{"database": "metadata", "table": "run_metadata", "is_view": false, "human_description_en": "where devstage_curation = \"Hatching\" and experiment.library_selection = \"Oligo-dT\"", "rows": [[25308, "SRR25793380", "SRX21515634", "SRS18742881", "SRP457465", "PRJNA1010662", "The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.", "PRJNA1010662", "Other", "Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. The loss of miR 144 leads to impaired chromatin condensation during erythrocyte maturation.", null, null, null, "RNA seq Erythrocytes miR 144    embryo", "miR 144 embryo", null, "isolate:miR 144 mutant|age:Embryo|collection date:N/A|geo loc name:N/A|sex:mixed|tissue:Blood|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Quant seq Erythrocytes miR 144 mutant Danio rerio 2 dpf replicate 3", "144 3 embryo blood", "144 3 embryo blood", "Libraries were made using QuantSeq three prime mRNA Seq Library Prep Kit for IlluminaLexogen", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "Illumina NovaSeq 6000", null, "SRP457465", null, null, "DC-144EL3_S18.fastq", "fastq", 687309797.0, 17039739.0, "DC 144EL3 S18.fastq", "0:40.34", "A:159186558;C:130452893;G:155820002;T:181676510;N:60173834", 40, null, null, null, 159186558, 130452893, 155820002, 181676510, 60173834, "SRX21515634", "SRS18742881", "SRA1701831", "University of East Anglia|Biological Sciences", "University of East Anglia", 1, 0.52966, null, 0.16941, null, 0.97615, null, 0.58418, null, 61, null, "B", null, "usable mapping rate", "illumina", "novaseq_era", "3prime", "poly_a", "lexogen", "bulk", "unknown", "unknown", null, "United Kingdom", "2023-08-30", "Hatching", "Embryo", "Blood", "Hematopoietic System"], [25309, "SRR25793381", "SRX21515633", "SRS18742881", "SRP457465", "PRJNA1010662", "The miR 144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis.", "PRJNA1010662", "Other", "Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post transcriptional regulatory layer instructs the chromatin regulation level via miR 144 and its targets to orchestrate chromatin condensation during erythropoiesis. 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"United States", "2019-07-28", "Hatching", "Embryo", "Embryo Imprecise", "All anatomical structures"], [51778, "SRR9850658", "SRX6605275", "SRS5170104", "SRP216607", "PRJNA529921", "mRNA Sequencing Identifies Liver as a Potential Target Organ for Triphenyl Phosphate in Embryonic Zebrafish", "PRJNA529921", "Other", "The objectives of this study were to 1 rely on mRNA sequencing to identify pathways before and post cardiac looping 30 hpf and 48 hpf  respectively that may be impacted following exposure to 10 \u00b5M TPHP from 24 hpf 48 hpf and 2 determine whether pre treatment with 2 \u00b5M fenretinide from 24 hpf 30 hpf mitigates cardiotoxicity related pathways within embryos exposed to TPHP from xxx 48 hpf.", null, null, null, null, "TPHP 48H 3 S11 rep1", null, "strain:5D|isolate:12|dev stage:48 hpf|sex:not applicable|tissue:embryo|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "TPHP 48H 3 S11 rep1", "TPHP 48H 3 S11 rep1", "TPHP 48H 3 S11 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"PRJNA529921", "mRNA Sequencing Identifies Liver as a Potential Target Organ for Triphenyl Phosphate in Embryonic Zebrafish", "PRJNA529921", "Other", "The objectives of this study were to 1 rely on mRNA sequencing to identify pathways before and post cardiac looping 30 hpf and 48 hpf  respectively that may be impacted following exposure to 10 \u00b5M TPHP from 24 hpf 48 hpf and 2 determine whether pre treatment with 2 \u00b5M fenretinide from 24 hpf 30 hpf mitigates cardiotoxicity related pathways within embryos exposed to TPHP from xxx 48 hpf.", null, null, null, null, "VC 48H 1 S3 rep1", null, "strain:5D|isolate:7|dev stage:48 hpf|sex:not applicable|tissue:embryo|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "VC 48H 1 S3 rep1", "VC 48H 1 S3 rep1", "VC 48H 1 S3 rep1", "QuantSeq three prime mRNA