1 /  zebrafish caused microvasculature alterations and glucose metabolism impairment via decreased proteasome activity", "GSE270442", "Transcriptome Analysis", "Dicarbonyl stress is characterized by the abnormal accumulation of dicarbonyl reactive metabolites  leading to increased modification of proteins  DNA and lipids  thereby contributing to cellular and tissue dysfunction in diabetes  diabetic complications and other diseases. glo1 knockout zebrafish exhibited moderately increased MG levels  yet this was inadequate to induce trunk vessels alterations due to elevated ALDH activity and mRNA expression levels  which partially act as compensatory mechanism. Excess 4 HNE induced pancreas dysfunction in aldh3a1 knockout zebrafish larvae  inhibiting insulin expression and thereby facilitating hyperglycemia and hyaloid vasculature alterations. To evaluate the combined function of Glo1 and Aldh3a1 in glucose homeostasis and diabetic microvasculature  glo1 / aldh3a1 /   zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish. glo1 / aldh3a1 /  zebrafish larvae displayed angiogenic hyaloid vasculature caused by the elevated MG H1 and decreased proteasomal chymotrypsin like activity  which could be rescued by the MG H1 scavenger L carnosine and proteasome activator Betulinic acid treatments. In adult glo1 / aldh3a1 /  zebrafish  impaired glucose metabolism  angiogenic retina vasculature and thickened GBM were observed. Thus  our data suggested that an important upstream factor contributing to these phenomena in the context of lacking glo1 and aldh3a1 is MG H1  possibly through reduced proteasome activity. Overall design: glo1 / aldh3a1 / zebrafish were generated using CRISPR/Cas9 technology.  Multiple experiments are performed regarding vasculature alterations  glucose homeostasis  transcriptome  and metabolomics in Tgfli1:EGFP zebrafish.", null, null, null, "WT1", "GSM8343021", null, "source name:larvae|tissue:larvae|cell line:Tgfli1:EGFP|cell type:larvae|genotype:WT|geo loc name:missing|collection date:missing", "WT1", "Raw sequence data with adapter sequences or low quality sequences was filtered. 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Due to its high water solubility and more negative reports on aquatic organisms in recent yrs  it is necessary to further study its environment.Zebrafish as an in vivo research model has its unique advantages in evaluating drug toxicity and safety as it can efficiently evaluate multiple organ toxicities at the same time. In this study  the PTA exposed and Control zebrafish larvae were collected at xxxdpf for each group of 4 replicates.The sample is used for RNA seq.", null, null, "Repeat two:the PTA solution was exposed and cultured ttwo xxxdpf", "PTA", "PTA2", null, "strain:not applicable|isolate:missing|breed:missing|cultivar:not applicable|ecotype:missing|age:4dpf stage:larval phase|collection date:2024 04|geo loc name:missing|sex:missing|tissue:missing|biomaterial provider:Fish stress response and immune response Research team|birth date:missing|birth location:missing|breeding history:missing|breeding method:missing|cell line:not applicable|cell subtype:missing|cell type:missing|collected by:ChenGuo|culture collection:missing|death date:missing|disease:missing|disease stg:missing|genotype:missing|growth protocol:missing|health state:health|isolation source:missing|lat lon:missing|phenotype:missing|sample type:missing|specimen voucher:missing|store cond:missing|stud book number:missing|treatment:missing|costumer description:6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "RNA seq of zebrafish", "PTA2", "PTA2", "Use the Invitrogen TRIzol kit to extract total RNA. 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