Seq Library Prep Kit FWD", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "Illumina MiniSeq", null, "SRP216607", null, null, "VC-48H-1_S3_L001_R1_001-rep1.fastq.gz", "fastq", 199373608.0, 2651116.0, "VC 48H 1 S3 L001 R1 001 rep1.fastq.gz", "0:75.20 1:0", "A:62058387;C:37016205;G:51022592;T:48998357;N:278067", 75, 0, null, null, 62058387, 37016205, 51022592, 48998357, 278067, "SRX6605262", "SRS5170091", "SRA928015", "University of California, Riverside|Environmental Sciences", "University of California, Riverside", 1, 0.83767, null, 0.16453, null, 0.79243, null, 0.53282, null, 73, null, "B", null, "usable mapping rate", "illumina", "miseq", "3prime", "poly_a", "lexogen", "bulk", "unknown", "unknown", null, "United States", "2019-07-28", "Hatching", "Embryo", "Embryo Imprecise", "All anatomical structures"], [51792, "SRR9850672", "SRX6605261", "SRS5170090", "SRP216607", "PRJNA529921", "mRNA Sequencing Identifies Liver as a Potential Target Organ for Triphenyl Phosphate in Embryonic Zebrafish", "PRJNA529921", "Other", "The objectives of this study were to 1 rely on mRNA sequencing to identify pathways before and post cardiac looping 30 hpf and 48 hpf  respectively that may be impacted following exposure to 10 \u00b5M TPHP from 24 hpf 48 hpf and 2 determine whether pre treatment with 2 \u00b5M fenretinide from 24 hpf 30 hpf mitigates cardiotoxicity related pathways within embryos exposed to TPHP from xxx 48 hpf.", null, null, null, null, "VC 48H 2 S8 rep1", null, "strain:5D|isolate:8|dev stage:48 hpf|sex:not applicable|tissue:embryo|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "VC 48H 2 S8 rep1", "VC 48H 2 S8 rep1", "VC 48H 2 S8 rep1", "QuantSeq three prime mRNA Seq Library Prep Kit FWD", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "Illumina MiniSeq", null, "SRP216607", null, null, "VC-48H-2_S8_L001_R1_001-rep1.fastq.gz", "fastq", 236060090.0, 3142163.0, "VC 48H 2 S8 L001 R1 001 rep1.fastq.gz", "0:75.13 1:0", "A:76374701;C:43421323;G:58231468;T:57673311;N:359287", 75, 0, null, null, 76374701, 43421323, 58231468, 57673311, 359287, "SRX6605261", "SRS5170090", "SRA928015", "University of California, Riverside|Environmental Sciences", "University of California, Riverside", 1, 0.81274, null, 0.15288, null, 0.79596, null, 0.54677, null, 76, null, "B", null, "usable mapping rate", "illumina", "miseq", "3prime", "poly_a", "lexogen", "bulk", "unknown", "unknown", null, "United States", "2019-07-28", "Hatching", "Embryo", "Embryo Imprecise", "All anatomical structures"], [51795, "SRR9850675", "SRX6605258", "SRS5170087", "SRP216607", "PRJNA529921", "mRNA Sequencing Identifies Liver as a Potential Target Organ for Triphenyl Phosphate in Embryonic Zebrafish", "PRJNA529921", "Other", "The objectives of this study were to 1 rely on mRNA sequencing to identify pathways before and post cardiac looping 30 hpf and 48 hpf  respectively that may be impacted following exposure to 10 \u00b5M TPHP from 24 hpf 48 hpf and 2 determine whether pre treatment with 2 \u00b5M fenretinide from 24 hpf 30 hpf mitigates cardiotoxicity related pathways within embryos exposed to TPHP from xxx 48 hpf.", null, null, null, null, "Fen VC 2 S2", null, "strain:5D|isolate:31|dev stage:48 hpf|sex:not applicable|tissue:embryo|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Fen VC 2 S2", "Fen VC 2 S2", "Fen VC 2 S2", "QuantSeq three prime mRNA Seq Library Prep Kit FWD", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "Illumina MiniSeq", null, "SRP216607", null, null, "Fen-VC-2_S2_L001_R1_001.fastq.gz", "fastq", 213923713.0, 2847805.0, "Fen VC 2 S2 L001 R1 001.fastq.gz", "0:75.12 1:0", "A:69793245;C:38187626;G:70282310;T:35037868;N:622664", 75, 0, null, null, 69793245, 38187626, 70282310, 35037868, 622664, "SRX6605258", "SRS5170087", "SRA928015", "University of California, Riverside|Environmental Sciences", "University of California, Riverside", 1, 0.67115, null, 0.23332, null, 0.86028, null, 0.51162, null, 76, null, "B", null, "usable mapping rate", "illumina", "miseq", "3prime", "poly_a", "lexogen", "bulk", "unknown", "unknown", null, "United States", "2019-07-28", "Hatching", "Embryo", "Embryo Imprecise", "All anatomical structures"], [51796, "SRR9850676", "SRX6605257", "SRS5170086", "SRP216607", "PRJNA529921", "mRNA Sequencing Identifies Liver as a Potential Target Organ for Triphenyl Phosphate in Embryonic Zebrafish", "PRJNA529921", "Other", "The objectives of this study were to 1 rely on mRNA sequencing to identify pathways before and post cardiac looping 30 hpf and 48 hpf  respectively that may be impacted following exposure to 10 \u00b5M TPHP from 24 hpf 48 hpf and 2 determine whether pre treatment with 2 \u00b5M fenretinide from 24 hpf 30 hpf mitigates cardiotoxicity related pathways within embryos exposed to TPHP from xxx 48 hpf.", null, null, null, null, "Fen VC 3 S7", null, "strain:5D|isolate:32|dev stage:48 hpf|sex:not applicable|tissue:embryo|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Fen VC 3 S7", "Fen VC 3 S7", "Fen VC 3 S7", "QuantSeq three prime mRNA Seq Library Prep Kit FWD", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "Illumina MiniSeq", null, "SRP216607", null, null, "Fen-VC-3_S7_L001_R1_001.fastq.gz", "fastq", 183177986.0, 2432127.0, "Fen VC 3 S7 L001 R1 001.fastq.gz", "0:75.32 1:0", "A:58937811;C:33649799;G:54160481;T:36179359;N:250536", 75, 0, null, null, 58937811, 33649799, 54160481, 36179359, 250536, "SRX6605257", "SRS5170086", "SRA928015", "University of California, Riverside|Environmental Sciences", "University of California, Riverside", 1, 0.7458, null, 0.21388, null, 0.83108, null, 0.54862, null, 75, null, "B", null, "usable mapping rate", "illumina", "miseq", "3prime", "poly_a", "lexogen", "bulk", "unknown", "unknown", null, "United States", "2019-07-28", "Hatching", "Embryo", "Embryo Imprecise", "All anatomical structures"], [51797, "SRR9850677", "SRX6605256", "SRS5170085", "SRP216607", "PRJNA529921", "mRNA Sequencing Identifies Liver as a Potential Target Organ for Triphenyl Phosphate in Embryonic Zebrafish", "PRJNA529921", "Other", "The objectives of this study were to 1 rely on mRNA sequencing to identify pathways before and post cardiac looping 30 hpf and 48 hpf  respectively that may be impacted following exposure to 10 \u00b5M TPHP from 24 hpf 48 hpf and 2 determine whether pre treatment with 2 \u00b5M fenretinide from 24 hpf 30 hpf mitigates cardiotoxicity related pathways within embryos exposed to TPHP from xxx 48 hpf.", null, null, null, null, "Fen VC 4 S1", null, "strain:5D|isolate:33|dev stage:48 hpf|sex:not applicable|tissue:embryo|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Fen VC 4 S1", "Fen VC 4 S1", "Fen VC 4 S1", "QuantSeq three prime mRNA Seq Library Prep Kit FWD", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "Illumina MiniSeq", null, "SRP216607", null, null, "Fen-VC-4_S1_L001_R1_001.fastq.gz", "fastq", 199039773.0, 2642212.0, "Fen VC 4 S1 L001 R1 001.fastq.gz", "0:75.33 1:0", "A:62965541;C:38429612;G:58610294;T:38798412;N:235914", 75, 0, null, null, 62965541, 38429612, 58610294, 38798412, 235914, "SRX6605256", "SRS5170085", "SRA928015", "University of California, Riverside|Environmental Sciences", "University of California, Riverside", 1, 0.75416, null, 0.25114, null, 0.83347, null, 0.57992, null, 76, null, "B", null, "usable mapping rate", "illumina", "miseq", "3prime", "poly_a", "lexogen", "bulk", "unknown", "unknown", null, "United States", "2019-07-28", "Hatching", "Embryo", "Embryo Imprecise", "All anatomical structures"], [51798, "SRR9850678", "SRX6605255", "SRS5170084", "SRP216607", "PRJNA529921", "mRNA Sequencing Identifies Liver as a Potential Target Organ for Triphenyl Phosphate in Embryonic Zebrafish", "PRJNA529921", "Other", "The objectives of this study were to 1 rely on mRNA sequencing to identify pathways before and post cardiac looping 30 hpf and 48 hpf  respectively that may be impacted following exposure to 10 \u00b5M TPHP from 24 hpf 48 hpf and 2 determine whether pre treatment with 2 \u00b5M fenretinide from 24 hpf 30 hpf mitigates cardiotoxicity related pathways within embryos exposed to TPHP from xxx 48 hpf.", null, null, null, null, "Fen TPHP 2 S11", null, "strain:5D|isolate:34|dev stage:48 hpf|sex:not applicable|tissue:embryo|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Fen TPHP 2 S11", "Fen TPHP 2 S11", "Fen TPHP 2 S11", "QuantSeq three prime mRNA Seq Library Prep Kit FWD", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "Illumina MiniSeq", null, "SRP216607", null, null, "Fen-TPHP-2_S11_L001_R1_001.fastq.gz", "fastq", 182345016.0, 2422305.0, "Fen TPHP 2 S11 L001 R1 001.fastq.gz", "0:75.28 1:0", "A:58172182;C:32950553;G:56399463;T:34467517;N:355301", 75, 0, null, null, 58172182, 32950553, 56399463, 34467517, 355301, "SRX6605255", "SRS5170084", "SRA928015", "University of California, Riverside|Environmental Sciences", "University of California, Riverside", 1, 0.73784, null, 0.22193, null, 0.84027, null, 0.45083, null, 76, null, "B", null, "usable mapping rate", "illumina", "miseq", "3prime", "poly_a", "lexogen", "bulk", "unknown", "unknown", null, "United States", "2019-07-28", "Hatching", "Embryo", "Embryo Imprecise", "All anatomical structures"], [55536, "SRR10532692", "SRX7216663", "SRS5719129", "SRP233258", "PRJNA591815", "Ago2 dependent processing allows miR 451 to evade the global microRNA turnover elicited during erythropoiesis", "PRJNA591815", "Other", "MicroRNAs are sequentially processed by two RNAse III enzymes  Drosha and Dicer. miR 451 is the only known miRNA whose processing bypasses Dicer and instead relies on the slicer activity of Argonaute 2 Ago2. MiR 451 is highly conserved in vertebrates and regulates erythrocyte maturation  where it becomes the most abundant miRNA. However  the basis for the non canonical biogenesis of miR 451 is unclear. In this study we tested the hypothesis that miR 144 represses Dicer in a negative feedback loop during erythropoiesis and enhances miR 451 biogenesis. Loss of miR 144 mediated Dicer repression in zebrafish embryos and human cells leads to increased canonical miRNA production and impaired miR 451 maturation.", null, null, null, null, "miR 451 mutant", null, "isolate:Lab reared|age:2 days|sex:not applicable|tissue:peripheral blood|genotype:miR 451 / |phenotype:wild type|treatment:n1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Transcriptomic profiling of peripheral blood from 2 dpf zebrafish embryos", "mRNA Mut miR 451", "mRNA Mut miR 451", "mRNA libraries were cloned from polyA+ RNA isolated from peripheral blood of 2 dpf WT and mutant zebrafish embryos according to Illumina TruSeq protocol. Libraries were cloned and sequenced at Boston University Microarray and Sequencing core.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "NextSeq 500", null, "SRP233258", null, null, "mRNA-miR-451.fastq.gz", "fastq", 7904410367.0, 104613601.0, "mRNA miR 451.fastq.gz", "0:75.56 1:0", "A:1795110678;C:2004074141;G:2113982350;T:1989843693;N:1399505", 75, 0, null, null, 1795110678, 2004074141, 2113982350, 1989843693, 1399505, "SRX7216663", "SRS5719129", "SRA1002853", "University of East Anglia|Biological Sciences", "University of East Anglia", 1, 0.97314, null, 0.03847, null, 0.81744, null, 0.4673, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "trueseq", "bulk", "unknown", "unknown", null, "United Kingdom", "2019-11-26", "Hatching", "Embryo", "Blood", "Hematopoietic System"], [55537, "SRR10532693", "SRX7216662", "SRS5719128", "SRP233258", "PRJNA591815", "Ago2 dependent processing allows miR 451 to evade the global microRNA turnover elicited during erythropoiesis", "PRJNA591815", "Other", "MicroRNAs are sequentially processed by two RNAse III enzymes  Drosha and Dicer. miR 451 is the only known miRNA whose processing bypasses Dicer and instead relies on the slicer activity of Argonaute 2 Ago2. MiR 451 is highly conserved in vertebrates and regulates erythrocyte maturation  where it becomes the most abundant miRNA. However  the basis for the non canonical biogenesis of miR 451 is unclear. In this study we tested the hypothesis that miR 144 represses Dicer in a negative feedback loop during erythropoiesis and enhances miR 451 biogenesis. Loss of miR 144 mediated Dicer repression in zebrafish embryos and human cells leads to increased canonical miRNA production and impaired miR 451 maturation.", null, null, null, null, "miR 144 mutant", null, "isolate:Lab reared|age:2 days|sex:not applicable|tissue:peripheral blood|genotype:miR 144 / |phenotype:wild type|treatment:n1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Transcriptomic profiling of peripheral blood from 2 dpf zebrafish embryos", "mRNA Mut miR 144", "mRNA Mut miR 144", "mRNA libraries were cloned from polyA+ RNA isolated from peripheral blood of 2 dpf WT and mutant zebrafish embryos according to Illumina TruSeq protocol. Libraries were cloned and sequenced at Boston University Microarray and Sequencing core.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "NextSeq 500", null, "SRP233258", null, null, "mRNA-miR-144.fastq.gz", "fastq", 21666521349.0, 286736059.0, "mRNA miR 144.fastq.gz", "0:75.56 1:0", "A:4937891523;C:5429635867;G:5884853915;T:5410789187;N:3350857", 75, 0, null, null, 4937891523, 5429635867, 5884853915, 5410789187, 3350857, "SRX7216662", "SRS5719128", "SRA1002853", "University of East Anglia|Biological Sciences", "University of East Anglia", 1, 0.97729, null, 0.02379, null, 0.84102, null, 0.45517, null, 76, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "trueseq", "bulk", "unknown", "unknown", null, "United Kingdom", "2019-11-26", "Hatching", "Embryo", "Blood", "Hematopoietic System"], [55538, "SRR10532694", "SRX7216661", "SRS5719127", "SRP233258", "PRJNA591815", "Ago2 dependent processing allows miR 451 to evade the global microRNA turnover elicited during erythropoiesis", "PRJNA591815", "Other", "MicroRNAs are sequentially processed by two RNAse III enzymes  Drosha and Dicer. miR 451 is the only known miRNA whose processing bypasses Dicer and instead relies on the slicer activity of Argonaute 2 Ago2. MiR 451 is highly conserved in vertebrates and regulates erythrocyte maturation  where it becomes the most abundant miRNA. However  the basis for the non canonical biogenesis of miR 451 is unclear. In this study we tested the hypothesis that miR 144 represses Dicer in a negative feedback loop during erythropoiesis and enhances miR 451 biogenesis. Loss of miR 144 mediated Dicer repression in zebrafish embryos and human cells leads to increased canonical miRNA production and impaired miR 451 maturation.", null, null, null, null, "wild type", null, "isolate:Lab reared|age:2 days|sex:not applicable|tissue:peripheral blood|genotype:wild type|phenotype:wild type|treatment:n1|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Transcriptomic profiling of peripheral blood from 2 dpf zebrafish embryos", "mRNA WT", "mRNA WT", "mRNA libraries were cloned from polyA+ RNA isolated from peripheral blood of 2 dpf WT and mutant zebrafish embryos according to Illumina TruSeq protocol. Libraries were cloned and sequenced at Boston University Microarray and Sequencing core.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "NextSeq 500", null, "SRP233258", null, null, "mRNA-WT.fastq.gz", "fastq", 5359234061.0, 70925969.0, "mRNA WT.fastq.gz", "0:75.56 1:0", "A:1229417939;C:1341096472;G:1448568683;T:1339375309;N:775658", 75, 0, null, null, 1229417939, 1341096472, 1448568683, 1339375309, 775658, "SRX7216661", "SRS5719127", "SRA1002853", "University of East Anglia|Biological Sciences", "University of East Anglia", 1, 0.97314, null, 0.02809, null, 0.83179, null, 0.40499, null, 75, null, "B", null, "usable mapping rate", "illumina", "nextseq", "unknown", "poly_a", "trueseq", "bulk", "unknown", "unknown", null, "United Kingdom", "2019-11-26", "Hatching", "Embryo", "Blood", "Hematopoietic System"], [57271, "SRR12577970", "SRX9064853", "SRS7314026", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ctrl 3 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 6'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ctrl 3 zebrafish", "Ctrl 3 zebrafish", "Ctrl 3 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ctrl_3_1.fq.gz", "fastq", 1061227250.0, 21224545.0, "Ctrl 3 1.fq.gz", "0:50", "A:286099732;C:241244619;G:246876865;T:287006034;N:0", 50, null, null, null, 286099732, 241244619, 246876865, 287006034, 0, "SRX9064853", "SRS7314026", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94563, null, 0.10453, null, 0.70552, null, 0.46655, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57272, "SRR12577971", "SRX9064852", "SRS7314025", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ctrl 2 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 5 prime|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ctrl 2 zebrafish", "Ctrl 2 zebrafish", "Ctrl 2 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ctrl_2_1.fq.gz", "fastq", 1058116700.0, 21162334.0, "Ctrl 2 1.fq.gz", "0:50", "A:287223905;C:238707750;G:244987559;T:287197486;N:0", 50, null, null, null, 287223905, 238707750, 244987559, 287197486, 0, "SRX9064852", "SRS7314025", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94534, null, 0.11174, null, 0.70104, null, 0.47946, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57273, "SRR12577972", "SRX9064851", "SRS7314024", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ctrl 1 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 4'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ctrl 1 zebrafish", "Ctrl 1 zebrafish", "Ctrl 1 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ctrl_1_1.fq.gz", "fastq", 1065919600.0, 21318392.0, "Ctrl 1 1.fq.gz", "0:50", "A:295920720;C:242146677;G:242962633;T:284889570;N:0", 50, null, null, null, 295920720, 242146677, 242962633, 284889570, 0, "SRX9064851", "SRS7314024", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94228, null, 0.15007, null, 0.68028, null, 0.46845, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57274, "SRR12577973", "SRX9064850", "SRS7314023", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator STS 3 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 3 prime|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator STS 3 zebrafish", "Ator STS 3 zebrafish", "Ator STS 3 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_STS_3_1.fq.gz", "fastq", 1059717350.0, 21194347.0, "Ator STS 3 1.fq.gz", "0:50", "A:287279590;C:239708340;G:245740313;T:286989107;N:0", 50, null, null, null, 287279590, 239708340, 245740313, 286989107, 0, "SRX9064850", "SRS7314023", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94345, null, 0.10458, null, 0.69686, null, 0.4755, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57275, "SRR12577974", "SRX9064849", "SRS7314022", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator STS 2 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 2'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator STS 2 zebrafish", "Ator STS 2 zebrafish", "Ator STS 2 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_STS_2_1.fq.gz", "fastq", 1057950250.0, 21159005.0, "Ator STS 2 1.fq.gz", "0:50", "A:286256354;C:238832868;G:244078781;T:288782247;N:0", 50, null, null, null, 286256354, 238832868, 244078781, 288782247, 0, "SRX9064849", "SRS7314022", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94307, null, 0.10974, null, 0.69631, null, 0.4703, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57276, "SRR12577975", "SRX9064848", "SRS7314021", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator STS 1 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 1'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator STS 1 zebrafish", "Ator STS 1 zebrafish", "Ator STS 1 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_STS_1_1.fq.gz", "fastq", 1070136700.0, 21402734.0, "Ator STS 1 1.fq.gz", "0:50", "A:297601042;C:243837062;G:243583907;T:285114689;N:0", 50, null, null, null, 297601042, 243837062, 243583907, 285114689, 0, "SRX9064848", "SRS7314021", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94665, null, 0.12219, null, 0.67953, null, 0.46393, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57277, "SRR12577976", "SRX9064847", "SRS7314020", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator 3 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 3 prime|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator 3 zebrafish", "Ator 3 zebrafish", "Ator 3 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_3_1.fq.gz", "fastq", 1058031900.0, 21160638.0, "Ator 3 1.fq.gz", "0:50", "A:285399527;C:239993172;G:245571467;T:287067734;N:0", 50, null, null, null, 285399527, 239993172, 245571467, 287067734, 0, "SRX9064847", "SRS7314020", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94536, null, 0.11052, null, 0.6957, null, 0.48195, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57278, "SRR12577977", "SRX9064846", "SRS7314019", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator 2 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 2'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator 2 zebrafish", "Ator 2 zebrafish", "Ator 2 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_2_1.fq.gz", "fastq", 1059618400.0, 21192368.0, "Ator 2 1.fq.gz", "0:50", "A:283429136;C:243023053;G:248904818;T:284261393;N:0", 50, null, null, null, 283429136, 243023053, 248904818, 284261393, 0, "SRX9064846", "SRS7314019", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94743, null, 0.09493, null, 0.70218, null, 0.475, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [57279, "SRR12577978", "SRX9064845", "SRS7314018", "SRP279881", "PRJNA612371", "Danio rerio strain:TU Raw sequence reads", "PRJNA612371", "Whole Genome Sequencing", "Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in humans. Sodium tanshinone IIA sulfonate STS is a water soluble derivative of tanshinone IIA  which is the main active ingredient of Salvia miltiorrhiza Bge known as Danshen in Chinese and has been approved as a commercial drug for treating cardiovascular disease by the China Food and Drug Administration. In our previous study  we established a HMG COA inhibitor atorvastatin Ator induced zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area  although the underlying mechanism was not fully elucidated. Therefore  in the present study  we conducted transcriptome analysis of the protective effect of STS against Ator induced cerebral hemorrhage in zebrafish using RNA Seq technology  and further clarify its underlying molecular mechanisms on HIF 1 and its regulators  i.e.  the PI3K/Akt and MAPK signaling pathways were verified by real time PCR analysis and specific pharmacological inhibitors. We are also able to show that hemoglobin  carbonic anhydrase  Na+/H+ exchanger and HIF 1 genes might be potential biomarkers of Ator induced cerebral hemorrhage in zebrafish  as well as pharmacological targets of STS. This study also provided evidence of bio markers involved in hemorrhage stroke and improved understanding of the effects of HMG COA inhibition on vascular permeability and cerebral hemorrhage.", null, null, null, null, "Ator 1 zebrafish", null, "strain:TU|isolate:not collected|breed:not collected|cultivar:not collected|ecotype:not collected|age:2dpf|dev stage:not collected|sex:not applicable|tissue:head|geo loc name:China:Shanghai|sample type:model organism|replicate:replicate=biological replicate 1'|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "Ator 1 zebrafish", "Ator 1 zebrafish", "Ator 1 zebrafish", "transcriptome", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "BGISEQ", "BGISEQ-500", null, "SRP279881", null, null, "Ator_1_1.fq.gz", "fastq", 1075695950.0, 21513919.0, "Ator 1 1.fq.gz", "0:50", "A:297768036;C:244470267;G:243768925;T:289688722;N:0", 50, null, null, null, 297768036, 244470267, 243768925, 289688722, 0, "SRX9064845", "SRS7314018", "SRA1120721", "Shanghai University of Traditional Chinese Medicine|Longhua Hospital", "Shanghai University of Traditional Chinese Medicine", 1, 0.94468, null, 0.13183, null, 0.68363, null, 0.46288, null, 50, null, "B", null, "usable mapping rate", "bgi", "bgi", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "China", "2020-09-03", "Hatching", "Embryo", "Head", "Nervous System"], [60104, "SRR12142045", "SRX8663215", "SRS6944340", "SRP269853", "PRJNA643885", "performance test of DeLTa Seq", "PRJNA643885", "Other", "This data set were used for development and performance evaluation of Direct lysate targeted RNA Seq DeLTa Seq", null, null, "RNA Seq of lysate for FigS2", null, "zebrafish lysate biological replicate 4", null, "strain:AB|age:2 days|sex:hermaphrodite|tissue:whole|sample type:lysate|fig:S2|replicate:biological replicate 4|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "DeLTa Seq", "Dre 4", "Dre 4", "cDNA was synthesized with the lysate. Non targeted RNA Seq were conducted according to Lasy Seq ver. 1.1 protocol18 https://sites.google.com/view/lasy seq/.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP269853", null, null, "DreSceMix_g004_1.fastq.gz", "fastq", 509713380.0, 9994380.0, "DreSceMix g004 1.fastq.gz", "0:51", "A:251366594;C:61585710;G:62159129;T:134578953;N:22994", 51, null, null, null, 251366594, 61585710, 62159129, 134578953, 22994, "SRX8663215", "SRS6944340", "SRA1094353", "Ryukoku university|Fauculity of Agriculture", "Ryukoku university", 1, 0.67392, null, 0.54102, null, 0.86476, null, 0.37091, null, 51, null, "B", null, "usable mapping rate", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Japan", "2020-07-03", "Hatching", "Embryo", "Undetermined", "Embryo Imprecise"], [60105, "SRR12141709", "SRX8663075", "SRS6944200", "SRP269853", "PRJNA643885", "performance test of DeLTa Seq", "PRJNA643885", "Other", "This data set were used for development and performance evaluation of Direct lysate targeted RNA Seq DeLTa Seq", null, null, "RNA Seq of lysate for FigS2", null, "zebrafish lysate biological replicate 3", null, "strain:AB|age:2 days|sex:hermaphrodite|tissue:whole|sample type:lysate|fig:S2|replicate:biological replicate 3|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "DeLTa Seq", "Dre 3", "Dre 3", "cDNA was synthesized with the lysate. Non targeted RNA Seq were conducted according to Lasy Seq ver. 1.1 protocol18 https://sites.google.com/view/lasy seq/.", null, null, "RNA-Seq", "TRANSCRIPTOMIC", "Oligo-dT", "SINGLE", "ILLUMINA", "Illumina HiSeq 2500", null, "SRP269853", null, null, "DreSceMix_g003_1.fastq.gz", "fastq", 499717482.0, 9798382.0, "DreSceMix g003 1.fastq.gz", "0:51", "A:263221073;C:56114768;G:56547079;T:123812019;N:22543", 51, null, null, null, 263221073, 56114768, 56547079, 123812019, 22543, "SRX8663075", "SRS6944200", "SRA1094353", "Ryukoku university|Fauculity of Agriculture", "Ryukoku university", 1, 0.63258, null, 0.48288, null, 0.86819, null, 0.35874, null, 51, null, "B", null, "usable mapping rate", "illumina", "hiseq_era", "unknown", "poly_a", "unknown", "bulk", "unknown", "unknown", null, "Japan", "2020-07-03", "Hatching", "Embryo", "Undetermined", "Embryo Imprecise"], [60106, "SRR12141808", "SRX8662976", "SRS6944101", "SRP269853", "PRJNA643885", "performance test of DeLTa Seq", "PRJNA643885", "Other", "This data set were used for development and performance evaluation of Direct lysate targeted RNA Seq DeLTa Seq", null, null, "RNA Seq of purified RNA from lysate for Fig.S2", null, "zebrafish purifiedRNA biological replicate 6", null, "strain:AB|age:2 days|sex:hermaphrodite|tissue:whole|sample type:purified from lysate|fig:S2|replicate:biological replicate 6|BioSampleModel:Model organism or animal", null, null, null, null, null, null, null, null, "DeLTa Seq", "Dre 12", "Dre 12", "cDNA was synthesized with the purified RNA. 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